Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HU25_LEIIN

TriTrypDb:

LINF_090017700

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HU25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.568
CLV_C14_Caspase3-7	95	99	PF00656	0.437
CLV_NRD_NRD_1	116	118	PF00675	0.538
CLV_NRD_NRD_1	171	173	PF00675	0.714
CLV_NRD_NRD_1	195	197	PF00675	0.530
CLV_NRD_NRD_1	216	218	PF00675	0.623
CLV_NRD_NRD_1	230	232	PF00675	0.521
CLV_NRD_NRD_1	36	38	PF00675	0.679
CLV_PCSK_FUR_1	214	218	PF00082	0.606
CLV_PCSK_FUR_1	34	38	PF00082	0.628
CLV_PCSK_KEX2_1	116	118	PF00082	0.538
CLV_PCSK_KEX2_1	194	196	PF00082	0.538
CLV_PCSK_KEX2_1	204	206	PF00082	0.430
CLV_PCSK_KEX2_1	216	218	PF00082	0.623
CLV_PCSK_KEX2_1	230	232	PF00082	0.521
CLV_PCSK_KEX2_1	36	38	PF00082	0.635
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.484
CLV_PCSK_SKI1_1	116	120	PF00082	0.623
CLV_PCSK_SKI1_1	246	250	PF00082	0.500
CLV_PCSK_SKI1_1	254	258	PF00082	0.412
DEG_SPOP_SBC_1	18	22	PF00917	0.615
DEG_SPOP_SBC_1	223	227	PF00917	0.646
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.570
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.600
DOC_MAPK_gen_1	204	210	PF00069	0.520
DOC_PP4_FxxP_1	44	47	PF00568	0.623
DOC_USP7_MATH_1	12	16	PF00917	0.694
DOC_USP7_MATH_1	165	169	PF00917	0.637
DOC_USP7_MATH_1	222	226	PF00917	0.761
DOC_USP7_MATH_1	26	30	PF00917	0.537
DOC_USP7_MATH_1	299	303	PF00917	0.558
DOC_WW_Pin1_4	10	15	PF00397	0.629
DOC_WW_Pin1_4	167	172	PF00397	0.649
DOC_WW_Pin1_4	43	48	PF00397	0.805
LIG_14-3-3_CanoR_1	16	25	PF00244	0.614
LIG_14-3-3_CanoR_1	205	211	PF00244	0.491
LIG_14-3-3_CanoR_1	277	286	PF00244	0.501
LIG_14-3-3_CanoR_1	37	43	PF00244	0.691
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_BRCT_BRCA1_1	240	244	PF00533	0.527
LIG_IBAR_NPY_1	54	56	PF08397	0.632
LIG_LIR_Apic_2	41	47	PF02991	0.614
LIG_SH2_STAP1	102	106	PF00017	0.607
LIG_SH2_STAP1	197	201	PF00017	0.448
LIG_SH3_1	141	147	PF00018	0.587
LIG_SH3_3	141	147	PF00018	0.647
LIG_SH3_3	159	165	PF00018	0.684
LIG_SH3_3	4	10	PF00018	0.754
MOD_CDC14_SPxK_1	13	16	PF00782	0.628
MOD_CDC14_SPxK_1	170	173	PF00782	0.587
MOD_CDK_SPK_2	167	172	PF00069	0.649
MOD_CDK_SPxK_1	10	16	PF00069	0.630
MOD_CDK_SPxK_1	167	173	PF00069	0.608
MOD_CK1_1	225	231	PF00069	0.674
MOD_CK1_1	232	238	PF00069	0.547
MOD_CK1_1	29	35	PF00069	0.572
MOD_CK1_1	302	308	PF00069	0.605
MOD_CK1_1	82	88	PF00069	0.533
MOD_Cter_Amidation	34	37	PF01082	0.601
MOD_GlcNHglycan	22	25	PF01048	0.621
MOD_GlcNHglycan	232	235	PF01048	0.634
MOD_GlcNHglycan	240	244	PF01048	0.468
MOD_GlcNHglycan	301	304	PF01048	0.590
MOD_GlcNHglycan	305	308	PF01048	0.587
MOD_GlcNHglycan	31	34	PF01048	0.604
MOD_GSK3_1	10	17	PF00069	0.673
MOD_GSK3_1	222	229	PF00069	0.755
MOD_GSK3_1	250	257	PF00069	0.590
MOD_GSK3_1	299	306	PF00069	0.603
MOD_GSK3_1	79	86	PF00069	0.550
MOD_N-GLC_1	238	243	PF02516	0.500
MOD_N-GLC_1	299	304	PF02516	0.596
MOD_NEK2_1	123	128	PF00069	0.656
MOD_NEK2_2	14	19	PF00069	0.549
MOD_PKA_1	230	236	PF00069	0.600
MOD_PKA_2	229	235	PF00069	0.603
MOD_PKA_2	278	284	PF00069	0.486
MOD_Plk_1	239	245	PF00069	0.482
MOD_ProDKin_1	10	16	PF00069	0.630
MOD_ProDKin_1	167	173	PF00069	0.645
MOD_ProDKin_1	43	49	PF00069	0.803
MOD_SUMO_rev_2	241	251	PF00179	0.414
TRG_DiLeu_BaEn_1	59	64	PF01217	0.621
TRG_ENDOCYTIC_2	197	200	PF00928	0.594
TRG_ER_diArg_1	108	111	PF00400	0.522
TRG_ER_diArg_1	193	196	PF00400	0.525
TRG_ER_diArg_1	214	217	PF00400	0.597
TRG_ER_diArg_1	277	280	PF00400	0.503
TRG_ER_diArg_1	34	37	PF00400	0.601
TRG_ER_diArg_1	60	63	PF00400	0.629
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQV2	Leishmania donovani	98%	100%
A4H5T2	Leishmania braziliensis	65%	100%
E9AMV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	96%
Q4QHS1	Leishmania major	90%	100%