DNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

ATP-dependent DNA helicase - putative

Species:

Leishmania infantum

UniProt:

A4HTY0_LEIIN

TriTrypDb:

LINF_090011800

Length:

996

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HTY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTY0

Function

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Biological processes
Term	Name	Level	Count
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003678	DNA helicase activity	3	7
GO:0003824	catalytic activity	1	7
GO:0004386	helicase activity	2	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008094	ATP-dependent activity, acting on DNA	2	7
GO:0016787	hydrolase activity	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	703	707	PF00656	0.630
CLV_NRD_NRD_1	116	118	PF00675	0.375
CLV_NRD_NRD_1	365	367	PF00675	0.307
CLV_NRD_NRD_1	383	385	PF00675	0.307
CLV_NRD_NRD_1	466	468	PF00675	0.407
CLV_NRD_NRD_1	697	699	PF00675	0.700
CLV_NRD_NRD_1	94	96	PF00675	0.307
CLV_PCSK_FUR_1	380	384	PF00082	0.307
CLV_PCSK_KEX2_1	116	118	PF00082	0.375
CLV_PCSK_KEX2_1	297	299	PF00082	0.307

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P480	Leptomonas seymouri	65%	86%
A0A3Q8I8J3	Leishmania donovani	99%	100%
A4H5P1	Leishmania braziliensis	83%	100%
E9AMR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4QHW5	Leishmania major	94%	100%

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