Elongation factor-1 gamma

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

elongation factor-1 gamma

Species:

Leishmania infantum

UniProt:

A4HU18_LEIIN

TriTrypDb:

LINF_090016050

Length:

453

Annotations

Annotations by Jardim et al.

Translation, Elongation factor-1 gamma EF1G

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HU18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU18

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003746	translation elongation factor activity	4	13
GO:0005488	binding	1	13
GO:0008135	translation factor activity, RNA binding	3	13
GO:0045182	translation regulator activity	1	13
GO:0090079	translation regulator activity, nucleic acid binding	2	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.389
CLV_NRD_NRD_1	373	375	PF00675	0.286
CLV_PCSK_KEX2_1	315	317	PF00082	0.286
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.286
CLV_PCSK_SKI1_1	196	200	PF00082	0.293
CLV_PCSK_SKI1_1	375	379	PF00082	0.286
CLV_PCSK_SKI1_1	444	448	PF00082	0.380
DOC_CYCLIN_yCln2_LP_2	54	60	PF00134	0.408
DOC_MAPK_gen_1	374	382	PF00069	0.286
DOC_MAPK_MEF2A_6	375	384	PF00069	0.286
DOC_PP2B_LxvP_1	26	29	PF13499	0.462
DOC_PP2B_LxvP_1	54	57	PF13499	0.390
DOC_USP7_MATH_1	140	144	PF00917	0.447
DOC_USP7_MATH_1	174	178	PF00917	0.327
DOC_USP7_UBL2_3	130	134	PF12436	0.466
DOC_USP7_UBL2_3	264	268	PF12436	0.556
DOC_USP7_UBL2_3	275	279	PF12436	0.571
DOC_USP7_UBL2_3	293	297	PF12436	0.648
DOC_WW_Pin1_4	136	141	PF00397	0.399
DOC_WW_Pin1_4	30	35	PF00397	0.548
DOC_WW_Pin1_4	89	94	PF00397	0.357
DOC_WW_Pin1_4	97	102	PF00397	0.257
LIG_14-3-3_CanoR_1	203	207	PF00244	0.305
LIG_14-3-3_CanoR_1	238	244	PF00244	0.286
LIG_BIR_II_1	1	5	PF00653	0.457
LIG_BIR_III_2	302	306	PF00653	0.417
LIG_BRCT_BRCA1_1	209	213	PF00533	0.366
LIG_CtBP_PxDLS_1	226	231	PF00389	0.366
LIG_deltaCOP1_diTrp_1	147	152	PF00928	0.347
LIG_deltaCOP1_diTrp_1	190	198	PF00928	0.307
LIG_EH1_1	377	385	PF00400	0.286
LIG_EVH1_2	305	309	PF00568	0.286
LIG_FHA_1	195	201	PF00498	0.286
LIG_FHA_1	247	253	PF00498	0.368
LIG_FHA_1	321	327	PF00498	0.288
LIG_FHA_1	357	363	PF00498	0.302
LIG_FHA_1	430	436	PF00498	0.329
LIG_FHA_1	49	55	PF00498	0.556
LIG_FHA_2	137	143	PF00498	0.391
LIG_FHA_2	179	185	PF00498	0.402
LIG_FHA_2	203	209	PF00498	0.286
LIG_LIR_Gen_1	147	157	PF02991	0.347
LIG_LIR_Gen_1	337	347	PF02991	0.415
LIG_LIR_Gen_1	417	426	PF02991	0.373
LIG_LIR_Nem_3	147	152	PF02991	0.349
LIG_LIR_Nem_3	167	172	PF02991	0.154
LIG_LIR_Nem_3	19	25	PF02991	0.474
LIG_LIR_Nem_3	337	343	PF02991	0.298
LIG_LIR_Nem_3	394	398	PF02991	0.360
LIG_LIR_Nem_3	417	421	PF02991	0.368
LIG_LIR_Nem_3	51	55	PF02991	0.449
LIG_LYPXL_SIV_4	73	81	PF13949	0.366
LIG_Pex14_1	256	260	PF04695	0.511
LIG_Pex14_2	213	217	PF04695	0.286
LIG_SH2_CRK	240	244	PF00017	0.299
LIG_SH2_CRK	52	56	PF00017	0.399
LIG_SH2_GRB2like	318	321	PF00017	0.286
LIG_SH2_GRB2like	74	77	PF00017	0.366
LIG_SH2_NCK_1	74	78	PF00017	0.366
LIG_SH2_SRC	27	30	PF00017	0.458
LIG_SH2_SRC	74	77	PF00017	0.366
LIG_SH2_STAP1	340	344	PF00017	0.293
LIG_SH2_STAT5	114	117	PF00017	0.366
LIG_SH2_STAT5	164	167	PF00017	0.366
LIG_SH2_STAT5	27	30	PF00017	0.458
LIG_SH2_STAT5	330	333	PF00017	0.286
LIG_SH2_STAT5	340	343	PF00017	0.286
LIG_SH2_STAT5	434	437	PF00017	0.324
LIG_SH3_3	323	329	PF00018	0.286
LIG_SH3_3	437	443	PF00018	0.357
LIG_SH3_3	54	60	PF00018	0.486
LIG_SUMO_SIM_anti_2	249	254	PF11976	0.368
LIG_TRAF2_1	181	184	PF00917	0.417
LIG_TRAF2_1	292	295	PF00917	0.684
LIG_UBA3_1	121	130	PF00899	0.417
LIG_WRC_WIRS_1	166	171	PF05994	0.303
LIG_WRC_WIRS_1	392	397	PF05994	0.303
MOD_CDC14_SPxK_1	33	36	PF00782	0.470
MOD_CDK_SPK_2	30	35	PF00069	0.463
MOD_CDK_SPxK_1	30	36	PF00069	0.465
MOD_CDK_SPxxK_3	97	104	PF00069	0.305
MOD_CK1_1	107	113	PF00069	0.366
MOD_CK1_1	30	36	PF00069	0.706
MOD_CK2_1	136	142	PF00069	0.374
MOD_CK2_1	178	184	PF00069	0.346
MOD_CK2_1	288	294	PF00069	0.574
MOD_GlcNHglycan	129	133	PF01048	0.403
MOD_GlcNHglycan	176	179	PF01048	0.334
MOD_GlcNHglycan	22	25	PF01048	0.478
MOD_GlcNHglycan	287	293	PF01048	0.745
MOD_GlcNHglycan	38	41	PF01048	0.756
MOD_GlcNHglycan	61	64	PF01048	0.438
MOD_GSK3_1	12	19	PF00069	0.541
MOD_GSK3_1	136	143	PF00069	0.493
MOD_GSK3_1	174	181	PF00069	0.450
MOD_GSK3_1	316	323	PF00069	0.286
MOD_GSK3_1	334	341	PF00069	0.286
MOD_N-GLC_1	89	94	PF02516	0.305
MOD_N-GLC_1	97	102	PF02516	0.305
MOD_NEK2_1	115	120	PF00069	0.409
MOD_NEK2_1	141	146	PF00069	0.389
MOD_NEK2_1	165	170	PF00069	0.498
MOD_NEK2_1	182	187	PF00069	0.261
MOD_NEK2_1	239	244	PF00069	0.286
MOD_PIKK_1	141	147	PF00454	0.343
MOD_PIKK_1	27	33	PF00454	0.458
MOD_PKA_2	202	208	PF00069	0.286
MOD_Plk_1	141	147	PF00069	0.423
MOD_Plk_1	182	188	PF00069	0.417
MOD_Plk_1	207	213	PF00069	0.366
MOD_Plk_2-3	202	208	PF00069	0.286
MOD_Plk_4	239	245	PF00069	0.286
MOD_Plk_4	305	311	PF00069	0.402
MOD_Plk_4	391	397	PF00069	0.324
MOD_ProDKin_1	136	142	PF00069	0.393
MOD_ProDKin_1	30	36	PF00069	0.550
MOD_ProDKin_1	89	95	PF00069	0.357
MOD_ProDKin_1	97	103	PF00069	0.257
MOD_SUMO_for_1	274	277	PF00179	0.598
MOD_SUMO_for_1	292	295	PF00179	0.701
MOD_SUMO_rev_2	271	280	PF00179	0.729
MOD_SUMO_rev_2	288	298	PF00179	0.588
MOD_SUMO_rev_2	414	424	PF00179	0.495
MOD_SUMO_rev_2	78	83	PF00179	0.303
TRG_DiLeu_BaEn_2	193	199	PF01217	0.286
TRG_ENDOCYTIC_2	240	243	PF00928	0.299
TRG_ENDOCYTIC_2	340	343	PF00928	0.286
TRG_ENDOCYTIC_2	52	55	PF00928	0.447
TRG_ENDOCYTIC_2	74	77	PF00928	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSJ4	Leptomonas seymouri	80%	100%
A0A1X0NID9	Trypanosomatidae	69%	100%
A0A3Q8I8H5	Leishmania donovani	100%	100%
A0A3R7LEF5	Trypanosoma rangeli	60%	100%
A0A3S7WQR4	Leishmania donovani	100%	100%
A2Q127	Equus caballus	32%	100%
A4H5S5	Leishmania braziliensis	91%	100%
A4HU19	Leishmania infantum	100%	100%
D0A9I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	97%
D0A9K2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AMU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O04487	Arabidopsis thaliana	36%	100%
P12261	Artemia salina	29%	100%
P26641	Homo sapiens	32%	100%
P26642	Xenopus laevis	31%	100%
P29547	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P29694	Oryctolagus cuniculus	32%	100%
P34715	Trypanosoma cruzi	65%	100%
P36008	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P40921	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P54412	Caenorhabditis elegans	30%	100%
Q29387	Sus scrofa	32%	100%
Q3SZV3	Bos taurus	31%	100%
Q4R7H5	Macaca fascicularis	32%	100%
Q5Z627	Oryza sativa subsp. japonica	36%	100%
Q66NE0	Leishmania major	98%	100%
Q68FR6	Rattus norvegicus	32%	100%
Q6PE25	Danio rerio	32%	100%
Q6YW46	Oryza sativa subsp. japonica	36%	100%
Q90YC0	Carassius auratus	33%	100%
Q91375	Xenopus laevis	31%	100%
Q9D8N0	Mus musculus	33%	100%
Q9FUM1	Prunus avium	33%	100%
Q9FVT2	Arabidopsis thaliana	36%	100%
Q9NJH0	Drosophila melanogaster	30%	100%
Q9ZRI7	Oryza sativa subsp. japonica	36%	100%