Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MSP (Major sperm protein) domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HU27_LEIIN

TriTrypDb:

LINF_090017900

Length:

250

Annotations

LeishMANIAdb annotations

As the MSP domain is involved in providing cell motility, this protein is likely involved in the same function.. Has a number of plant (E1ZCB1_CHLVA), fungal (G8B4Z0_CANPC) and animal orthologs.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0005886	plasma membrane	3	1
GO:0020016	ciliary pocket	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HU27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU27

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022406	membrane docking	2	1
GO:0051179	localization	1	1
GO:0051640	organelle localization	2	1
GO:0051643	endoplasmic reticulum localization	3	1
GO:0061024	membrane organization	4	1
GO:0061817	endoplasmic reticulum-plasma membrane tethering	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090158	endoplasmic reticulum membrane organization	5	1
GO:0140056	organelle localization by membrane tethering	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.675
CLV_NRD_NRD_1	182	184	PF00675	0.545
CLV_NRD_NRD_1	201	203	PF00675	0.350
CLV_PCSK_KEX2_1	199	201	PF00082	0.459
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.495
CLV_PCSK_SKI1_1	133	137	PF00082	0.374
CLV_PCSK_SKI1_1	184	188	PF00082	0.544
DEG_Nend_UBRbox_2	1	3	PF02207	0.708
DOC_PP2B_PxIxI_1	5	11	PF00149	0.606
DOC_USP7_MATH_1	120	124	PF00917	0.613
DOC_USP7_MATH_1	138	142	PF00917	0.595
DOC_USP7_MATH_1	155	159	PF00917	0.718
DOC_USP7_UBL2_3	55	59	PF12436	0.501
LIG_14-3-3_CanoR_1	183	191	PF00244	0.760
LIG_14-3-3_CanoR_1	40	46	PF00244	0.487
LIG_BIR_III_4	166	170	PF00653	0.732
LIG_FHA_1	24	30	PF00498	0.561
LIG_FHA_1	42	48	PF00498	0.393
LIG_FHA_1	65	71	PF00498	0.507
LIG_FHA_1	87	93	PF00498	0.556
LIG_FHA_2	193	199	PF00498	0.652
LIG_FHA_2	72	78	PF00498	0.588
LIG_LIR_Gen_1	13	21	PF02991	0.539
LIG_LIR_Nem_3	13	18	PF02991	0.518
LIG_PTB_Apo_2	28	35	PF02174	0.487
LIG_PTB_Phospho_1	28	34	PF10480	0.567
LIG_SH2_CRK	215	219	PF00017	0.478
LIG_SH2_STAP1	34	38	PF00017	0.567
LIG_SH2_STAT5	129	132	PF00017	0.606
LIG_SH2_STAT5	50	53	PF00017	0.489
LIG_SH2_STAT5	85	88	PF00017	0.531
LIG_TYR_ITIM	32	37	PF00017	0.567
MOD_CK2_1	171	177	PF00069	0.657
MOD_CK2_1	192	198	PF00069	0.661
MOD_CK2_1	71	77	PF00069	0.568
MOD_Cter_Amidation	181	184	PF01082	0.544
MOD_GlcNHglycan	157	160	PF01048	0.515
MOD_GlcNHglycan	171	174	PF01048	0.504
MOD_GlcNHglycan	180	183	PF01048	0.551
MOD_GlcNHglycan	204	207	PF01048	0.549
MOD_GlcNHglycan	62	65	PF01048	0.343
MOD_GSK3_1	178	185	PF00069	0.746
MOD_GSK3_1	23	30	PF00069	0.567
MOD_GSK3_1	60	67	PF00069	0.497
MOD_N-GLC_1	120	125	PF02516	0.422
MOD_N-GLC_1	202	207	PF02516	0.559
MOD_N-GLC_1	60	65	PF02516	0.294
MOD_NEK2_1	27	32	PF00069	0.518
MOD_NEK2_1	51	56	PF00069	0.518
MOD_NEK2_2	64	69	PF00069	0.528
MOD_PKA_2	169	175	PF00069	0.704
MOD_PKA_2	182	188	PF00069	0.775
MOD_PKA_2	41	47	PF00069	0.547
MOD_PKA_2	83	89	PF00069	0.538
MOD_PKB_1	200	208	PF00069	0.751
MOD_Plk_1	120	126	PF00069	0.589
MOD_Plk_1	23	29	PF00069	0.493
MOD_Plk_2-3	192	198	PF00069	0.661
MOD_Plk_2-3	23	29	PF00069	0.565
MOD_Plk_4	121	127	PF00069	0.572
TRG_DiLeu_BaEn_1	13	18	PF01217	0.582
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.537
TRG_ENDOCYTIC_2	215	218	PF00928	0.484
TRG_ENDOCYTIC_2	34	37	PF00928	0.567
TRG_ER_diArg_1	200	202	PF00400	0.724
TRG_ER_diArg_1	39	42	PF00400	0.567
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9W8	Leptomonas seymouri	63%	100%
A0A1X0NI22	Trypanosomatidae	28%	91%
A0A3S7WQS6	Leishmania donovani	100%	100%
A0A422MXK0	Trypanosoma rangeli	31%	100%
A4H5T4	Leishmania braziliensis	81%	99%
D0A9K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AMV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	96%
Q4QHR9	Leishmania major	90%	99%
V5BI56	Trypanosoma cruzi	32%	100%