LeishMANIAdb
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Prolyl endopeptidase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Prolyl endopeptidase
Gene product:
oligopeptidase b
Species:
Leishmania infantum
UniProt:
A4HTZ8_LEIIN
TriTrypDb:
LINF_090013900
Length:
731

Annotations

Annotations by Jardim et al.

Proteases, Oligopeptidase bwith=GeneDB:LmjF09.0770 OPB

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 2
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0005829 cytosol 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HTZ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTZ8

PDB structure(s): 2xe4_A

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0019538 protein metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004175 endopeptidase activity 4 12
GO:0004252 serine-type endopeptidase activity 5 12
GO:0008233 peptidase activity 3 12
GO:0008236 serine-type peptidase activity 4 12
GO:0016787 hydrolase activity 2 12
GO:0017171 serine hydrolase activity 3 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:0070012 oligopeptidase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 223 227 PF00656 0.502
CLV_MEL_PAP_1 122 128 PF00089 0.185
CLV_NRD_NRD_1 283 285 PF00675 0.241
CLV_NRD_NRD_1 366 368 PF00675 0.237
CLV_NRD_NRD_1 462 464 PF00675 0.394
CLV_NRD_NRD_1 55 57 PF00675 0.265
CLV_PCSK_KEX2_1 186 188 PF00082 0.229
CLV_PCSK_KEX2_1 283 285 PF00082 0.365
CLV_PCSK_KEX2_1 366 368 PF00082 0.252
CLV_PCSK_KEX2_1 462 464 PF00082 0.362
CLV_PCSK_KEX2_1 546 548 PF00082 0.263
CLV_PCSK_PC1ET2_1 186 188 PF00082 0.229
CLV_PCSK_PC1ET2_1 546 548 PF00082 0.263
CLV_PCSK_SKI1_1 113 117 PF00082 0.269
CLV_PCSK_SKI1_1 463 467 PF00082 0.393
CLV_PCSK_SKI1_1 542 546 PF00082 0.278
CLV_PCSK_SKI1_1 595 599 PF00082 0.334
CLV_PCSK_SKI1_1 719 723 PF00082 0.297
CLV_Separin_Metazoa 292 296 PF03568 0.469
DEG_APCC_DBOX_1 366 374 PF00400 0.437
DEG_APCC_DBOX_1 589 597 PF00400 0.302
DEG_Nend_Nbox_1 1 3 PF02207 0.465
DOC_CKS1_1 425 430 PF01111 0.426
DOC_CKS1_1 565 570 PF01111 0.292
DOC_MAPK_gen_1 18 25 PF00069 0.511
DOC_MAPK_gen_1 719 729 PF00069 0.471
DOC_MAPK_MEF2A_6 647 656 PF00069 0.303
DOC_MAPK_MEF2A_6 722 729 PF00069 0.360
DOC_PP1_RVXF_1 20 26 PF00149 0.484
DOC_PP2B_LxvP_1 328 331 PF13499 0.446
DOC_PP2B_PxIxI_1 651 657 PF00149 0.357
DOC_PP4_MxPP_1 38 41 PF00568 0.426
DOC_USP7_MATH_1 355 359 PF00917 0.446
DOC_USP7_UBL2_3 542 546 PF12436 0.263
DOC_USP7_UBL2_3 672 676 PF12436 0.263
DOC_USP7_UBL2_3 701 705 PF12436 0.398
DOC_WW_Pin1_4 268 273 PF00397 0.454
DOC_WW_Pin1_4 424 429 PF00397 0.426
DOC_WW_Pin1_4 564 569 PF00397 0.292
DOC_WW_Pin1_4 638 643 PF00397 0.288
LIG_14-3-3_CanoR_1 187 191 PF00244 0.513
LIG_14-3-3_CanoR_1 22 26 PF00244 0.532
LIG_14-3-3_CanoR_1 372 377 PF00244 0.437
LIG_14-3-3_CanoR_1 462 468 PF00244 0.404
LIG_14-3-3_CanoR_1 547 551 PF00244 0.263
LIG_APCC_ABBA_1 242 247 PF00400 0.426
LIG_APCC_ABBAyCdc20_2 83 89 PF00400 0.528
LIG_BRCT_BRCA1_1 694 698 PF00533 0.263
LIG_Clathr_ClatBox_1 688 692 PF01394 0.263
LIG_deltaCOP1_diTrp_1 621 625 PF00928 0.301
LIG_FHA_1 110 116 PF00498 0.454
LIG_FHA_1 260 266 PF00498 0.431
LIG_FHA_1 272 278 PF00498 0.422
LIG_FHA_1 288 294 PF00498 0.476
LIG_FHA_1 308 314 PF00498 0.421
LIG_FHA_1 373 379 PF00498 0.443
LIG_FHA_1 400 406 PF00498 0.475
LIG_FHA_1 722 728 PF00498 0.362
LIG_FHA_1 86 92 PF00498 0.478
LIG_FHA_2 192 198 PF00498 0.575
LIG_FHA_2 200 206 PF00498 0.465
LIG_FHA_2 217 223 PF00498 0.402
LIG_FHA_2 428 434 PF00498 0.440
LIG_FHA_2 464 470 PF00498 0.391
LIG_FHA_2 547 553 PF00498 0.263
LIG_FHA_2 607 613 PF00498 0.263
LIG_FHA_2 616 622 PF00498 0.296
LIG_LIR_Apic_2 412 416 PF02991 0.523
LIG_LIR_Apic_2 623 628 PF02991 0.292
LIG_LIR_Gen_1 336 343 PF02991 0.477
LIG_LIR_Gen_1 358 368 PF02991 0.469
LIG_LIR_Gen_1 371 380 PF02991 0.468
LIG_LIR_Gen_1 421 428 PF02991 0.457
LIG_LIR_Gen_1 430 436 PF02991 0.440
LIG_LIR_Gen_1 549 557 PF02991 0.263
LIG_LIR_LC3C_4 358 363 PF02991 0.516
LIG_LIR_Nem_3 119 123 PF02991 0.453
LIG_LIR_Nem_3 182 188 PF02991 0.531
LIG_LIR_Nem_3 24 28 PF02991 0.397
LIG_LIR_Nem_3 336 341 PF02991 0.452
LIG_LIR_Nem_3 358 363 PF02991 0.479
LIG_LIR_Nem_3 421 425 PF02991 0.463
LIG_LIR_Nem_3 430 434 PF02991 0.424
LIG_LIR_Nem_3 549 553 PF02991 0.263
LIG_LIR_Nem_3 630 636 PF02991 0.263
LIG_LIR_Nem_3 639 643 PF02991 0.263
LIG_LIR_Nem_3 650 654 PF02991 0.256
LIG_LYPXL_yS_3 651 654 PF13949 0.263
LIG_NRP_CendR_1 730 731 PF00754 0.463
LIG_PTB_Apo_2 246 253 PF02174 0.528
LIG_SH2_CRK 123 127 PF00017 0.537
LIG_SH2_CRK 422 426 PF00017 0.528
LIG_SH2_NCK_1 413 417 PF00017 0.486
LIG_SH2_NCK_1 640 644 PF00017 0.221
LIG_SH2_SRC 103 106 PF00017 0.482
LIG_SH2_SRC 27 30 PF00017 0.550
LIG_SH2_SRC 413 416 PF00017 0.480
LIG_SH2_SRC 537 540 PF00017 0.339
LIG_SH2_STAP1 111 115 PF00017 0.457
LIG_SH2_STAP1 181 185 PF00017 0.474
LIG_SH2_STAP1 303 307 PF00017 0.437
LIG_SH2_STAP1 422 426 PF00017 0.516
LIG_SH2_STAP1 634 638 PF00017 0.406
LIG_SH2_STAP1 87 91 PF00017 0.518
LIG_SH2_STAT3 303 306 PF00017 0.528
LIG_SH2_STAT5 103 106 PF00017 0.436
LIG_SH2_STAT5 111 114 PF00017 0.458
LIG_SH2_STAT5 123 126 PF00017 0.474
LIG_SH2_STAT5 181 184 PF00017 0.437
LIG_SH2_STAT5 217 220 PF00017 0.426
LIG_SH2_STAT5 27 30 PF00017 0.500
LIG_SH2_STAT5 360 363 PF00017 0.528
LIG_SH2_STAT5 48 51 PF00017 0.541
LIG_SH2_STAT5 514 517 PF00017 0.289
LIG_SH2_STAT5 543 546 PF00017 0.312
LIG_SH2_STAT5 71 74 PF00017 0.458
LIG_SH2_STAT5 87 90 PF00017 0.426
LIG_SH3_2 37 42 PF14604 0.451
LIG_SH3_3 158 164 PF00018 0.421
LIG_SH3_3 204 210 PF00018 0.477
LIG_SH3_3 34 40 PF00018 0.479
LIG_SH3_3 610 616 PF00018 0.273
LIG_SUMO_SIM_anti_2 290 295 PF11976 0.532
LIG_SUMO_SIM_anti_2 310 317 PF11976 0.363
LIG_SUMO_SIM_par_1 310 317 PF11976 0.425
LIG_TRAF2_1 136 139 PF00917 0.559
LIG_TYR_ITIM 638 643 PF00017 0.230
LIG_WW_1 40 43 PF00397 0.398
LIG_WW_3 39 43 PF00397 0.278
MOD_CK1_1 271 277 PF00069 0.295
MOD_CK1_1 3 9 PF00069 0.625
MOD_CK1_1 336 342 PF00069 0.343
MOD_CK1_1 424 430 PF00069 0.279
MOD_CK2_1 173 179 PF00069 0.297
MOD_CK2_1 199 205 PF00069 0.406
MOD_CK2_1 216 222 PF00069 0.406
MOD_CK2_1 615 621 PF00069 0.277
MOD_CMANNOS 622 625 PF00535 0.302
MOD_Cter_Amidation 364 367 PF01082 0.278
MOD_GlcNHglycan 174 178 PF01048 0.322
MOD_GlcNHglycan 199 202 PF01048 0.381
MOD_GlcNHglycan 2 5 PF01048 0.673
MOD_GlcNHglycan 252 255 PF01048 0.312
MOD_GlcNHglycan 576 579 PF01048 0.263
MOD_GlcNHglycan 694 697 PF01048 0.263
MOD_GlcNHglycan 698 701 PF01048 0.263
MOD_GlcNHglycan 709 712 PF01048 0.263
MOD_GlcNHglycan 75 78 PF01048 0.470
MOD_GlcNHglycan 9 12 PF01048 0.574
MOD_GlcNHglycan 96 102 PF01048 0.285
MOD_GSK3_1 169 176 PF00069 0.300
MOD_GSK3_1 216 223 PF00069 0.367
MOD_GSK3_1 3 10 PF00069 0.630
MOD_GSK3_1 368 375 PF00069 0.278
MOD_GSK3_1 420 427 PF00069 0.300
MOD_GSK3_1 495 502 PF00069 0.474
MOD_GSK3_1 542 549 PF00069 0.281
MOD_GSK3_1 611 618 PF00069 0.274
MOD_GSK3_1 692 699 PF00069 0.271
MOD_GSK3_1 85 92 PF00069 0.408
MOD_LATS_1 525 531 PF00433 0.406
MOD_NEK2_1 307 312 PF00069 0.322
MOD_NEK2_1 350 355 PF00069 0.402
MOD_NEK2_1 361 366 PF00069 0.414
MOD_NEK2_1 385 390 PF00069 0.279
MOD_NEK2_1 420 425 PF00069 0.331
MOD_NEK2_1 483 488 PF00069 0.395
MOD_NEK2_1 721 726 PF00069 0.460
MOD_NEK2_2 399 404 PF00069 0.389
MOD_PIKK_1 266 272 PF00454 0.339
MOD_PIKK_1 483 489 PF00454 0.536
MOD_PIKK_1 566 572 PF00454 0.382
MOD_PKA_1 186 192 PF00069 0.398
MOD_PKA_1 546 552 PF00069 0.263
MOD_PKA_2 124 130 PF00069 0.206
MOD_PKA_2 186 192 PF00069 0.389
MOD_PKA_2 21 27 PF00069 0.542
MOD_PKA_2 546 552 PF00069 0.263
MOD_Plk_1 210 216 PF00069 0.322
MOD_Plk_1 220 226 PF00069 0.339
MOD_Plk_1 336 342 PF00069 0.440
MOD_Plk_1 420 426 PF00069 0.379
MOD_Plk_2-3 179 185 PF00069 0.377
MOD_Plk_4 211 217 PF00069 0.336
MOD_Plk_4 427 433 PF00069 0.283
MOD_Plk_4 473 479 PF00069 0.337
MOD_ProDKin_1 268 274 PF00069 0.302
MOD_ProDKin_1 424 430 PF00069 0.263
MOD_ProDKin_1 564 570 PF00069 0.292
MOD_ProDKin_1 638 644 PF00069 0.288
MOD_SUMO_rev_2 143 153 PF00179 0.296
MOD_SUMO_rev_2 155 162 PF00179 0.378
MOD_SUMO_rev_2 179 188 PF00179 0.406
MOD_SUMO_rev_2 221 229 PF00179 0.278
MOD_SUMO_rev_2 675 682 PF00179 0.299
TRG_DiLeu_BaLyEn_6 723 728 PF01217 0.454
TRG_ENDOCYTIC_2 123 126 PF00928 0.413
TRG_ENDOCYTIC_2 360 363 PF00928 0.377
TRG_ENDOCYTIC_2 422 425 PF00928 0.263
TRG_ENDOCYTIC_2 48 51 PF00928 0.406
TRG_ENDOCYTIC_2 634 637 PF00928 0.274
TRG_ENDOCYTIC_2 640 643 PF00928 0.279
TRG_ENDOCYTIC_2 651 654 PF00928 0.263
TRG_ER_diArg_1 282 284 PF00400 0.357
TRG_ER_diArg_1 294 297 PF00400 0.235
TRG_ER_diArg_1 462 464 PF00400 0.396
TRG_ER_diArg_1 729 731 PF00400 0.456

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7J4 Leptomonas seymouri 81% 100%
A0A0N1PDP3 Leptomonas seymouri 23% 84%
A0A0S4IIS9 Bodo saltans 25% 100%
A0A0S4JND1 Bodo saltans 57% 98%
A0A1X0NKN5 Trypanosomatidae 25% 80%
A0A1X0NMH6 Trypanosomatidae 66% 100%
A0A3Q8IGZ3 Leishmania donovani 100% 100%
A0A3S5H5P5 Leishmania donovani 24% 81%
A0A422N761 Trypanosoma rangeli 66% 100%
A4H4J9 Leishmania braziliensis 24% 100%
A4H5Q8 Leishmania braziliensis 87% 100%
A4HSS5 Leishmania infantum 24% 81%
A4ICB5 Leishmania infantum 25% 100%
A5LFV8 Macaca fascicularis 25% 100%
C9ZTC4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 81%
D0A9G2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E2JFG1 Amanita bisporigera 23% 96%
E2JFG2 Amanita bisporigera 25% 100%
E9AKR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AMS8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
H2E7Q7 Galerina marginata (strain CBS 339.88) 24% 99%
H2E7Q8 Galerina marginata (strain CBS 339.88) 25% 100%
O07834 Pseudoxanthomonas mexicana 38% 100%
O70196 Rattus norvegicus 25% 100%
P23687 Sus scrofa 24% 100%
P24555 Escherichia coli (strain K12) 36% 100%
P27028 Elizabethkingia meningoseptica 27% 100%
P27195 Elizabethkingia miricola 27% 100%
P48147 Homo sapiens 24% 100%
P55627 Sinorhizobium fredii (strain NBRC 101917 / NGR234) 26% 97%
P55656 Sinorhizobium fredii (strain NBRC 101917 / NGR234) 26% 100%
Q06903 Aeromonas hydrophila 25% 100%
Q4QHU7 Leishmania major 96% 100%
Q4QJ45 Leishmania major 23% 100%
Q59536 Moraxella lacunata 38% 100%
Q9QUR6 Mus musculus 25% 100%
Q9XTA2 Bos taurus 25% 100%
V5B5S3 Trypanosoma cruzi 25% 85%
V5B860 Trypanosoma cruzi 64% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS