LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HU38_LEIIN
TriTrypDb:
LINF_090018900
Length:
739

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A4HU38
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU38

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 125 129 PF00656 0.617
CLV_C14_Caspase3-7 452 456 PF00656 0.698
CLV_NRD_NRD_1 166 168 PF00675 0.438
CLV_NRD_NRD_1 21 23 PF00675 0.423
CLV_NRD_NRD_1 342 344 PF00675 0.426
CLV_NRD_NRD_1 479 481 PF00675 0.520
CLV_NRD_NRD_1 52 54 PF00675 0.480
CLV_NRD_NRD_1 678 680 PF00675 0.666
CLV_NRD_NRD_1 718 720 PF00675 0.658
CLV_NRD_NRD_1 73 75 PF00675 0.479
CLV_PCSK_FUR_1 676 680 PF00082 0.629
CLV_PCSK_KEX2_1 20 22 PF00082 0.515
CLV_PCSK_KEX2_1 290 292 PF00082 0.487
CLV_PCSK_KEX2_1 479 481 PF00082 0.511
CLV_PCSK_KEX2_1 678 680 PF00082 0.628
CLV_PCSK_KEX2_1 718 720 PF00082 0.618
CLV_PCSK_KEX2_1 73 75 PF00082 0.479
CLV_PCSK_PC1ET2_1 290 292 PF00082 0.493
CLV_PCSK_SKI1_1 194 198 PF00082 0.438
CLV_PCSK_SKI1_1 21 25 PF00082 0.420
CLV_PCSK_SKI1_1 214 218 PF00082 0.406
CLV_PCSK_SKI1_1 287 291 PF00082 0.600
CLV_PCSK_SKI1_1 430 434 PF00082 0.413
CLV_PCSK_SKI1_1 462 466 PF00082 0.469
CLV_PCSK_SKI1_1 482 486 PF00082 0.446
CLV_PCSK_SKI1_1 59 63 PF00082 0.356
CLV_PCSK_SKI1_1 617 621 PF00082 0.461
CLV_PCSK_SKI1_1 98 102 PF00082 0.335
DEG_APCC_DBOX_1 549 557 PF00400 0.709
DEG_APCC_DBOX_1 635 643 PF00400 0.509
DEG_Nend_UBRbox_3 1 3 PF02207 0.679
DEG_SPOP_SBC_1 464 468 PF00917 0.733
DOC_ANK_TNKS_1 72 79 PF00023 0.646
DOC_CYCLIN_yCln2_LP_2 642 648 PF00134 0.372
DOC_MAPK_gen_1 167 176 PF00069 0.651
DOC_MAPK_gen_1 428 435 PF00069 0.626
DOC_MAPK_gen_1 726 735 PF00069 0.451
DOC_MAPK_HePTP_8 164 176 PF00069 0.694
DOC_MAPK_MEF2A_6 167 176 PF00069 0.620
DOC_MAPK_MEF2A_6 428 435 PF00069 0.640
DOC_PP1_RVXF_1 57 64 PF00149 0.570
DOC_PP2B_LxvP_1 642 645 PF13499 0.372
DOC_PP4_FxxP_1 186 189 PF00568 0.632
DOC_USP7_MATH_1 15 19 PF00917 0.669
DOC_USP7_MATH_1 361 365 PF00917 0.701
DOC_USP7_MATH_1 464 468 PF00917 0.749
DOC_USP7_UBL2_3 410 414 PF12436 0.627
DOC_USP7_UBL2_3 485 489 PF12436 0.624
DOC_USP7_UBL2_3 529 533 PF12436 0.588
DOC_WW_Pin1_4 274 279 PF00397 0.744
DOC_WW_Pin1_4 280 285 PF00397 0.742
DOC_WW_Pin1_4 554 559 PF00397 0.753
DOC_WW_Pin1_4 82 87 PF00397 0.725
LIG_14-3-3_CanoR_1 20 29 PF00244 0.744
LIG_14-3-3_CanoR_1 231 237 PF00244 0.784
LIG_14-3-3_CanoR_1 343 347 PF00244 0.719
LIG_BRCT_BRCA1_1 119 123 PF00533 0.538
LIG_BRCT_BRCA1_1 92 96 PF00533 0.616
LIG_Clathr_ClatBox_1 175 179 PF01394 0.599
LIG_CSL_BTD_1 642 645 PF09270 0.372
LIG_FHA_1 159 165 PF00498 0.760
LIG_FHA_1 471 477 PF00498 0.683
LIG_FHA_2 326 332 PF00498 0.628
LIG_FHA_2 495 501 PF00498 0.691
LIG_FHA_2 600 606 PF00498 0.598
LIG_LIR_Apic_2 202 208 PF02991 0.655
LIG_LIR_Gen_1 130 141 PF02991 0.620
LIG_LIR_Gen_1 308 319 PF02991 0.632
LIG_LIR_Gen_1 416 427 PF02991 0.697
LIG_LIR_Gen_1 584 594 PF02991 0.592
LIG_LIR_Nem_3 130 136 PF02991 0.611
LIG_LIR_Nem_3 308 314 PF02991 0.598
LIG_LIR_Nem_3 331 337 PF02991 0.611
LIG_LIR_Nem_3 416 422 PF02991 0.690
LIG_LIR_Nem_3 584 590 PF02991 0.597
LIG_LIR_Nem_3 60 66 PF02991 0.571
LIG_LIR_Nem_3 633 638 PF02991 0.638
LIG_LIR_Nem_3 656 660 PF02991 0.419
LIG_LIR_Nem_3 661 665 PF02991 0.345
LIG_LYPXL_yS_3 574 577 PF13949 0.707
LIG_MYND_1 554 558 PF01753 0.714
LIG_NRBOX 171 177 PF00104 0.599
LIG_NRBOX 684 690 PF00104 0.399
LIG_Pex14_1 333 337 PF04695 0.575
LIG_Pex14_2 186 190 PF04695 0.597
LIG_Pex14_2 62 66 PF04695 0.615
LIG_Pex14_2 96 100 PF04695 0.605
LIG_SH2_CRK 587 591 PF00017 0.520
LIG_SH2_GRB2like 336 339 PF00017 0.668
LIG_SH2_GRB2like 638 641 PF00017 0.393
LIG_SH2_SRC 379 382 PF00017 0.758
LIG_SH2_SRC 625 628 PF00017 0.603
LIG_SH2_SRC 638 641 PF00017 0.393
LIG_SH2_STAP1 587 591 PF00017 0.520
LIG_SH2_STAP1 92 96 PF00017 0.589
LIG_SH2_STAT3 359 362 PF00017 0.657
LIG_SH2_STAT3 492 495 PF00017 0.666
LIG_SH2_STAT3 72 75 PF00017 0.690
LIG_SH2_STAT3 92 95 PF00017 0.545
LIG_SH2_STAT5 133 136 PF00017 0.596
LIG_SH2_STAT5 406 409 PF00017 0.534
LIG_SH2_STAT5 597 600 PF00017 0.614
LIG_SH2_STAT5 618 621 PF00017 0.592
LIG_SH2_STAT5 638 641 PF00017 0.389
LIG_SH3_1 291 297 PF00018 0.670
LIG_SH3_2 294 299 PF14604 0.696
LIG_SH3_3 234 240 PF00018 0.742
LIG_SH3_3 278 284 PF00018 0.753
LIG_SH3_3 291 297 PF00018 0.605
LIG_SH3_3 548 554 PF00018 0.729
LIG_SUMO_SIM_par_1 221 230 PF11976 0.650
LIG_SUMO_SIM_par_1 325 331 PF11976 0.609
LIG_TRAF2_1 497 500 PF00917 0.630
LIG_TYR_ITIM 404 409 PF00017 0.657
LIG_UBA3_1 422 430 PF00899 0.667
LIG_UBA3_1 530 535 PF00899 0.675
LIG_WW_2 551 554 PF00397 0.733
MOD_CDK_SPxxK_3 280 287 PF00069 0.754
MOD_CK1_1 227 233 PF00069 0.707
MOD_CK1_1 277 283 PF00069 0.821
MOD_CK1_1 467 473 PF00069 0.748
MOD_CK1_1 566 572 PF00069 0.713
MOD_CK1_1 6 12 PF00069 0.748
MOD_CK2_1 230 236 PF00069 0.750
MOD_CK2_1 494 500 PF00069 0.640
MOD_CK2_1 599 605 PF00069 0.632
MOD_Cter_Amidation 51 54 PF01082 0.494
MOD_Cter_Amidation 727 730 PF01082 0.648
MOD_GlcNHglycan 232 235 PF01048 0.484
MOD_GlcNHglycan 30 33 PF01048 0.553
MOD_GlcNHglycan 347 350 PF01048 0.551
MOD_GlcNHglycan 401 404 PF01048 0.397
MOD_GlcNHglycan 451 454 PF01048 0.527
MOD_GlcNHglycan 50 53 PF01048 0.499
MOD_GlcNHglycan 587 590 PF01048 0.358
MOD_GlcNHglycan 87 90 PF01048 0.431
MOD_GlcNHglycan 9 12 PF01048 0.599
MOD_GSK3_1 2 9 PF00069 0.666
MOD_GSK3_1 462 469 PF00069 0.711
MOD_GSK3_1 511 518 PF00069 0.630
MOD_GSK3_1 713 720 PF00069 0.411
MOD_GSK3_1 77 84 PF00069 0.760
MOD_LATS_1 544 550 PF00433 0.659
MOD_N-GLC_1 698 703 PF02516 0.663
MOD_N-GLC_1 706 711 PF02516 0.674
MOD_N-GLC_1 713 718 PF02516 0.713
MOD_NEK2_1 1 6 PF00069 0.783
MOD_NEK2_1 342 347 PF00069 0.703
MOD_NEK2_1 399 404 PF00069 0.615
MOD_NEK2_1 418 423 PF00069 0.716
MOD_NEK2_1 463 468 PF00069 0.667
MOD_NEK2_1 511 516 PF00069 0.658
MOD_NEK2_1 706 711 PF00069 0.499
MOD_NEK2_1 713 718 PF00069 0.372
MOD_NEK2_2 15 20 PF00069 0.702
MOD_PIKK_1 21 27 PF00454 0.707
MOD_PIKK_1 342 348 PF00454 0.660
MOD_PKA_1 21 27 PF00069 0.621
MOD_PKA_1 718 724 PF00069 0.450
MOD_PKA_2 158 164 PF00069 0.718
MOD_PKA_2 21 27 PF00069 0.676
MOD_PKA_2 230 236 PF00069 0.781
MOD_PKA_2 342 348 PF00069 0.712
MOD_PKA_2 373 379 PF00069 0.734
MOD_PKA_2 717 723 PF00069 0.413
MOD_Plk_1 566 572 PF00069 0.694
MOD_Plk_1 706 712 PF00069 0.486
MOD_Plk_1 713 719 PF00069 0.520
MOD_Plk_4 117 123 PF00069 0.608
MOD_Plk_4 136 142 PF00069 0.503
MOD_Plk_4 325 331 PF00069 0.610
MOD_Plk_4 418 424 PF00069 0.613
MOD_Plk_4 630 636 PF00069 0.588
MOD_Plk_4 653 659 PF00069 0.293
MOD_ProDKin_1 274 280 PF00069 0.745
MOD_ProDKin_1 554 560 PF00069 0.752
MOD_ProDKin_1 82 88 PF00069 0.719
MOD_SUMO_rev_2 162 169 PF00179 0.616
TRG_DiLeu_BaEn_1 526 531 PF01217 0.556
TRG_DiLeu_BaEn_4 626 632 PF01217 0.572
TRG_DiLeu_BaLyEn_6 642 647 PF01217 0.393
TRG_ENDOCYTIC_2 104 107 PF00928 0.529
TRG_ENDOCYTIC_2 133 136 PF00928 0.596
TRG_ENDOCYTIC_2 336 339 PF00928 0.640
TRG_ENDOCYTIC_2 406 409 PF00928 0.549
TRG_ENDOCYTIC_2 415 418 PF00928 0.622
TRG_ENDOCYTIC_2 574 577 PF00928 0.690
TRG_ENDOCYTIC_2 587 590 PF00928 0.546
TRG_ENDOCYTIC_2 657 660 PF00928 0.505
TRG_ER_diArg_1 19 22 PF00400 0.735
TRG_ER_diArg_1 43 46 PF00400 0.671
TRG_ER_diArg_1 479 482 PF00400 0.714
TRG_ER_diArg_1 676 679 PF00400 0.377
TRG_ER_diArg_1 717 719 PF00400 0.413
TRG_ER_diArg_1 72 74 PF00400 0.669
TRG_NLS_Bipartite_1 718 733 PF00514 0.363
TRG_NLS_MonoExtC_3 728 734 PF00514 0.388
TRG_NLS_MonoExtN_4 726 733 PF00514 0.381
TRG_Pf-PMV_PEXEL_1 424 429 PF00026 0.530
TRG_Pf-PMV_PEXEL_1 439 443 PF00026 0.418
TRG_Pf-PMV_PEXEL_1 489 493 PF00026 0.491

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HTV6 Leptomonas seymouri 54% 100%
A0A0S4JUS6 Bodo saltans 24% 100%
A0A3Q8IH12 Leishmania donovani 100% 100%
A0A422NZM2 Trypanosoma rangeli 30% 100%
A4H5U4 Leishmania braziliensis 76% 100%
E9AMW7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 99%
Q4QHQ9 Leishmania major 94% 100%
V5DEB6 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS