Putative ef-hand protein 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ef-hand protein 5 - putative

Species:

Leishmania infantum

UniProt:

A4HU12_LEIIN

TriTrypDb:

LINF_090015300

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HU12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU12

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.695
CLV_PCSK_KEX2_1	15	17	PF00082	0.704
CLV_PCSK_KEX2_1	20	22	PF00082	0.675
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.744
CLV_PCSK_PC7_1	16	22	PF00082	0.589
CLV_PCSK_SKI1_1	119	123	PF00082	0.429
CLV_PCSK_SKI1_1	136	140	PF00082	0.456
CLV_PCSK_SKI1_1	33	37	PF00082	0.629
CLV_PCSK_SKI1_1	49	53	PF00082	0.342
CLV_PCSK_SKI1_1	63	67	PF00082	0.483
DOC_MAPK_gen_1	135	143	PF00069	0.562
DOC_MAPK_MEF2A_6	174	183	PF00069	0.471
DOC_USP7_MATH_1	161	165	PF00917	0.584
DOC_USP7_MATH_1	7	11	PF00917	0.726
DOC_USP7_UBL2_3	63	67	PF12436	0.481
DOC_WW_Pin1_4	5	10	PF00397	0.776
LIG_14-3-3_CanoR_1	119	125	PF00244	0.519
LIG_BIR_II_1	1	5	PF00653	0.716
LIG_FHA_1	105	111	PF00498	0.394
LIG_FHA_1	128	134	PF00498	0.432
LIG_FHA_1	92	98	PF00498	0.459
LIG_FHA_2	161	167	PF00498	0.646
LIG_FHA_2	74	80	PF00498	0.503
LIG_LIR_Gen_1	120	126	PF02991	0.496
LIG_LIR_Gen_1	171	180	PF02991	0.386
LIG_LIR_Gen_1	98	106	PF02991	0.425
LIG_LIR_Nem_3	120	125	PF02991	0.450
LIG_LIR_Nem_3	171	175	PF02991	0.388
LIG_LIR_Nem_3	46	51	PF02991	0.429
LIG_LIR_Nem_3	64	69	PF02991	0.491
LIG_LIR_Nem_3	98	102	PF02991	0.423
LIG_NRBOX	178	184	PF00104	0.469
LIG_Pex14_2	138	142	PF04695	0.449
LIG_SH2_CRK	172	176	PF00017	0.452
LIG_SH2_CRK	48	52	PF00017	0.540
LIG_SUMO_SIM_anti_2	155	166	PF11976	0.581
LIG_SUMO_SIM_anti_2	178	183	PF11976	0.468
LIG_TRAF2_1	114	117	PF00917	0.541
LIG_TRAF2_1	150	153	PF00917	0.477
LIG_TRAF2_1	163	166	PF00917	0.478
LIG_TRAF2_1	76	79	PF00917	0.469
LIG_TYR_ITIM	170	175	PF00017	0.462
LIG_UBA3_1	103	108	PF00899	0.550
MOD_CK1_1	120	126	PF00069	0.496
MOD_CK1_1	25	31	PF00069	0.657
MOD_CK2_1	111	117	PF00069	0.507
MOD_CK2_1	141	147	PF00069	0.508
MOD_CK2_1	160	166	PF00069	0.406
MOD_CK2_1	73	79	PF00069	0.484
MOD_GlcNHglycan	119	122	PF01048	0.452
MOD_GlcNHglycan	144	147	PF01048	0.694
MOD_GlcNHglycan	149	152	PF01048	0.524
MOD_GlcNHglycan	24	27	PF01048	0.643
MOD_GlcNHglycan	28	31	PF01048	0.592
MOD_GlcNHglycan	38	41	PF01048	0.551
MOD_GlcNHglycan	52	55	PF01048	0.500
MOD_GSK3_1	120	127	PF00069	0.554
MOD_GSK3_1	142	149	PF00069	0.603
MOD_GSK3_1	22	29	PF00069	0.652
MOD_GSK3_1	5	12	PF00069	0.740
MOD_N-GLC_1	127	132	PF02516	0.558
MOD_N-GLC_1	36	41	PF02516	0.626
MOD_NEK2_1	141	146	PF00069	0.477
MOD_NEK2_1	36	41	PF00069	0.616
MOD_PIKK_1	9	15	PF00454	0.735
MOD_Plk_1	111	117	PF00069	0.524
MOD_Plk_1	91	97	PF00069	0.566
MOD_Plk_2-3	111	117	PF00069	0.555
MOD_ProDKin_1	5	11	PF00069	0.776
MOD_SUMO_rev_2	109	115	PF00179	0.551
TRG_DiLeu_BaEn_1	101	106	PF01217	0.482
TRG_DiLeu_BaEn_1	153	158	PF01217	0.478
TRG_DiLeu_BaEn_1	178	183	PF01217	0.468
TRG_DiLeu_BaEn_1	80	85	PF01217	0.546
TRG_DiLeu_BaEn_2	97	103	PF01217	0.534
TRG_DiLeu_BaEn_4	155	161	PF01217	0.582
TRG_ENDOCYTIC_2	172	175	PF00928	0.380
TRG_ENDOCYTIC_2	48	51	PF00928	0.509
TRG_ER_diArg_1	19	21	PF00400	0.587
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P206	Leptomonas seymouri	27%	100%
A0A0N0P2H6	Leptomonas seymouri	74%	100%
A0A0S4IS38	Bodo saltans	27%	100%
A0A0S4J1R1	Bodo saltans	35%	100%
A0A0S4J7U6	Bodo saltans	26%	100%
A0A0S4JFC8	Bodo saltans	27%	100%
A0A1X0NEW2	Trypanosomatidae	29%	97%
A0A1X0NMM5	Trypanosomatidae	27%	100%
A0A1X0NN63	Trypanosomatidae	47%	96%
A0A3R7LX73	Trypanosoma rangeli	45%	92%
A0A3S5H6E1	Leishmania donovani	99%	100%
A0A422N5Z1	Trypanosoma rangeli	30%	98%
A2WN93	Oryza sativa subsp. indica	27%	100%
A2WNH1	Oryza sativa subsp. indica	25%	100%
A2Y609	Oryza sativa subsp. indica	28%	100%
A4H5R8	Leishmania braziliensis	82%	100%
A4H5R9	Leishmania braziliensis	27%	100%
A4HU13	Leishmania infantum	27%	100%
B1PSN3	Leishmania donovani	27%	100%
D0A9H7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	95%
D0A9H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A9H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AMU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AMU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O02367	Ciona intestinalis	27%	100%
O23320	Arabidopsis thaliana	26%	100%
O82018	Mougeotia scalaris	27%	100%
O82659	Arabidopsis thaliana	28%	100%
O96081	Halocynthia roretzi	27%	100%
O96102	Physarum polycephalum	27%	100%
O97341	Suberites domuncula	27%	100%
P02585	Homo sapiens	30%	100%
P02586	Oryctolagus cuniculus	30%	100%
P02587	Sus scrofa	29%	100%
P02588	Gallus gallus	28%	100%
P02589	Pelophylax lessonae	30%	100%
P02591	Oryctolagus cuniculus	25%	100%
P02595	Patinopecten sp.	27%	100%
P02597	Gallus gallus	26%	100%
P02599	Dictyostelium discoideum	26%	100%
P04352	Chlamydomonas reinhardtii	28%	100%
P04353	Spinacia oleracea	27%	100%
P04464	Triticum aestivum	27%	100%
P04630	Caenorhabditis elegans	28%	100%
P05434	Chlamydomonas reinhardtii	28%	100%
P05932	Arbacia punctulata	26%	100%
P05936	Coturnix japonica	26%	100%
P09860	Gallus gallus	27%	100%
P0DH97	Arabidopsis thaliana	27%	100%
P0DH98	Arabidopsis thaliana	27%	100%
P10246	Meleagris gallopavo	28%	100%
P11118	Euglena gracilis	29%	100%
P18061	Trypanosoma cruzi	27%	100%
P19123	Mus musculus	25%	100%
P20801	Mus musculus	30%	100%
P23286	Candida albicans	27%	100%
P25027	Trypanosoma brucei brucei	42%	97%
P27161	Solanum lycopersicum	27%	100%
P41041	Pneumocystis carinii	26%	100%
P41045	Leishmania tarentolae	88%	100%
P41048	Trypanosoma cruzi	45%	89%
P41049	Trypanosoma cruzi	44%	89%
P41210	Atriplex nummularia	26%	100%
P43646	Tetraselmis striata	27%	100%
P53440	Naegleria gruberi	26%	100%
P54213	Dunaliella salina	30%	100%
P59220	Arabidopsis thaliana	26%	100%
P62162	Hordeum vulgare	27%	100%
P62163	Glycine max	27%	100%
P62184	Renilla reniformis	27%	100%
P62199	Petunia hybrida	26%	100%
P62200	Daucus carota	26%	100%
P62201	Lilium longiflorum	26%	100%
P62202	Bryonia dioica	26%	100%
P63315	Bos taurus	27%	100%
P63316	Homo sapiens	25%	100%
P63317	Sus scrofa	27%	100%
P69097	Trypanosoma brucei brucei	27%	100%
P69098	Trypanosoma brucei gambiense	27%	100%
P81660	Anguilla anguilla	32%	100%
P93087	Capsicum annuum	25%	100%
P93171	Helianthus annuus	26%	100%
Q03509	Arabidopsis thaliana	27%	100%
Q06827	Scherffelia dubia	28%	100%
Q0JNL7	Oryza sativa subsp. japonica	26%	100%
Q0JNS6	Oryza sativa subsp. japonica	27%	100%
Q2R1Z5	Oryza sativa subsp. japonica	24%	100%
Q2TBN3	Bos taurus	28%	100%
Q338P8	Oryza sativa subsp. japonica	26%	97%
Q4QHT2	Leishmania major	27%	100%
Q4QHT4	Leishmania major	99%	100%
Q5U206	Rattus norvegicus	26%	100%
Q682T9	Arabidopsis thaliana	27%	100%
Q6F332	Oryza sativa subsp. japonica	28%	100%
Q7DMN9	Solanum tuberosum	25%	100%
Q7F0J0	Oryza sativa subsp. japonica	28%	100%
Q7Y052	Euphorbia characias	26%	100%
Q8S1Y9	Oryza sativa subsp. japonica	26%	99%
Q95NI4	Halichondria okadai	28%	100%
Q9CQ46	Mus musculus	27%	100%
Q9D6P8	Mus musculus	25%	100%
Q9R1K9	Mus musculus	27%	100%
V5DQ66	Trypanosoma cruzi	30%	98%