HIG1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HU58_LEIIN

TriTrypDb:

LINF_090021000

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	4
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HU58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU58

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.438
CLV_NRD_NRD_1	46	48	PF00675	0.369
CLV_PCSK_FUR_1	112	116	PF00082	0.410
CLV_PCSK_KEX2_1	114	116	PF00082	0.438
CLV_PCSK_KEX2_1	46	48	PF00082	0.369
CLV_PCSK_SKI1_1	114	118	PF00082	0.351
CLV_PCSK_SKI1_1	171	175	PF00082	0.434
CLV_PCSK_SKI1_1	187	191	PF00082	0.432
DEG_MDM2_SWIB_1	78	85	PF02201	0.487
DEG_Nend_UBRbox_3	1	3	PF02207	0.703
DEG_SPOP_SBC_1	4	8	PF00917	0.609
DOC_CKS1_1	116	121	PF01111	0.374
DOC_PP4_FxxP_1	38	41	PF00568	0.492
DOC_USP7_MATH_1	4	8	PF00917	0.609
DOC_USP7_MATH_1	99	103	PF00917	0.416
DOC_WW_Pin1_4	115	120	PF00397	0.364
DOC_WW_Pin1_4	23	28	PF00397	0.556
LIG_14-3-3_CanoR_1	114	119	PF00244	0.498
LIG_14-3-3_CanoR_1	20	29	PF00244	0.601
LIG_14-3-3_CanoR_1	92	97	PF00244	0.472
LIG_APCC_Cbox_1	162	168	PF00515	0.416
LIG_FHA_1	115	121	PF00498	0.491
LIG_FHA_1	24	30	PF00498	0.550
LIG_FHA_2	6	12	PF00498	0.608
LIG_LIR_Apic_2	95	99	PF02991	0.404
LIG_LIR_Nem_3	121	126	PF02991	0.514
LIG_LIR_Nem_3	138	142	PF02991	0.317
LIG_PCNA_yPIPBox_3	101	115	PF02747	0.536
LIG_Pex14_2	78	82	PF04695	0.495
LIG_SH2_STAP1	137	141	PF00017	0.495
LIG_SH2_STAP1	65	69	PF00017	0.433
LIG_SH2_STAT5	44	47	PF00017	0.363
LIG_SH2_STAT5	65	68	PF00017	0.448
LIG_SH3_3	26	32	PF00018	0.513
MOD_CK1_1	19	25	PF00069	0.685
MOD_CK1_1	7	13	PF00069	0.609
MOD_CK2_1	156	162	PF00069	0.472
MOD_CK2_1	19	25	PF00069	0.638
MOD_CK2_1	5	11	PF00069	0.608
MOD_GlcNHglycan	144	148	PF01048	0.539
MOD_GSK3_1	114	121	PF00069	0.411
MOD_GSK3_1	15	22	PF00069	0.595
MOD_GSK3_1	3	10	PF00069	0.606
MOD_GSK3_1	88	95	PF00069	0.455
MOD_NEK2_1	126	131	PF00069	0.357
MOD_NEK2_1	156	161	PF00069	0.429
MOD_PKA_1	114	120	PF00069	0.492
MOD_PKA_2	114	120	PF00069	0.511
MOD_PKA_2	150	156	PF00069	0.410
MOD_PKA_2	19	25	PF00069	0.614
MOD_PKB_1	112	120	PF00069	0.402
MOD_Plk_4	99	105	PF00069	0.391
MOD_ProDKin_1	115	121	PF00069	0.357
MOD_ProDKin_1	23	29	PF00069	0.545
MOD_SUMO_rev_2	175	182	PF00179	0.516
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.437
TRG_ER_diArg_1	112	115	PF00400	0.465
TRG_ER_diArg_1	45	47	PF00400	0.396
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7T5	Leptomonas seymouri	65%	96%
A0A1X0NJH0	Trypanosomatidae	35%	100%
A0A3Q8IH21	Leishmania donovani	99%	100%
A0A3R7KP70	Trypanosoma rangeli	38%	100%
A4H5W3	Leishmania braziliensis	80%	100%
D0A9N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AMY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHP0	Leishmania major	94%	100%
V5BI27	Trypanosoma cruzi	38%	100%