Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bromodomain - putative

Species:

Leishmania infantum

UniProt:

A4HU48_LEIIN

TriTrypDb:

LINF_090020000

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HU48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU48

PDB structure(s): 5tck_A , 5tck_B , 5tcm_A , 5tcm_B , 5tcm_C , 6bya_A , 6bya_B , 6bya_C , 6bya_D

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.449
CLV_C14_Caspase3-7	196	200	PF00656	0.319
CLV_C14_Caspase3-7	551	555	PF00656	0.466
CLV_NRD_NRD_1	179	181	PF00675	0.441
CLV_NRD_NRD_1	201	203	PF00675	0.367
CLV_NRD_NRD_1	276	278	PF00675	0.421
CLV_NRD_NRD_1	354	356	PF00675	0.621
CLV_NRD_NRD_1	407	409	PF00675	0.402
CLV_NRD_NRD_1	422	424	PF00675	0.370
CLV_NRD_NRD_1	50	52	PF00675	0.385
CLV_PCSK_KEX2_1	179	181	PF00082	0.441
CLV_PCSK_KEX2_1	276	278	PF00082	0.421
CLV_PCSK_KEX2_1	356	358	PF00082	0.710
CLV_PCSK_KEX2_1	406	408	PF00082	0.411
CLV_PCSK_KEX2_1	422	424	PF00082	0.370
CLV_PCSK_KEX2_1	50	52	PF00082	0.348
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.710
CLV_PCSK_PC7_1	418	424	PF00082	0.464
CLV_PCSK_SKI1_1	105	109	PF00082	0.459
CLV_PCSK_SKI1_1	407	411	PF00082	0.507
DEG_APCC_DBOX_1	104	112	PF00400	0.442
DEG_APCC_DBOX_1	417	425	PF00400	0.516
DEG_APCC_DBOX_1	622	630	PF00400	0.494
DEG_SPOP_SBC_1	458	462	PF00917	0.502
DOC_CDC14_PxL_1	34	42	PF14671	0.291
DOC_CYCLIN_yCln2_LP_2	371	377	PF00134	0.569
DOC_MAPK_gen_1	241	250	PF00069	0.385
DOC_MAPK_gen_1	370	377	PF00069	0.572
DOC_MAPK_gen_1	422	428	PF00069	0.587
DOC_MAPK_gen_1	479	488	PF00069	0.396
DOC_MAPK_gen_1	620	628	PF00069	0.485
DOC_MAPK_JIP1_4	207	213	PF00069	0.295
DOC_MAPK_MEF2A_6	241	250	PF00069	0.297
DOC_MAPK_MEF2A_6	507	515	PF00069	0.562
DOC_MAPK_NFAT4_5	243	251	PF00069	0.367
DOC_PP2B_LxvP_1	127	130	PF13499	0.654
DOC_PP2B_LxvP_1	371	374	PF13499	0.600
DOC_PP2B_LxvP_1	399	402	PF13499	0.501
DOC_PP2B_LxvP_1	433	436	PF13499	0.482
DOC_SPAK_OSR1_1	580	584	PF12202	0.401
DOC_USP7_MATH_1	130	134	PF00917	0.603
DOC_USP7_MATH_1	151	155	PF00917	0.716
DOC_USP7_MATH_1	305	309	PF00917	0.771
DOC_USP7_MATH_1	312	316	PF00917	0.716
DOC_USP7_MATH_1	323	327	PF00917	0.542
DOC_USP7_MATH_1	351	355	PF00917	0.663
DOC_USP7_MATH_1	459	463	PF00917	0.634
DOC_USP7_MATH_1	470	474	PF00917	0.504
DOC_USP7_MATH_1	491	495	PF00917	0.487
DOC_USP7_MATH_1	548	552	PF00917	0.492
DOC_USP7_MATH_1	596	600	PF00917	0.510
DOC_USP7_MATH_1	615	619	PF00917	0.666
DOC_WD40_RPTOR_TOS_1	186	192	PF00400	0.486
DOC_WW_Pin1_4	1	6	PF00397	0.646
DOC_WW_Pin1_4	327	332	PF00397	0.769
DOC_WW_Pin1_4	384	389	PF00397	0.579
DOC_WW_Pin1_4	390	395	PF00397	0.491
DOC_WW_Pin1_4	436	441	PF00397	0.535
DOC_WW_Pin1_4	594	599	PF00397	0.457
LIG_14-3-3_CanoR_1	251	257	PF00244	0.365
LIG_14-3-3_CanoR_1	290	295	PF00244	0.457
LIG_14-3-3_CanoR_1	406	412	PF00244	0.599
LIG_14-3-3_CanoR_1	423	429	PF00244	0.336
LIG_Actin_WH2_2	183	200	PF00022	0.404
LIG_Actin_WH2_2	275	292	PF00022	0.368
LIG_AP2alpha_1	498	502	PF02296	0.585
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_deltaCOP1_diTrp_1	261	270	PF00928	0.373
LIG_eIF4E_1	577	583	PF01652	0.386
LIG_FHA_1	2	8	PF00498	0.583
LIG_FHA_1	253	259	PF00498	0.322
LIG_FHA_1	335	341	PF00498	0.527
LIG_FHA_1	385	391	PF00498	0.627
LIG_FHA_1	461	467	PF00498	0.524
LIG_LIR_Gen_1	261	270	PF02991	0.391
LIG_LIR_Gen_1	42	49	PF02991	0.293
LIG_LIR_Gen_1	509	520	PF02991	0.428
LIG_LIR_Gen_1	542	549	PF02991	0.488
LIG_LIR_Gen_1	572	583	PF02991	0.387
LIG_LIR_Gen_1	636	646	PF02991	0.436
LIG_LIR_Nem_3	192	197	PF02991	0.420
LIG_LIR_Nem_3	199	204	PF02991	0.291
LIG_LIR_Nem_3	261	266	PF02991	0.402
LIG_LIR_Nem_3	269	273	PF02991	0.319
LIG_LIR_Nem_3	35	40	PF02991	0.412
LIG_LIR_Nem_3	42	47	PF02991	0.267
LIG_LIR_Nem_3	509	515	PF02991	0.366
LIG_LIR_Nem_3	542	546	PF02991	0.481
LIG_LIR_Nem_3	572	578	PF02991	0.386
LIG_LIR_Nem_3	636	642	PF02991	0.432
LIG_LYPXL_yS_3	194	197	PF13949	0.291
LIG_LYPXL_yS_3	37	40	PF13949	0.291
LIG_OCRL_FandH_1	280	292	PF00620	0.345
LIG_PCNA_yPIPBox_3	251	264	PF02747	0.385
LIG_Pex14_2	498	502	PF04695	0.491
LIG_Pex14_2	581	585	PF04695	0.362
LIG_RPA_C_Fungi	604	616	PF08784	0.469
LIG_SH2_CRK	201	205	PF00017	0.319
LIG_SH2_CRK	44	48	PF00017	0.291
LIG_SH2_CRK	89	93	PF00017	0.385
LIG_SH2_NCK_1	8	12	PF00017	0.407
LIG_SH2_STAP1	66	70	PF00017	0.294
LIG_SH2_STAP1	96	100	PF00017	0.325
LIG_SH2_STAT5	223	226	PF00017	0.331
LIG_SH2_STAT5	39	42	PF00017	0.306
LIG_SH2_STAT5	44	47	PF00017	0.275
LIG_SH2_STAT5	512	515	PF00017	0.375
LIG_SH2_STAT5	575	578	PF00017	0.311
LIG_SH3_3	391	397	PF00018	0.559
LIG_SH3_3	580	586	PF00018	0.399
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.293
LIG_SUMO_SIM_anti_2	514	521	PF11976	0.389
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.328
LIG_SUMO_SIM_par_1	336	342	PF11976	0.525
LIG_TRAF2_1	134	137	PF00917	0.662
LIG_TRAF2_1	506	509	PF00917	0.404
LIG_TRAF2_1	645	648	PF00917	0.457
LIG_UBA3_1	211	219	PF00899	0.363
MOD_CDK_SPK_2	1	6	PF00069	0.585
MOD_CK1_1	150	156	PF00069	0.757
MOD_CK1_1	262	268	PF00069	0.513
MOD_CK1_1	446	452	PF00069	0.586
MOD_CK2_1	163	169	PF00069	0.503
MOD_CK2_1	502	508	PF00069	0.508
MOD_GlcNHglycan	1	4	PF01048	0.535
MOD_GlcNHglycan	132	135	PF01048	0.784
MOD_GlcNHglycan	139	142	PF01048	0.720
MOD_GlcNHglycan	149	152	PF01048	0.644
MOD_GlcNHglycan	153	156	PF01048	0.673
MOD_GlcNHglycan	224	227	PF01048	0.405
MOD_GlcNHglycan	307	310	PF01048	0.755
MOD_GlcNHglycan	314	317	PF01048	0.586
MOD_GlcNHglycan	324	328	PF01048	0.658
MOD_GlcNHglycan	341	344	PF01048	0.583
MOD_GlcNHglycan	347	350	PF01048	0.681
MOD_GlcNHglycan	366	369	PF01048	0.471
MOD_GlcNHglycan	448	452	PF01048	0.767
MOD_GlcNHglycan	472	475	PF01048	0.395
MOD_GlcNHglycan	493	496	PF01048	0.507
MOD_GlcNHglycan	504	507	PF01048	0.389
MOD_GlcNHglycan	536	539	PF01048	0.406
MOD_GlcNHglycan	603	606	PF01048	0.562
MOD_GlcNHglycan	611	614	PF01048	0.461
MOD_GlcNHglycan	93	96	PF01048	0.363
MOD_GSK3_1	137	144	PF00069	0.754
MOD_GSK3_1	147	154	PF00069	0.617
MOD_GSK3_1	222	229	PF00069	0.398
MOD_GSK3_1	231	238	PF00069	0.298
MOD_GSK3_1	262	269	PF00069	0.452
MOD_GSK3_1	310	317	PF00069	0.733
MOD_GSK3_1	323	330	PF00069	0.598
MOD_GSK3_1	334	341	PF00069	0.716
MOD_GSK3_1	443	450	PF00069	0.734
MOD_GSK3_1	468	475	PF00069	0.506
MOD_GSK3_1	498	505	PF00069	0.501
MOD_GSK3_1	587	594	PF00069	0.479
MOD_GSK3_1	597	604	PF00069	0.507
MOD_GSK3_1	615	622	PF00069	0.608
MOD_N-GLC_1	303	308	PF02516	0.632
MOD_NEK2_1	173	178	PF00069	0.392
MOD_NEK2_1	197	202	PF00069	0.385
MOD_NEK2_1	266	271	PF00069	0.441
MOD_NEK2_1	289	294	PF00069	0.404
MOD_NEK2_1	40	45	PF00069	0.325
MOD_NEK2_1	481	486	PF00069	0.409
MOD_NEK2_1	498	503	PF00069	0.412
MOD_NEK2_1	511	516	PF00069	0.380
MOD_NEK2_1	591	596	PF00069	0.498
MOD_NEK2_1	81	86	PF00069	0.385
MOD_NEK2_2	226	231	PF00069	0.343
MOD_NEK2_2	548	553	PF00069	0.464
MOD_NEK2_2	615	620	PF00069	0.545
MOD_PIKK_1	132	138	PF00454	0.678
MOD_PIKK_1	633	639	PF00454	0.437
MOD_PKA_1	147	153	PF00069	0.674
MOD_PKA_1	407	413	PF00069	0.485
MOD_PKA_2	122	128	PF00069	0.547
MOD_PKA_2	130	136	PF00069	0.573
MOD_PKA_2	197	203	PF00069	0.385
MOD_PKA_2	289	295	PF00069	0.419
MOD_PKA_2	407	413	PF00069	0.488
MOD_PKA_2	414	420	PF00069	0.428
MOD_PKA_2	481	487	PF00069	0.427
MOD_PKA_2	619	625	PF00069	0.464
MOD_Plk_4	226	232	PF00069	0.402
MOD_Plk_4	259	265	PF00069	0.481
MOD_Plk_4	424	430	PF00069	0.340
MOD_Plk_4	481	487	PF00069	0.392
MOD_Plk_4	511	517	PF00069	0.436
MOD_ProDKin_1	1	7	PF00069	0.633
MOD_ProDKin_1	327	333	PF00069	0.768
MOD_ProDKin_1	384	390	PF00069	0.576
MOD_ProDKin_1	436	442	PF00069	0.539
MOD_ProDKin_1	594	600	PF00069	0.468
MOD_SUMO_for_1	101	104	PF00179	0.472
MOD_SUMO_for_1	258	261	PF00179	0.421
MOD_SUMO_rev_2	439	446	PF00179	0.681
TRG_DiLeu_BaEn_1	169	174	PF01217	0.386
TRG_DiLeu_BaEn_1	244	249	PF01217	0.385
TRG_DiLeu_BaEn_2	637	643	PF01217	0.454
TRG_DiLeu_BaEn_4	508	514	PF01217	0.431
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.517
TRG_ENDOCYTIC_2	194	197	PF00928	0.291
TRG_ENDOCYTIC_2	201	204	PF00928	0.291
TRG_ENDOCYTIC_2	37	40	PF00928	0.291
TRG_ENDOCYTIC_2	44	47	PF00928	0.291
TRG_ENDOCYTIC_2	512	515	PF00928	0.382
TRG_ENDOCYTIC_2	575	578	PF00928	0.400
TRG_ER_diArg_1	126	129	PF00400	0.618
TRG_ER_diArg_1	214	217	PF00400	0.309
TRG_ER_diArg_1	276	278	PF00400	0.452
TRG_ER_diArg_1	405	408	PF00400	0.403
TRG_ER_diArg_1	421	423	PF00400	0.381
TRG_ER_diArg_1	49	51	PF00400	0.385
TRG_Pf-PMV_PEXEL_1	407	412	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3P5	Leptomonas seymouri	56%	98%
A0A3Q8I8I6	Leishmania donovani	100%	100%
A0A3R7RQU7	Trypanosoma rangeli	36%	92%
A4H5V4	Leishmania braziliensis	82%	100%
D0A9M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	80%
E9AMX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QHP9	Leishmania major	94%	100%