Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTZ2_LEIIN

TriTrypDb:

LINF_090013300

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTZ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.535
CLV_C14_Caspase3-7	306	310	PF00656	0.673
CLV_C14_Caspase3-7	389	393	PF00656	0.580
CLV_NRD_NRD_1	198	200	PF00675	0.506
CLV_NRD_NRD_1	302	304	PF00675	0.597
CLV_NRD_NRD_1	31	33	PF00675	0.538
CLV_NRD_NRD_1	312	314	PF00675	0.543
CLV_NRD_NRD_1	316	318	PF00675	0.553
CLV_NRD_NRD_1	416	418	PF00675	0.410
CLV_PCSK_KEX2_1	198	200	PF00082	0.506
CLV_PCSK_KEX2_1	301	303	PF00082	0.615
CLV_PCSK_KEX2_1	31	33	PF00082	0.538
CLV_PCSK_KEX2_1	312	314	PF00082	0.540
CLV_PCSK_KEX2_1	355	357	PF00082	0.711
CLV_PCSK_KEX2_1	416	418	PF00082	0.410
CLV_PCSK_KEX2_1	508	510	PF00082	0.534
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.711
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.534
CLV_PCSK_SKI1_1	100	104	PF00082	0.451
CLV_PCSK_SKI1_1	189	193	PF00082	0.519
CLV_PCSK_SKI1_1	198	202	PF00082	0.531
CLV_PCSK_SKI1_1	31	35	PF00082	0.535
CLV_PCSK_SKI1_1	93	97	PF00082	0.451
DEG_Nend_UBRbox_1	1	4	PF02207	0.763
DEG_SCF_FBW7_1	374	380	PF00400	0.710
DEG_SPOP_SBC_1	21	25	PF00917	0.648
DOC_CKS1_1	374	379	PF01111	0.772
DOC_CYCLIN_RxL_1	492	502	PF00134	0.431
DOC_CYCLIN_yClb3_PxF_3	56	64	PF00134	0.611
DOC_MAPK_MEF2A_6	483	490	PF00069	0.432
DOC_MAPK_NFAT4_5	483	491	PF00069	0.437
DOC_PP1_RVXF_1	185	191	PF00149	0.487
DOC_PP1_RVXF_1	494	501	PF00149	0.507
DOC_PP1_SILK_1	259	264	PF00149	0.604
DOC_USP7_MATH_1	121	125	PF00917	0.648
DOC_USP7_MATH_1	129	133	PF00917	0.685
DOC_USP7_MATH_1	137	141	PF00917	0.616
DOC_USP7_MATH_1	21	25	PF00917	0.515
DOC_USP7_MATH_1	257	261	PF00917	0.657
DOC_USP7_MATH_1	274	278	PF00917	0.507
DOC_USP7_MATH_1	431	435	PF00917	0.592
DOC_USP7_MATH_1	9	13	PF00917	0.757
DOC_WW_Pin1_4	12	17	PF00397	0.685
DOC_WW_Pin1_4	155	160	PF00397	0.698
DOC_WW_Pin1_4	191	196	PF00397	0.504
DOC_WW_Pin1_4	253	258	PF00397	0.580
DOC_WW_Pin1_4	373	378	PF00397	0.685
DOC_WW_Pin1_4	383	388	PF00397	0.732
DOC_WW_Pin1_4	411	416	PF00397	0.408
DOC_WW_Pin1_4	49	54	PF00397	0.669
DOC_WW_Pin1_4	67	72	PF00397	0.653
LIG_14-3-3_CanoR_1	189	195	PF00244	0.510
LIG_14-3-3_CanoR_1	31	38	PF00244	0.530
LIG_14-3-3_CanoR_1	93	99	PF00244	0.450
LIG_APCC_ABBA_1	264	269	PF00400	0.521
LIG_APCC_ABBA_1	497	502	PF00400	0.569
LIG_APCC_ABBAyCdc20_2	263	269	PF00400	0.518
LIG_APCC_ABBAyCdc20_2	496	502	PF00400	0.570
LIG_CtBP_PxDLS_1	438	442	PF00389	0.598
LIG_FHA_1	103	109	PF00498	0.614
LIG_FHA_1	146	152	PF00498	0.690
LIG_FHA_1	156	162	PF00498	0.613
LIG_FHA_1	32	38	PF00498	0.527
LIG_FHA_1	83	89	PF00498	0.626
LIG_FHA_2	21	27	PF00498	0.601
LIG_FHA_2	346	352	PF00498	0.641
LIG_FHA_2	384	390	PF00498	0.765
LIG_FHA_2	451	457	PF00498	0.416
LIG_LIR_Apic_2	124	129	PF02991	0.745
LIG_LIR_Gen_1	176	186	PF02991	0.453
LIG_LIR_Gen_1	331	340	PF02991	0.608
LIG_LIR_Gen_1	452	463	PF02991	0.453
LIG_LIR_Nem_3	176	182	PF02991	0.473
LIG_LIR_Nem_3	208	213	PF02991	0.491
LIG_LIR_Nem_3	331	337	PF02991	0.603
LIG_LIR_Nem_3	452	458	PF02991	0.450
LIG_Pex14_2	210	214	PF04695	0.545
LIG_SH2_STAT5	419	422	PF00017	0.406
LIG_SH3_3	156	162	PF00018	0.687
LIG_SH3_3	242	248	PF00018	0.551
LIG_SH3_3	251	257	PF00018	0.573
LIG_SH3_3	371	377	PF00018	0.660
LIG_SH3_3	48	54	PF00018	0.669
LIG_SH3_3	65	71	PF00018	0.552
LIG_SUMO_SIM_par_1	437	443	PF11976	0.595
LIG_UBA3_1	261	265	PF00899	0.582
MOD_CDC14_SPxK_1	414	417	PF00782	0.390
MOD_CDK_SPK_2	155	160	PF00069	0.622
MOD_CDK_SPK_2	253	258	PF00069	0.676
MOD_CDK_SPK_2	383	388	PF00069	0.604
MOD_CDK_SPK_2	411	416	PF00069	0.408
MOD_CDK_SPxK_1	411	417	PF00069	0.404
MOD_CDK_SPxxK_3	191	198	PF00069	0.500
MOD_CK1_1	12	18	PF00069	0.682
MOD_CK1_1	140	146	PF00069	0.773
MOD_CK1_1	22	28	PF00069	0.686
MOD_CK1_1	220	226	PF00069	0.756
MOD_CK1_1	230	236	PF00069	0.483
MOD_CK1_1	277	283	PF00069	0.686
MOD_CK1_1	332	338	PF00069	0.560
MOD_CK1_1	70	76	PF00069	0.755
MOD_CK2_1	119	125	PF00069	0.757
MOD_CK2_1	20	26	PF00069	0.731
MOD_CK2_1	253	259	PF00069	0.674
MOD_CK2_1	345	351	PF00069	0.640
MOD_CK2_1	383	389	PF00069	0.720
MOD_CK2_1	437	443	PF00069	0.567
MOD_CK2_1	70	76	PF00069	0.759
MOD_Cter_Amidation	196	199	PF01082	0.505
MOD_DYRK1A_RPxSP_1	155	159	PF00069	0.713
MOD_GlcNHglycan	100	103	PF01048	0.626
MOD_GlcNHglycan	11	14	PF01048	0.760
MOD_GlcNHglycan	121	124	PF01048	0.704
MOD_GlcNHglycan	138	142	PF01048	0.745
MOD_GlcNHglycan	222	225	PF01048	0.719
MOD_GlcNHglycan	271	275	PF01048	0.668
MOD_GlcNHglycan	284	287	PF01048	0.576
MOD_GlcNHglycan	331	334	PF01048	0.566
MOD_GlcNHglycan	361	364	PF01048	0.613
MOD_GlcNHglycan	38	41	PF01048	0.586
MOD_GlcNHglycan	472	475	PF01048	0.489
MOD_GlcNHglycan	72	75	PF01048	0.658
MOD_GSK3_1	117	124	PF00069	0.732
MOD_GSK3_1	233	240	PF00069	0.662
MOD_GSK3_1	253	260	PF00069	0.548
MOD_GSK3_1	270	277	PF00069	0.496
MOD_GSK3_1	278	285	PF00069	0.620
MOD_GSK3_1	3	10	PF00069	0.656
MOD_GSK3_1	359	366	PF00069	0.609
MOD_GSK3_1	373	380	PF00069	0.715
MOD_GSK3_1	94	101	PF00069	0.445
MOD_LATS_1	115	121	PF00433	0.666
MOD_N-GLC_1	19	24	PF02516	0.669
MOD_N-GLC_1	383	388	PF02516	0.756
MOD_N-GLC_1	431	436	PF02516	0.602
MOD_NEK2_1	94	99	PF00069	0.445
MOD_PKA_1	31	37	PF00069	0.530
MOD_PKA_1	449	455	PF00069	0.540
MOD_PKA_2	218	224	PF00069	0.630
MOD_PKA_2	31	37	PF00069	0.530
MOD_PKB_1	187	195	PF00069	0.607
MOD_Plk_1	137	143	PF00069	0.745
MOD_Plk_2-3	180	186	PF00069	0.515
MOD_Plk_4	230	236	PF00069	0.604
MOD_Plk_4	238	244	PF00069	0.566
MOD_Plk_4	257	263	PF00069	0.488
MOD_ProDKin_1	12	18	PF00069	0.685
MOD_ProDKin_1	155	161	PF00069	0.690
MOD_ProDKin_1	191	197	PF00069	0.498
MOD_ProDKin_1	253	259	PF00069	0.575
MOD_ProDKin_1	373	379	PF00069	0.686
MOD_ProDKin_1	383	389	PF00069	0.731
MOD_ProDKin_1	411	417	PF00069	0.404
MOD_ProDKin_1	49	55	PF00069	0.670
MOD_ProDKin_1	67	73	PF00069	0.653
MOD_SUMO_for_1	354	357	PF00179	0.708
TRG_DiLeu_BaEn_4	314	320	PF01217	0.639
TRG_DiLeu_BaLyEn_6	493	498	PF01217	0.422
TRG_DiLeu_LyEn_5	502	507	PF01217	0.573
TRG_ENDOCYTIC_2	455	458	PF00928	0.457
TRG_ER_diArg_1	187	190	PF00400	0.599
TRG_ER_diArg_1	301	303	PF00400	0.619
TRG_ER_diArg_1	31	33	PF00400	0.538
TRG_ER_diArg_1	311	313	PF00400	0.538
TRG_ER_diArg_1	415	417	PF00400	0.388
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	317	322	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	496	501	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILK1	Leptomonas seymouri	39%	98%
A0A3S7WQP0	Leishmania donovani	100%	100%
A4H5Q2	Leishmania braziliensis	72%	100%
E9AMS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHV3	Leishmania major	91%	100%