Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA) - putative

Species:

Leishmania infantum

UniProt:

A4HU03_LEIIN

TriTrypDb:

LINF_090014400

Length:

530

Annotations

LeishMANIAdb annotations

Probably a secreted protein, similarly to its distant eukaryotic torsin homologs, involved in secretory processes. Also similar to bacterial ClpB ATPases, with chaperoning function.. Might be associated to known or unknown protein secretion pathways.. Localization: Endosomal (by homology)

Annotations by Jardim et al.

ER/Golgi Proteins, AAA ATPase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 2
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HU03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU03

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0016887	ATP hydrolysis activity	7	8
GO:0017076	purine nucleotide binding	4	8
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.416
CLV_C14_Caspase3-7	520	524	PF00656	0.580
CLV_NRD_NRD_1	114	116	PF00675	0.445
CLV_NRD_NRD_1	145	147	PF00675	0.345
CLV_NRD_NRD_1	447	449	PF00675	0.387
CLV_PCSK_KEX2_1	145	147	PF00082	0.345
CLV_PCSK_KEX2_1	307	309	PF00082	0.503
CLV_PCSK_KEX2_1	447	449	PF00082	0.387
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.503
CLV_PCSK_SKI1_1	486	490	PF00082	0.373
DEG_APCC_KENBOX_2	439	443	PF00400	0.384
DEG_SCF_FBW7_1	488	495	PF00400	0.509
DOC_CKS1_1	489	494	PF01111	0.504
DOC_MAPK_DCC_7	96	106	PF00069	0.546
DOC_MAPK_gen_1	96	106	PF00069	0.541
DOC_MAPK_HePTP_8	126	138	PF00069	0.432
DOC_MAPK_MEF2A_6	129	138	PF00069	0.427
DOC_MAPK_MEF2A_6	152	159	PF00069	0.359
DOC_MAPK_MEF2A_6	469	478	PF00069	0.474
DOC_MAPK_MEF2A_6	99	108	PF00069	0.514
DOC_MAPK_RevD_3	134	147	PF00069	0.376
DOC_PP1_RVXF_1	473	479	PF00149	0.439
DOC_PP2B_LxvP_1	104	107	PF13499	0.471
DOC_USP7_MATH_1	276	280	PF00917	0.583
DOC_USP7_MATH_1	317	321	PF00917	0.707
DOC_USP7_MATH_1	325	329	PF00917	0.755
DOC_USP7_MATH_1	36	40	PF00917	0.623
DOC_USP7_MATH_1	390	394	PF00917	0.391
DOC_USP7_MATH_1	42	46	PF00917	0.490
DOC_USP7_MATH_1	492	496	PF00917	0.573
DOC_USP7_MATH_1	505	509	PF00917	0.492
DOC_USP7_MATH_1	51	55	PF00917	0.326
DOC_USP7_UBL2_3	61	65	PF12436	0.489
DOC_WW_Pin1_4	488	493	PF00397	0.487
DOC_WW_Pin1_4	55	60	PF00397	0.486
LIG_14-3-3_CanoR_1	172	180	PF00244	0.348
LIG_14-3-3_CanoR_1	351	357	PF00244	0.505
LIG_14-3-3_CanoR_1	401	411	PF00244	0.434
LIG_14-3-3_CanoR_1	496	502	PF00244	0.544
LIG_APCC_ABBA_1	458	463	PF00400	0.405
LIG_APCC_ABBA_1	474	479	PF00400	0.400
LIG_APCC_ABBAyCdc20_2	473	479	PF00400	0.373
LIG_BRCT_BRCA1_1	8	12	PF00533	0.454
LIG_FHA_1	168	174	PF00498	0.359
LIG_FHA_1	285	291	PF00498	0.601
LIG_FHA_1	80	86	PF00498	0.553
LIG_FHA_2	199	205	PF00498	0.389
LIG_FHA_2	219	225	PF00498	0.259
LIG_FHA_2	235	241	PF00498	0.401
LIG_FHA_2	280	286	PF00498	0.540
LIG_FHA_2	359	365	PF00498	0.438
LIG_FHA_2	418	424	PF00498	0.427
LIG_LIR_Gen_1	370	379	PF02991	0.432
LIG_LIR_Gen_1	9	19	PF02991	0.533
LIG_LIR_LC3C_4	456	460	PF02991	0.310
LIG_LIR_Nem_3	201	206	PF02991	0.517
LIG_LIR_Nem_3	370	374	PF02991	0.373
LIG_LIR_Nem_3	383	389	PF02991	0.340
LIG_LIR_Nem_3	9	15	PF02991	0.632
LIG_PDZ_Class_1	525	530	PF00595	0.568
LIG_SH2_CRK	375	379	PF00017	0.388
LIG_SH2_SRC	73	76	PF00017	0.404
LIG_SH2_STAP1	382	386	PF00017	0.406
LIG_SH2_STAT5	382	385	PF00017	0.412
LIG_SH2_STAT5	66	69	PF00017	0.403
LIG_SH2_STAT5	73	76	PF00017	0.437
LIG_SH3_3	133	139	PF00018	0.412
LIG_SH3_3	148	154	PF00018	0.418
LIG_SH3_3	23	29	PF00018	0.622
LIG_SH3_3	331	337	PF00018	0.517
LIG_SH3_3	384	390	PF00018	0.446
LIG_SH3_3	45	51	PF00018	0.421
LIG_Sin3_3	12	19	PF02671	0.549
LIG_SUMO_SIM_anti_2	2	7	PF11976	0.580
LIG_SUMO_SIM_par_1	12	18	PF11976	0.506
LIG_SUMO_SIM_par_1	229	235	PF11976	0.354
LIG_SUMO_SIM_par_1	73	79	PF11976	0.414
LIG_UBA3_1	140	147	PF00899	0.409
MOD_CDK_SPxK_1	55	61	PF00069	0.495
MOD_CK1_1	242	248	PF00069	0.404
MOD_CK1_1	265	271	PF00069	0.615
MOD_CK1_1	279	285	PF00069	0.503
MOD_CK1_1	31	37	PF00069	0.601
MOD_CK1_1	327	333	PF00069	0.601
MOD_CK1_1	40	46	PF00069	0.539
MOD_CK1_1	402	408	PF00069	0.424
MOD_CK1_1	419	425	PF00069	0.415
MOD_CK1_1	495	501	PF00069	0.568
MOD_CK1_1	76	82	PF00069	0.567
MOD_CK2_1	204	210	PF00069	0.455
MOD_CK2_1	279	285	PF00069	0.544
MOD_CK2_1	317	323	PF00069	0.525
MOD_CK2_1	356	362	PF00069	0.502
MOD_CK2_1	435	441	PF00069	0.610
MOD_CK2_1	504	510	PF00069	0.651
MOD_CK2_1	91	97	PF00069	0.575
MOD_DYRK1A_RPxSP_1	55	59	PF00069	0.466
MOD_GlcNHglycan	17	20	PF01048	0.580
MOD_GlcNHglycan	244	247	PF01048	0.390
MOD_GlcNHglycan	297	300	PF01048	0.663
MOD_GlcNHglycan	330	333	PF01048	0.603
MOD_GlcNHglycan	392	395	PF01048	0.426
MOD_GlcNHglycan	401	404	PF01048	0.385
MOD_GlcNHglycan	437	440	PF01048	0.448
MOD_GlcNHglycan	55	58	PF01048	0.425
MOD_GlcNHglycan	70	73	PF01048	0.573
MOD_GlcNHglycan	82	85	PF01048	0.451
MOD_GSK3_1	172	179	PF00069	0.348
MOD_GSK3_1	194	201	PF00069	0.395
MOD_GSK3_1	259	266	PF00069	0.648
MOD_GSK3_1	279	286	PF00069	0.463
MOD_GSK3_1	28	35	PF00069	0.650
MOD_GSK3_1	319	326	PF00069	0.693
MOD_GSK3_1	352	359	PF00069	0.436
MOD_GSK3_1	36	43	PF00069	0.584
MOD_GSK3_1	415	422	PF00069	0.420
MOD_GSK3_1	488	495	PF00069	0.509
MOD_GSK3_1	51	58	PF00069	0.346
MOD_GSK3_1	76	83	PF00069	0.572
MOD_NEK2_1	283	288	PF00069	0.611
MOD_NEK2_1	324	329	PF00069	0.651
MOD_NEK2_1	374	379	PF00069	0.436
MOD_NEK2_1	415	420	PF00069	0.391
MOD_NEK2_2	73	78	PF00069	0.504
MOD_PIKK_1	172	178	PF00454	0.383
MOD_PIKK_1	336	342	PF00454	0.447
MOD_PIKK_1	453	459	PF00454	0.410
MOD_PIKK_1	497	503	PF00454	0.561
MOD_PKA_2	295	301	PF00069	0.609
MOD_PKA_2	495	501	PF00069	0.502
MOD_Plk_1	234	240	PF00069	0.427
MOD_Plk_1	481	487	PF00069	0.458
MOD_Plk_2-3	204	210	PF00069	0.455
MOD_Plk_4	239	245	PF00069	0.448
MOD_Plk_4	374	380	PF00069	0.383
MOD_Plk_4	424	430	PF00069	0.341
MOD_Plk_4	6	12	PF00069	0.492
MOD_ProDKin_1	488	494	PF00069	0.497
MOD_ProDKin_1	55	61	PF00069	0.489
TRG_DiLeu_BaEn_2	423	429	PF01217	0.418
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.401
TRG_DiLeu_BaLyEn_6	411	416	PF01217	0.447
TRG_ENDOCYTIC_2	375	378	PF00928	0.397
TRG_ENDOCYTIC_2	388	391	PF00928	0.353
TRG_ER_diArg_1	144	146	PF00400	0.345
TRG_ER_diArg_1	212	215	PF00400	0.376
TRG_ER_diArg_1	446	448	PF00400	0.389
TRG_ER_diArg_1	473	476	PF00400	0.454
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFB4	Leptomonas seymouri	63%	100%
A0A3Q8I8K7	Leishmania donovani	99%	100%
A4H5R3	Leishmania braziliensis	79%	100%
E9AMT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QHU2	Leishmania major	93%	100%
V5B864	Trypanosoma cruzi	36%	100%