Putative mitochondrial carrier protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein - putative

Species:

Leishmania infantum

UniProt:

A4HU49_LEIIN

TriTrypDb:

LINF_090020100

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Phosphorylation

Amastigote: 118

Expansion

Sequence features

A4HU49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU49

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	256	258	PF00675	0.717
CLV_PCSK_KEX2_1	337	339	PF00082	0.668
CLV_PCSK_KEX2_1	99	101	PF00082	0.294
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.649
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.307
DEG_SPOP_SBC_1	246	250	PF00917	0.533
DOC_ANK_TNKS_1	120	127	PF00023	0.351
DOC_CKS1_1	8	13	PF01111	0.469
DOC_CYCLIN_yCln2_LP_2	300	306	PF00134	0.541
DOC_MAPK_MEF2A_6	87	95	PF00069	0.466
DOC_PP1_RVXF_1	214	221	PF00149	0.364
DOC_PP1_RVXF_1	98	105	PF00149	0.342
DOC_PP4_FxxP_1	237	240	PF00568	0.438
DOC_USP7_MATH_1	117	121	PF00917	0.427
DOC_USP7_MATH_1	240	244	PF00917	0.568
DOC_USP7_MATH_1	268	272	PF00917	0.454
DOC_USP7_MATH_1	4	8	PF00917	0.532
DOC_WW_Pin1_4	7	12	PF00397	0.487
LIG_14-3-3_CanoR_1	188	198	PF00244	0.467
LIG_14-3-3_CanoR_1	67	71	PF00244	0.486
LIG_BIR_II_1	1	5	PF00653	0.401
LIG_BIR_III_3	1	5	PF00653	0.401
LIG_BRCT_BRCA1_1	100	104	PF00533	0.342
LIG_BRCT_BRCA1_1	151	155	PF00533	0.310
LIG_Clathr_ClatBox_1	278	282	PF01394	0.428
LIG_deltaCOP1_diTrp_1	108	113	PF00928	0.360
LIG_deltaCOP1_diTrp_1	329	334	PF00928	0.331
LIG_FHA_1	192	198	PF00498	0.504
LIG_FHA_1	27	33	PF00498	0.345
LIG_FHA_1	272	278	PF00498	0.320
LIG_FHA_1	41	47	PF00498	0.308
LIG_FHA_1	51	57	PF00498	0.541
LIG_FHA_1	8	14	PF00498	0.538
LIG_FHA_2	242	248	PF00498	0.547
LIG_LIR_Apic_2	7	11	PF02991	0.464
LIG_LIR_Gen_1	18	27	PF02991	0.477
LIG_LIR_Gen_1	329	339	PF02991	0.235
LIG_LIR_Nem_3	18	24	PF02991	0.483
LIG_LIR_Nem_3	201	207	PF02991	0.513
LIG_LIR_Nem_3	274	278	PF02991	0.315
LIG_LIR_Nem_3	329	335	PF02991	0.207
LIG_LIR_Nem_3	83	89	PF02991	0.466
LIG_PCNA_yPIPBox_3	99	110	PF02747	0.392
LIG_Pex14_1	109	113	PF04695	0.360
LIG_Pex14_1	275	279	PF04695	0.307
LIG_Pex14_2	206	210	PF04695	0.392
LIG_RPA_C_Fungi	116	128	PF08784	0.420
LIG_SH2_CRK	228	232	PF00017	0.360
LIG_SH2_CRK	307	311	PF00017	0.307
LIG_SH2_CRK	86	90	PF00017	0.300
LIG_SH2_STAP1	328	332	PF00017	0.412
LIG_SH2_STAT5	224	227	PF00017	0.321
LIG_SH3_3	233	239	PF00018	0.401
LIG_SH3_3	3	9	PF00018	0.689
LIG_SH3_3	86	92	PF00018	0.293
LIG_SUMO_SIM_anti_2	29	36	PF11976	0.442
LIG_TYR_ITIM	305	310	PF00017	0.422
LIG_UBA3_1	23	28	PF00899	0.568
LIG_UBA3_1	277	285	PF00899	0.308
LIG_UBA3_1	94	99	PF00899	0.241
MOD_CK1_1	241	247	PF00069	0.677
MOD_CK1_1	256	262	PF00069	0.443
MOD_CK1_1	271	277	PF00069	0.235
MOD_CK1_1	7	13	PF00069	0.668
MOD_CK1_1	75	81	PF00069	0.431
MOD_CK2_1	241	247	PF00069	0.697
MOD_GlcNHglycan	116	120	PF01048	0.506
MOD_GlcNHglycan	240	243	PF01048	0.684
MOD_GlcNHglycan	265	268	PF01048	0.363
MOD_GlcNHglycan	320	323	PF01048	0.366
MOD_GlcNHglycan	59	62	PF01048	0.405
MOD_GSK3_1	176	183	PF00069	0.307
MOD_GSK3_1	189	196	PF00069	0.307
MOD_GSK3_1	238	245	PF00069	0.647
MOD_GSK3_1	246	253	PF00069	0.661
MOD_GSK3_1	62	69	PF00069	0.320
MOD_N-GLC_2	260	262	PF02516	0.241
MOD_NEK2_1	27	32	PF00069	0.511
MOD_NEK2_1	310	315	PF00069	0.327
MOD_NEK2_2	193	198	PF00069	0.416
MOD_NEK2_2	280	285	PF00069	0.307
MOD_PIKK_1	176	182	PF00454	0.307
MOD_PKA_2	253	259	PF00069	0.616
MOD_PKA_2	66	72	PF00069	0.378
MOD_Plk_1	328	334	PF00069	0.412
MOD_Plk_4	151	157	PF00069	0.379
MOD_Plk_4	163	169	PF00069	0.272
MOD_Plk_4	27	33	PF00069	0.517
MOD_Plk_4	283	289	PF00069	0.388
MOD_Plk_4	295	301	PF00069	0.342
MOD_Plk_4	310	316	PF00069	0.323
MOD_Plk_4	41	47	PF00069	0.383
MOD_Plk_4	69	75	PF00069	0.336
MOD_Plk_4	81	87	PF00069	0.279
MOD_ProDKin_1	7	13	PF00069	0.630
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.343
TRG_ENDOCYTIC_2	207	210	PF00928	0.319
TRG_ENDOCYTIC_2	224	227	PF00928	0.215
TRG_ENDOCYTIC_2	228	231	PF00928	0.349
TRG_ENDOCYTIC_2	307	310	PF00928	0.305
TRG_ENDOCYTIC_2	86	89	PF00928	0.300
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2K309	Rattus norvegicus	22%	100%
A0A0N0P7X0	Leptomonas seymouri	25%	100%
A0A0N0P7Y4	Leptomonas seymouri	22%	100%
A0A0N1HX25	Leptomonas seymouri	61%	96%
A0A0N1IMA2	Leptomonas seymouri	23%	100%
A0A0S4IV98	Bodo saltans	24%	100%
A0A0S4J045	Bodo saltans	23%	96%
A0A0S4JIA4	Bodo saltans	25%	80%
A0A0S4JM95	Bodo saltans	23%	100%
A0A0S4JQI3	Bodo saltans	40%	95%
A0A0S4JR63	Bodo saltans	21%	100%
A0A1X0NFT4	Trypanosomatidae	25%	100%
A0A1X0NIA3	Trypanosomatidae	47%	99%
A0A1X0NJD2	Trypanosomatidae	26%	100%
A0A1X0NLW7	Trypanosomatidae	25%	100%
A0A1X0P4Q9	Trypanosomatidae	24%	100%
A0A3R7KGU8	Trypanosoma rangeli	25%	100%
A0A3R7N0M4	Trypanosoma rangeli	50%	98%
A0A3R7RT89	Trypanosoma rangeli	25%	100%
A0A3S5H6E6	Leishmania donovani	99%	100%
A0A3S7WTS6	Leishmania donovani	22%	100%
A0A3S7WVJ8	Leishmania donovani	21%	99%
A0A3S7WYS1	Leishmania donovani	23%	100%
A0A422NF39	Trypanosoma rangeli	24%	100%
A0PC02	Ochotona dauurica	24%	100%
A1CIF6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	22%	100%
A1CWA4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	23%	100%
A1DI57	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	25%	100%
A2ASZ8	Mus musculus	24%	73%
A2CEQ0	Danio rerio	23%	73%
A2Q9F0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	22%	100%
A2R5A0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	100%
A3LVX1	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	24%	100%
A4H5V5	Leishmania braziliensis	75%	100%
A4H8E6	Leishmania braziliensis	22%	92%
A4HWR9	Leishmania infantum	22%	100%
A4HYC8	Leishmania infantum	21%	99%
A4I163	Leishmania infantum	23%	100%
A4QNX2	Danio rerio	25%	100%
A4RPU0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	24%	100%
A5DX39	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	23%	100%
A5PJZ1	Bos taurus	23%	72%
A6RAY2	Ajellomyces capsulatus (strain NAm1 / WU24)	24%	98%
A6RF73	Ajellomyces capsulatus (strain NAm1 / WU24)	25%	100%
A6ZXL1	Saccharomyces cerevisiae (strain YJM789)	25%	100%
A7TIQ0	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	26%	100%
B0Y4J4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	23%	100%
B2VSU4	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	25%	100%
B3LH09	Saccharomyces cerevisiae (strain RM11-1a)	25%	100%
C9ZW54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZYS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
D0A5E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A728	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A9N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AMX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AQH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	95%
E9AX97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	94%
F1R4U0	Danio rerio	22%	100%
O18757	Oryctolagus cuniculus	22%	72%
O43772	Homo sapiens	24%	100%
O77792	Bos taurus	24%	100%
O94370	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
O97562	Sus scrofa	24%	100%
P04633	Rattus norvegicus	24%	100%
P10861	Bos taurus	25%	100%
P32089	Rattus norvegicus	21%	100%
P32331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P33303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P38087	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P38921	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
P53007	Homo sapiens	21%	100%
P55851	Homo sapiens	26%	100%
P56499	Rattus norvegicus	22%	100%
P56500	Rattus norvegicus	26%	100%
P56501	Mus musculus	23%	100%
P70406	Mus musculus	26%	100%
P79110	Bos taurus	22%	100%
Q07534	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q08DK7	Bos taurus	25%	100%
Q0CEN9	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	26%	100%
Q0CT66	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	25%	100%
Q0UUH1	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	24%	100%
Q0V7M4	Bos taurus	24%	73%
Q10248	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q12289	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q1DRJ3	Coccidioides immitis (strain RS)	25%	99%
Q1E7P0	Coccidioides immitis (strain RS)	26%	100%
Q1LZB3	Bos taurus	24%	100%
Q23125	Caenorhabditis elegans	25%	100%
Q27257	Caenorhabditis elegans	24%	100%
Q287T7	Danio rerio	23%	100%
Q2H608	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	24%	100%
Q2UCW8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	25%	100%
Q3MHI3	Bos taurus	23%	100%
Q3SZI5	Bos taurus	25%	100%
Q3TZX3	Mus musculus	23%	100%
Q4QA75	Leishmania major	22%	92%
Q4QF00	Leishmania major	21%	92%
Q4QHP8	Leishmania major	91%	100%
Q4WQC5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	100%
Q4X022	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q54BM3	Dictyostelium discoideum	23%	100%
Q54FE6	Dictyostelium discoideum	23%	100%
Q54S10	Dictyostelium discoideum	22%	88%
Q55E45	Dictyostelium discoideum	22%	100%
Q55E85	Dictyostelium discoideum	21%	99%
Q55GE2	Dictyostelium discoideum	24%	100%
Q59Q36	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	100%
Q5B717	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	100%
Q5HZE0	Rattus norvegicus	23%	100%
Q5R5A8	Pongo abelii	26%	100%
Q5XHA0	Xenopus tropicalis	23%	72%
Q66L49	Danio rerio	22%	72%
Q6C6I3	Yarrowia lipolytica (strain CLIB 122 / E 150)	23%	100%
Q6CNY8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	100%
Q6DHS9	Danio rerio	23%	100%
Q6FR88	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	100%
Q6GQS1	Mus musculus	24%	73%
Q6KCM7	Homo sapiens	24%	73%
Q6NUK1	Homo sapiens	21%	72%
Q6NYZ6	Danio rerio	23%	73%
Q6ZT89	Homo sapiens	25%	100%
Q74Z23	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	100%
Q75EP3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	21%	100%
Q7S2H8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	100%
Q7T0U6	Xenopus laevis	23%	72%
Q7T292	Danio rerio	23%	91%
Q7ZY36	Xenopus laevis	22%	72%
Q86AV5	Dictyostelium discoideum	23%	100%
Q86HN8	Dictyostelium discoideum	25%	78%
Q8BL03	Mus musculus	23%	100%
Q8BMD8	Mus musculus	22%	72%
Q8BW66	Mus musculus	23%	100%
Q8BZ09	Mus musculus	23%	100%
Q8HXY2	Macaca fascicularis	24%	100%
Q8N8R3	Homo sapiens	25%	100%
Q8R0Z5	Mus musculus	23%	94%
Q93XM7	Arabidopsis thaliana	23%	100%
Q96A46	Homo sapiens	24%	94%
Q96CQ1	Homo sapiens	23%	100%
Q96U08	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	98%
Q9BSK2	Homo sapiens	24%	100%
Q9BV35	Homo sapiens	26%	73%
Q9BXI2	Homo sapiens	25%	100%
Q9CA93	Arabidopsis thaliana	28%	100%
Q9DAM5	Mus musculus	24%	100%
Q9FI43	Arabidopsis thaliana	23%	70%
Q9FLS8	Arabidopsis thaliana	24%	72%
Q9LJX5	Arabidopsis thaliana	21%	98%
Q9N2J1	Canis lupus familiaris	25%	100%
Q9NYZ2	Homo sapiens	23%	100%
Q9P3T7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9P6N6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9VAY3	Drosophila melanogaster	24%	90%
Q9VM51	Drosophila melanogaster	26%	100%
Q9VQG4	Drosophila melanogaster	25%	100%
Q9W720	Danio rerio	24%	100%
Q9W725	Cyprinus carpio	23%	100%
Q9WVD5	Mus musculus	23%	100%
Q9Y619	Homo sapiens	23%	100%
Q9Z2Z6	Mus musculus	24%	100%
V5BDR1	Trypanosoma cruzi	26%	100%
V5BI33	Trypanosoma cruzi	50%	100%
V5BP20	Trypanosoma cruzi	24%	100%
V5BSW1	Trypanosoma cruzi	23%	100%
V5BVW0	Trypanosoma cruzi	26%	100%
W5PSH7	Ovis aries	25%	100%