Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HU59_LEIIN

TriTrypDb:

LINF_090021200

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HU59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.823
CLV_NRD_NRD_1	201	203	PF00675	0.704
CLV_NRD_NRD_1	248	250	PF00675	0.830
CLV_PCSK_KEX2_1	102	104	PF00082	0.524
CLV_PCSK_KEX2_1	201	203	PF00082	0.704
CLV_PCSK_KEX2_1	229	231	PF00082	0.766
CLV_PCSK_KEX2_1	248	250	PF00082	0.728
CLV_PCSK_KEX2_1	52	54	PF00082	0.596
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.547
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.685
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.596
CLV_PCSK_PC7_1	225	231	PF00082	0.675
CLV_PCSK_PC7_1	244	250	PF00082	0.726
CLV_PCSK_SKI1_1	111	115	PF00082	0.534
CLV_PCSK_SKI1_1	121	125	PF00082	0.414
DEG_APCC_DBOX_1	214	222	PF00400	0.674
DOC_PP2B_LxvP_1	40	43	PF13499	0.800
DOC_USP7_MATH_1	126	130	PF00917	0.630
DOC_USP7_MATH_1	139	143	PF00917	0.548
DOC_USP7_MATH_1	67	71	PF00917	0.642
DOC_WW_Pin1_4	175	180	PF00397	0.668
DOC_WW_Pin1_4	184	189	PF00397	0.676
DOC_WW_Pin1_4	192	197	PF00397	0.679
DOC_WW_Pin1_4	239	244	PF00397	0.664
DOC_WW_Pin1_4	253	258	PF00397	0.644
DOC_WW_Pin1_4	8	13	PF00397	0.782
LIG_14-3-3_CanoR_1	111	116	PF00244	0.503
LIG_14-3-3_CanoR_1	138	144	PF00244	0.560
LIG_14-3-3_CanoR_1	180	188	PF00244	0.735
LIG_14-3-3_CanoR_1	215	219	PF00244	0.757
LIG_14-3-3_CanoR_1	230	235	PF00244	0.588
LIG_14-3-3_CanoR_1	248	257	PF00244	0.710
LIG_14-3-3_CanoR_1	68	76	PF00244	0.566
LIG_Actin_WH2_2	217	234	PF00022	0.673
LIG_BIR_III_2	41	45	PF00653	0.591
LIG_CaM_IQ_9	95	111	PF13499	0.506
LIG_Clathr_ClatBox_1	112	116	PF01394	0.623
LIG_FHA_1	99	105	PF00498	0.408
LIG_FHA_2	112	118	PF00498	0.545
LIG_LIR_Apic_2	191	196	PF02991	0.801
LIG_SH2_CRK	193	197	PF00017	0.795
LIG_SH2_NCK_1	193	197	PF00017	0.678
LIG_SH3_1	9	15	PF00018	0.690
LIG_SH3_2	44	49	PF14604	0.591
LIG_SH3_3	40	46	PF00018	0.621
LIG_SH3_3	9	15	PF00018	0.705
LIG_SUMO_SIM_par_1	111	118	PF11976	0.625
LIG_TRAF2_1	114	117	PF00917	0.626
LIG_TRAF2_1	217	220	PF00917	0.660
MOD_CDC14_SPxK_1	11	14	PF00782	0.637
MOD_CDK_SPK_2	175	180	PF00069	0.661
MOD_CDK_SPK_2	239	244	PF00069	0.641
MOD_CDK_SPxK_1	184	190	PF00069	0.639
MOD_CDK_SPxK_1	8	14	PF00069	0.632
MOD_CDK_SPxxK_3	192	199	PF00069	0.700
MOD_CK1_1	233	239	PF00069	0.717
MOD_CK1_1	253	259	PF00069	0.466
MOD_CK1_1	54	60	PF00069	0.662
MOD_CK1_1	61	67	PF00069	0.618
MOD_CK1_1	8	14	PF00069	0.593
MOD_CK2_1	111	117	PF00069	0.547
MOD_CK2_1	214	220	PF00069	0.678
MOD_Cter_Amidation	199	202	PF01082	0.592
MOD_Cter_Amidation	50	53	PF01082	0.593
MOD_GlcNHglycan	116	120	PF01048	0.629
MOD_GlcNHglycan	15	18	PF01048	0.647
MOD_GlcNHglycan	203	206	PF01048	0.694
MOD_GlcNHglycan	238	242	PF01048	0.687
MOD_GlcNHglycan	60	63	PF01048	0.684
MOD_GlcNHglycan	64	67	PF01048	0.604
MOD_GSK3_1	111	118	PF00069	0.547
MOD_GSK3_1	180	187	PF00069	0.760
MOD_GSK3_1	210	217	PF00069	0.720
MOD_GSK3_1	230	237	PF00069	0.479
MOD_GSK3_1	249	256	PF00069	0.710
MOD_GSK3_1	54	61	PF00069	0.707
MOD_NEK2_1	115	120	PF00069	0.497
MOD_NEK2_1	5	10	PF00069	0.589
MOD_NEK2_1	98	103	PF00069	0.539
MOD_PIKK_1	105	111	PF00454	0.517
MOD_PIKK_1	210	216	PF00454	0.802
MOD_PIKK_1	250	256	PF00454	0.808
MOD_PK_1	230	236	PF00069	0.707
MOD_PKA_1	201	207	PF00069	0.762
MOD_PKA_1	248	254	PF00069	0.819
MOD_PKA_2	13	19	PF00069	0.675
MOD_PKA_2	201	207	PF00069	0.709
MOD_PKA_2	214	220	PF00069	0.678
MOD_PKA_2	224	230	PF00069	0.669
MOD_PKA_2	247	253	PF00069	0.724
MOD_PKA_2	67	73	PF00069	0.569
MOD_ProDKin_1	175	181	PF00069	0.675
MOD_ProDKin_1	184	190	PF00069	0.677
MOD_ProDKin_1	192	198	PF00069	0.679
MOD_ProDKin_1	239	245	PF00069	0.724
MOD_ProDKin_1	253	259	PF00069	0.709
MOD_ProDKin_1	8	14	PF00069	0.784
MOD_SUMO_rev_2	94	104	PF00179	0.413
TRG_DiLeu_BaEn_4	159	165	PF01217	0.533
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.760
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A2	Leptomonas seymouri	44%	97%
A0A3S5H6E8	Leishmania donovani	100%	100%
A4H5W4	Leishmania braziliensis	69%	100%
E9AMY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHN8	Leishmania major	91%	100%