Putative cleavage and polyadenylation specificity factor 30 kDa subunit

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cleavage and polyadenylation specificity factor 30 kDa subunit - putative

Species:

Leishmania infantum

UniProt:

A4HTZ3_LEIIN

TriTrypDb:

LINF_090013400

Length:

336

Annotations

Annotations by Jardim et al.

RNA Processing, cleavage and polyadenylation specificity factor 30 kDa subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HTZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTZ3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006379	mRNA cleavage	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	12
GO:0090501	RNA phosphodiester bond hydrolysis	6	12
GO:0098787	mRNA cleavage involved in mRNA processing	8	12
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0031426	polycistronic mRNA processing	8	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.347
CLV_NRD_NRD_1	250	252	PF00675	0.263
CLV_NRD_NRD_1	298	300	PF00675	0.596
CLV_NRD_NRD_1	301	303	PF00675	0.590
CLV_NRD_NRD_1	329	331	PF00675	0.703
CLV_PCSK_FUR_1	299	303	PF00082	0.693
CLV_PCSK_KEX2_1	122	124	PF00082	0.354
CLV_PCSK_KEX2_1	138	140	PF00082	0.379
CLV_PCSK_KEX2_1	174	176	PF00082	0.521
CLV_PCSK_KEX2_1	250	252	PF00082	0.387
CLV_PCSK_KEX2_1	297	299	PF00082	0.599
CLV_PCSK_KEX2_1	301	303	PF00082	0.588
CLV_PCSK_KEX2_1	328	330	PF00082	0.705
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.503
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.515
CLV_PCSK_PC7_1	297	303	PF00082	0.695
CLV_PCSK_SKI1_1	135	139	PF00082	0.354
CLV_PCSK_SKI1_1	174	178	PF00082	0.529
CLV_PCSK_SKI1_1	192	196	PF00082	0.355
CLV_PCSK_SKI1_1	251	255	PF00082	0.385
DEG_Nend_Nbox_1	1	3	PF02207	0.456
DOC_MAPK_gen_1	174	182	PF00069	0.375
DOC_USP7_MATH_1	111	115	PF00917	0.534
DOC_USP7_MATH_1	214	218	PF00917	0.543
DOC_USP7_MATH_1	285	289	PF00917	0.697
LIG_14-3-3_CanoR_1	48	57	PF00244	0.471
LIG_Actin_WH2_2	54	69	PF00022	0.323
LIG_BIR_III_2	43	47	PF00653	0.506
LIG_BIR_III_4	5	9	PF00653	0.537
LIG_FHA_1	231	237	PF00498	0.691
LIG_FHA_2	259	265	PF00498	0.367
LIG_FHA_2	7	13	PF00498	0.544
LIG_FHA_2	98	104	PF00498	0.415
LIG_LIR_Nem_3	52	57	PF02991	0.488
LIG_PCNA_PIPBox_1	58	67	PF02747	0.335
LIG_REV1ctd_RIR_1	90	99	PF16727	0.506
LIG_SH2_CRK	54	58	PF00017	0.483
LIG_SH2_GRB2like	82	85	PF00017	0.479
LIG_SH2_STAP1	167	171	PF00017	0.440
LIG_SH2_STAP1	82	86	PF00017	0.330
LIG_SH2_STAT3	86	89	PF00017	0.445
LIG_SH2_STAT5	146	149	PF00017	0.429
LIG_SH2_STAT5	78	81	PF00017	0.241
LIG_SH2_STAT5	86	89	PF00017	0.302
LIG_SH3_3	124	130	PF00018	0.339
LIG_SH3_3	149	155	PF00018	0.466
LIG_SH3_3	206	212	PF00018	0.413
LIG_SH3_3	226	232	PF00018	0.292
LIG_SH3_3	279	285	PF00018	0.757
LIG_SH3_3	99	105	PF00018	0.404
LIG_TRAF2_1	162	165	PF00917	0.422
MOD_CK2_1	111	117	PF00069	0.399
MOD_CK2_1	97	103	PF00069	0.432
MOD_Cter_Amidation	326	329	PF01082	0.616
MOD_GlcNHglycan	140	143	PF01048	0.541
MOD_GlcNHglycan	192	195	PF01048	0.480
MOD_GlcNHglycan	237	240	PF01048	0.743
MOD_GlcNHglycan	287	290	PF01048	0.705
MOD_GlcNHglycan	312	315	PF01048	0.732
MOD_GlcNHglycan	51	54	PF01048	0.433
MOD_GSK3_1	186	193	PF00069	0.522
MOD_GSK3_1	49	56	PF00069	0.360
MOD_LATS_1	136	142	PF00433	0.479
MOD_N-GLC_1	111	116	PF02516	0.446
MOD_N-GLC_1	190	195	PF02516	0.369
MOD_NEK2_1	106	111	PF00069	0.589
MOD_NEK2_1	13	18	PF00069	0.500
MOD_NEK2_1	190	195	PF00069	0.490
MOD_PIKK_1	111	117	PF00454	0.436
MOD_PKA_1	138	144	PF00069	0.476
MOD_PKA_2	138	144	PF00069	0.428
MOD_Plk_1	13	19	PF00069	0.505
MOD_Plk_2-3	258	264	PF00069	0.384
MOD_Plk_4	214	220	PF00069	0.530
MOD_SUMO_for_1	137	140	PF00179	0.481
MOD_SUMO_rev_2	20	28	PF00179	0.580
TRG_ENDOCYTIC_2	54	57	PF00928	0.487
TRG_ER_diArg_1	121	123	PF00400	0.334
TRG_ER_diArg_1	297	299	PF00400	0.688
TRG_ER_diArg_1	300	302	PF00400	0.678
TRG_ER_diArg_1	328	330	PF00400	0.707
TRG_ER_diArg_1	38	41	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEE4	Leptomonas seymouri	87%	100%
A0A0S4KP33	Bodo saltans	50%	97%
A0A1X0NMX4	Trypanosomatidae	59%	100%
A0A3Q8IAT5	Leishmania donovani	100%	99%
A0A3R7KCZ6	Trypanosoma rangeli	60%	100%
A4H5Q3	Leishmania braziliensis	97%	100%
D0A9F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AMS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O95639	Homo sapiens	33%	100%
Q4QHV2	Leishmania major	98%	100%
V5D8L4	Trypanosoma cruzi	65%	100%