Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HU40_LEIIN

TriTrypDb:

LINF_090019100

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HU40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU40

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.648
CLV_C14_Caspase3-7	484	488	PF00656	0.682
CLV_C14_Caspase3-7	505	509	PF00656	0.643
CLV_C14_Caspase3-7	521	525	PF00656	0.546
CLV_NRD_NRD_1	152	154	PF00675	0.656
CLV_NRD_NRD_1	188	190	PF00675	0.601
CLV_NRD_NRD_1	457	459	PF00675	0.578
CLV_NRD_NRD_1	466	468	PF00675	0.566
CLV_NRD_NRD_1	471	473	PF00675	0.551
CLV_NRD_NRD_1	547	549	PF00675	0.631
CLV_NRD_NRD_1	705	707	PF00675	0.571
CLV_PCSK_KEX2_1	105	107	PF00082	0.664
CLV_PCSK_KEX2_1	152	154	PF00082	0.656
CLV_PCSK_KEX2_1	188	190	PF00082	0.601
CLV_PCSK_KEX2_1	351	353	PF00082	0.608
CLV_PCSK_KEX2_1	456	458	PF00082	0.548
CLV_PCSK_KEX2_1	466	468	PF00082	0.559
CLV_PCSK_KEX2_1	471	473	PF00082	0.568
CLV_PCSK_KEX2_1	547	549	PF00082	0.610
CLV_PCSK_KEX2_1	705	707	PF00082	0.607
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.664
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.608
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.534
CLV_PCSK_PC7_1	462	468	PF00082	0.554
CLV_PCSK_SKI1_1	219	223	PF00082	0.547
CLV_PCSK_SKI1_1	360	364	PF00082	0.590
CLV_PCSK_SKI1_1	435	439	PF00082	0.472
CLV_PCSK_SKI1_1	590	594	PF00082	0.419
CLV_PCSK_SKI1_1	633	637	PF00082	0.561
DEG_COP1_1	316	324	PF00400	0.631
DEG_SPOP_SBC_1	124	128	PF00917	0.699
DEG_SPOP_SBC_1	158	162	PF00917	0.589
DEG_SPOP_SBC_1	361	365	PF00917	0.580
DOC_ANK_TNKS_1	555	562	PF00023	0.620
DOC_CKS1_1	260	265	PF01111	0.645
DOC_CKS1_1	560	565	PF01111	0.619
DOC_CKS1_1	74	79	PF01111	0.698
DOC_CYCLIN_yCln2_LP_2	577	583	PF00134	0.426
DOC_MAPK_gen_1	188	196	PF00069	0.557
DOC_MAPK_gen_1	705	713	PF00069	0.507
DOC_MAPK_MEF2A_6	215	222	PF00069	0.629
DOC_MAPK_MEF2A_6	426	434	PF00069	0.411
DOC_PP2B_LxvP_1	577	580	PF13499	0.351
DOC_PP2B_LxvP_1	598	601	PF13499	0.462
DOC_PP2B_LxvP_1	636	639	PF13499	0.463
DOC_PP4_MxPP_1	637	640	PF00568	0.525
DOC_USP7_MATH_1	157	161	PF00917	0.702
DOC_USP7_MATH_1	17	21	PF00917	0.579
DOC_USP7_MATH_1	229	233	PF00917	0.661
DOC_USP7_MATH_1	289	293	PF00917	0.611
DOC_USP7_MATH_1	317	321	PF00917	0.601
DOC_USP7_MATH_1	32	36	PF00917	0.550
DOC_USP7_MATH_1	361	365	PF00917	0.624
DOC_USP7_MATH_1	391	395	PF00917	0.616
DOC_USP7_MATH_1	418	422	PF00917	0.559
DOC_USP7_MATH_1	539	543	PF00917	0.648
DOC_USP7_MATH_1	99	103	PF00917	0.611
DOC_WW_Pin1_4	134	139	PF00397	0.683
DOC_WW_Pin1_4	23	28	PF00397	0.661
DOC_WW_Pin1_4	243	248	PF00397	0.694
DOC_WW_Pin1_4	251	256	PF00397	0.645
DOC_WW_Pin1_4	259	264	PF00397	0.508
DOC_WW_Pin1_4	284	289	PF00397	0.674
DOC_WW_Pin1_4	299	304	PF00397	0.546
DOC_WW_Pin1_4	320	325	PF00397	0.668
DOC_WW_Pin1_4	331	336	PF00397	0.623
DOC_WW_Pin1_4	385	390	PF00397	0.646
DOC_WW_Pin1_4	46	51	PF00397	0.662
DOC_WW_Pin1_4	525	530	PF00397	0.604
DOC_WW_Pin1_4	53	58	PF00397	0.636
DOC_WW_Pin1_4	559	564	PF00397	0.696
DOC_WW_Pin1_4	583	588	PF00397	0.388
DOC_WW_Pin1_4	619	624	PF00397	0.480
DOC_WW_Pin1_4	73	78	PF00397	0.553
LIG_14-3-3_CanoR_1	188	194	PF00244	0.658
LIG_14-3-3_CanoR_1	242	247	PF00244	0.691
LIG_14-3-3_CanoR_1	291	301	PF00244	0.550
LIG_14-3-3_CanoR_1	373	383	PF00244	0.554
LIG_14-3-3_CanoR_1	426	431	PF00244	0.420
LIG_14-3-3_CanoR_1	678	682	PF00244	0.435
LIG_14-3-3_CanoR_1	7	15	PF00244	0.612
LIG_AP_GAE_1	524	530	PF02883	0.629
LIG_APCC_ABBAyCdc20_2	590	596	PF00400	0.390
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_BRCT_BRCA1_1	161	165	PF00533	0.643
LIG_FHA_1	1	7	PF00498	0.582
LIG_FHA_1	293	299	PF00498	0.667
LIG_FHA_1	314	320	PF00498	0.671
LIG_FHA_1	361	367	PF00498	0.574
LIG_FHA_1	420	426	PF00498	0.553
LIG_FHA_1	427	433	PF00498	0.394
LIG_FHA_1	576	582	PF00498	0.471
LIG_FHA_1	706	712	PF00498	0.500
LIG_FHA_1	74	80	PF00498	0.699
LIG_FHA_1	8	14	PF00498	0.606
LIG_FHA_2	264	270	PF00498	0.613
LIG_FHA_2	519	525	PF00498	0.661
LIG_FHA_2	646	652	PF00498	0.474
LIG_FHA_2	66	72	PF00498	0.632
LIG_HP1_1	580	584	PF01393	0.454
LIG_Integrin_isoDGR_2	147	149	PF01839	0.725
LIG_LIR_Apic_2	251	255	PF02991	0.705
LIG_LIR_Apic_2	619	623	PF02991	0.462
LIG_LIR_Gen_1	589	600	PF02991	0.441
LIG_LIR_Nem_3	591	597	PF02991	0.372
LIG_Pex14_1	588	592	PF04695	0.436
LIG_Pex14_1	671	675	PF04695	0.420
LIG_SH2_CRK	620	624	PF00017	0.566
LIG_SH2_STAT5	550	553	PF00017	0.588
LIG_SH3_3	244	250	PF00018	0.650
LIG_SH3_3	305	311	PF00018	0.660
LIG_SH3_3	316	322	PF00018	0.583
LIG_SH3_3	51	57	PF00018	0.606
LIG_SH3_3	533	539	PF00018	0.630
LIG_SH3_3	557	563	PF00018	0.745
LIG_SH3_3	636	642	PF00018	0.507
LIG_SH3_5	616	620	PF00018	0.471
LIG_SUMO_SIM_anti_2	648	654	PF11976	0.421
LIG_SUMO_SIM_par_1	316	323	PF11976	0.577
LIG_SUMO_SIM_par_1	580	586	PF11976	0.434
LIG_TRAF2_1	719	722	PF00917	0.661
LIG_TRAF2_1	81	84	PF00917	0.705
LIG_TRAF2_1	88	91	PF00917	0.637
LIG_UBA3_1	430	438	PF00899	0.461
LIG_UBA3_1	649	657	PF00899	0.431
MOD_CDK_SPxxK_3	284	291	PF00069	0.559
MOD_CDK_SPxxK_3	299	306	PF00069	0.539
MOD_CDK_SPxxK_3	53	60	PF00069	0.607
MOD_CDK_SPxxK_3	583	590	PF00069	0.395
MOD_CK1_1	108	114	PF00069	0.663
MOD_CK1_1	125	131	PF00069	0.541
MOD_CK1_1	160	166	PF00069	0.658
MOD_CK1_1	167	173	PF00069	0.618
MOD_CK1_1	174	180	PF00069	0.566
MOD_CK1_1	2	8	PF00069	0.589
MOD_CK1_1	232	238	PF00069	0.702
MOD_CK1_1	25	31	PF00069	0.587
MOD_CK1_1	254	260	PF00069	0.654
MOD_CK1_1	292	298	PF00069	0.650
MOD_CK1_1	302	308	PF00069	0.565
MOD_CK1_1	320	326	PF00069	0.537
MOD_CK1_1	329	335	PF00069	0.597
MOD_CK1_1	35	41	PF00069	0.566
MOD_CK1_1	392	398	PF00069	0.668
MOD_CK1_1	407	413	PF00069	0.533
MOD_CK1_1	46	52	PF00069	0.593
MOD_CK1_1	477	483	PF00069	0.663
MOD_CK1_1	488	494	PF00069	0.599
MOD_CK1_1	495	501	PF00069	0.535
MOD_CK1_1	503	509	PF00069	0.545
MOD_CK1_1	520	526	PF00069	0.589
MOD_CK1_1	528	534	PF00069	0.682
MOD_CK1_1	56	62	PF00069	0.649
MOD_CK1_1	65	71	PF00069	0.593
MOD_CK1_1	701	707	PF00069	0.507
MOD_CK1_1	75	81	PF00069	0.533
MOD_CK2_1	124	130	PF00069	0.656
MOD_CK2_1	290	296	PF00069	0.621
MOD_CK2_1	583	589	PF00069	0.530
MOD_CK2_1	645	651	PF00069	0.477
MOD_CK2_1	701	707	PF00069	0.650
MOD_CK2_1	78	84	PF00069	0.705
MOD_CK2_1	85	91	PF00069	0.640
MOD_Cter_Amidation	103	106	PF01082	0.671
MOD_Cter_Amidation	454	457	PF01082	0.448
MOD_DYRK1A_RPxSP_1	385	389	PF00069	0.587
MOD_GlcNHglycan	101	104	PF01048	0.638
MOD_GlcNHglycan	134	137	PF01048	0.638
MOD_GlcNHglycan	178	181	PF01048	0.625
MOD_GlcNHglycan	19	22	PF01048	0.613
MOD_GlcNHglycan	234	237	PF01048	0.697
MOD_GlcNHglycan	239	242	PF01048	0.672
MOD_GlcNHglycan	331	334	PF01048	0.688
MOD_GlcNHglycan	340	343	PF01048	0.616
MOD_GlcNHglycan	353	356	PF01048	0.544
MOD_GlcNHglycan	376	379	PF01048	0.583
MOD_GlcNHglycan	385	388	PF01048	0.564
MOD_GlcNHglycan	394	397	PF01048	0.496
MOD_GlcNHglycan	406	409	PF01048	0.571
MOD_GlcNHglycan	45	48	PF01048	0.587
MOD_GlcNHglycan	478	482	PF01048	0.692
MOD_GlcNHglycan	487	491	PF01048	0.606
MOD_GlcNHglycan	494	497	PF01048	0.529
MOD_GlcNHglycan	502	505	PF01048	0.552
MOD_GlcNHglycan	541	544	PF01048	0.704
MOD_GlcNHglycan	80	83	PF01048	0.686
MOD_GSK3_1	118	125	PF00069	0.657
MOD_GSK3_1	134	141	PF00069	0.596
MOD_GSK3_1	157	164	PF00069	0.688
MOD_GSK3_1	166	173	PF00069	0.642
MOD_GSK3_1	2	9	PF00069	0.660
MOD_GSK3_1	237	244	PF00069	0.662
MOD_GSK3_1	259	266	PF00069	0.608
MOD_GSK3_1	290	297	PF00069	0.625
MOD_GSK3_1	313	320	PF00069	0.672
MOD_GSK3_1	325	332	PF00069	0.618
MOD_GSK3_1	343	350	PF00069	0.532
MOD_GSK3_1	35	42	PF00069	0.650
MOD_GSK3_1	385	392	PF00069	0.657
MOD_GSK3_1	414	421	PF00069	0.572
MOD_GSK3_1	46	53	PF00069	0.595
MOD_GSK3_1	486	493	PF00069	0.635
MOD_GSK3_1	495	502	PF00069	0.600
MOD_GSK3_1	503	510	PF00069	0.525
MOD_GSK3_1	514	521	PF00069	0.509
MOD_GSK3_1	55	62	PF00069	0.604
MOD_GSK3_1	555	562	PF00069	0.694
MOD_GSK3_1	65	72	PF00069	0.545
MOD_GSK3_1	677	684	PF00069	0.369
MOD_GSK3_1	697	704	PF00069	0.373
MOD_LATS_1	187	193	PF00433	0.578
MOD_N-GLC_1	139	144	PF02516	0.659
MOD_N-GLC_1	167	172	PF02516	0.586
MOD_N-GLC_2	22	24	PF02516	0.635
MOD_NEK2_1	176	181	PF00069	0.641
MOD_NEK2_1	230	235	PF00069	0.616
MOD_NEK2_1	290	295	PF00069	0.621
MOD_NEK2_1	325	330	PF00069	0.618
MOD_NEK2_1	362	367	PF00069	0.614
MOD_NEK2_1	383	388	PF00069	0.614
MOD_NEK2_1	499	504	PF00069	0.643
MOD_NEK2_1	6	11	PF00069	0.685
MOD_NEK2_1	605	610	PF00069	0.420
MOD_OFUCOSY	253	258	PF10250	0.652
MOD_PIKK_1	62	68	PF00454	0.604
MOD_PK_1	294	300	PF00069	0.605
MOD_PKA_1	105	111	PF00069	0.659
MOD_PKA_1	188	194	PF00069	0.562
MOD_PKA_1	351	357	PF00069	0.630
MOD_PKA_1	705	711	PF00069	0.501
MOD_PKA_2	105	111	PF00069	0.696
MOD_PKA_2	187	193	PF00069	0.632
MOD_PKA_2	241	247	PF00069	0.713
MOD_PKA_2	290	296	PF00069	0.566
MOD_PKA_2	351	357	PF00069	0.608
MOD_PKA_2	372	378	PF00069	0.559
MOD_PKA_2	425	431	PF00069	0.418
MOD_PKA_2	555	561	PF00069	0.604
MOD_PKA_2	59	65	PF00069	0.684
MOD_PKA_2	6	12	PF00069	0.612
MOD_PKA_2	677	683	PF00069	0.437
MOD_PKA_2	697	703	PF00069	0.319
MOD_PKA_2	705	711	PF00069	0.444
MOD_PKB_1	472	480	PF00069	0.615
MOD_Plk_1	325	331	PF00069	0.600
MOD_Plk_1	517	523	PF00069	0.666
MOD_Plk_2-3	518	524	PF00069	0.670
MOD_Plk_4	189	195	PF00069	0.656
MOD_Plk_4	426	432	PF00069	0.471
MOD_Plk_4	600	606	PF00069	0.433
MOD_Plk_4	65	71	PF00069	0.668
MOD_Plk_4	75	81	PF00069	0.640
MOD_ProDKin_1	134	140	PF00069	0.685
MOD_ProDKin_1	23	29	PF00069	0.659
MOD_ProDKin_1	243	249	PF00069	0.690
MOD_ProDKin_1	251	257	PF00069	0.644
MOD_ProDKin_1	259	265	PF00069	0.510
MOD_ProDKin_1	284	290	PF00069	0.672
MOD_ProDKin_1	299	305	PF00069	0.544
MOD_ProDKin_1	320	326	PF00069	0.666
MOD_ProDKin_1	331	337	PF00069	0.621
MOD_ProDKin_1	385	391	PF00069	0.647
MOD_ProDKin_1	46	52	PF00069	0.661
MOD_ProDKin_1	525	531	PF00069	0.607
MOD_ProDKin_1	53	59	PF00069	0.635
MOD_ProDKin_1	559	565	PF00069	0.693
MOD_ProDKin_1	583	589	PF00069	0.381
MOD_ProDKin_1	619	625	PF00069	0.486
MOD_ProDKin_1	73	79	PF00069	0.554
MOD_SUMO_for_1	711	714	PF00179	0.523
MOD_SUMO_rev_2	478	488	PF00179	0.589
MOD_SUMO_rev_2	624	632	PF00179	0.503
TRG_DiLeu_BaEn_1	688	693	PF01217	0.454
TRG_ENDOCYTIC_2	594	597	PF00928	0.448
TRG_ER_diArg_1	152	155	PF00400	0.654
TRG_ER_diArg_1	465	467	PF00400	0.604
TRG_ER_diArg_1	470	472	PF00400	0.610
TRG_ER_diArg_1	546	548	PF00400	0.616
TRG_NLS_MonoCore_2	455	460	PF00514	0.524
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.685
TRG_Pf-PMV_PEXEL_1	647	651	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6E5	Leishmania donovani	100%	72%
A4H5U6	Leishmania braziliensis	64%	100%
E9AMW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QHQ7	Leishmania major	88%	100%