LeishMANIAdb
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Putative translation initiation factor EIF-2B gamma subunit

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative translation initiation factor EIF-2B gamma subunit
Gene product:
translation initiation factor EIF-2B gamma subunit - putative
Species:
Leishmania infantum
UniProt:
A4HU30_LEIIN
TriTrypDb:
LINF_090018200
Length:
601

Annotations

Annotations by Jardim et al.

Translation, translation initiation factor EIF-2B gamma subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 27
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005850 eukaryotic translation initiation factor 2 complex 2 2
GO:0032991 protein-containing complex 1 2
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HU30
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU30

Function

Biological processes
Term Name Level Count
GO:0001731 formation of translation preinitiation complex 7 2
GO:0006417 regulation of translation 6 2
GO:0006450 regulation of translational fidelity 3 2
GO:0009889 regulation of biosynthetic process 4 2
GO:0009891 positive regulation of biosynthetic process 5 2
GO:0009893 positive regulation of metabolic process 4 2
GO:0009987 cellular process 1 2
GO:0010468 regulation of gene expression 5 2
GO:0010556 regulation of macromolecule biosynthetic process 5 2
GO:0010557 positive regulation of macromolecule biosynthetic process 6 2
GO:0010604 positive regulation of macromolecule metabolic process 5 2
GO:0010608 post-transcriptional regulation of gene expression 6 2
GO:0010628 positive regulation of gene expression 6 2
GO:0016043 cellular component organization 3 2
GO:0019222 regulation of metabolic process 3 2
GO:0022607 cellular component assembly 4 2
GO:0022618 ribonucleoprotein complex assembly 6 2
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031325 positive regulation of cellular metabolic process 5 2
GO:0031326 regulation of cellular biosynthetic process 5 2
GO:0031328 positive regulation of cellular biosynthetic process 6 2
GO:0034248 regulation of amide metabolic process 5 2
GO:0034250 positive regulation of amide metabolic process 6 2
GO:0043933 protein-containing complex organization 4 2
GO:0045727 positive regulation of translation 7 2
GO:0045903 positive regulation of translational fidelity 4 2
GO:0048518 positive regulation of biological process 3 2
GO:0048522 positive regulation of cellular process 4 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051173 positive regulation of nitrogen compound metabolic process 5 2
GO:0051246 regulation of protein metabolic process 5 2
GO:0051247 positive regulation of protein metabolic process 6 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0065003 protein-containing complex assembly 5 2
GO:0065007 biological regulation 1 2
GO:0065008 regulation of biological quality 2 2
GO:0071826 ribonucleoprotein complex subunit organization 5 2
GO:0071840 cellular component organization or biogenesis 2 2
GO:0080090 regulation of primary metabolic process 4 2
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003676 nucleic acid binding 3 11
GO:0003743 translation initiation factor activity 4 11
GO:0003824 catalytic activity 1 10
GO:0003924 GTPase activity 7 10
GO:0005488 binding 1 11
GO:0005525 GTP binding 5 11
GO:0008135 translation factor activity, RNA binding 3 11
GO:0016462 pyrophosphatase activity 5 10
GO:0016787 hydrolase activity 2 10
GO:0016817 hydrolase activity, acting on acid anhydrides 3 10
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 10
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 10
GO:0019001 guanyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032561 guanyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0045182 translation regulator activity 1 11
GO:0090079 translation regulator activity, nucleic acid binding 2 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0000049 tRNA binding 5 5
GO:0003723 RNA binding 4 5
GO:0003746 translation elongation factor activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 114 118 PF00656 0.656
CLV_C14_Caspase3-7 430 434 PF00656 0.649
CLV_NRD_NRD_1 251 253 PF00675 0.497
CLV_NRD_NRD_1 312 314 PF00675 0.477
CLV_NRD_NRD_1 319 321 PF00675 0.455
CLV_NRD_NRD_1 408 410 PF00675 0.678
CLV_NRD_NRD_1 518 520 PF00675 0.326
CLV_NRD_NRD_1 576 578 PF00675 0.354
CLV_PCSK_KEX2_1 131 133 PF00082 0.456
CLV_PCSK_KEX2_1 251 253 PF00082 0.523
CLV_PCSK_KEX2_1 311 313 PF00082 0.464
CLV_PCSK_KEX2_1 319 321 PF00082 0.455
CLV_PCSK_KEX2_1 408 410 PF00082 0.678
CLV_PCSK_KEX2_1 518 520 PF00082 0.386
CLV_PCSK_PC1ET2_1 131 133 PF00082 0.456
CLV_PCSK_PC7_1 404 410 PF00082 0.525
CLV_PCSK_SKI1_1 279 283 PF00082 0.482
CLV_PCSK_SKI1_1 46 50 PF00082 0.612
CLV_PCSK_SKI1_1 475 479 PF00082 0.422
CLV_PCSK_SKI1_1 568 572 PF00082 0.326
DEG_SPOP_SBC_1 426 430 PF00917 0.642
DOC_CDC14_PxL_1 301 309 PF14671 0.411
DOC_CYCLIN_yCln2_LP_2 556 562 PF00134 0.326
DOC_MAPK_gen_1 383 391 PF00069 0.415
DOC_MAPK_gen_1 76 85 PF00069 0.656
DOC_MAPK_MEF2A_6 524 533 PF00069 0.378
DOC_MAPK_MEF2A_6 79 87 PF00069 0.656
DOC_MAPK_RevD_3 305 320 PF00069 0.478
DOC_PP1_RVXF_1 578 585 PF00149 0.386
DOC_PP2B_LxvP_1 480 483 PF13499 0.521
DOC_PP4_FxxP_1 169 172 PF00568 0.656
DOC_PP4_FxxP_1 361 364 PF00568 0.380
DOC_USP7_MATH_1 165 169 PF00917 0.656
DOC_USP7_MATH_1 206 210 PF00917 0.440
DOC_USP7_MATH_1 420 424 PF00917 0.753
DOC_USP7_MATH_1 436 440 PF00917 0.701
DOC_USP7_MATH_1 597 601 PF00917 0.523
DOC_WW_Pin1_4 116 121 PF00397 0.656
DOC_WW_Pin1_4 331 336 PF00397 0.496
DOC_WW_Pin1_4 409 414 PF00397 0.636
DOC_WW_Pin1_4 422 427 PF00397 0.614
DOC_WW_Pin1_4 432 437 PF00397 0.602
DOC_WW_Pin1_4 444 449 PF00397 0.540
DOC_WW_Pin1_4 555 560 PF00397 0.373
LIG_14-3-3_CanoR_1 132 137 PF00244 0.656
LIG_14-3-3_CanoR_1 346 350 PF00244 0.463
LIG_14-3-3_CanoR_1 404 408 PF00244 0.510
LIG_14-3-3_CanoR_1 511 517 PF00244 0.378
LIG_Actin_WH2_2 460 477 PF00022 0.401
LIG_Actin_WH2_2 529 546 PF00022 0.326
LIG_Actin_WH2_2 575 591 PF00022 0.331
LIG_APCC_ABBA_1 461 466 PF00400 0.397
LIG_BIR_II_1 1 5 PF00653 0.749
LIG_BIR_III_2 433 437 PF00653 0.579
LIG_FHA_1 125 131 PF00498 0.656
LIG_FHA_1 345 351 PF00498 0.482
LIG_FHA_1 38 44 PF00498 0.646
LIG_FHA_1 47 53 PF00498 0.416
LIG_FHA_1 84 90 PF00498 0.656
LIG_FHA_2 370 376 PF00498 0.476
LIG_FHA_2 428 434 PF00498 0.649
LIG_FHA_2 8 14 PF00498 0.763
LIG_LIR_Apic_2 167 172 PF02991 0.656
LIG_LIR_Apic_2 339 344 PF02991 0.408
LIG_LIR_Apic_2 358 364 PF02991 0.396
LIG_LIR_Gen_1 27 36 PF02991 0.621
LIG_LIR_Gen_1 39 48 PF02991 0.476
LIG_LIR_Nem_3 106 111 PF02991 0.656
LIG_LIR_Nem_3 27 31 PF02991 0.593
LIG_PCNA_PIPBox_1 207 216 PF02747 0.494
LIG_PCNA_PIPBox_1 465 474 PF02747 0.434
LIG_PCNA_yPIPBox_3 465 475 PF02747 0.426
LIG_REV1ctd_RIR_1 469 479 PF16727 0.404
LIG_SH2_CRK 259 263 PF00017 0.388
LIG_SH2_CRK 341 345 PF00017 0.457
LIG_SH2_GRB2like 259 262 PF00017 0.384
LIG_SH2_GRB2like 91 94 PF00017 0.656
LIG_SH2_NCK_1 221 225 PF00017 0.494
LIG_SH2_SRC 464 467 PF00017 0.373
LIG_SH2_SRC 91 94 PF00017 0.656
LIG_SH2_STAT5 214 217 PF00017 0.537
LIG_SH2_STAT5 243 246 PF00017 0.545
LIG_SH2_STAT5 331 334 PF00017 0.468
LIG_SH2_STAT5 574 577 PF00017 0.326
LIG_SH3_3 134 140 PF00018 0.656
LIG_SH3_3 222 228 PF00018 0.537
LIG_SH3_3 242 248 PF00018 0.415
LIG_SH3_3 265 271 PF00018 0.434
LIG_SH3_3 329 335 PF00018 0.465
LIG_Sin3_3 158 165 PF02671 0.656
LIG_SUMO_SIM_anti_2 187 193 PF11976 0.496
LIG_SUMO_SIM_anti_2 299 305 PF11976 0.413
LIG_SUMO_SIM_par_1 366 373 PF11976 0.452
LIG_SUMO_SIM_par_1 451 456 PF11976 0.533
LIG_SUMO_SIM_par_1 525 535 PF11976 0.331
LIG_UBA3_1 189 195 PF00899 0.494
LIG_WRC_WIRS_1 263 268 PF05994 0.466
LIG_WRC_WIRS_1 38 43 PF05994 0.632
MOD_CK1_1 400 406 PF00069 0.568
MOD_CK1_1 421 427 PF00069 0.840
MOD_CK1_1 532 538 PF00069 0.531
MOD_CK1_1 558 564 PF00069 0.302
MOD_CK2_1 322 328 PF00069 0.483
MOD_GlcNHglycan 324 327 PF01048 0.485
MOD_GlcNHglycan 420 423 PF01048 0.670
MOD_GlcNHglycan 438 441 PF01048 0.717
MOD_GlcNHglycan 560 563 PF01048 0.326
MOD_GlcNHglycan 69 72 PF01048 0.456
MOD_GSK3_1 103 110 PF00069 0.630
MOD_GSK3_1 111 118 PF00069 0.586
MOD_GSK3_1 262 269 PF00069 0.453
MOD_GSK3_1 370 377 PF00069 0.482
MOD_GSK3_1 418 425 PF00069 0.636
MOD_GSK3_1 42 49 PF00069 0.589
MOD_GSK3_1 428 435 PF00069 0.649
MOD_GSK3_1 525 532 PF00069 0.363
MOD_GSK3_1 534 541 PF00069 0.417
MOD_GSK3_1 67 74 PF00069 0.656
MOD_N-GLC_1 165 170 PF02516 0.456
MOD_N-GLC_1 235 240 PF02516 0.331
MOD_N-GLC_1 83 88 PF02516 0.456
MOD_NEK2_1 145 150 PF00069 0.656
MOD_NEK2_1 266 271 PF00069 0.430
MOD_NEK2_1 345 350 PF00069 0.425
MOD_NEK2_1 543 548 PF00069 0.326
MOD_NEK2_1 83 88 PF00069 0.656
MOD_OFUCOSY 102 107 PF10250 0.456
MOD_PIKK_1 111 117 PF00454 0.656
MOD_PIKK_1 71 77 PF00454 0.656
MOD_PKA_2 103 109 PF00069 0.656
MOD_PKA_2 345 351 PF00069 0.465
MOD_PKA_2 400 406 PF00069 0.498
MOD_PKA_2 543 549 PF00069 0.326
MOD_Plk_1 165 171 PF00069 0.656
MOD_Plk_1 235 241 PF00069 0.531
MOD_Plk_1 266 272 PF00069 0.450
MOD_Plk_1 525 531 PF00069 0.331
MOD_Plk_1 7 13 PF00069 0.764
MOD_Plk_1 83 89 PF00069 0.656
MOD_Plk_4 145 151 PF00069 0.656
MOD_Plk_4 185 191 PF00069 0.494
MOD_Plk_4 206 212 PF00069 0.477
MOD_Plk_4 345 351 PF00069 0.598
MOD_Plk_4 525 531 PF00069 0.351
MOD_Plk_4 538 544 PF00069 0.443
MOD_Plk_4 583 589 PF00069 0.331
MOD_Plk_4 61 67 PF00069 0.656
MOD_ProDKin_1 116 122 PF00069 0.656
MOD_ProDKin_1 331 337 PF00069 0.503
MOD_ProDKin_1 409 415 PF00069 0.637
MOD_ProDKin_1 422 428 PF00069 0.615
MOD_ProDKin_1 432 438 PF00069 0.600
MOD_ProDKin_1 444 450 PF00069 0.538
MOD_ProDKin_1 555 561 PF00069 0.373
MOD_SUMO_rev_2 8 17 PF00179 0.694
TRG_ENDOCYTIC_2 259 262 PF00928 0.384
TRG_ENDOCYTIC_2 464 467 PF00928 0.432
TRG_ER_diArg_1 250 252 PF00400 0.482
TRG_ER_diArg_1 310 313 PF00400 0.506
TRG_ER_diArg_1 318 320 PF00400 0.489
TRG_ER_diArg_1 398 401 PF00400 0.544
TRG_ER_diArg_1 407 409 PF00400 0.652
TRG_ER_diArg_1 518 520 PF00400 0.326
TRG_NES_CRM1_1 182 193 PF08389 0.656
TRG_Pf-PMV_PEXEL_1 594 598 PF00026 0.530

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0M5 Leptomonas seymouri 63% 100%
A0A3S7WQT0 Leishmania donovani 70% 100%
A4H5T6 Leishmania braziliensis 68% 100%
A4H5T7 Leishmania braziliensis 85% 100%
A4HU29 Leishmania infantum 70% 100%
E9AMV9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 69% 100%
E9AMW0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 99%
Q4QHR6 Leishmania major 95% 100%
Q4QHR7 Leishmania major 69% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS