Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zeta toxin - putative

Species:

Leishmania infantum

UniProt:

A4HTY6_LEIIN

TriTrypDb:

LINF_090012400

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTY6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	327	329	PF00675	0.404
CLV_NRD_NRD_1	477	479	PF00675	0.628
CLV_NRD_NRD_1	480	482	PF00675	0.668
CLV_NRD_NRD_1	598	600	PF00675	0.560
CLV_NRD_NRD_1	93	95	PF00675	0.366
CLV_PCSK_FUR_1	475	479	PF00082	0.512
CLV_PCSK_KEX2_1	327	329	PF00082	0.427
CLV_PCSK_KEX2_1	346	348	PF00082	0.338
CLV_PCSK_KEX2_1	477	479	PF00082	0.636
CLV_PCSK_KEX2_1	480	482	PF00082	0.679
CLV_PCSK_KEX2_1	598	600	PF00082	0.560
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.338
CLV_PCSK_PC7_1	323	329	PF00082	0.390
CLV_PCSK_SKI1_1	249	253	PF00082	0.457
CLV_PCSK_SKI1_1	425	429	PF00082	0.408
CLV_PCSK_SKI1_1	481	485	PF00082	0.526
CLV_PCSK_SKI1_1	552	556	PF00082	0.558
CLV_PCSK_SKI1_1	599	603	PF00082	0.565
CLV_PCSK_SKI1_1	76	80	PF00082	0.429
CLV_PCSK_SKI1_1	81	85	PF00082	0.401
DEG_APCC_DBOX_1	75	83	PF00400	0.439
DEG_COP1_1	9	18	PF00400	0.621
DEG_SCF_FBW7_1	127	134	PF00400	0.654
DEG_SPOP_SBC_1	529	533	PF00917	0.594
DOC_CKS1_1	15	20	PF01111	0.620
DOC_CYCLIN_RxL_1	549	556	PF00134	0.552
DOC_CYCLIN_yCln2_LP_2	115	121	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.510
DOC_MAPK_DCC_7	137	147	PF00069	0.515
DOC_MAPK_gen_1	327	333	PF00069	0.358
DOC_MAPK_gen_1	346	352	PF00069	0.347
DOC_MAPK_gen_1	540	549	PF00069	0.594
DOC_MAPK_MEF2A_6	137	145	PF00069	0.530
DOC_MAPK_MEF2A_6	211	218	PF00069	0.368
DOC_MAPK_MEF2A_6	354	362	PF00069	0.326
DOC_MAPK_RevD_3	312	328	PF00069	0.370
DOC_MAPK_RevD_3	331	347	PF00069	0.341
DOC_PP2B_LxvP_1	115	118	PF13499	0.488
DOC_PP2B_LxvP_1	139	142	PF13499	0.520
DOC_PP2B_LxvP_1	169	172	PF13499	0.378
DOC_PP2B_LxvP_1	237	240	PF13499	0.369
DOC_PP4_FxxP_1	132	135	PF00568	0.604
DOC_USP7_MATH_1	206	210	PF00917	0.463
DOC_USP7_MATH_1	224	228	PF00917	0.183
DOC_USP7_MATH_1	528	532	PF00917	0.627
DOC_USP7_MATH_1	604	608	PF00917	0.567
DOC_WW_Pin1_4	123	128	PF00397	0.657
DOC_WW_Pin1_4	131	136	PF00397	0.666
DOC_WW_Pin1_4	3	8	PF00397	0.662
DOC_WW_Pin1_4	45	50	PF00397	0.651
DOC_WW_Pin1_4	524	529	PF00397	0.654
DOC_WW_Pin1_4	9	14	PF00397	0.603
LIG_14-3-3_CanoR_1	200	204	PF00244	0.318
LIG_14-3-3_CanoR_1	379	384	PF00244	0.509
LIG_14-3-3_CanoR_1	389	395	PF00244	0.488
LIG_14-3-3_CanoR_1	40	49	PF00244	0.541
LIG_14-3-3_CanoR_1	493	499	PF00244	0.610
LIG_14-3-3_CanoR_1	540	549	PF00244	0.530
LIG_14-3-3_CanoR_1	598	602	PF00244	0.586
LIG_14-3-3_CanoR_1	92	101	PF00244	0.518
LIG_BIR_II_1	1	5	PF00653	0.583
LIG_BRCT_BRCA1_1	128	132	PF00533	0.559
LIG_BRCT_BRCA1_1	587	591	PF00533	0.569
LIG_FAT_LD_1	317	325	PF03623	0.342
LIG_FHA_1	114	120	PF00498	0.468
LIG_FHA_1	243	249	PF00498	0.304
LIG_FHA_1	457	463	PF00498	0.489
LIG_FHA_2	275	281	PF00498	0.487
LIG_FHA_2	419	425	PF00498	0.518
LIG_FHA_2	431	437	PF00498	0.373
LIG_HP1_1	118	122	PF01393	0.499
LIG_LIR_Apic_2	129	135	PF02991	0.595
LIG_LIR_Gen_1	199	206	PF02991	0.397
LIG_LIR_Gen_1	424	435	PF02991	0.391
LIG_LIR_Gen_1	437	448	PF02991	0.408
LIG_LIR_Nem_3	199	204	PF02991	0.397
LIG_LIR_Nem_3	260	266	PF02991	0.412
LIG_LIR_Nem_3	29	34	PF02991	0.488
LIG_LIR_Nem_3	393	397	PF02991	0.361
LIG_LIR_Nem_3	424	430	PF02991	0.405
LIG_LIR_Nem_3	437	443	PF02991	0.397
LIG_LIR_Nem_3	72	77	PF02991	0.413
LIG_NRBOX	100	106	PF00104	0.439
LIG_NRBOX	320	326	PF00104	0.391
LIG_OCRL_FandH_1	426	438	PF00620	0.400
LIG_Pex14_2	263	267	PF04695	0.401
LIG_RPA_C_Fungi	384	396	PF08784	0.372
LIG_RPA_C_Plants	384	395	PF08784	0.433
LIG_SH2_CRK	440	444	PF00017	0.419
LIG_SH2_NCK_1	109	113	PF00017	0.483
LIG_SH2_STAP1	109	113	PF00017	0.505
LIG_SH2_STAT3	306	309	PF00017	0.350
LIG_SH2_STAT5	109	112	PF00017	0.532
LIG_SH2_STAT5	167	170	PF00017	0.471
LIG_SH2_STAT5	342	345	PF00017	0.390
LIG_SH2_STAT5	390	393	PF00017	0.404
LIG_SH3_3	10	16	PF00018	0.676
LIG_SH3_3	138	144	PF00018	0.520
LIG_SH3_3	359	365	PF00018	0.378
LIG_SH3_3	513	519	PF00018	0.595
LIG_SH3_3	626	632	PF00018	0.602
LIG_SUMO_SIM_par_1	116	123	PF11976	0.515
LIG_SUMO_SIM_par_1	143	149	PF11976	0.481
LIG_SUMO_SIM_par_1	412	419	PF11976	0.391
LIG_WRC_WIRS_1	391	396	PF05994	0.388
MOD_CDC14_SPxK_1	134	137	PF00782	0.561
MOD_CDK_SPxK_1	127	133	PF00069	0.588
MOD_CK1_1	126	132	PF00069	0.559
MOD_CK1_1	199	205	PF00069	0.412
MOD_CK1_1	244	250	PF00069	0.369
MOD_CK1_1	45	51	PF00069	0.660
MOD_CK1_1	491	497	PF00069	0.614
MOD_CK1_1	531	537	PF00069	0.642
MOD_CK1_1	563	569	PF00069	0.614
MOD_CK1_1	6	12	PF00069	0.624
MOD_CK1_1	72	78	PF00069	0.455
MOD_CK2_1	20	26	PF00069	0.541
MOD_CK2_1	266	272	PF00069	0.370
MOD_CK2_1	293	299	PF00069	0.672
MOD_CK2_1	366	372	PF00069	0.457
MOD_CK2_1	430	436	PF00069	0.438
MOD_CK2_1	47	53	PF00069	0.649
MOD_GlcNHglycan	105	108	PF01048	0.488
MOD_GlcNHglycan	154	157	PF01048	0.539
MOD_GlcNHglycan	208	211	PF01048	0.456
MOD_GlcNHglycan	221	224	PF01048	0.259
MOD_GlcNHglycan	283	286	PF01048	0.628
MOD_GlcNHglycan	288	291	PF01048	0.599
MOD_GlcNHglycan	295	298	PF01048	0.477
MOD_GlcNHglycan	481	484	PF01048	0.611
MOD_GlcNHglycan	49	52	PF01048	0.649
MOD_GlcNHglycan	496	499	PF01048	0.743
MOD_GlcNHglycan	542	545	PF01048	0.544
MOD_GlcNHglycan	578	581	PF01048	0.579
MOD_GSK3_1	103	110	PF00069	0.438
MOD_GSK3_1	123	130	PF00069	0.571
MOD_GSK3_1	172	179	PF00069	0.584
MOD_GSK3_1	224	231	PF00069	0.307
MOD_GSK3_1	41	48	PF00069	0.595
MOD_GSK3_1	430	437	PF00069	0.390
MOD_GSK3_1	481	488	PF00069	0.716
MOD_GSK3_1	524	531	PF00069	0.706
MOD_GSK3_1	571	578	PF00069	0.653
MOD_GSK3_1	630	637	PF00069	0.606
MOD_N-GLC_1	123	128	PF02516	0.487
MOD_N-GLC_1	159	164	PF02516	0.488
MOD_N-GLC_1	286	291	PF02516	0.529
MOD_N-GLC_1	488	493	PF02516	0.665
MOD_NEK2_1	1	6	PF00069	0.645
MOD_NEK2_1	151	156	PF00069	0.492
MOD_NEK2_1	232	237	PF00069	0.307
MOD_NEK2_1	266	271	PF00069	0.395
MOD_NEK2_1	350	355	PF00069	0.428
MOD_NEK2_1	416	421	PF00069	0.386
MOD_NEK2_1	423	428	PF00069	0.414
MOD_NEK2_1	430	435	PF00069	0.370
MOD_NEK2_1	461	466	PF00069	0.452
MOD_NEK2_1	611	616	PF00069	0.725
MOD_NEK2_2	390	395	PF00069	0.440
MOD_PIKK_1	159	165	PF00454	0.579
MOD_PIKK_1	232	238	PF00454	0.304
MOD_PK_1	327	333	PF00069	0.358
MOD_PKA_1	327	333	PF00069	0.358
MOD_PKA_2	199	205	PF00069	0.319
MOD_PKA_2	327	333	PF00069	0.358
MOD_PKA_2	479	485	PF00069	0.558
MOD_PKA_2	563	569	PF00069	0.614
MOD_PKA_2	597	603	PF00069	0.684
MOD_PKA_2	93	99	PF00069	0.552
MOD_PKB_1	377	385	PF00069	0.483
MOD_Plk_1	423	429	PF00069	0.398
MOD_Plk_4	228	234	PF00069	0.325
MOD_Plk_4	26	32	PF00069	0.419
MOD_Plk_4	327	333	PF00069	0.383
MOD_Plk_4	430	436	PF00069	0.409
MOD_Plk_4	571	577	PF00069	0.663
MOD_Plk_4	630	636	PF00069	0.766
MOD_ProDKin_1	123	129	PF00069	0.662
MOD_ProDKin_1	131	137	PF00069	0.665
MOD_ProDKin_1	14	20	PF00069	0.544
MOD_ProDKin_1	3	9	PF00069	0.661
MOD_ProDKin_1	45	51	PF00069	0.657
MOD_ProDKin_1	524	530	PF00069	0.654
MOD_SUMO_rev_2	482	488	PF00179	0.509
TRG_DiLeu_BaEn_1	334	339	PF01217	0.336
TRG_DiLeu_BaEn_1	630	635	PF01217	0.645
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.366
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.429
TRG_ENDOCYTIC_2	440	443	PF00928	0.434
TRG_ER_diArg_1	252	255	PF00400	0.423
TRG_ER_diArg_1	376	379	PF00400	0.447
TRG_ER_diArg_1	474	477	PF00400	0.534
TRG_ER_diArg_1	478	481	PF00400	0.580
TRG_ER_diArg_1	539	542	PF00400	0.639
TRG_ER_diArg_1	597	599	PF00400	0.626
TRG_Pf-PMV_PEXEL_1	552	556	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I622	Leptomonas seymouri	46%	96%
A0A3S5H6D7	Leishmania donovani	99%	100%
A4H5P6	Leishmania braziliensis	78%	100%
E9AMR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHV9	Leishmania major	91%	97%