Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTZ4_LEIIN

TriTrypDb:

LINF_090013500

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	263	269	PF00089	0.583
CLV_NRD_NRD_1	106	108	PF00675	0.522
CLV_NRD_NRD_1	114	116	PF00675	0.499
CLV_NRD_NRD_1	156	158	PF00675	0.623
CLV_NRD_NRD_1	162	164	PF00675	0.614
CLV_NRD_NRD_1	33	35	PF00675	0.614
CLV_PCSK_KEX2_1	106	108	PF00082	0.522
CLV_PCSK_KEX2_1	114	116	PF00082	0.499
CLV_PCSK_KEX2_1	33	35	PF00082	0.614
CLV_PCSK_KEX2_1	577	579	PF00082	0.626
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.574
CLV_PCSK_SKI1_1	324	328	PF00082	0.446
CLV_PCSK_SKI1_1	339	343	PF00082	0.473
CLV_PCSK_SKI1_1	370	374	PF00082	0.541
CLV_PCSK_SKI1_1	52	56	PF00082	0.543
CLV_PCSK_SKI1_1	595	599	PF00082	0.544
DEG_APCC_DBOX_1	369	377	PF00400	0.407
DEG_Nend_UBRbox_2	1	3	PF02207	0.671
DEG_SPOP_SBC_1	64	68	PF00917	0.528
DOC_CKS1_1	192	197	PF01111	0.570
DOC_CYCLIN_RxL_1	321	330	PF00134	0.445
DOC_MAPK_gen_1	33	42	PF00069	0.545
DOC_MAPK_gen_1	71	78	PF00069	0.478
DOC_MAPK_MEF2A_6	181	190	PF00069	0.536
DOC_MAPK_MEF2A_6	324	331	PF00069	0.512
DOC_PP4_FxxP_1	234	237	PF00568	0.535
DOC_USP7_MATH_1	12	16	PF00917	0.579
DOC_USP7_MATH_1	244	248	PF00917	0.554
DOC_USP7_MATH_1	269	273	PF00917	0.606
DOC_USP7_MATH_1	461	465	PF00917	0.750
DOC_USP7_MATH_1	559	563	PF00917	0.596
DOC_USP7_MATH_1	65	69	PF00917	0.549
DOC_WW_Pin1_4	17	22	PF00397	0.523
DOC_WW_Pin1_4	191	196	PF00397	0.546
DOC_WW_Pin1_4	233	238	PF00397	0.495
DOC_WW_Pin1_4	3	8	PF00397	0.643
DOC_WW_Pin1_4	602	607	PF00397	0.500
LIG_14-3-3_CanoR_1	208	215	PF00244	0.589
LIG_14-3-3_CanoR_1	339	345	PF00244	0.468
LIG_14-3-3_CanoR_1	399	405	PF00244	0.571
LIG_14-3-3_CanoR_1	411	420	PF00244	0.397
LIG_14-3-3_CanoR_1	482	488	PF00244	0.594
LIG_14-3-3_CanoR_1	52	60	PF00244	0.546
LIG_14-3-3_CanoR_1	590	598	PF00244	0.511
LIG_14-3-3_CanoR_1	612	620	PF00244	0.587
LIG_Actin_WH2_2	334	350	PF00022	0.530
LIG_Actin_WH2_2	405	423	PF00022	0.517
LIG_AP2alpha_1	281	285	PF02296	0.521
LIG_BRCT_BRCA1_1	18	22	PF00533	0.563
LIG_BRCT_BRCA1_1	216	220	PF00533	0.500
LIG_Clathr_ClatBox_1	212	216	PF01394	0.498
LIG_eIF4E_1	316	322	PF01652	0.418
LIG_FHA_1	118	124	PF00498	0.485
LIG_FHA_1	30	36	PF00498	0.539
LIG_FHA_1	341	347	PF00498	0.550
LIG_FHA_1	433	439	PF00498	0.634
LIG_FHA_2	304	310	PF00498	0.473
LIG_FHA_2	363	369	PF00498	0.484
LIG_FHA_2	92	98	PF00498	0.512
LIG_GBD_Chelix_1	292	300	PF00786	0.527
LIG_GBD_Chelix_1	317	325	PF00786	0.436
LIG_LIR_Gen_1	116	125	PF02991	0.523
LIG_LIR_Gen_1	607	618	PF02991	0.628
LIG_LIR_Nem_3	116	121	PF02991	0.362
LIG_LIR_Nem_3	343	347	PF02991	0.440
LIG_LIR_Nem_3	50	54	PF02991	0.473
LIG_LIR_Nem_3	607	613	PF02991	0.563
LIG_LIR_Nem_3	96	102	PF02991	0.486
LIG_Pex14_2	281	285	PF04695	0.521
LIG_PTAP_UEV_1	555	560	PF05743	0.565
LIG_SH2_CRK	323	327	PF00017	0.450
LIG_SH2_CRK	51	55	PF00017	0.528
LIG_SH2_PTP2	379	382	PF00017	0.473
LIG_SH2_SRC	379	382	PF00017	0.421
LIG_SH2_STAT3	601	604	PF00017	0.489
LIG_SH2_STAT5	316	319	PF00017	0.447
LIG_SH2_STAT5	379	382	PF00017	0.460
LIG_SH2_STAT5	387	390	PF00017	0.499
LIG_SH2_STAT5	53	56	PF00017	0.510
LIG_SH2_STAT5	601	604	PF00017	0.489
LIG_SH2_STAT5	91	94	PF00017	0.558
LIG_SH3_1	189	195	PF00018	0.619
LIG_SH3_3	15	21	PF00018	0.570
LIG_SH3_3	189	195	PF00018	0.619
LIG_SH3_3	380	386	PF00018	0.494
LIG_SH3_3	553	559	PF00018	0.627
LIG_Sin3_3	318	325	PF02671	0.438
LIG_SUMO_SIM_anti_2	381	386	PF11976	0.466
LIG_SUMO_SIM_par_1	246	253	PF11976	0.500
LIG_SUMO_SIM_par_1	325	330	PF11976	0.514
LIG_SUMO_SIM_par_1	508	513	PF11976	0.563
LIG_TRAF2_1	286	289	PF00917	0.475
LIG_TYR_ITIM	321	326	PF00017	0.439
LIG_TYR_ITIM	49	54	PF00017	0.468
MOD_CDK_SPK_2	233	238	PF00069	0.480
MOD_CK1_1	16	22	PF00069	0.598
MOD_CK1_1	273	279	PF00069	0.616
MOD_CK1_1	29	35	PF00069	0.485
MOD_CK1_1	66	72	PF00069	0.579
MOD_CK2_1	283	289	PF00069	0.521
MOD_CK2_1	303	309	PF00069	0.387
MOD_CK2_1	362	368	PF00069	0.531
MOD_CK2_1	510	516	PF00069	0.671
MOD_CK2_1	91	97	PF00069	0.512
MOD_CMANNOS	173	176	PF00535	0.515
MOD_Cter_Amidation	575	578	PF01082	0.741
MOD_DYRK1A_RPxSP_1	191	195	PF00069	0.545
MOD_GlcNHglycan	146	149	PF01048	0.582
MOD_GlcNHglycan	216	220	PF01048	0.500
MOD_GlcNHglycan	27	31	PF01048	0.443
MOD_GlcNHglycan	275	278	PF01048	0.682
MOD_GlcNHglycan	285	288	PF01048	0.456
MOD_GlcNHglycan	357	360	PF01048	0.535
MOD_GlcNHglycan	413	416	PF01048	0.604
MOD_GlcNHglycan	462	466	PF01048	0.593
MOD_GlcNHglycan	492	495	PF01048	0.573
MOD_GlcNHglycan	518	521	PF01048	0.650
MOD_GlcNHglycan	559	562	PF01048	0.646
MOD_GlcNHglycan	586	589	PF01048	0.705
MOD_GlcNHglycan	8	11	PF01048	0.644
MOD_GSK3_1	12	19	PF00069	0.539
MOD_GSK3_1	144	151	PF00069	0.589
MOD_GSK3_1	2	9	PF00069	0.655
MOD_GSK3_1	239	246	PF00069	0.592
MOD_GSK3_1	269	276	PF00069	0.571
MOD_GSK3_1	394	401	PF00069	0.552
MOD_GSK3_1	407	414	PF00069	0.430
MOD_GSK3_1	434	441	PF00069	0.771
MOD_GSK3_1	508	515	PF00069	0.679
MOD_GSK3_1	579	586	PF00069	0.623
MOD_GSK3_1	60	67	PF00069	0.504
MOD_GSK3_1	600	607	PF00069	0.501
MOD_NEK2_1	1	6	PF00069	0.659
MOD_NEK2_1	131	136	PF00069	0.502
MOD_NEK2_1	215	220	PF00069	0.477
MOD_NEK2_1	327	332	PF00069	0.459
MOD_NEK2_1	355	360	PF00069	0.685
MOD_NEK2_1	398	403	PF00069	0.520
MOD_NEK2_1	490	495	PF00069	0.587
MOD_NEK2_1	502	507	PF00069	0.574
MOD_NEK2_1	510	515	PF00069	0.570
MOD_NEK2_1	533	538	PF00069	0.647
MOD_NEK2_1	54	59	PF00069	0.544
MOD_NEK2_1	584	589	PF00069	0.585
MOD_NEK2_1	60	65	PF00069	0.515
MOD_NEK2_1	78	83	PF00069	0.409
MOD_NEK2_1	8	13	PF00069	0.584
MOD_PIKK_1	589	595	PF00454	0.544
MOD_PIKK_1	600	606	PF00454	0.457
MOD_PK_1	72	78	PF00069	0.476
MOD_PKA_1	71	77	PF00069	0.476
MOD_PKA_2	207	213	PF00069	0.536
MOD_PKA_2	398	404	PF00069	0.595
MOD_PKA_2	589	595	PF00069	0.472
MOD_PKA_2	611	617	PF00069	0.636
MOD_Plk_1	215	221	PF00069	0.472
MOD_Plk_1	327	333	PF00069	0.522
MOD_Plk_1	579	585	PF00069	0.629
MOD_Plk_4	117	123	PF00069	0.483
MOD_Plk_4	13	19	PF00069	0.576
MOD_Plk_4	244	250	PF00069	0.556
MOD_Plk_4	527	533	PF00069	0.608
MOD_Plk_4	579	585	PF00069	0.629
MOD_ProDKin_1	17	23	PF00069	0.524
MOD_ProDKin_1	191	197	PF00069	0.546
MOD_ProDKin_1	233	239	PF00069	0.499
MOD_ProDKin_1	3	9	PF00069	0.644
MOD_ProDKin_1	602	608	PF00069	0.507
MOD_SUMO_for_1	415	418	PF00179	0.501
MOD_SUMO_rev_2	511	520	PF00179	0.548
MOD_SUMO_rev_2	66	74	PF00179	0.476
TRG_DiLeu_BaEn_4	470	476	PF01217	0.592
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.446
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.537
TRG_ENDOCYTIC_2	323	326	PF00928	0.454
TRG_ENDOCYTIC_2	379	382	PF00928	0.473
TRG_ENDOCYTIC_2	51	54	PF00928	0.484
TRG_ENDOCYTIC_2	599	602	PF00928	0.564
TRG_ENDOCYTIC_2	99	102	PF00928	0.485
TRG_ER_diArg_1	106	108	PF00400	0.449
TRG_ER_diArg_1	188	191	PF00400	0.570
TRG_ER_diArg_1	222	225	PF00400	0.466
TRG_ER_diArg_1	33	35	PF00400	0.614
TRG_ER_diArg_1	480	483	PF00400	0.611
TRG_NES_CRM1_1	375	389	PF08389	0.445
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV8	Leptomonas seymouri	38%	100%
A0A3S7WQR1	Leishmania donovani	100%	100%
A4H5Q4	Leishmania braziliensis	69%	100%
E9AMS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QHV1	Leishmania major	90%	100%