Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 5 - putative

Species:

Leishmania infantum

UniProt:

A4HTY5_LEIIN

TriTrypDb:

LINF_090012300

Length:

500

Annotations

Annotations by Jardim et al.

Protein pamitoylation, Palmitoyltransferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HTY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTY5

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016409	palmitoyltransferase activity	5	12
GO:0016417	S-acyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	12
GO:0019707	protein-cysteine S-acyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	190	192	PF00675	0.385
CLV_NRD_NRD_1	269	271	PF00675	0.231
CLV_NRD_NRD_1	409	411	PF00675	0.426
CLV_NRD_NRD_1	421	423	PF00675	0.250
CLV_NRD_NRD_1	452	454	PF00675	0.316
CLV_NRD_NRD_1	63	65	PF00675	0.332
CLV_PCSK_KEX2_1	163	165	PF00082	0.378
CLV_PCSK_KEX2_1	190	192	PF00082	0.395
CLV_PCSK_KEX2_1	269	271	PF00082	0.231
CLV_PCSK_KEX2_1	454	456	PF00082	0.405
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.388
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.405
CLV_PCSK_SKI1_1	156	160	PF00082	0.353
CLV_PCSK_SKI1_1	163	167	PF00082	0.385
CLV_PCSK_SKI1_1	191	195	PF00082	0.353
CLV_PCSK_SKI1_1	288	292	PF00082	0.249
CLV_PCSK_SKI1_1	313	317	PF00082	0.456
CLV_PCSK_SKI1_1	41	45	PF00082	0.535
CLV_PCSK_SKI1_1	425	429	PF00082	0.379
CLV_PCSK_SKI1_1	454	458	PF00082	0.338
CLV_PCSK_SKI1_1	72	76	PF00082	0.322
DEG_APCC_DBOX_1	287	295	PF00400	0.431
DEG_APCC_DBOX_1	412	420	PF00400	0.539
DEG_APCC_KENBOX_2	446	450	PF00400	0.555
DEG_Nend_Nbox_1	1	3	PF02207	0.652
DOC_ANK_TNKS_1	205	212	PF00023	0.541
DOC_CDC14_PxL_1	102	110	PF14671	0.354
DOC_CYCLIN_RxL_1	160	170	PF00134	0.536
DOC_CYCLIN_RxL_1	422	432	PF00134	0.558
DOC_CYCLIN_yClb5_NLxxxL_5	474	480	PF00134	0.459
DOC_MAPK_gen_1	285	293	PF00069	0.446
DOC_MAPK_gen_1	38	48	PF00069	0.335
DOC_MAPK_gen_1	422	430	PF00069	0.652
DOC_MAPK_HePTP_8	112	124	PF00069	0.246
DOC_MAPK_MEF2A_6	115	124	PF00069	0.322
DOC_MAPK_MEF2A_6	41	50	PF00069	0.335
DOC_MAPK_MEF2A_6	474	481	PF00069	0.582
DOC_PP1_RVXF_1	113	120	PF00149	0.298
DOC_PP4_FxxP_1	134	137	PF00568	0.495
DOC_USP7_MATH_1	184	188	PF00917	0.782
DOC_USP7_MATH_1	215	219	PF00917	0.672
DOC_USP7_MATH_1	255	259	PF00917	0.445
DOC_USP7_UBL2_3	454	458	PF12436	0.584
DOC_WW_Pin1_4	180	185	PF00397	0.720
DOC_WW_Pin1_4	193	198	PF00397	0.456
DOC_WW_Pin1_4	231	236	PF00397	0.606
LIG_14-3-3_CanoR_1	190	194	PF00244	0.568
LIG_14-3-3_CanoR_1	41	47	PF00244	0.335
LIG_Actin_WH2_2	371	389	PF00022	0.411
LIG_Actin_WH2_2	472	489	PF00022	0.568
LIG_Actin_WH2_2	95	111	PF00022	0.414
LIG_BRCT_BRCA1_1	191	195	PF00533	0.507
LIG_BRCT_BRCA1_1	55	59	PF00533	0.349
LIG_CtBP_PxDLS_1	335	339	PF00389	0.322
LIG_DCNL_PONY_1	1	4	PF03556	0.562
LIG_deltaCOP1_diTrp_1	126	134	PF00928	0.411
LIG_deltaCOP1_diTrp_1	80	88	PF00928	0.474
LIG_EH1_1	206	214	PF00400	0.535
LIG_eIF4E_1	289	295	PF01652	0.337
LIG_FHA_1	247	253	PF00498	0.431
LIG_FHA_1	331	337	PF00498	0.311
LIG_FHA_1	373	379	PF00498	0.565
LIG_FHA_1	399	405	PF00498	0.597
LIG_FHA_1	459	465	PF00498	0.489
LIG_FHA_1	494	500	PF00498	0.516
LIG_FHA_2	131	137	PF00498	0.391
LIG_FHA_2	380	386	PF00498	0.442
LIG_FHA_2	75	81	PF00498	0.556
LIG_GBD_Chelix_1	35	43	PF00786	0.527
LIG_Integrin_isoDGR_2	330	332	PF01839	0.513
LIG_LIR_Apic_2	133	137	PF02991	0.379
LIG_LIR_Apic_2	231	235	PF02991	0.637
LIG_LIR_Gen_1	118	127	PF02991	0.364
LIG_LIR_Gen_1	18	27	PF02991	0.378
LIG_LIR_Gen_1	300	309	PF02991	0.312
LIG_LIR_Gen_1	339	348	PF02991	0.262
LIG_LIR_Gen_1	97	108	PF02991	0.276
LIG_LIR_LC3C_4	118	123	PF02991	0.381
LIG_LIR_Nem_3	118	122	PF02991	0.311
LIG_LIR_Nem_3	18	24	PF02991	0.366
LIG_LIR_Nem_3	287	293	PF02991	0.453
LIG_LIR_Nem_3	300	306	PF02991	0.257
LIG_LIR_Nem_3	339	344	PF02991	0.262
LIG_LIR_Nem_3	80	86	PF02991	0.439
LIG_LIR_Nem_3	97	103	PF02991	0.215
LIG_NRBOX	290	296	PF00104	0.411
LIG_NRBOX	38	44	PF00104	0.393
LIG_Pex14_1	324	328	PF04695	0.278
LIG_Pex14_2	356	360	PF04695	0.365
LIG_Pex14_2	84	88	PF04695	0.318
LIG_PTAP_UEV_1	481	486	PF05743	0.551
LIG_PTB_Apo_2	201	208	PF02174	0.519
LIG_PTB_Phospho_1	201	207	PF10480	0.517
LIG_Rb_pABgroove_1	462	470	PF01858	0.499
LIG_SH2_CRK	232	236	PF00017	0.627
LIG_SH2_NCK_1	214	218	PF00017	0.674
LIG_SH2_NCK_1	232	236	PF00017	0.543
LIG_SH2_PTP2	21	24	PF00017	0.289
LIG_SH2_PTP2	89	92	PF00017	0.266
LIG_SH2_SRC	214	217	PF00017	0.666
LIG_SH2_SRC	271	274	PF00017	0.474
LIG_SH2_SRC	442	445	PF00017	0.646
LIG_SH2_STAT5	100	103	PF00017	0.274
LIG_SH2_STAT5	207	210	PF00017	0.499
LIG_SH2_STAT5	21	24	PF00017	0.289
LIG_SH2_STAT5	232	235	PF00017	0.590
LIG_SH2_STAT5	289	292	PF00017	0.337
LIG_SH2_STAT5	341	344	PF00017	0.235
LIG_SH2_STAT5	89	92	PF00017	0.279
LIG_SH3_2	482	487	PF14604	0.558
LIG_SH3_3	100	106	PF00018	0.349
LIG_SH3_3	234	240	PF00018	0.591
LIG_SH3_3	249	255	PF00018	0.404
LIG_SH3_3	394	400	PF00018	0.552
LIG_SH3_3	430	436	PF00018	0.643
LIG_SH3_3	476	482	PF00018	0.505
LIG_SUMO_SIM_anti_2	118	126	PF11976	0.287
LIG_SUMO_SIM_anti_2	401	406	PF11976	0.606
LIG_SUMO_SIM_par_1	118	126	PF11976	0.319
LIG_SUMO_SIM_par_1	394	401	PF11976	0.553
LIG_SUMO_SIM_par_1	426	432	PF11976	0.563
LIG_SUMO_SIM_par_1	89	95	PF11976	0.262
LIG_TRAF2_1	197	200	PF00917	0.577
LIG_TYR_ITIM	87	92	PF00017	0.281
LIG_UBA3_1	101	109	PF00899	0.381
LIG_UBA3_1	427	431	PF00899	0.332
LIG_WRC_WIRS_1	16	21	PF05994	0.386
LIG_WRC_WIRS_1	6	11	PF05994	0.359
MOD_CK1_1	111	117	PF00069	0.382
MOD_CK1_1	167	173	PF00069	0.566
MOD_CK1_1	189	195	PF00069	0.566
MOD_CK1_1	246	252	PF00069	0.409
MOD_CK1_1	253	259	PF00069	0.386
MOD_CK2_1	193	199	PF00069	0.346
MOD_CK2_1	74	80	PF00069	0.440
MOD_GlcNHglycan	482	485	PF01048	0.534
MOD_GlcNHglycan	488	491	PF01048	0.527
MOD_GSK3_1	111	118	PF00069	0.370
MOD_GSK3_1	132	139	PF00069	0.463
MOD_GSK3_1	152	159	PF00069	0.436
MOD_GSK3_1	180	187	PF00069	0.644
MOD_GSK3_1	189	196	PF00069	0.427
MOD_GSK3_1	246	253	PF00069	0.341
MOD_N-GLC_1	336	341	PF02516	0.381
MOD_N-GLC_1	379	384	PF02516	0.266
MOD_NEK2_1	101	106	PF00069	0.379
MOD_NEK2_1	108	113	PF00069	0.337
MOD_NEK2_1	15	20	PF00069	0.378
MOD_NEK2_1	243	248	PF00069	0.345
MOD_NEK2_1	299	304	PF00069	0.402
MOD_NEK2_1	309	314	PF00069	0.385
MOD_NEK2_1	315	320	PF00069	0.357
MOD_NEK2_1	336	341	PF00069	0.396
MOD_NEK2_1	395	400	PF00069	0.477
MOD_NEK2_1	42	47	PF00069	0.405
MOD_NEK2_1	486	491	PF00069	0.550
MOD_NEK2_1	53	58	PF00069	0.252
MOD_NEK2_1	68	73	PF00069	0.445
MOD_NEK2_2	74	79	PF00069	0.591
MOD_OFUCOSY	296	301	PF10250	0.360
MOD_OFUCOSY	51	57	PF10250	0.361
MOD_PIKK_1	336	342	PF00454	0.331
MOD_PKA_2	167	173	PF00069	0.579
MOD_PKA_2	189	195	PF00069	0.518
MOD_PKA_2	253	259	PF00069	0.266
MOD_PKA_2	284	290	PF00069	0.287
MOD_PKA_2	309	315	PF00069	0.210
MOD_PKA_2	406	412	PF00069	0.361
MOD_PKA_2	486	492	PF00069	0.548
MOD_Plk_1	336	342	PF00069	0.353
MOD_Plk_1	379	385	PF00069	0.300
MOD_Plk_1	389	395	PF00069	0.373
MOD_Plk_4	115	121	PF00069	0.315
MOD_Plk_4	15	21	PF00069	0.306
MOD_Plk_4	5	11	PF00069	0.341
MOD_ProDKin_1	180	186	PF00069	0.670
MOD_ProDKin_1	193	199	PF00069	0.301
MOD_ProDKin_1	231	237	PF00069	0.511
MOD_SUMO_for_1	436	439	PF00179	0.571
MOD_SUMO_rev_2	417	424	PF00179	0.581
MOD_SUMO_rev_2	462	467	PF00179	0.393
TRG_DiLeu_BaEn_1	97	102	PF01217	0.360
TRG_DiLeu_BaEn_2	79	85	PF01217	0.414
TRG_DiLeu_BaLyEn_6	161	166	PF01217	0.451
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.491
TRG_ENDOCYTIC_2	100	103	PF00928	0.266
TRG_ENDOCYTIC_2	21	24	PF00928	0.288
TRG_ENDOCYTIC_2	341	344	PF00928	0.300
TRG_ENDOCYTIC_2	89	92	PF00928	0.266
TRG_ER_diArg_1	268	270	PF00400	0.266
TRG_ER_diArg_1	452	455	PF00400	0.506
TRG_NES_CRM1_1	340	352	PF08389	0.287
TRG_NES_CRM1_1	373	385	PF08389	0.301
TRG_NLS_MonoExtC_3	452	457	PF00514	0.502
TRG_NLS_MonoExtN_4	453	458	PF00514	0.473
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD29	Leptomonas seymouri	64%	98%
A0A0S4JKC0	Bodo saltans	37%	100%
A0A1X0NN08	Trypanosomatidae	50%	100%
A0A3Q8I8F6	Leishmania donovani	100%	100%
A0A3R7L7T0	Trypanosoma rangeli	48%	100%
A4H5P5	Leishmania braziliensis	82%	100%
D0A9E1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AMR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHW0	Leishmania major	94%	100%
V5BSN7	Trypanosoma cruzi	49%	97%