LeishMANIAdb
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Putative phospholipid:diacylglycerol acyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative phospholipid:diacylglycerol acyltransferase
Gene product:
phospholipid:diacylglycerol acyltransferase - putative
Species:
Leishmania infantum
UniProt:
A4HU26_LEIIN
TriTrypDb:
LINF_090017800
Length:
686

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, phospholipid:diacylglycerol acyltransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 10
GO:0016020 membrane 2 9

Expansion

Sequence features

A4HU26
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU26

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 12
GO:0008152 metabolic process 1 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0008080 N-acetyltransferase activity 6 7
GO:0008374 O-acyltransferase activity 5 12
GO:0016407 acetyltransferase activity 5 7
GO:0016410 N-acyltransferase activity 5 7
GO:0016740 transferase activity 2 12
GO:0016746 acyltransferase activity 3 12
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 12
GO:0046027 phospholipid:diacylglycerol acyltransferase activity 7 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 5 9 PF00656 0.708
CLV_NRD_NRD_1 122 124 PF00675 0.343
CLV_NRD_NRD_1 176 178 PF00675 0.494
CLV_NRD_NRD_1 29 31 PF00675 0.545
CLV_NRD_NRD_1 320 322 PF00675 0.522
CLV_NRD_NRD_1 390 392 PF00675 0.525
CLV_NRD_NRD_1 552 554 PF00675 0.497
CLV_NRD_NRD_1 632 634 PF00675 0.582
CLV_NRD_NRD_1 654 656 PF00675 0.590
CLV_NRD_NRD_1 93 95 PF00675 0.433
CLV_PCSK_KEX2_1 121 123 PF00082 0.392
CLV_PCSK_KEX2_1 176 178 PF00082 0.494
CLV_PCSK_KEX2_1 29 31 PF00082 0.578
CLV_PCSK_KEX2_1 322 324 PF00082 0.515
CLV_PCSK_KEX2_1 552 554 PF00082 0.454
CLV_PCSK_KEX2_1 632 634 PF00082 0.582
CLV_PCSK_KEX2_1 93 95 PF00082 0.443
CLV_PCSK_PC1ET2_1 322 324 PF00082 0.518
CLV_PCSK_SKI1_1 204 208 PF00082 0.629
CLV_PCSK_SKI1_1 391 395 PF00082 0.430
CLV_PCSK_SKI1_1 557 561 PF00082 0.430
CLV_PCSK_SKI1_1 659 663 PF00082 0.638
DEG_APCC_DBOX_1 122 130 PF00400 0.474
DEG_APCC_DBOX_1 309 317 PF00400 0.255
DEG_Kelch_Keap1_1 621 626 PF01344 0.480
DEG_SCF_TRCP1_1 252 257 PF00400 0.325
DOC_CDC14_PxL_1 469 477 PF14671 0.255
DOC_CKS1_1 508 513 PF01111 0.203
DOC_CYCLIN_yClb1_LxF_4 310 316 PF00134 0.325
DOC_CYCLIN_yClb5_NLxxxL_5 645 654 PF00134 0.335
DOC_MAPK_gen_1 121 130 PF00069 0.463
DOC_MAPK_gen_1 176 182 PF00069 0.262
DOC_MAPK_gen_1 319 327 PF00069 0.293
DOC_MAPK_gen_1 93 104 PF00069 0.662
DOC_MAPK_HePTP_8 119 131 PF00069 0.513
DOC_MAPK_MEF2A_6 121 130 PF00069 0.443
DOC_MAPK_MEF2A_6 176 183 PF00069 0.346
DOC_PP2B_LxvP_1 102 105 PF13499 0.564
DOC_PP4_FxxP_1 79 82 PF00568 0.644
DOC_USP7_MATH_1 103 107 PF00917 0.619
DOC_USP7_MATH_1 23 27 PF00917 0.720
DOC_USP7_MATH_1 537 541 PF00917 0.274
DOC_USP7_MATH_1 663 667 PF00917 0.413
DOC_USP7_MATH_1 82 86 PF00917 0.706
DOC_USP7_UBL2_3 579 583 PF12436 0.323
DOC_WW_Pin1_4 16 21 PF00397 0.706
DOC_WW_Pin1_4 292 297 PF00397 0.241
DOC_WW_Pin1_4 507 512 PF00397 0.323
DOC_WW_Pin1_4 78 83 PF00397 0.631
LIG_14-3-3_CanoR_1 158 164 PF00244 0.369
LIG_14-3-3_CanoR_1 202 207 PF00244 0.387
LIG_14-3-3_CanoR_1 24 31 PF00244 0.722
LIG_14-3-3_CanoR_1 310 314 PF00244 0.316
LIG_14-3-3_CanoR_1 408 417 PF00244 0.248
LIG_14-3-3_CanoR_1 528 536 PF00244 0.325
LIG_14-3-3_CanoR_1 61 66 PF00244 0.630
LIG_14-3-3_CanoR_1 637 646 PF00244 0.291
LIG_14-3-3_CanoR_1 93 99 PF00244 0.630
LIG_Actin_WH2_2 560 578 PF00022 0.323
LIG_APCC_Cbox_2 352 358 PF00515 0.325
LIG_BIR_III_2 156 160 PF00653 0.356
LIG_BRCT_BRCA1_1 311 315 PF00533 0.316
LIG_BRCT_BRCA1_1 515 519 PF00533 0.323
LIG_BRCT_BRCA1_1 63 67 PF00533 0.656
LIG_EH1_1 124 132 PF00400 0.362
LIG_EH1_1 590 598 PF00400 0.304
LIG_FHA_1 186 192 PF00498 0.314
LIG_FHA_1 332 338 PF00498 0.257
LIG_FHA_1 381 387 PF00498 0.268
LIG_FHA_1 440 446 PF00498 0.332
LIG_FHA_1 508 514 PF00498 0.318
LIG_FHA_1 533 539 PF00498 0.245
LIG_FHA_1 625 631 PF00498 0.432
LIG_FHA_2 150 156 PF00498 0.414
LIG_FHA_2 238 244 PF00498 0.230
LIG_FHA_2 3 9 PF00498 0.704
LIG_FHA_2 466 472 PF00498 0.381
LIG_FHA_2 618 624 PF00498 0.418
LIG_FXI_DFP_1 72 76 PF00024 0.449
LIG_GBD_Chelix_1 126 134 PF00786 0.365
LIG_HP1_1 179 183 PF01393 0.291
LIG_Integrin_RGD_1 169 171 PF01839 0.570
LIG_LIR_Apic_2 257 263 PF02991 0.307
LIG_LIR_Apic_2 76 82 PF02991 0.639
LIG_LIR_Gen_1 252 263 PF02991 0.301
LIG_LIR_Gen_1 407 418 PF02991 0.276
LIG_LIR_Gen_1 57 67 PF02991 0.656
LIG_LIR_Gen_1 636 646 PF02991 0.293
LIG_LIR_Gen_1 70 80 PF02991 0.649
LIG_LIR_Nem_3 162 167 PF02991 0.376
LIG_LIR_Nem_3 205 210 PF02991 0.395
LIG_LIR_Nem_3 252 258 PF02991 0.301
LIG_LIR_Nem_3 303 309 PF02991 0.230
LIG_LIR_Nem_3 407 413 PF02991 0.260
LIG_LIR_Nem_3 422 428 PF02991 0.239
LIG_LIR_Nem_3 57 62 PF02991 0.660
LIG_LIR_Nem_3 636 642 PF02991 0.296
LIG_LIR_Nem_3 70 75 PF02991 0.691
LIG_OCRL_FandH_1 349 361 PF00620 0.325
LIG_Pex14_1 230 234 PF04695 0.325
LIG_Pex14_2 206 210 PF04695 0.363
LIG_Pex14_2 75 79 PF04695 0.721
LIG_REV1ctd_RIR_1 161 170 PF16727 0.385
LIG_REV1ctd_RIR_1 337 345 PF16727 0.325
LIG_SH2_GRB2like 358 361 PF00017 0.316
LIG_SH2_GRB2like 619 622 PF00017 0.375
LIG_SH2_NCK_1 619 623 PF00017 0.379
LIG_SH2_NCK_1 639 643 PF00017 0.225
LIG_SH2_PTP2 358 361 PF00017 0.325
LIG_SH2_SRC 31 34 PF00017 0.713
LIG_SH2_SRC 358 361 PF00017 0.324
LIG_SH2_STAP1 290 294 PF00017 0.230
LIG_SH2_STAT3 280 283 PF00017 0.241
LIG_SH2_STAT5 173 176 PF00017 0.414
LIG_SH2_STAT5 221 224 PF00017 0.292
LIG_SH2_STAT5 260 263 PF00017 0.316
LIG_SH2_STAT5 358 361 PF00017 0.265
LIG_SH2_STAT5 498 501 PF00017 0.233
LIG_SH2_STAT5 512 515 PF00017 0.325
LIG_SH2_STAT5 619 622 PF00017 0.418
LIG_SH3_1 657 663 PF00018 0.407
LIG_SH3_3 134 140 PF00018 0.453
LIG_SH3_3 17 23 PF00018 0.723
LIG_SH3_3 178 184 PF00018 0.328
LIG_SH3_3 470 476 PF00018 0.231
LIG_SH3_3 486 492 PF00018 0.222
LIG_SH3_3 606 612 PF00018 0.419
LIG_SH3_3 657 663 PF00018 0.407
LIG_SUMO_SIM_anti_2 592 598 PF11976 0.300
LIG_SUMO_SIM_par_1 14 19 PF11976 0.753
LIG_UBA3_1 233 239 PF00899 0.255
LIG_UBA3_1 593 599 PF00899 0.277
LIG_WRC_WIRS_1 394 399 PF05994 0.316
LIG_WRC_WIRS_1 462 467 PF05994 0.381
LIG_WRC_WIRS_1 62 67 PF05994 0.621
MOD_CDC14_SPxK_1 295 298 PF00782 0.255
MOD_CDK_SPxK_1 292 298 PF00069 0.255
MOD_CK1_1 205 211 PF00069 0.355
MOD_CK1_1 568 574 PF00069 0.280
MOD_CK1_1 676 682 PF00069 0.512
MOD_CK2_1 149 155 PF00069 0.414
MOD_CK2_1 450 456 PF00069 0.317
MOD_CK2_1 461 467 PF00069 0.302
MOD_GlcNHglycan 207 210 PF01048 0.613
MOD_GlcNHglycan 25 28 PF01048 0.534
MOD_GlcNHglycan 252 255 PF01048 0.485
MOD_GlcNHglycan 347 350 PF01048 0.506
MOD_GlcNHglycan 372 375 PF01048 0.432
MOD_GlcNHglycan 452 455 PF01048 0.503
MOD_GlcNHglycan 49 52 PF01048 0.489
MOD_GlcNHglycan 567 570 PF01048 0.452
MOD_GlcNHglycan 580 583 PF01048 0.412
MOD_GlcNHglycan 601 604 PF01048 0.470
MOD_GlcNHglycan 675 678 PF01048 0.693
MOD_GlcNHglycan 84 87 PF01048 0.514
MOD_GSK3_1 250 257 PF00069 0.300
MOD_GSK3_1 327 334 PF00069 0.272
MOD_GSK3_1 404 411 PF00069 0.325
MOD_GSK3_1 432 439 PF00069 0.345
MOD_GSK3_1 461 468 PF00069 0.350
MOD_GSK3_1 565 572 PF00069 0.323
MOD_GSK3_1 617 624 PF00069 0.414
MOD_GSK3_1 645 652 PF00069 0.325
MOD_GSK3_1 675 682 PF00069 0.495
MOD_GSK3_1 78 85 PF00069 0.646
MOD_GSK3_1 88 95 PF00069 0.642
MOD_LATS_1 635 641 PF00433 0.357
MOD_N-GLC_1 432 437 PF02516 0.508
MOD_N-GLC_1 479 484 PF02516 0.413
MOD_N-GLC_1 514 519 PF02516 0.490
MOD_N-GLC_1 520 525 PF02516 0.504
MOD_N-GLC_1 563 568 PF02516 0.534
MOD_N-GLC_1 617 622 PF02516 0.518
MOD_NEK2_1 393 398 PF00069 0.250
MOD_NEK2_1 406 411 PF00069 0.265
MOD_NEK2_1 49 54 PF00069 0.764
MOD_NEK2_1 563 568 PF00069 0.323
MOD_NEK2_1 617 622 PF00069 0.474
MOD_NEK2_1 673 678 PF00069 0.465
MOD_NEK2_2 159 164 PF00069 0.366
MOD_NEK2_2 514 519 PF00069 0.301
MOD_PIKK_1 396 402 PF00454 0.325
MOD_PIKK_1 88 94 PF00454 0.664
MOD_PKA_2 23 29 PF00069 0.698
MOD_PKA_2 309 315 PF00069 0.316
MOD_PKA_2 345 351 PF00069 0.255
MOD_PKA_2 380 386 PF00069 0.323
MOD_PKA_2 439 445 PF00069 0.337
MOD_PKA_2 527 533 PF00069 0.325
MOD_PKA_2 92 98 PF00069 0.629
MOD_Plk_1 194 200 PF00069 0.376
MOD_Plk_1 3 9 PF00069 0.667
MOD_Plk_1 479 485 PF00069 0.191
MOD_Plk_1 514 520 PF00069 0.290
MOD_Plk_1 532 538 PF00069 0.325
MOD_Plk_1 563 569 PF00069 0.303
MOD_Plk_1 625 631 PF00069 0.365
MOD_Plk_4 103 109 PF00069 0.631
MOD_Plk_4 159 165 PF00069 0.342
MOD_Plk_4 169 175 PF00069 0.398
MOD_Plk_4 202 208 PF00069 0.361
MOD_Plk_4 393 399 PF00069 0.316
MOD_Plk_4 412 418 PF00069 0.300
MOD_Plk_4 426 432 PF00069 0.290
MOD_Plk_4 461 467 PF00069 0.355
MOD_Plk_4 514 520 PF00069 0.325
MOD_ProDKin_1 16 22 PF00069 0.705
MOD_ProDKin_1 292 298 PF00069 0.241
MOD_ProDKin_1 507 513 PF00069 0.323
MOD_ProDKin_1 78 84 PF00069 0.633
MOD_SUMO_rev_2 243 249 PF00179 0.343
TRG_ENDOCYTIC_2 221 224 PF00928 0.268
TRG_ENDOCYTIC_2 358 361 PF00928 0.300
TRG_ENDOCYTIC_2 497 500 PF00928 0.350
TRG_ENDOCYTIC_2 591 594 PF00928 0.299
TRG_ENDOCYTIC_2 639 642 PF00928 0.291
TRG_ER_diArg_1 121 123 PF00400 0.542
TRG_ER_diArg_1 175 177 PF00400 0.321
TRG_ER_diArg_1 210 213 PF00400 0.298
TRG_ER_diArg_1 29 31 PF00400 0.698
TRG_ER_diArg_1 551 553 PF00400 0.297
TRG_ER_diArg_1 60 63 PF00400 0.669
TRG_ER_diArg_1 632 634 PF00400 0.382
TRG_NLS_MonoExtC_3 654 659 PF00514 0.409
TRG_NLS_MonoExtN_4 319 325 PF00514 0.315
TRG_NLS_MonoExtN_4 655 660 PF00514 0.423
TRG_Pf-PMV_PEXEL_1 314 318 PF00026 0.486

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HU70 Leptomonas seymouri 67% 90%
A0A0S4J6G5 Bodo saltans 37% 100%
A0A1X0NHY0 Trypanosomatidae 46% 86%
A0A3R7KCW2 Trypanosoma rangeli 43% 100%
A0A3S7WQS8 Leishmania donovani 100% 100%
A4H5T3 Leishmania braziliensis 85% 100%
D0A9K5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AMV6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O94680 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
P40345 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
Q4QHS0 Leishmania major 95% 100%
V5BDI6 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS