BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HU39_LEIIN

TriTrypDb:

LINF_090019000

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HU39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU39

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	127	133	PF00089	0.489
CLV_NRD_NRD_1	163	165	PF00675	0.540
CLV_NRD_NRD_1	182	184	PF00675	0.627
CLV_PCSK_KEX2_1	182	184	PF00082	0.627
CLV_PCSK_SKI1_1	164	168	PF00082	0.503
CLV_PCSK_SKI1_1	25	29	PF00082	0.536
CLV_PCSK_SKI1_1	69	73	PF00082	0.553
CLV_PCSK_SKI1_1	92	96	PF00082	0.496
DOC_CYCLIN_yCln2_LP_2	80	83	PF00134	0.574
DOC_MAPK_gen_1	112	122	PF00069	0.502
DOC_PP2B_LxvP_1	80	83	PF13499	0.584
DOC_USP7_MATH_2	83	89	PF00917	0.383
LIG_14-3-3_CanoR_1	130	137	PF00244	0.472
LIG_14-3-3_CanoR_1	86	94	PF00244	0.529
LIG_Actin_WH2_2	116	132	PF00022	0.521
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_FHA_1	55	61	PF00498	0.602
LIG_FHA_1	85	91	PF00498	0.539
LIG_FHA_1	93	99	PF00498	0.446
LIG_FHA_2	172	178	PF00498	0.475
LIG_FHA_2	21	27	PF00498	0.541
LIG_GBD_Chelix_1	119	127	PF00786	0.487
LIG_NRBOX	118	124	PF00104	0.441
LIG_SH2_CRK	141	145	PF00017	0.443
LIG_SH2_CRK	78	82	PF00017	0.502
LIG_SH2_STAP1	15	19	PF00017	0.550
LIG_SH2_STAP1	187	191	PF00017	0.486
LIG_SH2_STAP1	67	71	PF00017	0.413
LIG_SH2_STAT5	118	121	PF00017	0.442
LIG_SH3_3	14	20	PF00018	0.464
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.528
LIG_SxIP_EBH_1	86	96	PF03271	0.544
LIG_TRAF2_1	174	177	PF00917	0.501
LIG_TRAF2_1	2	5	PF00917	0.616
LIG_TRFH_1	78	82	PF08558	0.525
MOD_CK1_1	10	16	PF00069	0.564
MOD_CK1_1	132	138	PF00069	0.486
MOD_CK2_1	171	177	PF00069	0.478
MOD_CK2_1	20	26	PF00069	0.544
MOD_GlcNHglycan	12	15	PF01048	0.608
MOD_GlcNHglycan	134	137	PF01048	0.483
MOD_N-GLC_1	10	15	PF02516	0.578
MOD_NEK2_1	129	134	PF00069	0.470
MOD_NEK2_1	7	12	PF00069	0.508
MOD_PIKK_1	129	135	PF00454	0.471
MOD_PIKK_1	92	98	PF00454	0.568
MOD_PK_1	86	92	PF00069	0.560
MOD_PKA_2	129	135	PF00069	0.471
MOD_PKA_2	7	13	PF00069	0.518
MOD_PKA_2	85	91	PF00069	0.490
MOD_SUMO_for_1	60	63	PF00179	0.616
TRG_DiLeu_BaEn_4	176	182	PF01217	0.480
TRG_ENDOCYTIC_2	141	144	PF00928	0.464
TRG_ENDOCYTIC_2	78	81	PF00928	0.468
TRG_ER_diArg_1	181	183	PF00400	0.594
TRG_NES_CRM1_1	117	133	PF08389	0.496
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1U4	Leptomonas seymouri	65%	96%
A0A0S4J983	Bodo saltans	31%	77%
A0A0S4JCU4	Bodo saltans	28%	100%
A0A1X0NIG1	Trypanosomatidae	38%	100%
A0A3S7WQT5	Leishmania donovani	100%	100%
A0A422NZK1	Trypanosoma rangeli	39%	100%
A4H5U5	Leishmania braziliensis	90%	100%
D0A9L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AMW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QHQ8	Leishmania major	97%	100%
V5BDJ1	Trypanosoma cruzi	39%	100%