LeishMANIAdb
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Lem3/Cdc50

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Lem3/Cdc50
Gene product:
LEM3 (ligand-effect modulator 3) family / CDC50 family - putative
Species:
Leishmania infantum
UniProt:
A4HU24_LEIIN
TriTrypDb:
LINF_090017600
Length:
595

Annotations

LeishMANIAdb annotations

Homologous to animal CDC50 family phospholipid flippase (ATPase) proteins.. This family has expanded in kinetoplastids

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19
GO:0005783 endoplasmic reticulum 5 2
GO:0005794 Golgi apparatus 5 2
GO:0005886 plasma membrane 3 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

A4HU24
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU24

Function

Biological processes
Term Name Level Count
GO:0033036 macromolecule localization 2 19
GO:0051179 localization 1 19
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 66 70 PF00656 0.644
CLV_NRD_NRD_1 322 324 PF00675 0.439
CLV_NRD_NRD_1 447 449 PF00675 0.459
CLV_NRD_NRD_1 478 480 PF00675 0.490
CLV_NRD_NRD_1 558 560 PF00675 0.403
CLV_NRD_NRD_1 569 571 PF00675 0.375
CLV_PCSK_FUR_1 104 108 PF00082 0.370
CLV_PCSK_FUR_1 528 532 PF00082 0.337
CLV_PCSK_FUR_1 556 560 PF00082 0.395
CLV_PCSK_KEX2_1 106 108 PF00082 0.470
CLV_PCSK_KEX2_1 530 532 PF00082 0.446
CLV_PCSK_KEX2_1 536 538 PF00082 0.417
CLV_PCSK_KEX2_1 558 560 PF00082 0.369
CLV_PCSK_PC1ET2_1 106 108 PF00082 0.368
CLV_PCSK_PC1ET2_1 530 532 PF00082 0.446
CLV_PCSK_PC1ET2_1 536 538 PF00082 0.417
CLV_PCSK_SKI1_1 107 111 PF00082 0.368
CLV_PCSK_SKI1_1 300 304 PF00082 0.534
CLV_PCSK_SKI1_1 323 327 PF00082 0.532
CLV_PCSK_SKI1_1 392 396 PF00082 0.479
DEG_ODPH_VHL_1 309 321 PF01847 0.290
DEG_SPOP_SBC_1 26 30 PF00917 0.601
DEG_SPOP_SBC_1 345 349 PF00917 0.319
DEG_SPOP_SBC_1 40 44 PF00917 0.759
DEG_SPOP_SBC_1 51 55 PF00917 0.727
DOC_CDC14_PxL_1 335 343 PF14671 0.208
DOC_CYCLIN_yCln2_LP_2 155 161 PF00134 0.364
DOC_CYCLIN_yCln2_LP_2 267 273 PF00134 0.214
DOC_MAPK_FxFP_2 140 143 PF00069 0.631
DOC_MAPK_gen_1 387 396 PF00069 0.320
DOC_MAPK_gen_1 448 458 PF00069 0.261
DOC_MAPK_gen_1 477 484 PF00069 0.309
DOC_MAPK_MEF2A_6 216 223 PF00069 0.266
DOC_MAPK_MEF2A_6 449 458 PF00069 0.214
DOC_MAPK_MEF2A_6 493 501 PF00069 0.267
DOC_PP1_RVXF_1 385 392 PF00149 0.280
DOC_PP2B_LxvP_1 155 158 PF13499 0.351
DOC_PP4_FxxP_1 140 143 PF00568 0.631
DOC_PP4_FxxP_1 23 26 PF00568 0.604
DOC_USP7_MATH_1 190 194 PF00917 0.338
DOC_USP7_MATH_1 26 30 PF00917 0.601
DOC_USP7_MATH_1 428 432 PF00917 0.254
DOC_USP7_MATH_1 51 55 PF00917 0.657
DOC_USP7_MATH_1 535 539 PF00917 0.617
DOC_USP7_MATH_1 56 60 PF00917 0.646
DOC_USP7_MATH_1 77 81 PF00917 0.674
DOC_USP7_MATH_1 91 95 PF00917 0.687
DOC_USP7_UBL2_3 106 110 PF12436 0.589
DOC_WW_Pin1_4 141 146 PF00397 0.548
DOC_WW_Pin1_4 280 285 PF00397 0.302
DOC_WW_Pin1_4 29 34 PF00397 0.641
DOC_WW_Pin1_4 3 8 PF00397 0.595
DOC_WW_Pin1_4 323 328 PF00397 0.325
DOC_WW_Pin1_4 346 351 PF00397 0.311
DOC_WW_Pin1_4 35 40 PF00397 0.639
LIG_14-3-3_CanoR_1 300 305 PF00244 0.372
LIG_14-3-3_CanoR_1 392 397 PF00244 0.319
LIG_14-3-3_CanoR_1 440 450 PF00244 0.244
LIG_14-3-3_CanoR_1 477 483 PF00244 0.301
LIG_14-3-3_CanoR_1 62 68 PF00244 0.663
LIG_Actin_WH2_2 554 572 PF00022 0.638
LIG_AP2alpha_1 315 319 PF02296 0.247
LIG_EH1_1 514 522 PF00400 0.348
LIG_FHA_1 316 322 PF00498 0.256
LIG_FHA_1 346 352 PF00498 0.340
LIG_FHA_1 460 466 PF00498 0.349
LIG_FHA_1 512 518 PF00498 0.334
LIG_FHA_2 215 221 PF00498 0.274
LIG_FHA_2 284 290 PF00498 0.312
LIG_FHA_2 324 330 PF00498 0.308
LIG_FHA_2 393 399 PF00498 0.239
LIG_FHA_2 407 413 PF00498 0.292
LIG_FHA_2 41 47 PF00498 0.607
LIG_Integrin_isoDGR_2 249 251 PF01839 0.513
LIG_LIR_Apic_2 402 408 PF02991 0.275
LIG_LIR_Gen_1 144 154 PF02991 0.439
LIG_LIR_Gen_1 172 180 PF02991 0.375
LIG_LIR_Gen_1 215 223 PF02991 0.326
LIG_LIR_Gen_1 468 476 PF02991 0.326
LIG_LIR_Nem_3 144 149 PF02991 0.427
LIG_LIR_Nem_3 172 176 PF02991 0.301
LIG_LIR_Nem_3 177 183 PF02991 0.285
LIG_LIR_Nem_3 215 221 PF02991 0.293
LIG_LIR_Nem_3 272 276 PF02991 0.239
LIG_LIR_Nem_3 317 322 PF02991 0.220
LIG_LIR_Nem_3 388 394 PF02991 0.272
LIG_LIR_Nem_3 398 404 PF02991 0.212
LIG_LIR_Nem_3 444 450 PF02991 0.237
LIG_LIR_Nem_3 468 474 PF02991 0.223
LIG_LIR_Nem_3 538 542 PF02991 0.613
LIG_LIR_Nem_3 546 552 PF02991 0.556
LIG_Pex14_1 400 404 PF04695 0.236
LIG_Pex14_2 315 319 PF04695 0.247
LIG_Pex14_2 443 447 PF04695 0.244
LIG_PTB_Apo_2 413 420 PF02174 0.211
LIG_PTB_Phospho_1 413 419 PF10480 0.214
LIG_SH2_CRK 186 190 PF00017 0.342
LIG_SH2_CRK 271 275 PF00017 0.326
LIG_SH2_CRK 322 326 PF00017 0.301
LIG_SH2_CRK 451 455 PF00017 0.274
LIG_SH2_CRK 471 475 PF00017 0.158
LIG_SH2_CRK 529 533 PF00017 0.544
LIG_SH2_NCK_1 471 475 PF00017 0.326
LIG_SH2_NCK_1 88 92 PF00017 0.584
LIG_SH2_SRC 186 189 PF00017 0.346
LIG_SH2_STAP1 433 437 PF00017 0.235
LIG_SH2_STAT3 540 543 PF00017 0.656
LIG_SH2_STAT5 153 156 PF00017 0.388
LIG_SH2_STAT5 188 191 PF00017 0.361
LIG_SH2_STAT5 266 269 PF00017 0.308
LIG_SH2_STAT5 271 274 PF00017 0.288
LIG_SH2_STAT5 301 304 PF00017 0.326
LIG_SH2_STAT5 413 416 PF00017 0.277
LIG_SH2_STAT5 419 422 PF00017 0.277
LIG_SH2_STAT5 463 466 PF00017 0.265
LIG_SH2_STAT5 540 543 PF00017 0.554
LIG_SH3_3 144 150 PF00018 0.537
LIG_SH3_3 292 298 PF00018 0.320
LIG_SH3_3 454 460 PF00018 0.328
LIG_SH3_3 538 544 PF00018 0.649
LIG_SUMO_SIM_anti_2 346 355 PF11976 0.279
LIG_SUMO_SIM_par_1 282 289 PF11976 0.239
LIG_SUMO_SIM_par_1 462 469 PF11976 0.289
LIG_TRFH_1 146 150 PF08558 0.403
LIG_TYR_ITIM 320 325 PF00017 0.326
LIG_WRC_WIRS_1 473 478 PF05994 0.234
MOD_CDC14_SPxK_1 32 35 PF00782 0.640
MOD_CDK_SPxK_1 29 35 PF00069 0.638
MOD_CK1_1 100 106 PF00069 0.659
MOD_CK1_1 132 138 PF00069 0.646
MOD_CK1_1 191 197 PF00069 0.226
MOD_CK1_1 29 35 PF00069 0.749
MOD_CK1_1 42 48 PF00069 0.750
MOD_CK1_1 442 448 PF00069 0.244
MOD_CK1_1 50 56 PF00069 0.759
MOD_CK1_1 6 12 PF00069 0.698
MOD_CK1_1 60 66 PF00069 0.754
MOD_CK2_1 214 220 PF00069 0.249
MOD_CK2_1 323 329 PF00069 0.305
MOD_CK2_1 392 398 PF00069 0.279
MOD_CK2_1 40 46 PF00069 0.747
MOD_CK2_1 406 412 PF00069 0.324
MOD_CK2_1 67 73 PF00069 0.644
MOD_Cter_Amidation 477 480 PF01082 0.490
MOD_GlcNHglycan 15 18 PF01048 0.458
MOD_GlcNHglycan 335 338 PF01048 0.506
MOD_GlcNHglycan 367 370 PF01048 0.503
MOD_GlcNHglycan 49 52 PF01048 0.571
MOD_GlcNHglycan 54 57 PF01048 0.581
MOD_GlcNHglycan 79 82 PF01048 0.564
MOD_GlcNHglycan 93 96 PF01048 0.557
MOD_GSK3_1 2 9 PF00069 0.752
MOD_GSK3_1 21 28 PF00069 0.759
MOD_GSK3_1 345 352 PF00069 0.275
MOD_GSK3_1 35 42 PF00069 0.782
MOD_GSK3_1 365 372 PF00069 0.254
MOD_GSK3_1 47 54 PF00069 0.719
MOD_GSK3_1 56 63 PF00069 0.804
MOD_N-GLC_1 191 196 PF02516 0.639
MOD_N-GLC_1 221 226 PF02516 0.510
MOD_N-GLC_1 315 320 PF02516 0.456
MOD_N-GLC_1 333 338 PF02516 0.333
MOD_N-GLC_1 355 360 PF02516 0.453
MOD_N-GLC_1 392 397 PF02516 0.526
MOD_N-GLC_1 56 61 PF02516 0.429
MOD_N-GLC_2 374 376 PF02516 0.414
MOD_NEK2_1 315 320 PF00069 0.263
MOD_NEK2_1 367 372 PF00069 0.214
MOD_NEK2_1 379 384 PF00069 0.366
MOD_NEK2_1 439 444 PF00069 0.265
MOD_NEK2_1 511 516 PF00069 0.372
MOD_NEK2_2 121 126 PF00069 0.658
MOD_PIKK_1 129 135 PF00454 0.644
MOD_PIKK_1 251 257 PF00454 0.239
MOD_PIKK_1 290 296 PF00454 0.272
MOD_PKA_2 100 106 PF00069 0.719
MOD_PKA_2 439 445 PF00069 0.259
MOD_PKA_2 478 484 PF00069 0.270
MOD_PKA_2 61 67 PF00069 0.670
MOD_PKB_1 390 398 PF00069 0.170
MOD_Plk_1 178 184 PF00069 0.376
MOD_Plk_1 191 197 PF00069 0.271
MOD_Plk_1 315 321 PF00069 0.263
MOD_Plk_1 392 398 PF00069 0.326
MOD_Plk_4 315 321 PF00069 0.229
MOD_Plk_4 349 355 PF00069 0.201
MOD_Plk_4 459 465 PF00069 0.350
MOD_Plk_4 478 484 PF00069 0.270
MOD_Plk_4 505 511 PF00069 0.366
MOD_ProDKin_1 141 147 PF00069 0.546
MOD_ProDKin_1 280 286 PF00069 0.302
MOD_ProDKin_1 29 35 PF00069 0.644
MOD_ProDKin_1 3 9 PF00069 0.596
MOD_ProDKin_1 323 329 PF00069 0.325
MOD_ProDKin_1 346 352 PF00069 0.311
TRG_DiLeu_BaEn_1 575 580 PF01217 0.471
TRG_ENDOCYTIC_2 153 156 PF00928 0.428
TRG_ENDOCYTIC_2 173 176 PF00928 0.275
TRG_ENDOCYTIC_2 180 183 PF00928 0.254
TRG_ENDOCYTIC_2 186 189 PF00928 0.293
TRG_ENDOCYTIC_2 234 237 PF00928 0.253
TRG_ENDOCYTIC_2 273 276 PF00928 0.239
TRG_ENDOCYTIC_2 322 325 PF00928 0.326
TRG_ENDOCYTIC_2 451 454 PF00928 0.298
TRG_ENDOCYTIC_2 471 474 PF00928 0.133
TRG_ENDOCYTIC_2 529 532 PF00928 0.666
TRG_ENDOCYTIC_2 552 555 PF00928 0.558
TRG_ER_diArg_1 476 479 PF00400 0.283
TRG_ER_diArg_1 555 558 PF00400 0.624
TRG_NLS_MonoExtN_4 107 114 PF00514 0.637
TRG_Pf-PMV_PEXEL_1 530 534 PF00026 0.362

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0U8 Leptomonas seymouri 65% 95%
A0A0S4IMK4 Bodo saltans 32% 100%
A0A0S4JQR9 Bodo saltans 36% 100%
A0A1X0NHQ5 Trypanosomatidae 45% 100%
A0A1X0P5L3 Trypanosomatidae 34% 100%
A0A3Q8IBY5 Leishmania donovani 99% 100%
A0A3R7LIN7 Trypanosoma rangeli 47% 100%
A0A3S7X9N4 Leishmania donovani 35% 100%
A0A422NR22 Trypanosoma rangeli 33% 100%
A4H5T1 Leishmania braziliensis 80% 100%
A4HN07 Leishmania braziliensis 36% 100%
A4IBN0 Leishmania infantum 35% 100%
D0A9K3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AFG4 Leishmania major 35% 100%
E9AMV4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9B6L9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
P42838 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
Q4QHS2 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS