Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HU17_LEIIN

TriTrypDb:

LINF_090015900

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HU17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.484
CLV_C14_Caspase3-7	184	188	PF00656	0.735
CLV_C14_Caspase3-7	219	223	PF00656	0.470
CLV_C14_Caspase3-7	391	395	PF00656	0.581
CLV_MEL_PAP_1	417	423	PF00089	0.677
CLV_PCSK_SKI1_1	118	122	PF00082	0.513
CLV_PCSK_SKI1_1	293	297	PF00082	0.623
CLV_PCSK_SKI1_1	327	331	PF00082	0.608
CLV_PCSK_SKI1_1	458	462	PF00082	0.666
CLV_PCSK_SKI1_1	600	604	PF00082	0.507
DEG_ODPH_VHL_1	247	260	PF01847	0.526
DEG_SPOP_SBC_1	515	519	PF00917	0.732
DEG_SPOP_SBC_1	52	56	PF00917	0.749
DOC_MAPK_MEF2A_6	251	260	PF00069	0.540
DOC_MAPK_MEF2A_6	609	616	PF00069	0.554
DOC_PP1_RVXF_1	436	443	PF00149	0.552
DOC_USP7_MATH_1	116	120	PF00917	0.570
DOC_USP7_MATH_1	299	303	PF00917	0.640
DOC_USP7_MATH_1	372	376	PF00917	0.713
DOC_USP7_MATH_1	515	519	PF00917	0.788
DOC_USP7_MATH_1	53	57	PF00917	0.691
DOC_USP7_MATH_1	580	584	PF00917	0.560
DOC_USP7_MATH_1	605	609	PF00917	0.501
DOC_WW_Pin1_4	342	347	PF00397	0.535
DOC_WW_Pin1_4	475	480	PF00397	0.624
DOC_WW_Pin1_4	483	488	PF00397	0.699
DOC_WW_Pin1_4	511	516	PF00397	0.780
DOC_WW_Pin1_4	57	62	PF00397	0.717
LIG_14-3-3_CanoR_1	327	336	PF00244	0.597
LIG_14-3-3_CanoR_1	453	457	PF00244	0.650
LIG_14-3-3_CanoR_1	570	576	PF00244	0.664
LIG_14-3-3_CanoR_1	579	585	PF00244	0.376
LIG_BIR_II_1	1	5	PF00653	0.636
LIG_BIR_III_2	187	191	PF00653	0.567
LIG_BRCT_BRCA1_1	230	234	PF00533	0.492
LIG_BRCT_BRCA1_1	35	39	PF00533	0.651
LIG_BRCT_BRCA1_1	485	489	PF00533	0.607
LIG_Clathr_ClatBox_1	103	107	PF01394	0.470
LIG_deltaCOP1_diTrp_1	197	205	PF00928	0.734
LIG_DLG_GKlike_1	420	428	PF00625	0.694
LIG_FHA_1	19	25	PF00498	0.555
LIG_FHA_1	356	362	PF00498	0.599
LIG_FHA_1	375	381	PF00498	0.572
LIG_FHA_1	402	408	PF00498	0.491
LIG_FHA_1	488	494	PF00498	0.639
LIG_FHA_1	495	501	PF00498	0.625
LIG_FHA_1	547	553	PF00498	0.525
LIG_FHA_1	572	578	PF00498	0.627
LIG_FHA_1	98	104	PF00498	0.536
LIG_FHA_2	127	133	PF00498	0.550
LIG_FHA_2	175	181	PF00498	0.722
LIG_FHA_2	182	188	PF00498	0.691
LIG_FHA_2	306	312	PF00498	0.538
LIG_LIR_Gen_1	288	299	PF02991	0.520
LIG_LIR_Nem_3	288	294	PF02991	0.497
LIG_LIR_Nem_3	583	587	PF02991	0.506
LIG_LYPXL_SIV_4	595	603	PF13949	0.560
LIG_MYND_1	576	580	PF01753	0.524
LIG_PDZ_Class_2	611	616	PF00595	0.375
LIG_Pex14_2	234	238	PF04695	0.407
LIG_Pex14_2	542	546	PF04695	0.443
LIG_SH2_CRK	414	418	PF00017	0.740
LIG_SH2_SRC	4	7	PF00017	0.605
LIG_SH2_STAT3	347	350	PF00017	0.589
LIG_SH2_STAT5	273	276	PF00017	0.394
LIG_SH2_STAT5	4	7	PF00017	0.761
LIG_SH2_STAT5	561	564	PF00017	0.493
LIG_SH3_3	574	580	PF00018	0.645
LIG_SH3_3	58	64	PF00018	0.684
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.492
LIG_SUMO_SIM_anti_2	259	264	PF11976	0.385
LIG_SUMO_SIM_anti_2	41	49	PF11976	0.745
LIG_SUMO_SIM_anti_2	549	556	PF11976	0.432
LIG_SUMO_SIM_anti_2	86	97	PF11976	0.494
LIG_SUMO_SIM_par_1	102	107	PF11976	0.551
LIG_SUMO_SIM_par_1	157	162	PF11976	0.380
LIG_SUMO_SIM_par_1	261	268	PF11976	0.374
LIG_SUMO_SIM_par_1	549	556	PF11976	0.434
LIG_TRAF2_1	13	16	PF00917	0.764
LIG_TRAF2_1	177	180	PF00917	0.812
LIG_TRAF2_1	556	559	PF00917	0.404
LIG_TRAF2_2	452	457	PF00917	0.682
LIG_TRFH_1	342	346	PF08558	0.531
LIG_TYR_ITIM	412	417	PF00017	0.659
LIG_WRC_WIRS_1	581	586	PF05994	0.558
MOD_CDC14_SPxK_1	478	481	PF00782	0.582
MOD_CDK_SPxK_1	475	481	PF00069	0.585
MOD_CK1_1	151	157	PF00069	0.454
MOD_CK1_1	174	180	PF00069	0.812
MOD_CK1_1	302	308	PF00069	0.716
MOD_CK1_1	374	380	PF00069	0.540
MOD_CK1_1	416	422	PF00069	0.683
MOD_CK1_1	510	516	PF00069	0.744
MOD_CK1_1	519	525	PF00069	0.694
MOD_CK1_1	529	535	PF00069	0.636
MOD_CK1_1	57	63	PF00069	0.699
MOD_CK1_1	571	577	PF00069	0.628
MOD_CK1_1	583	589	PF00069	0.549
MOD_CK1_1	79	85	PF00069	0.608
MOD_CK2_1	116	122	PF00069	0.454
MOD_CK2_1	173	179	PF00069	0.736
MOD_CK2_1	234	240	PF00069	0.508
MOD_CK2_1	305	311	PF00069	0.604
MOD_CK2_1	372	378	PF00069	0.669
MOD_CK2_1	456	462	PF00069	0.635
MOD_CK2_1	553	559	PF00069	0.494
MOD_CK2_1	583	589	PF00069	0.600
MOD_GlcNHglycan	124	127	PF01048	0.578
MOD_GlcNHglycan	150	153	PF01048	0.484
MOD_GlcNHglycan	169	172	PF01048	0.701
MOD_GlcNHglycan	207	210	PF01048	0.658
MOD_GlcNHglycan	267	270	PF01048	0.492
MOD_GlcNHglycan	304	307	PF01048	0.713
MOD_GlcNHglycan	31	34	PF01048	0.622
MOD_GlcNHglycan	311	315	PF01048	0.758
MOD_GlcNHglycan	374	377	PF01048	0.649
MOD_GlcNHglycan	457	461	PF01048	0.679
MOD_GlcNHglycan	509	512	PF01048	0.667
MOD_GlcNHglycan	528	531	PF01048	0.646
MOD_GlcNHglycan	539	542	PF01048	0.439
MOD_GlcNHglycan	555	558	PF01048	0.477
MOD_GlcNHglycan	570	573	PF01048	0.509
MOD_GlcNHglycan	70	73	PF01048	0.473
MOD_GSK3_1	118	125	PF00069	0.558
MOD_GSK3_1	167	174	PF00069	0.701
MOD_GSK3_1	199	206	PF00069	0.744
MOD_GSK3_1	29	36	PF00069	0.593
MOD_GSK3_1	298	305	PF00069	0.661
MOD_GSK3_1	318	325	PF00069	0.698
MOD_GSK3_1	372	379	PF00069	0.650
MOD_GSK3_1	416	423	PF00069	0.685
MOD_GSK3_1	452	459	PF00069	0.651
MOD_GSK3_1	475	482	PF00069	0.713
MOD_GSK3_1	483	490	PF00069	0.599
MOD_GSK3_1	507	514	PF00069	0.735
MOD_GSK3_1	515	522	PF00069	0.692
MOD_GSK3_1	53	60	PF00069	0.667
MOD_GSK3_1	79	86	PF00069	0.485
MOD_GSK3_1	93	100	PF00069	0.361
MOD_N-GLC_1	171	176	PF02516	0.698
MOD_NEK2_1	226	231	PF00069	0.542
MOD_NEK2_1	234	239	PF00069	0.344
MOD_NEK2_1	329	334	PF00069	0.621
MOD_NEK2_1	371	376	PF00069	0.606
MOD_NEK2_1	401	406	PF00069	0.556
MOD_NEK2_1	456	461	PF00069	0.633
MOD_NEK2_1	603	608	PF00069	0.524
MOD_PIKK_1	305	311	PF00454	0.629
MOD_PIKK_1	401	407	PF00454	0.496
MOD_PKA_2	167	173	PF00069	0.663
MOD_PKA_2	29	35	PF00069	0.477
MOD_PKA_2	452	458	PF00069	0.600
MOD_Plk_1	116	122	PF00069	0.490
MOD_Plk_1	456	462	PF00069	0.669
MOD_Plk_4	234	240	PF00069	0.541
MOD_Plk_4	583	589	PF00069	0.516
MOD_ProDKin_1	342	348	PF00069	0.539
MOD_ProDKin_1	475	481	PF00069	0.624
MOD_ProDKin_1	483	489	PF00069	0.691
MOD_ProDKin_1	511	517	PF00069	0.782
MOD_ProDKin_1	57	63	PF00069	0.706
TRG_DiLeu_BaEn_1	41	46	PF01217	0.568
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.581
TRG_ENDOCYTIC_2	414	417	PF00928	0.663
TRG_NES_CRM1_1	34	49	PF08389	0.641
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	245	250	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H8	Leptomonas seymouri	47%	81%
A0A1X0NMF5	Trypanosomatidae	30%	100%
A0A3S7WQU1	Leishmania donovani	100%	100%
A4H5S4	Leishmania braziliensis	76%	100%
D0A9I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AMU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHS8	Leishmania major	91%	100%
V5B2B3	Trypanosoma cruzi	32%	100%