Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HU45_LEIIN

TriTrypDb:

LINF_090019600

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HU45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU45

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.475
CLV_C14_Caspase3-7	128	132	PF00656	0.460
CLV_C14_Caspase3-7	191	195	PF00656	0.463
CLV_MEL_PAP_1	330	336	PF00089	0.506
CLV_NRD_NRD_1	238	240	PF00675	0.559
CLV_NRD_NRD_1	285	287	PF00675	0.504
CLV_NRD_NRD_1	294	296	PF00675	0.552
CLV_NRD_NRD_1	332	334	PF00675	0.511
CLV_PCSK_FUR_1	236	240	PF00082	0.559
CLV_PCSK_KEX2_1	123	125	PF00082	0.646
CLV_PCSK_KEX2_1	238	240	PF00082	0.562
CLV_PCSK_KEX2_1	285	287	PF00082	0.545
CLV_PCSK_KEX2_1	294	296	PF00082	0.592
CLV_PCSK_KEX2_1	332	334	PF00082	0.511
CLV_PCSK_KEX2_1	408	410	PF00082	0.677
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.646
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.677
CLV_PCSK_SKI1_1	161	165	PF00082	0.618
CLV_PCSK_SKI1_1	286	290	PF00082	0.530
DEG_SCF_TRCP1_1	243	249	PF00400	0.400
DEG_SPOP_SBC_1	349	353	PF00917	0.396
DOC_ANK_TNKS_1	294	301	PF00023	0.387
DOC_ANK_TNKS_1	365	372	PF00023	0.421
DOC_CDC14_PxL_1	198	206	PF14671	0.434
DOC_CYCLIN_yCln2_LP_2	200	203	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.397
DOC_MAPK_gen_1	332	339	PF00069	0.310
DOC_MAPK_gen_1	77	87	PF00069	0.523
DOC_MAPK_MEF2A_6	154	162	PF00069	0.354
DOC_MAPK_MEF2A_6	80	89	PF00069	0.500
DOC_MAPK_RevD_3	395	409	PF00069	0.374
DOC_PP2B_LxvP_1	200	203	PF13499	0.426
DOC_PP2B_LxvP_1	36	39	PF13499	0.614
DOC_PP2B_LxvP_1	60	63	PF13499	0.599
DOC_PP4_FxxP_1	16	19	PF00568	0.608
DOC_PP4_FxxP_1	99	102	PF00568	0.399
DOC_SPAK_OSR1_1	333	337	PF12202	0.303
DOC_USP7_MATH_1	246	250	PF00917	0.446
DOC_USP7_MATH_1	308	312	PF00917	0.339
DOC_USP7_MATH_1	378	382	PF00917	0.419
DOC_USP7_MATH_1	432	436	PF00917	0.432
DOC_USP7_MATH_1	47	51	PF00917	0.731
DOC_WW_Pin1_4	264	269	PF00397	0.427
DOC_WW_Pin1_4	43	48	PF00397	0.658
LIG_14-3-3_CanoR_1	124	130	PF00244	0.369
LIG_14-3-3_CanoR_1	341	346	PF00244	0.378
LIG_14-3-3_CanoR_1	7	12	PF00244	0.715
LIG_14-3-3_CanoR_1	71	77	PF00244	0.469
LIG_APCC_ABBA_1	160	165	PF00400	0.362
LIG_BIR_III_4	111	115	PF00653	0.477
LIG_BRCT_BRCA1_1	91	95	PF00533	0.313
LIG_eIF4E_1	276	282	PF01652	0.310
LIG_EVH1_1	201	205	PF00568	0.411
LIG_EVH1_1	60	64	PF00568	0.561
LIG_EVH1_2	12	16	PF00568	0.609
LIG_FHA_1	114	120	PF00498	0.444
LIG_FHA_1	144	150	PF00498	0.347
LIG_FHA_1	151	157	PF00498	0.374
LIG_FHA_1	259	265	PF00498	0.466
LIG_FHA_1	345	351	PF00498	0.362
LIG_FHA_1	399	405	PF00498	0.482
LIG_FHA_1	88	94	PF00498	0.376
LIG_FHA_2	177	183	PF00498	0.421
LIG_FHA_2	81	87	PF00498	0.458
LIG_GBD_Chelix_1	24	32	PF00786	0.330
LIG_LIR_Apic_2	14	19	PF02991	0.619
LIG_LIR_Apic_2	165	170	PF02991	0.389
LIG_LIR_Apic_2	342	346	PF02991	0.366
LIG_LIR_Gen_1	267	277	PF02991	0.382
LIG_LIR_Gen_1	90	99	PF02991	0.305
LIG_LIR_Nem_3	267	272	PF02991	0.381
LIG_LIR_Nem_3	274	279	PF02991	0.366
LIG_LIR_Nem_3	413	419	PF02991	0.461
LIG_LIR_Nem_3	90	94	PF02991	0.399
LIG_LYPXL_yS_3	309	312	PF13949	0.362
LIG_MLH1_MIPbox_1	91	95	PF16413	0.313
LIG_MYND_1	199	203	PF01753	0.402
LIG_PCNA_yPIPBox_3	324	333	PF02747	0.310
LIG_Pex14_1	219	223	PF04695	0.297
LIG_Pex14_2	163	167	PF04695	0.361
LIG_Pex14_2	94	98	PF04695	0.360
LIG_Pex14_2	99	103	PF04695	0.400
LIG_PTAP_UEV_1	345	350	PF05743	0.384
LIG_PTB_Apo_2	263	270	PF02174	0.403
LIG_SH2_CRK	152	156	PF00017	0.359
LIG_SH2_CRK	276	280	PF00017	0.312
LIG_SH2_NCK_1	343	347	PF00017	0.381
LIG_SH2_STAP1	152	156	PF00017	0.359
LIG_SH2_STAP1	321	325	PF00017	0.351
LIG_SH2_STAP1	81	85	PF00017	0.476
LIG_SH2_STAP1	91	95	PF00017	0.257
LIG_SH2_STAT3	321	324	PF00017	0.352
LIG_SH2_STAT5	152	155	PF00017	0.362
LIG_SH2_STAT5	343	346	PF00017	0.353
LIG_SH2_STAT5	355	358	PF00017	0.365
LIG_SH3_1	343	349	PF00018	0.378
LIG_SH3_2	2	7	PF14604	0.634
LIG_SH3_2	310	315	PF14604	0.346
LIG_SH3_3	15	21	PF00018	0.626
LIG_SH3_3	152	158	PF00018	0.352
LIG_SH3_3	196	202	PF00018	0.495
LIG_SH3_3	307	313	PF00018	0.372
LIG_SH3_3	343	349	PF00018	0.378
LIG_SH3_3	55	61	PF00018	0.638
LIG_SUMO_SIM_anti_2	322	329	PF11976	0.383
LIG_TRAF2_1	435	438	PF00917	0.397
LIG_TRAF2_1	50	53	PF00917	0.697
LIG_UBA3_1	280	289	PF00899	0.296
LIG_WW_2	202	205	PF00397	0.407
MOD_CK1_1	183	189	PF00069	0.457
MOD_CK1_1	46	52	PF00069	0.661
MOD_CK2_1	176	182	PF00069	0.416
MOD_CK2_1	432	438	PF00069	0.420
MOD_CK2_1	47	53	PF00069	0.729
MOD_CK2_1	80	86	PF00069	0.488
MOD_GlcNHglycan	182	185	PF01048	0.684
MOD_GlcNHglycan	243	246	PF01048	0.694
MOD_GlcNHglycan	421	424	PF01048	0.658
MOD_GlcNHglycan	49	52	PF01048	0.520
MOD_GlcNHglycan	9	12	PF01048	0.493
MOD_GSK3_1	176	183	PF00069	0.417
MOD_GSK3_1	335	342	PF00069	0.330
MOD_GSK3_1	344	351	PF00069	0.343
MOD_GSK3_1	43	50	PF00069	0.691
MOD_GSK3_1	7	14	PF00069	0.709
MOD_N-GLC_1	264	269	PF02516	0.631
MOD_NEK2_1	339	344	PF00069	0.442
MOD_NEK2_1	419	424	PF00069	0.452
MOD_NEK2_1	89	94	PF00069	0.455
MOD_PIKK_1	143	149	PF00454	0.316
MOD_PKA_2	225	231	PF00069	0.433
MOD_PKA_2	378	384	PF00069	0.412
MOD_PKA_2	6	12	PF00069	0.719
MOD_Plk_2-3	433	439	PF00069	0.384
MOD_Plk_4	12	18	PF00069	0.635
MOD_Plk_4	323	329	PF00069	0.369
MOD_Plk_4	350	356	PF00069	0.472
MOD_Plk_4	89	95	PF00069	0.342
MOD_ProDKin_1	264	270	PF00069	0.426
MOD_ProDKin_1	43	49	PF00069	0.660
MOD_SUMO_for_1	367	370	PF00179	0.473
MOD_SUMO_rev_2	118	125	PF00179	0.405
TRG_DiLeu_BaEn_1	275	280	PF01217	0.299
TRG_DiLeu_BaEn_2	29	35	PF01217	0.563
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.437
TRG_ENDOCYTIC_2	152	155	PF00928	0.362
TRG_ENDOCYTIC_2	276	279	PF00928	0.382
TRG_ENDOCYTIC_2	309	312	PF00928	0.362
TRG_ENDOCYTIC_2	91	94	PF00928	0.349
TRG_ER_diArg_1	236	239	PF00400	0.357
TRG_ER_diArg_1	284	286	PF00400	0.356
TRG_ER_diArg_1	331	333	PF00400	0.310
TRG_ER_diArg_1	376	379	PF00400	0.436
TRG_NLS_MonoCore_2	405	410	PF00514	0.388
TRG_NLS_MonoExtC_3	406	412	PF00514	0.387
TRG_NLS_MonoExtN_4	406	411	PF00514	0.389
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.653
TRG_PTS1	438	441	PF00515	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P570	Leptomonas seymouri	44%	100%
A0A0S4JNP6	Bodo saltans	22%	100%
A0A3S7WQU3	Leishmania donovani	99%	100%
A4H5V1	Leishmania braziliensis	65%	99%
E9AMX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QHQ2	Leishmania major	91%	100%