Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HU41_LEIIN

TriTrypDb:

LINF_090019200

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HU41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.526
CLV_C14_Caspase3-7	279	283	PF00656	0.530
CLV_C14_Caspase3-7	492	496	PF00656	0.709
CLV_C14_Caspase3-7	580	584	PF00656	0.515
CLV_C14_Caspase3-7	75	79	PF00656	0.749
CLV_NRD_NRD_1	240	242	PF00675	0.574
CLV_NRD_NRD_1	268	270	PF00675	0.438
CLV_NRD_NRD_1	285	287	PF00675	0.558
CLV_NRD_NRD_1	386	388	PF00675	0.486
CLV_NRD_NRD_1	389	391	PF00675	0.560
CLV_NRD_NRD_1	458	460	PF00675	0.722
CLV_NRD_NRD_1	468	470	PF00675	0.623
CLV_NRD_NRD_1	479	481	PF00675	0.682
CLV_NRD_NRD_1	89	91	PF00675	0.723
CLV_PCSK_FUR_1	387	391	PF00082	0.542
CLV_PCSK_FUR_1	476	480	PF00082	0.679
CLV_PCSK_KEX2_1	240	242	PF00082	0.577
CLV_PCSK_KEX2_1	268	270	PF00082	0.438
CLV_PCSK_KEX2_1	285	287	PF00082	0.558
CLV_PCSK_KEX2_1	386	388	PF00082	0.486
CLV_PCSK_KEX2_1	389	391	PF00082	0.560
CLV_PCSK_KEX2_1	458	460	PF00082	0.743
CLV_PCSK_KEX2_1	464	466	PF00082	0.729
CLV_PCSK_KEX2_1	476	478	PF00082	0.601
CLV_PCSK_KEX2_1	479	481	PF00082	0.590
CLV_PCSK_KEX2_1	89	91	PF00082	0.571
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.746
CLV_PCSK_PC7_1	264	270	PF00082	0.444
CLV_PCSK_SKI1_1	264	268	PF00082	0.542
CLV_PCSK_SKI1_1	523	527	PF00082	0.680
CLV_PCSK_SKI1_1	89	93	PF00082	0.637
CLV_Separin_Metazoa	20	24	PF03568	0.625
CLV_Separin_Metazoa	383	387	PF03568	0.536
DEG_APCC_DBOX_1	263	271	PF00400	0.509
DEG_SCF_FBW7_2	13	20	PF00400	0.692
DOC_CKS1_1	62	67	PF01111	0.594
DOC_MAPK_gen_1	23	32	PF00069	0.598
DOC_MAPK_MEF2A_6	325	334	PF00069	0.573
DOC_PP2B_LxvP_1	327	330	PF13499	0.586
DOC_PP2B_LxvP_1	418	421	PF13499	0.705
DOC_USP7_MATH_1	126	130	PF00917	0.685
DOC_USP7_MATH_1	132	136	PF00917	0.719
DOC_USP7_MATH_1	140	144	PF00917	0.524
DOC_USP7_MATH_1	15	19	PF00917	0.716
DOC_USP7_MATH_1	188	192	PF00917	0.648
DOC_USP7_MATH_1	195	199	PF00917	0.500
DOC_USP7_MATH_1	262	266	PF00917	0.491
DOC_USP7_MATH_1	273	277	PF00917	0.462
DOC_USP7_MATH_1	284	288	PF00917	0.531
DOC_USP7_MATH_1	306	310	PF00917	0.586
DOC_USP7_MATH_1	321	325	PF00917	0.583
DOC_USP7_MATH_1	444	448	PF00917	0.756
DOC_USP7_MATH_1	463	467	PF00917	0.627
DOC_USP7_MATH_1	535	539	PF00917	0.660
DOC_USP7_MATH_1	60	64	PF00917	0.649
DOC_WW_Pin1_4	13	18	PF00397	0.813
DOC_WW_Pin1_4	138	143	PF00397	0.557
DOC_WW_Pin1_4	61	66	PF00397	0.593
LIG_14-3-3_CanoR_1	156	165	PF00244	0.655
LIG_14-3-3_CanoR_1	285	289	PF00244	0.497
LIG_14-3-3_CanoR_1	295	301	PF00244	0.385
LIG_14-3-3_CanoR_1	38	47	PF00244	0.583
LIG_14-3-3_CanoR_1	410	416	PF00244	0.550
LIG_14-3-3_CanoR_1	523	532	PF00244	0.576
LIG_14-3-3_CterR_2	595	598	PF00244	0.600
LIG_Actin_WH2_2	558	574	PF00022	0.545
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_BIR_III_4	97	101	PF00653	0.517
LIG_CtBP_PxDLS_1	331	335	PF00389	0.573
LIG_CtBP_PxDLS_1	365	369	PF00389	0.507
LIG_FHA_1	291	297	PF00498	0.519
LIG_FHA_1	401	407	PF00498	0.589
LIG_FHA_1	412	418	PF00498	0.541
LIG_FHA_1	432	438	PF00498	0.665
LIG_FHA_1	541	547	PF00498	0.561
LIG_FHA_2	578	584	PF00498	0.520
LIG_FHA_2	81	87	PF00498	0.602
LIG_LIR_Gen_1	157	166	PF02991	0.655
LIG_LIR_Gen_1	219	229	PF02991	0.381
LIG_LIR_Gen_1	41	47	PF02991	0.584
LIG_LIR_Nem_3	157	162	PF02991	0.644
LIG_LIR_Nem_3	219	224	PF02991	0.384
LIG_LIR_Nem_3	41	46	PF02991	0.587
LIG_LIR_Nem_3	575	581	PF02991	0.530
LIG_PAM2_1	332	344	PF00658	0.547
LIG_Pex14_1	106	110	PF04695	0.563
LIG_Pex14_1	297	301	PF04695	0.483
LIG_Pex14_2	155	159	PF04695	0.639
LIG_Pex14_2	39	43	PF04695	0.497
LIG_Pex3_1	99	110	PF04882	0.557
LIG_PTAP_UEV_1	64	69	PF05743	0.627
LIG_SH2_CRK	226	230	PF00017	0.471
LIG_SH2_NCK_1	226	230	PF00017	0.471
LIG_SH2_STAP1	40	44	PF00017	0.526
LIG_SH2_STAP1	532	536	PF00017	0.557
LIG_SH2_STAT5	226	229	PF00017	0.380
LIG_SH2_STAT5	301	304	PF00017	0.492
LIG_SH2_STAT5	40	43	PF00017	0.606
LIG_SH2_STAT5	570	573	PF00017	0.518
LIG_SH3_1	179	185	PF00018	0.646
LIG_SH3_3	179	185	PF00018	0.605
LIG_SH3_3	27	33	PF00018	0.689
LIG_SH3_3	427	433	PF00018	0.683
LIG_SH3_3	495	501	PF00018	0.597
LIG_SH3_3	550	556	PF00018	0.689
LIG_SH3_3	59	65	PF00018	0.684
LIG_SUMO_SIM_par_1	330	335	PF11976	0.592
LIG_SUMO_SIM_par_1	364	370	PF11976	0.455
LIG_TRAF2_1	120	123	PF00917	0.620
LIG_TRAF2_1	258	261	PF00917	0.491
LIG_TRAF2_1	527	530	PF00917	0.481
LIG_TYR_ITIM	224	229	PF00017	0.377
LIG_WW_3	20	24	PF00397	0.625
MOD_CK1_1	157	163	PF00069	0.690
MOD_CK1_1	209	215	PF00069	0.574
MOD_CK1_1	254	260	PF00069	0.586
MOD_CK1_1	396	402	PF00069	0.669
MOD_CK1_1	423	429	PF00069	0.662
MOD_CK1_1	512	518	PF00069	0.626
MOD_CK1_1	519	525	PF00069	0.574
MOD_CK1_1	63	69	PF00069	0.667
MOD_CK1_1	73	79	PF00069	0.833
MOD_CK2_1	195	201	PF00069	0.537
MOD_CK2_1	254	260	PF00069	0.525
MOD_CK2_1	273	279	PF00069	0.464
MOD_CK2_1	306	312	PF00069	0.591
MOD_CK2_1	493	499	PF00069	0.632
MOD_CK2_1	524	530	PF00069	0.530
MOD_Cter_Amidation	467	470	PF01082	0.618
MOD_GlcNHglycan	128	131	PF01048	0.751
MOD_GlcNHglycan	134	137	PF01048	0.633
MOD_GlcNHglycan	138	141	PF01048	0.485
MOD_GlcNHglycan	156	159	PF01048	0.433
MOD_GlcNHglycan	167	170	PF01048	0.685
MOD_GlcNHglycan	197	200	PF01048	0.455
MOD_GlcNHglycan	208	211	PF01048	0.407
MOD_GlcNHglycan	218	221	PF01048	0.412
MOD_GlcNHglycan	253	256	PF01048	0.675
MOD_GlcNHglycan	264	267	PF01048	0.478
MOD_GlcNHglycan	275	278	PF01048	0.464
MOD_GlcNHglycan	308	311	PF01048	0.535
MOD_GlcNHglycan	395	398	PF01048	0.656
MOD_GlcNHglycan	424	428	PF01048	0.653
MOD_GlcNHglycan	465	468	PF01048	0.589
MOD_GlcNHglycan	511	514	PF01048	0.699
MOD_GlcNHglycan	518	521	PF01048	0.592
MOD_GlcNHglycan	537	540	PF01048	0.660
MOD_GlcNHglycan	65	68	PF01048	0.710
MOD_GSK3_1	132	139	PF00069	0.646
MOD_GSK3_1	154	161	PF00069	0.695
MOD_GSK3_1	229	236	PF00069	0.418
MOD_GSK3_1	250	257	PF00069	0.620
MOD_GSK3_1	296	303	PF00069	0.491
MOD_GSK3_1	38	45	PF00069	0.591
MOD_GSK3_1	396	403	PF00069	0.747
MOD_GSK3_1	416	423	PF00069	0.635
MOD_GSK3_1	489	496	PF00069	0.605
MOD_GSK3_1	512	519	PF00069	0.730
MOD_GSK3_1	535	542	PF00069	0.643
MOD_GSK3_1	577	584	PF00069	0.540
MOD_GSK3_1	591	598	PF00069	0.480
MOD_GSK3_1	70	77	PF00069	0.843
MOD_LATS_1	391	397	PF00433	0.537
MOD_N-GLC_1	572	577	PF02516	0.641
MOD_NEK2_1	154	159	PF00069	0.579
MOD_NEK2_1	175	180	PF00069	0.732
MOD_NEK2_1	224	229	PF00069	0.480
MOD_NEK2_1	233	238	PF00069	0.557
MOD_NEK2_1	251	256	PF00069	0.522
MOD_NEK2_1	296	301	PF00069	0.483
MOD_NEK2_1	332	337	PF00069	0.512
MOD_NEK2_1	524	529	PF00069	0.574
MOD_NEK2_1	581	586	PF00069	0.524
MOD_NEK2_1	591	596	PF00069	0.563
MOD_NEK2_2	290	295	PF00069	0.488
MOD_OFUCOSY	222	228	PF10250	0.469
MOD_PIKK_1	235	241	PF00454	0.535
MOD_PIKK_1	45	51	PF00454	0.575
MOD_PIKK_1	524	530	PF00454	0.519
MOD_PIKK_1	581	587	PF00454	0.521
MOD_PKA_1	89	95	PF00069	0.541
MOD_PKA_2	175	181	PF00069	0.747
MOD_PKA_2	284	290	PF00069	0.468
MOD_PKA_2	563	569	PF00069	0.559
MOD_PKA_2	581	587	PF00069	0.651
MOD_PKA_2	71	77	PF00069	0.688
MOD_PKA_2	89	95	PF00069	0.498
MOD_Plk_1	343	349	PF00069	0.568
MOD_Plk_1	494	500	PF00069	0.820
MOD_Plk_2-3	489	495	PF00069	0.624
MOD_Plk_4	158	164	PF00069	0.562
MOD_Plk_4	229	235	PF00069	0.440
MOD_Plk_4	296	302	PF00069	0.433
MOD_Plk_4	332	338	PF00069	0.559
MOD_Plk_4	42	48	PF00069	0.531
MOD_Plk_4	444	450	PF00069	0.597
MOD_ProDKin_1	13	19	PF00069	0.814
MOD_ProDKin_1	138	144	PF00069	0.558
MOD_ProDKin_1	61	67	PF00069	0.594
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.446
TRG_ENDOCYTIC_2	226	229	PF00928	0.380
TRG_ENDOCYTIC_2	40	43	PF00928	0.499
TRG_ER_diArg_1	22	25	PF00400	0.628
TRG_ER_diArg_1	267	269	PF00400	0.451
TRG_ER_diArg_1	284	286	PF00400	0.479
TRG_ER_diArg_1	385	387	PF00400	0.474
TRG_ER_diArg_1	475	478	PF00400	0.714
TRG_ER_diArg_1	88	90	PF00400	0.579
TRG_Pf-PMV_PEXEL_1	588	593	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJF6	Leptomonas seymouri	31%	95%
A0A3S7WQU0	Leishmania donovani	99%	100%
A4H5U7	Leishmania braziliensis	64%	98%
E9AMX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4QHQ6	Leishmania major	86%	97%