Ubiquitin-60S ribosomal protein L40

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

polyubiquitin - putative

Species:

Leishmania infantum

UniProt:

A4HU11_LEIIN

TriTrypDb:

LINF_360043900

Length:

866

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005737	cytoplasm	2	3
GO:0005840	ribosome	5	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	2

Phosphorylation

Amastigote: 111, 187, 263, 339, 35, 415, 491, 567, 643, 719, 795

Expansion

Sequence features

A4HU11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	2
GO:0006518	peptide metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	3
GO:0019538	protein metabolic process	3	3
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043043	peptide biosynthetic process	5	2
GO:0043170	macromolecule metabolic process	3	3
GO:0043603	amide metabolic process	3	2
GO:0043604	amide biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	3
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:0006508	proteolysis	4	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0016567	protein ubiquitination	7	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044248	cellular catabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	2
GO:0005198	structural molecule activity	1	2
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031386	protein tag	1	1
GO:0031625	ubiquitin protein ligase binding	5	1
GO:0044389	ubiquitin-like protein ligase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	835	837	PF00675	0.228
CLV_NRD_NRD_1	848	850	PF00675	0.179
CLV_PCSK_KEX2_1	835	837	PF00082	0.228
CLV_PCSK_SKI1_1	136	140	PF00082	0.306
CLV_PCSK_SKI1_1	172	176	PF00082	0.265
CLV_PCSK_SKI1_1	20	24	PF00082	0.240
CLV_PCSK_SKI1_1	212	216	PF00082	0.353
CLV_PCSK_SKI1_1	248	252	PF00082	0.297
CLV_PCSK_SKI1_1	288	292	PF00082	0.265
CLV_PCSK_SKI1_1	324	328	PF00082	0.265
CLV_PCSK_SKI1_1	364	368	PF00082	0.265
CLV_PCSK_SKI1_1	400	404	PF00082	0.340
CLV_PCSK_SKI1_1	440	444	PF00082	0.305
CLV_PCSK_SKI1_1	476	480	PF00082	0.265
CLV_PCSK_SKI1_1	516	520	PF00082	0.275
CLV_PCSK_SKI1_1	552	556	PF00082	0.265
CLV_PCSK_SKI1_1	592	596	PF00082	0.272
CLV_PCSK_SKI1_1	60	64	PF00082	0.265
CLV_PCSK_SKI1_1	628	632	PF00082	0.253
CLV_PCSK_SKI1_1	668	672	PF00082	0.265
CLV_PCSK_SKI1_1	704	708	PF00082	0.265
CLV_PCSK_SKI1_1	744	748	PF00082	0.265
CLV_PCSK_SKI1_1	780	784	PF00082	0.265
CLV_PCSK_SKI1_1	96	100	PF00082	0.265
DEG_Nend_UBRbox_3	1	3	PF02207	0.313
DOC_MAPK_gen_1	126	135	PF00069	0.465
DOC_MAPK_gen_1	202	211	PF00069	0.465
DOC_MAPK_gen_1	278	287	PF00069	0.465
DOC_MAPK_gen_1	354	363	PF00069	0.490
DOC_MAPK_gen_1	430	439	PF00069	0.465
DOC_MAPK_gen_1	50	59	PF00069	0.440
DOC_MAPK_gen_1	506	515	PF00069	0.465
DOC_MAPK_gen_1	582	591	PF00069	0.522
DOC_MAPK_gen_1	658	667	PF00069	0.465
DOC_MAPK_gen_1	734	743	PF00069	0.465
DOC_MAPK_gen_1	835	843	PF00069	0.365
DOC_MAPK_HePTP_8	123	135	PF00069	0.465
DOC_MAPK_HePTP_8	199	211	PF00069	0.465
DOC_MAPK_HePTP_8	275	287	PF00069	0.465
DOC_MAPK_HePTP_8	351	363	PF00069	0.465
DOC_MAPK_HePTP_8	427	439	PF00069	0.465
DOC_MAPK_HePTP_8	47	59	PF00069	0.440
DOC_MAPK_HePTP_8	503	515	PF00069	0.465
DOC_MAPK_HePTP_8	579	591	PF00069	0.453
DOC_MAPK_HePTP_8	655	667	PF00069	0.465
DOC_MAPK_HePTP_8	731	743	PF00069	0.465
DOC_MAPK_MEF2A_6	117	125	PF00069	0.465
DOC_MAPK_MEF2A_6	126	135	PF00069	0.415
DOC_MAPK_MEF2A_6	193	201	PF00069	0.465
DOC_MAPK_MEF2A_6	202	211	PF00069	0.415
DOC_MAPK_MEF2A_6	269	277	PF00069	0.465
DOC_MAPK_MEF2A_6	278	287	PF00069	0.415
DOC_MAPK_MEF2A_6	345	353	PF00069	0.465
DOC_MAPK_MEF2A_6	354	363	PF00069	0.415
DOC_MAPK_MEF2A_6	41	49	PF00069	0.440
DOC_MAPK_MEF2A_6	421	429	PF00069	0.465
DOC_MAPK_MEF2A_6	430	439	PF00069	0.375
DOC_MAPK_MEF2A_6	497	505	PF00069	0.465
DOC_MAPK_MEF2A_6	50	59	PF00069	0.401
DOC_MAPK_MEF2A_6	506	515	PF00069	0.415
DOC_MAPK_MEF2A_6	573	581	PF00069	0.453
DOC_MAPK_MEF2A_6	582	591	PF00069	0.408
DOC_MAPK_MEF2A_6	649	657	PF00069	0.465
DOC_MAPK_MEF2A_6	658	667	PF00069	0.415
DOC_MAPK_MEF2A_6	725	733	PF00069	0.465
DOC_MAPK_MEF2A_6	734	743	PF00069	0.415
DOC_MAPK_MEF2A_6	801	809	PF00069	0.572
DOC_PP1_RVXF_1	170	176	PF00149	0.465
DOC_PP1_RVXF_1	18	24	PF00149	0.440
DOC_PP1_RVXF_1	246	252	PF00149	0.465
DOC_PP1_RVXF_1	322	328	PF00149	0.465
DOC_PP1_RVXF_1	398	404	PF00149	0.465
DOC_PP1_RVXF_1	474	480	PF00149	0.465
DOC_PP1_RVXF_1	550	556	PF00149	0.465
DOC_PP1_RVXF_1	626	632	PF00149	0.453
DOC_PP1_RVXF_1	702	708	PF00149	0.465
DOC_PP1_RVXF_1	778	784	PF00149	0.465
DOC_PP1_RVXF_1	94	100	PF00149	0.465
DOC_USP7_UBL2_3	159	163	PF12436	0.465
DOC_USP7_UBL2_3	235	239	PF12436	0.465
DOC_USP7_UBL2_3	311	315	PF12436	0.465
DOC_USP7_UBL2_3	387	391	PF12436	0.555
DOC_USP7_UBL2_3	463	467	PF12436	0.465
DOC_USP7_UBL2_3	539	543	PF12436	0.465
DOC_USP7_UBL2_3	615	619	PF12436	0.453
DOC_USP7_UBL2_3	691	695	PF12436	0.465
DOC_USP7_UBL2_3	767	771	PF12436	0.465
DOC_USP7_UBL2_3	83	87	PF12436	0.465
LIG_14-3-3_CanoR_1	108	115	PF00244	0.522
LIG_14-3-3_CanoR_1	184	191	PF00244	0.465
LIG_14-3-3_CanoR_1	260	267	PF00244	0.465
LIG_14-3-3_CanoR_1	32	39	PF00244	0.440
LIG_14-3-3_CanoR_1	336	343	PF00244	0.465
LIG_14-3-3_CanoR_1	412	419	PF00244	0.465
LIG_14-3-3_CanoR_1	488	495	PF00244	0.522
LIG_14-3-3_CanoR_1	564	571	PF00244	0.465
LIG_14-3-3_CanoR_1	640	647	PF00244	0.453
LIG_14-3-3_CanoR_1	716	723	PF00244	0.465
LIG_14-3-3_CanoR_1	792	799	PF00244	0.465
LIG_FHA_1	118	124	PF00498	0.519
LIG_FHA_1	140	146	PF00498	0.527
LIG_FHA_1	194	200	PF00498	0.465
LIG_FHA_1	216	222	PF00498	0.465
LIG_FHA_1	270	276	PF00498	0.465
LIG_FHA_1	292	298	PF00498	0.465
LIG_FHA_1	346	352	PF00498	0.465
LIG_FHA_1	368	374	PF00498	0.528
LIG_FHA_1	42	48	PF00498	0.440
LIG_FHA_1	422	428	PF00498	0.465
LIG_FHA_1	444	450	PF00498	0.468
LIG_FHA_1	498	504	PF00498	0.465
LIG_FHA_1	520	526	PF00498	0.465
LIG_FHA_1	574	580	PF00498	0.453
LIG_FHA_1	596	602	PF00498	0.453
LIG_FHA_1	64	70	PF00498	0.465
LIG_FHA_1	650	656	PF00498	0.465
LIG_FHA_1	672	678	PF00498	0.465
LIG_FHA_1	726	732	PF00498	0.517
LIG_FHA_1	748	754	PF00498	0.465
LIG_FHA_1	802	808	PF00498	0.465
LIG_FHA_2	107	113	PF00498	0.540
LIG_FHA_2	183	189	PF00498	0.465
LIG_FHA_2	259	265	PF00498	0.465
LIG_FHA_2	31	37	PF00498	0.440
LIG_FHA_2	335	341	PF00498	0.590
LIG_FHA_2	411	417	PF00498	0.465
LIG_FHA_2	487	493	PF00498	0.465
LIG_FHA_2	563	569	PF00498	0.465
LIG_FHA_2	639	645	PF00498	0.540
LIG_FHA_2	715	721	PF00498	0.465
LIG_FHA_2	791	797	PF00498	0.465
LIG_GBD_Chelix_1	123	131	PF00786	0.253
LIG_GBD_Chelix_1	199	207	PF00786	0.265
LIG_GBD_Chelix_1	275	283	PF00786	0.265
LIG_GBD_Chelix_1	351	359	PF00786	0.265
LIG_GBD_Chelix_1	427	435	PF00786	0.265
LIG_GBD_Chelix_1	47	55	PF00786	0.240
LIG_GBD_Chelix_1	503	511	PF00786	0.265
LIG_GBD_Chelix_1	579	587	PF00786	0.253
LIG_GBD_Chelix_1	655	663	PF00786	0.265
LIG_GBD_Chelix_1	731	739	PF00786	0.272
LIG_NRP_CendR_1	863	866	PF00754	0.165
LIG_SH2_CRK	838	842	PF00017	0.390
LIG_SH2_STAT3	113	116	PF00017	0.465
LIG_SH2_STAT3	189	192	PF00017	0.465
LIG_SH2_STAT3	265	268	PF00017	0.465
LIG_SH2_STAT3	341	344	PF00017	0.465
LIG_SH2_STAT3	37	40	PF00017	0.440
LIG_SH2_STAT3	417	420	PF00017	0.465
LIG_SH2_STAT3	493	496	PF00017	0.465
LIG_SH2_STAT3	569	572	PF00017	0.453
LIG_SH2_STAT3	645	648	PF00017	0.503
LIG_SH2_STAT3	721	724	PF00017	0.465
LIG_SH2_STAT3	797	800	PF00017	0.465
LIG_SH3_3	812	818	PF00018	0.170
LIG_SUMO_SIM_par_1	141	146	PF11976	0.528
LIG_SUMO_SIM_par_1	217	222	PF11976	0.465
LIG_SUMO_SIM_par_1	293	298	PF11976	0.465
LIG_SUMO_SIM_par_1	369	374	PF11976	0.465
LIG_SUMO_SIM_par_1	445	450	PF11976	0.465
LIG_SUMO_SIM_par_1	521	526	PF11976	0.540
LIG_SUMO_SIM_par_1	597	602	PF11976	0.453
LIG_SUMO_SIM_par_1	65	70	PF11976	0.465
LIG_SUMO_SIM_par_1	673	678	PF11976	0.465
LIG_SUMO_SIM_par_1	749	754	PF11976	0.503
MOD_NEK2_1	134	139	PF00069	0.465
MOD_NEK2_1	210	215	PF00069	0.468
MOD_NEK2_1	286	291	PF00069	0.465
MOD_NEK2_1	362	367	PF00069	0.465
MOD_NEK2_1	438	443	PF00069	0.547
MOD_NEK2_1	514	519	PF00069	0.465
MOD_NEK2_1	58	63	PF00069	0.590
MOD_NEK2_1	590	595	PF00069	0.453
MOD_NEK2_1	666	671	PF00069	0.590
MOD_NEK2_1	742	747	PF00069	0.465
MOD_PKA_2	843	849	PF00069	0.400
MOD_Plk_1	117	123	PF00069	0.477
MOD_Plk_1	193	199	PF00069	0.507
MOD_Plk_1	269	275	PF00069	0.465
MOD_Plk_1	345	351	PF00069	0.465
MOD_Plk_1	41	47	PF00069	0.440
MOD_Plk_1	421	427	PF00069	0.465
MOD_Plk_1	497	503	PF00069	0.465
MOD_Plk_1	573	579	PF00069	0.453
MOD_Plk_1	649	655	PF00069	0.465
MOD_Plk_1	725	731	PF00069	0.465
MOD_Plk_1	801	807	PF00069	0.465
MOD_Plk_2-3	106	112	PF00069	0.465
MOD_Plk_2-3	182	188	PF00069	0.529
MOD_Plk_2-3	258	264	PF00069	0.465
MOD_Plk_2-3	30	36	PF00069	0.440
MOD_Plk_2-3	334	340	PF00069	0.465
MOD_Plk_2-3	410	416	PF00069	0.465
MOD_Plk_2-3	486	492	PF00069	0.475
MOD_Plk_2-3	562	568	PF00069	0.465
MOD_Plk_2-3	638	644	PF00069	0.453
MOD_Plk_2-3	714	720	PF00069	0.465
MOD_Plk_2-3	790	796	PF00069	0.465
MOD_Plk_4	816	822	PF00069	0.365
TRG_DiLeu_BaEn_4	105	111	PF01217	0.465
TRG_DiLeu_BaEn_4	181	187	PF01217	0.465
TRG_DiLeu_BaEn_4	257	263	PF01217	0.465
TRG_DiLeu_BaEn_4	29	35	PF01217	0.440
TRG_DiLeu_BaEn_4	333	339	PF01217	0.465
TRG_DiLeu_BaEn_4	409	415	PF01217	0.465
TRG_DiLeu_BaEn_4	485	491	PF01217	0.465
TRG_DiLeu_BaEn_4	561	567	PF01217	0.465
TRG_DiLeu_BaEn_4	637	643	PF01217	0.453
TRG_DiLeu_BaEn_4	713	719	PF01217	0.465
TRG_DiLeu_BaEn_4	789	795	PF01217	0.465
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.465
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.440
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.465
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.465
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.465
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.465
TRG_DiLeu_BaLyEn_6	549	554	PF01217	0.465
TRG_DiLeu_BaLyEn_6	625	630	PF01217	0.453
TRG_DiLeu_BaLyEn_6	701	706	PF01217	0.465
TRG_DiLeu_BaLyEn_6	777	782	PF01217	0.465
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.465
TRG_ENDOCYTIC_2	838	841	PF00928	0.390
TRG_ER_diArg_1	125	128	PF00400	0.465
TRG_ER_diArg_1	201	204	PF00400	0.465
TRG_ER_diArg_1	277	280	PF00400	0.465
TRG_ER_diArg_1	353	356	PF00400	0.465
TRG_ER_diArg_1	429	432	PF00400	0.465
TRG_ER_diArg_1	49	52	PF00400	0.440
TRG_ER_diArg_1	505	508	PF00400	0.465
TRG_ER_diArg_1	581	584	PF00400	0.453
TRG_ER_diArg_1	657	660	PF00400	0.465
TRG_ER_diArg_1	733	736	PF00400	0.465
TRG_ER_diArg_1	809	812	PF00400	0.465
TRG_ER_diLys_1	862	866	PF00400	0.365
TRG_NLS_Bipartite_1	831	853	PF00514	0.365
TRG_NLS_MonoExtC_3	861	866	PF00514	0.365
TRG_NLS_MonoExtN_4	860	866	PF00514	0.365
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.232
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.240
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.214
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.226
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.232
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.232
TRG_Pf-PMV_PEXEL_1	558	562	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	564	568	PF00026	0.232
TRG_Pf-PMV_PEXEL_1	634	638	PF00026	0.253
TRG_Pf-PMV_PEXEL_1	640	644	PF00026	0.223
TRG_Pf-PMV_PEXEL_1	710	714	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	716	720	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	786	790	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	792	796	PF00026	0.232

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HFB9	Leishmania braziliensis	99%	100%
A4HPM0	Leishmania braziliensis	99%	100%
E9AHX6	Leishmania infantum	100%	100%
P0CG48	Homo sapiens	97%	100%
P0CG50	Mus musculus	97%	100%
P0CG61	Pongo pygmaeus	97%	100%
P0CG64	Pan troglodytes	97%	100%
P0CG66	Gorilla gorilla gorilla	97%	100%
P0CG69	Drosophila melanogaster	97%	100%
P0CG71	Caenorhabditis elegans	96%	100%
P0CH28	Bos taurus	97%	100%
P62976	Cricetulus griseus	97%	100%
Q39256	Arabidopsis thaliana	72%	100%
Q4Q165	Leishmania major	100%	100%
Q63429	Rattus norvegicus	93%	100%