Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger- C3HC4 type (RING finger) containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HU43_LEIIN

TriTrypDb:

LINF_090019400

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 2
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HU43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU43

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	355	359	PF00656	0.766
CLV_NRD_NRD_1	139	141	PF00675	0.469
CLV_NRD_NRD_1	145	147	PF00675	0.416
CLV_NRD_NRD_1	152	154	PF00675	0.339
CLV_NRD_NRD_1	378	380	PF00675	0.581
CLV_PCSK_FUR_1	362	366	PF00082	0.543
CLV_PCSK_KEX2_1	139	141	PF00082	0.467
CLV_PCSK_KEX2_1	147	149	PF00082	0.389
CLV_PCSK_KEX2_1	152	154	PF00082	0.337
CLV_PCSK_KEX2_1	203	205	PF00082	0.414
CLV_PCSK_KEX2_1	364	366	PF00082	0.551
CLV_PCSK_KEX2_1	378	380	PF00082	0.490
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.424
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.391
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.543
CLV_PCSK_PC7_1	148	154	PF00082	0.365
CLV_PCSK_SKI1_1	147	151	PF00082	0.458
CLV_PCSK_SKI1_1	157	161	PF00082	0.385
CLV_PCSK_SKI1_1	212	216	PF00082	0.405
CLV_PCSK_SKI1_1	227	231	PF00082	0.340
DEG_APCC_DBOX_1	325	333	PF00400	0.700
DOC_CKS1_1	51	56	PF01111	0.551
DOC_CYCLIN_RxL_1	144	155	PF00134	0.674
DOC_CYCLIN_RxL_1	224	234	PF00134	0.678
DOC_MAPK_gen_1	18	28	PF00069	0.446
DOC_MAPK_gen_1	323	331	PF00069	0.747
DOC_MAPK_MEF2A_6	21	30	PF00069	0.449
DOC_MAPK_NFAT4_5	21	29	PF00069	0.449
DOC_PP1_RVXF_1	128	135	PF00149	0.567
DOC_PP4_FxxP_1	219	222	PF00568	0.662
DOC_USP7_MATH_1	103	107	PF00917	0.503
DOC_USP7_MATH_1	296	300	PF00917	0.768
DOC_USP7_MATH_1	324	328	PF00917	0.742
DOC_USP7_MATH_1	342	346	PF00917	0.750
DOC_USP7_MATH_1	409	413	PF00917	0.748
DOC_WW_Pin1_4	187	192	PF00397	0.602
DOC_WW_Pin1_4	247	252	PF00397	0.788
DOC_WW_Pin1_4	371	376	PF00397	0.833
DOC_WW_Pin1_4	385	390	PF00397	0.706
DOC_WW_Pin1_4	50	55	PF00397	0.551
LIG_14-3-3_CanoR_1	323	332	PF00244	0.811
LIG_Actin_RPEL_3	123	142	PF02755	0.571
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BIR_III_2	69	73	PF00653	0.417
LIG_EH_1	340	344	PF12763	0.795
LIG_EH1_1	223	231	PF00400	0.671
LIG_eIF4E_1	145	151	PF01652	0.651
LIG_eIF4E_1	224	230	PF01652	0.664
LIG_FHA_1	326	332	PF00498	0.752
LIG_FHA_1	381	387	PF00498	0.806
LIG_FHA_1	402	408	PF00498	0.746
LIG_FHA_1	51	57	PF00498	0.564
LIG_FHA_1	92	98	PF00498	0.585
LIG_FHA_2	285	291	PF00498	0.826
LIG_LIR_Gen_1	20	30	PF02991	0.539
LIG_LIR_Gen_1	345	352	PF02991	0.760
LIG_LIR_Gen_1	412	419	PF02991	0.694
LIG_LIR_Gen_1	58	66	PF02991	0.542
LIG_LIR_Nem_3	20	26	PF02991	0.536
LIG_LIR_Nem_3	345	350	PF02991	0.786
LIG_LIR_Nem_3	412	418	PF02991	0.738
LIG_PCNA_PIPBox_1	125	134	PF02747	0.573
LIG_Pex14_2	23	27	PF04695	0.412
LIG_SH2_CRK	347	351	PF00017	0.808
LIG_SH2_CRK	51	55	PF00017	0.551
LIG_SH2_NCK_1	347	351	PF00017	0.808
LIG_SH2_PTP2	415	418	PF00017	0.701
LIG_SH2_STAP1	352	356	PF00017	0.635
LIG_SH2_STAT3	225	228	PF00017	0.661
LIG_SH2_STAT5	225	228	PF00017	0.661
LIG_SH2_STAT5	415	418	PF00017	0.701
LIG_SH2_STAT5	48	51	PF00017	0.552
LIG_SH3_3	383	389	PF00018	0.807
LIG_SH3_3	62	68	PF00018	0.579
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.399
LIG_SUMO_SIM_par_1	115	122	PF11976	0.399
LIG_TRAF2_1	270	273	PF00917	0.762
LIG_TRAF2_1	396	399	PF00917	0.771
MOD_CDK_SPxxK_3	371	378	PF00069	0.723
MOD_CK1_1	247	253	PF00069	0.750
MOD_CK1_1	292	298	PF00069	0.703
MOD_CK1_1	299	305	PF00069	0.677
MOD_CK1_1	306	312	PF00069	0.587
MOD_CK1_1	345	351	PF00069	0.702
MOD_CK1_1	85	91	PF00069	0.516
MOD_CK2_1	228	234	PF00069	0.597
MOD_CK2_1	247	253	PF00069	0.491
MOD_CK2_1	385	391	PF00069	0.700
MOD_GlcNHglycan	125	128	PF01048	0.483
MOD_GlcNHglycan	2	5	PF01048	0.705
MOD_GlcNHglycan	212	215	PF01048	0.500
MOD_GlcNHglycan	230	233	PF01048	0.385
MOD_GlcNHglycan	246	249	PF01048	0.533
MOD_GlcNHglycan	260	263	PF01048	0.549
MOD_GlcNHglycan	265	268	PF01048	0.508
MOD_GlcNHglycan	294	297	PF01048	0.784
MOD_GlcNHglycan	310	313	PF01048	0.548
MOD_GlcNHglycan	32	35	PF01048	0.640
MOD_GlcNHglycan	367	370	PF01048	0.807
MOD_GlcNHglycan	371	374	PF01048	0.796
MOD_GlcNHglycan	404	407	PF01048	0.761
MOD_GlcNHglycan	78	81	PF01048	0.680
MOD_GlcNHglycan	84	87	PF01048	0.593
MOD_GSK3_1	119	126	PF00069	0.485
MOD_GSK3_1	249	256	PF00069	0.671
MOD_GSK3_1	258	265	PF00069	0.610
MOD_GSK3_1	292	299	PF00069	0.720
MOD_GSK3_1	304	311	PF00069	0.610
MOD_GSK3_1	318	325	PF00069	0.533
MOD_GSK3_1	365	372	PF00069	0.830
MOD_GSK3_1	380	387	PF00069	0.591
MOD_GSK3_1	82	89	PF00069	0.516
MOD_N-GLC_1	91	96	PF02516	0.687
MOD_N-GLC_2	303	305	PF02516	0.600
MOD_NEK2_1	112	117	PF00069	0.483
MOD_NEK2_1	119	124	PF00069	0.327
MOD_NEK2_1	30	35	PF00069	0.593
MOD_NEK2_2	296	301	PF00069	0.581
MOD_OFUCOSY	83	90	PF10250	0.672
MOD_PKA_2	17	23	PF00069	0.599
MOD_PKA_2	322	328	PF00069	0.742
MOD_PKA_2	345	351	PF00069	0.769
MOD_Plk_1	171	177	PF00069	0.485
MOD_Plk_1	289	295	PF00069	0.679
MOD_Plk_2-3	289	295	PF00069	0.612
MOD_Plk_4	103	109	PF00069	0.388
MOD_Plk_4	112	118	PF00069	0.309
MOD_Plk_4	119	125	PF00069	0.327
MOD_Plk_4	9	15	PF00069	0.614
MOD_ProDKin_1	187	193	PF00069	0.483
MOD_ProDKin_1	247	253	PF00069	0.743
MOD_ProDKin_1	371	377	PF00069	0.807
MOD_ProDKin_1	385	391	PF00069	0.630
MOD_ProDKin_1	50	56	PF00069	0.692
MOD_SUMO_for_1	159	162	PF00179	0.617
MOD_SUMO_rev_2	162	171	PF00179	0.622
MOD_SUMO_rev_2	64	73	PF00179	0.617
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.489
TRG_ENDOCYTIC_2	347	350	PF00928	0.772
TRG_ENDOCYTIC_2	415	418	PF00928	0.681
TRG_ENDOCYTIC_2	59	62	PF00928	0.681
TRG_ER_diArg_1	139	141	PF00400	0.574
TRG_ER_diArg_1	145	148	PF00400	0.502
TRG_ER_diArg_1	151	153	PF00400	0.414
TRG_ER_diArg_1	343	346	PF00400	0.773
TRG_ER_diArg_1	377	379	PF00400	0.734
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQW1	Leishmania donovani	99%	100%
A4H5U9	Leishmania braziliensis	72%	100%
E9AMX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QHQ4	Leishmania major	91%	100%