LeishMANIAdb
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O-phosphoseryl-tRNA(Sec) selenium transferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
O-phosphoseryl-tRNA(Sec) selenium transferase
Gene product:
SLA/LP autoantigen-like protein
Species:
Leishmania infantum
UniProt:
A4HU16_LEIIN
TriTrypDb:
LINF_090015800
Length:
595

Annotations

Annotations by Jardim et al.

tRNA synthetase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4HU16
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU16

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006399 tRNA metabolic process 7 12
GO:0006412 translation 4 9
GO:0006518 peptide metabolic process 4 9
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009058 biosynthetic process 2 12
GO:0009059 macromolecule biosynthetic process 4 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0018130 heterocycle biosynthetic process 4 12
GO:0019438 aromatic compound biosynthetic process 4 12
GO:0019538 protein metabolic process 3 9
GO:0032774 RNA biosynthetic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 10
GO:0034654 nucleobase-containing compound biosynthetic process 4 12
GO:0034660 ncRNA metabolic process 6 12
GO:0043043 peptide biosynthetic process 5 9
GO:0043170 macromolecule metabolic process 3 12
GO:0043603 amide metabolic process 3 9
GO:0043604 amide biosynthetic process 4 9
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 10
GO:0044271 cellular nitrogen compound biosynthetic process 4 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:0097056 obsolete selenocysteinyl-tRNA(Sec) biosynthetic process 6 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901362 organic cyclic compound biosynthetic process 4 12
GO:1901564 organonitrogen compound metabolic process 3 9
GO:1901566 organonitrogen compound biosynthetic process 4 9
GO:1901576 organic substance biosynthetic process 3 12
GO:0001514 selenocysteine incorporation 7 1
GO:0006414 translational elongation 5 1
GO:0006417 regulation of translation 6 1
GO:0006451 translational readthrough 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0034248 regulation of amide metabolic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0000049 tRNA binding 5 12
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0016740 transferase activity 2 12
GO:0016785 selenotransferase activity 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0098621 phosphoseryl-selenocysteinyl-tRNA selenium transferase activity 4 12
GO:0140098 catalytic activity, acting on RNA 3 12
GO:0140101 catalytic activity, acting on a tRNA 4 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 258 262 PF00656 0.627
CLV_C14_Caspase3-7 351 355 PF00656 0.548
CLV_C14_Caspase3-7 578 582 PF00656 0.515
CLV_NRD_NRD_1 347 349 PF00675 0.308
CLV_NRD_NRD_1 418 420 PF00675 0.302
CLV_NRD_NRD_1 446 448 PF00675 0.289
CLV_PCSK_FUR_1 444 448 PF00082 0.332
CLV_PCSK_KEX2_1 347 349 PF00082 0.291
CLV_PCSK_KEX2_1 418 420 PF00082 0.300
CLV_PCSK_KEX2_1 446 448 PF00082 0.291
CLV_PCSK_SKI1_1 174 178 PF00082 0.665
CLV_PCSK_SKI1_1 224 228 PF00082 0.372
CLV_PCSK_SKI1_1 33 37 PF00082 0.440
CLV_PCSK_SKI1_1 348 352 PF00082 0.348
CLV_PCSK_SKI1_1 371 375 PF00082 0.243
CLV_PCSK_SKI1_1 4 8 PF00082 0.506
CLV_PCSK_SKI1_1 447 451 PF00082 0.321
CLV_PCSK_SKI1_1 534 538 PF00082 0.290
DEG_Nend_UBRbox_2 1 3 PF02207 0.444
DEG_SCF_FBW7_1 273 279 PF00400 0.575
DEG_SCF_FBW7_1 535 541 PF00400 0.548
DEG_SPOP_SBC_1 276 280 PF00917 0.628
DEG_SPOP_SBC_1 307 311 PF00917 0.454
DOC_CKS1_1 210 215 PF01111 0.487
DOC_CKS1_1 273 278 PF01111 0.593
DOC_CKS1_1 535 540 PF01111 0.548
DOC_CYCLIN_RxL_1 53 63 PF00134 0.471
DOC_CYCLIN_yCln2_LP_2 207 213 PF00134 0.540
DOC_MAPK_DCC_7 560 568 PF00069 0.493
DOC_MAPK_gen_1 201 209 PF00069 0.642
DOC_MAPK_gen_1 432 441 PF00069 0.532
DOC_MAPK_gen_1 444 452 PF00069 0.461
DOC_MAPK_HePTP_8 113 125 PF00069 0.484
DOC_MAPK_MEF2A_6 116 125 PF00069 0.484
DOC_MAPK_MEF2A_6 400 409 PF00069 0.468
DOC_MAPK_MEF2A_6 478 487 PF00069 0.506
DOC_MAPK_MEF2A_6 560 569 PF00069 0.493
DOC_MAPK_RevD_3 332 348 PF00069 0.548
DOC_MIT_MIM_1 581 590 PF04212 0.521
DOC_PP1_RVXF_1 212 219 PF00149 0.381
DOC_PP1_RVXF_1 359 365 PF00149 0.548
DOC_PP2B_LxvP_1 207 210 PF13499 0.583
DOC_PP4_FxxP_1 373 376 PF00568 0.443
DOC_USP7_MATH_1 108 112 PF00917 0.443
DOC_USP7_MATH_1 254 258 PF00917 0.652
DOC_USP7_MATH_1 276 280 PF00917 0.641
DOC_USP7_MATH_1 495 499 PF00917 0.548
DOC_USP7_MATH_1 538 542 PF00917 0.522
DOC_USP7_UBL2_3 157 161 PF12436 0.491
DOC_USP7_UBL2_3 224 228 PF12436 0.365
DOC_USP7_UBL2_3 387 391 PF12436 0.493
DOC_WW_Pin1_4 209 214 PF00397 0.509
DOC_WW_Pin1_4 269 274 PF00397 0.767
DOC_WW_Pin1_4 401 406 PF00397 0.454
DOC_WW_Pin1_4 534 539 PF00397 0.548
LIG_14-3-3_CanoR_1 204 208 PF00244 0.694
LIG_14-3-3_CanoR_1 26 32 PF00244 0.479
LIG_14-3-3_CanoR_1 400 404 PF00244 0.474
LIG_14-3-3_CanoR_1 419 425 PF00244 0.468
LIG_14-3-3_CanoR_1 56 61 PF00244 0.432
LIG_14-3-3_CanoR_1 78 86 PF00244 0.469
LIG_Actin_WH2_2 139 155 PF00022 0.484
LIG_BIR_III_4 231 235 PF00653 0.492
LIG_BRCT_BRCA1_1 279 283 PF00533 0.546
LIG_FAT_LD_1 580 588 PF03623 0.477
LIG_FHA_1 116 122 PF00498 0.511
LIG_FHA_1 145 151 PF00498 0.462
LIG_FHA_1 26 32 PF00498 0.499
LIG_FHA_1 320 326 PF00498 0.529
LIG_FHA_1 61 67 PF00498 0.415
LIG_FHA_1 90 96 PF00498 0.492
LIG_FHA_2 256 262 PF00498 0.623
LIG_FHA_2 349 355 PF00498 0.548
LIG_LIR_Apic_2 370 376 PF02991 0.443
LIG_LIR_Apic_2 589 594 PF02991 0.476
LIG_LIR_Nem_3 550 554 PF02991 0.460
LIG_PCNA_PIPBox_1 403 412 PF02747 0.548
LIG_PCNA_PIPBox_1 584 593 PF02747 0.515
LIG_PCNA_yPIPBox_3 116 126 PF02747 0.487
LIG_PDZ_Class_2 590 595 PF00595 0.432
LIG_Pex14_1 425 429 PF04695 0.454
LIG_PTB_Apo_2 336 343 PF02174 0.446
LIG_PTB_Phospho_1 336 342 PF10480 0.446
LIG_SH2_CRK 490 494 PF00017 0.548
LIG_SH2_SRC 17 20 PF00017 0.450
LIG_SH2_STAT3 342 345 PF00017 0.443
LIG_SH2_STAT5 17 20 PF00017 0.382
LIG_SH2_STAT5 215 218 PF00017 0.361
LIG_SH2_STAT5 328 331 PF00017 0.488
LIG_SH2_STAT5 336 339 PF00017 0.443
LIG_SH3_3 135 141 PF00018 0.468
LIG_SH3_3 186 192 PF00018 0.577
LIG_SH3_3 207 213 PF00018 0.564
LIG_SH3_3 233 239 PF00018 0.427
LIG_SH3_3 241 247 PF00018 0.515
LIG_SH3_3 270 276 PF00018 0.630
LIG_SH3_3 295 301 PF00018 0.465
LIG_SH3_3 313 319 PF00018 0.366
LIG_SH3_3 527 533 PF00018 0.454
LIG_SH3_3 537 543 PF00018 0.454
LIG_SH3_3 559 565 PF00018 0.484
LIG_Sin3_3 135 142 PF02671 0.548
LIG_SUMO_SIM_anti_2 147 152 PF11976 0.454
LIG_SUMO_SIM_anti_2 448 458 PF11976 0.529
LIG_SUMO_SIM_par_1 118 124 PF11976 0.529
LIG_SUMO_SIM_par_1 448 458 PF11976 0.529
LIG_TRAF2_1 188 191 PF00917 0.709
MOD_CDK_SPK_2 209 214 PF00069 0.509
MOD_CK1_1 182 188 PF00069 0.704
MOD_CK1_1 269 275 PF00069 0.729
MOD_CK1_1 278 284 PF00069 0.547
MOD_CK1_1 309 315 PF00069 0.468
MOD_CK1_1 468 474 PF00069 0.493
MOD_CK1_1 528 534 PF00069 0.484
MOD_CK1_1 541 547 PF00069 0.484
MOD_CK2_1 573 579 PF00069 0.485
MOD_Cter_Amidation 416 419 PF01082 0.329
MOD_DYRK1A_RPxSP_1 534 538 PF00069 0.548
MOD_GlcNHglycan 13 16 PF01048 0.470
MOD_GlcNHglycan 181 184 PF01048 0.703
MOD_GlcNHglycan 250 253 PF01048 0.697
MOD_GlcNHglycan 367 370 PF01048 0.268
MOD_GlcNHglycan 383 386 PF01048 0.254
MOD_GlcNHglycan 499 502 PF01048 0.293
MOD_GlcNHglycan 527 530 PF01048 0.269
MOD_GlcNHglycan 80 83 PF01048 0.339
MOD_GlcNHglycan 97 100 PF01048 0.158
MOD_GSK3_1 174 181 PF00069 0.594
MOD_GSK3_1 21 28 PF00069 0.454
MOD_GSK3_1 255 262 PF00069 0.722
MOD_GSK3_1 271 278 PF00069 0.645
MOD_GSK3_1 377 384 PF00069 0.522
MOD_GSK3_1 461 468 PF00069 0.511
MOD_GSK3_1 479 486 PF00069 0.452
MOD_GSK3_1 534 541 PF00069 0.490
MOD_GSK3_1 56 63 PF00069 0.432
MOD_NEK2_1 172 177 PF00069 0.594
MOD_NEK2_1 248 253 PF00069 0.709
MOD_NEK2_1 25 30 PF00069 0.446
MOD_NEK2_1 308 313 PF00069 0.443
MOD_NEK2_1 409 414 PF00069 0.456
MOD_NEK2_1 525 530 PF00069 0.484
MOD_NEK2_1 60 65 PF00069 0.313
MOD_NEK2_1 89 94 PF00069 0.497
MOD_NEK2_2 21 26 PF00069 0.494
MOD_NEK2_2 547 552 PF00069 0.459
MOD_OFUCOSY 306 313 PF10250 0.243
MOD_PIKK_1 299 305 PF00454 0.548
MOD_PIKK_1 465 471 PF00454 0.493
MOD_PKA_2 203 209 PF00069 0.630
MOD_PKA_2 21 27 PF00069 0.513
MOD_PKA_2 259 265 PF00069 0.642
MOD_PKA_2 399 405 PF00069 0.443
MOD_PKA_2 469 475 PF00069 0.498
MOD_PKA_2 510 516 PF00069 0.452
MOD_Plk_1 2 8 PF00069 0.473
MOD_Plk_1 202 208 PF00069 0.652
MOD_Plk_1 319 325 PF00069 0.529
MOD_Plk_1 461 467 PF00069 0.543
MOD_Plk_1 479 485 PF00069 0.443
MOD_Plk_4 109 115 PF00069 0.443
MOD_Plk_4 278 284 PF00069 0.512
MOD_Plk_4 377 383 PF00069 0.506
MOD_Plk_4 420 426 PF00069 0.522
MOD_Plk_4 56 62 PF00069 0.448
MOD_ProDKin_1 209 215 PF00069 0.500
MOD_ProDKin_1 269 275 PF00069 0.762
MOD_ProDKin_1 401 407 PF00069 0.454
MOD_ProDKin_1 534 540 PF00069 0.548
MOD_SUMO_rev_2 453 460 PF00179 0.541
TRG_DiLeu_BaEn_1 579 584 PF01217 0.504
TRG_DiLeu_BaLyEn_6 431 436 PF01217 0.548
TRG_DiLeu_BaLyEn_6 562 567 PF01217 0.484
TRG_ER_diArg_1 347 349 PF00400 0.507
TRG_ER_diArg_1 432 435 PF00400 0.454
TRG_ER_diArg_1 84 87 PF00400 0.529
TRG_Pf-PMV_PEXEL_1 434 438 PF00026 0.299
TRG_Pf-PMV_PEXEL_1 519 524 PF00026 0.325

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IGI4 Leptomonas seymouri 65% 100%
A0A0S4KH93 Bodo saltans 41% 100%
A0A1X0NN47 Trypanosomatidae 48% 88%
A0A3R7N0G5 Trypanosoma rangeli 52% 100%
A0A3S7WQS5 Leishmania donovani 100% 100%
A4H5S3 Leishmania braziliensis 84% 100%
D0A9I4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9AMU7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q28EN2 Xenopus tropicalis 34% 100%
Q4QHS9 Leishmania major 96% 100%
Q54VQ6 Dictyostelium discoideum 33% 100%
Q5RAK7 Pongo abelii 34% 100%
Q6P6M7 Mus musculus 34% 100%
Q803A7 Danio rerio 34% 100%
Q9HD40 Homo sapiens 34% 100%
V5BBE8 Trypanosoma cruzi 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS