Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PUB domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HU22_LEIIN

TriTrypDb:

LINF_090016300

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HU22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.541
CLV_NRD_NRD_1	181	183	PF00675	0.421
CLV_NRD_NRD_1	31	33	PF00675	0.279
CLV_NRD_NRD_1	57	59	PF00675	0.371
CLV_PCSK_KEX2_1	159	161	PF00082	0.670
CLV_PCSK_KEX2_1	31	33	PF00082	0.279
CLV_PCSK_KEX2_1	57	59	PF00082	0.222
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.719
CLV_PCSK_SKI1_1	183	187	PF00082	0.391
CLV_PCSK_SKI1_1	233	237	PF00082	0.449
CLV_PCSK_SKI1_1	295	299	PF00082	0.531
CLV_PCSK_SKI1_1	31	35	PF00082	0.309
CLV_PCSK_SKI1_1	47	51	PF00082	0.364
CLV_PCSK_SKI1_1	57	61	PF00082	0.261
DEG_APCC_DBOX_1	30	38	PF00400	0.297
DEG_Nend_UBRbox_3	1	3	PF02207	0.589
DOC_CYCLIN_RxL_1	178	188	PF00134	0.449
DOC_MAPK_gen_1	31	39	PF00069	0.279
DOC_MAPK_HePTP_8	29	41	PF00069	0.357
DOC_MAPK_MEF2A_6	32	41	PF00069	0.357
DOC_PP1_RVXF_1	270	277	PF00149	0.374
DOC_PP4_FxxP_1	41	44	PF00568	0.410
DOC_USP7_MATH_1	162	166	PF00917	0.673
DOC_USP7_UBL2_3	291	295	PF12436	0.463
DOC_USP7_UBL2_3	50	54	PF12436	0.410
LIG_14-3-3_CanoR_1	182	186	PF00244	0.418
LIG_14-3-3_CanoR_1	57	64	PF00244	0.334
LIG_BRCT_BRCA1_1	266	270	PF00533	0.506
LIG_BRCT_BRCA1_1	73	77	PF00533	0.410
LIG_BRCT_BRCA1_2	266	272	PF00533	0.503
LIG_BRCT_BRCA1_2	73	79	PF00533	0.246
LIG_deltaCOP1_diTrp_1	224	230	PF00928	0.272
LIG_FHA_1	141	147	PF00498	0.612
LIG_FHA_1	186	192	PF00498	0.431
LIG_FHA_1	246	252	PF00498	0.517
LIG_FHA_1	296	302	PF00498	0.516
LIG_FHA_1	58	64	PF00498	0.407
LIG_FHA_2	133	139	PF00498	0.597
LIG_FHA_2	165	171	PF00498	0.581
LIG_HCF-1_HBM_1	256	259	PF13415	0.345
LIG_Integrin_isoDGR_2	284	286	PF01839	0.562
LIG_LIR_Apic_2	40	44	PF02991	0.410
LIG_LIR_Gen_1	224	235	PF02991	0.394
LIG_LIR_Gen_1	69	78	PF02991	0.391
LIG_LIR_Nem_3	224	230	PF02991	0.365
LIG_LIR_Nem_3	69	75	PF02991	0.316
LIG_LIR_Nem_3	8	13	PF02991	0.534
LIG_NRBOX	33	39	PF00104	0.357
LIG_PDZ_Class_2	307	312	PF00595	0.375
LIG_PTB_Apo_2	190	197	PF02174	0.413
LIG_PTB_Apo_2	40	47	PF02174	0.378
LIG_Rb_LxCxE_1	97	110	PF01857	0.333
LIG_REV1ctd_RIR_1	193	203	PF16727	0.478
LIG_SH2_CRK	261	265	PF00017	0.420
LIG_SH2_STAP1	237	241	PF00017	0.334
LIG_SH2_STAT5	302	305	PF00017	0.406
LIG_SH3_3	1	7	PF00018	0.472
LIG_TRAF2_1	153	156	PF00917	0.620
LIG_TYR_ITIM	235	240	PF00017	0.351
LIG_UBA3_1	71	79	PF00899	0.266
MOD_CK1_1	202	208	PF00069	0.368
MOD_CK1_1	89	95	PF00069	0.355
MOD_CK2_1	132	138	PF00069	0.588
MOD_CK2_1	14	20	PF00069	0.344
MOD_CK2_1	162	168	PF00069	0.629
MOD_CK2_1	98	104	PF00069	0.375
MOD_GlcNHglycan	164	167	PF01048	0.672
MOD_GlcNHglycan	243	246	PF01048	0.477
MOD_GlcNHglycan	266	269	PF01048	0.475
MOD_GSK3_1	181	188	PF00069	0.398
MOD_GSK3_1	241	248	PF00069	0.381
MOD_GSK3_1	260	267	PF00069	0.422
MOD_GSK3_1	9	16	PF00069	0.521
MOD_NEK2_1	185	190	PF00069	0.408
MOD_NEK2_1	59	64	PF00069	0.378
MOD_NEK2_1	70	75	PF00069	0.273
MOD_PIKK_1	132	138	PF00454	0.512
MOD_PK_1	199	205	PF00069	0.405
MOD_PKA_1	57	63	PF00069	0.222
MOD_PKA_2	181	187	PF00069	0.419
MOD_PKA_2	57	63	PF00069	0.391
MOD_Plk_1	103	109	PF00069	0.523
MOD_Plk_1	199	205	PF00069	0.490
MOD_Plk_4	181	187	PF00069	0.509
MOD_Plk_4	95	101	PF00069	0.462
MOD_SUMO_for_1	78	81	PF00179	0.332
TRG_DiLeu_BaEn_1	283	288	PF01217	0.512
TRG_DiLeu_BaEn_4	8	14	PF01217	0.467
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.416
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.297
TRG_ENDOCYTIC_2	237	240	PF00928	0.370
TRG_ENDOCYTIC_2	261	264	PF00928	0.417
TRG_ER_diArg_1	120	123	PF00400	0.519
TRG_ER_diArg_1	148	151	PF00400	0.611
TRG_ER_diArg_1	30	32	PF00400	0.279
TRG_ER_diArg_1	56	58	PF00400	0.222
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBQ0	Leptomonas seymouri	61%	100%
A0A1X0NI65	Trypanosomatidae	39%	100%
A0A3S7WQS2	Leishmania donovani	99%	100%
A0A422N3Q8	Trypanosoma rangeli	41%	100%
A4H5S8	Leishmania braziliensis	73%	100%
D0A9J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AMV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHS4	Leishmania major	91%	100%
V5D6M9	Trypanosoma cruzi	41%	100%