Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTX8_LEIIN

TriTrypDb:

LINF_090011600

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	6	1
GO:0032991	protein-containing complex	1	1
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	5	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HTX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTX8

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.583
CLV_C14_Caspase3-7	315	319	PF00656	0.709
CLV_C14_Caspase3-7	427	431	PF00656	0.529
CLV_NRD_NRD_1	211	213	PF00675	0.543
CLV_NRD_NRD_1	231	233	PF00675	0.483
CLV_NRD_NRD_1	242	244	PF00675	0.507
CLV_NRD_NRD_1	379	381	PF00675	0.405
CLV_NRD_NRD_1	388	390	PF00675	0.417
CLV_NRD_NRD_1	79	81	PF00675	0.416
CLV_PCSK_FUR_1	376	380	PF00082	0.420
CLV_PCSK_KEX2_1	211	213	PF00082	0.543
CLV_PCSK_KEX2_1	378	380	PF00082	0.412
CLV_PCSK_KEX2_1	381	383	PF00082	0.407
CLV_PCSK_KEX2_1	388	390	PF00082	0.409
CLV_PCSK_KEX2_1	79	81	PF00082	0.420
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.412
DEG_APCC_DBOX_1	79	87	PF00400	0.393
DEG_SCF_FBW7_2	94	101	PF00400	0.573
DEG_SPOP_SBC_1	115	119	PF00917	0.535
DEG_SPOP_SBC_1	155	159	PF00917	0.528
DEG_SPOP_SBC_1	261	265	PF00917	0.691
DEG_SPOP_SBC_1	5	9	PF00917	0.555
DOC_ANK_TNKS_1	279	286	PF00023	0.654
DOC_CDC14_PxL_1	417	425	PF14671	0.467
DOC_MAPK_gen_1	388	394	PF00069	0.435
DOC_MAPK_gen_1	79	86	PF00069	0.378
DOC_MAPK_MEF2A_6	85	94	PF00069	0.432
DOC_MIT_MIM_1	384	393	PF04212	0.383
DOC_PP1_RVXF_1	366	373	PF00149	0.500
DOC_PP2B_LxvP_1	160	163	PF13499	0.495
DOC_PP2B_LxvP_1	297	300	PF13499	0.700
DOC_PP2B_LxvP_1	392	395	PF13499	0.438
DOC_USP7_MATH_1	109	113	PF00917	0.616
DOC_USP7_MATH_1	11	15	PF00917	0.574
DOC_USP7_MATH_1	115	119	PF00917	0.562
DOC_USP7_MATH_1	255	259	PF00917	0.710
DOC_USP7_MATH_1	260	264	PF00917	0.824
DOC_USP7_MATH_1	292	296	PF00917	0.693
DOC_USP7_MATH_1	3	7	PF00917	0.624
DOC_USP7_MATH_1	300	304	PF00917	0.601
DOC_USP7_MATH_1	32	36	PF00917	0.352
DOC_USP7_MATH_1	362	366	PF00917	0.422
DOC_WW_Pin1_4	1	6	PF00397	0.772
DOC_WW_Pin1_4	13	18	PF00397	0.567
DOC_WW_Pin1_4	262	267	PF00397	0.621
DOC_WW_Pin1_4	341	346	PF00397	0.445
DOC_WW_Pin1_4	62	67	PF00397	0.473
DOC_WW_Pin1_4	94	99	PF00397	0.653
LIG_14-3-3_CanoR_1	153	163	PF00244	0.516
LIG_14-3-3_CanoR_1	293	300	PF00244	0.618
LIG_14-3-3_CanoR_1	388	393	PF00244	0.441
LIG_14-3-3_CanoR_1	93	98	PF00244	0.650
LIG_Actin_WH2_2	77	95	PF00022	0.361
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_BIR_III_4	148	152	PF00653	0.668
LIG_BRCT_BRCA1_1	428	432	PF00533	0.508
LIG_EH1_1	360	368	PF00400	0.499
LIG_EH1_1	410	418	PF00400	0.454
LIG_eIF4E_1	361	367	PF01652	0.419
LIG_FHA_1	18	24	PF00498	0.426
LIG_FHA_1	385	391	PF00498	0.481
LIG_FHA_1	435	441	PF00498	0.465
LIG_FHA_1	89	95	PF00498	0.413
LIG_FHA_2	313	319	PF00498	0.708
LIG_LIR_Gen_1	35	45	PF02991	0.412
LIG_LIR_Gen_1	409	418	PF02991	0.448
LIG_LIR_Nem_3	178	183	PF02991	0.409
LIG_LIR_Nem_3	344	350	PF02991	0.403
LIG_LIR_Nem_3	35	40	PF02991	0.368
LIG_LIR_Nem_3	405	410	PF02991	0.476
LIG_PTAP_UEV_1	269	274	PF05743	0.658
LIG_SH2_CRK	418	422	PF00017	0.476
LIG_SH2_STAP1	183	187	PF00017	0.343
LIG_SH2_STAP1	54	58	PF00017	0.429
LIG_SH3_1	418	424	PF00018	0.525
LIG_SH3_3	264	270	PF00018	0.658
LIG_SH3_3	356	362	PF00018	0.488
LIG_SH3_3	418	424	PF00018	0.525
LIG_SUMO_SIM_anti_2	20	25	PF11976	0.403
LIG_TRAF2_1	236	239	PF00917	0.646
LIG_TRAF2_1	41	44	PF00917	0.461
LIG_TRAF2_1	424	427	PF00917	0.496
MOD_CK1_1	303	309	PF00069	0.632
MOD_CK1_1	312	318	PF00069	0.592
MOD_CK1_1	4	10	PF00069	0.774
MOD_CK1_1	473	479	PF00069	0.633
MOD_CK1_1	96	102	PF00069	0.598
MOD_CK2_1	161	167	PF00069	0.477
MOD_CK2_1	303	309	PF00069	0.603
MOD_CK2_1	478	484	PF00069	0.679
MOD_GlcNHglycan	1	4	PF01048	0.639
MOD_GlcNHglycan	13	16	PF01048	0.537
MOD_GlcNHglycan	218	221	PF01048	0.635
MOD_GlcNHglycan	270	273	PF01048	0.694
MOD_GlcNHglycan	289	292	PF01048	0.632
MOD_GlcNHglycan	323	328	PF01048	0.654
MOD_GlcNHglycan	472	475	PF01048	0.600
MOD_GlcNHglycan	480	483	PF01048	0.562
MOD_GlcNHglycan	71	74	PF01048	0.411
MOD_GlcNHglycan	76	79	PF01048	0.467
MOD_GlcNHglycan	98	101	PF01048	0.602
MOD_GSK3_1	1	8	PF00069	0.614
MOD_GSK3_1	116	123	PF00069	0.557
MOD_GSK3_1	13	20	PF00069	0.515
MOD_GSK3_1	167	174	PF00069	0.522
MOD_GSK3_1	216	223	PF00069	0.651
MOD_GSK3_1	244	251	PF00069	0.597
MOD_GSK3_1	300	307	PF00069	0.660
MOD_GSK3_1	308	315	PF00069	0.628
MOD_GSK3_1	384	391	PF00069	0.432
MOD_GSK3_1	434	441	PF00069	0.452
MOD_GSK3_1	466	473	PF00069	0.517
MOD_N-GLC_1	168	173	PF02516	0.370
MOD_N-GLC_1	188	193	PF02516	0.259
MOD_N-GLC_1	470	475	PF02516	0.556
MOD_N-GLC_1	62	67	PF02516	0.451
MOD_NEK2_1	397	402	PF00069	0.452
MOD_NEK2_2	156	161	PF00069	0.544
MOD_NEK2_2	168	173	PF00069	0.350
MOD_NEK2_2	88	93	PF00069	0.407
MOD_PIKK_1	255	261	PF00454	0.637
MOD_PKA_1	388	394	PF00069	0.435
MOD_PKA_2	214	220	PF00069	0.736
MOD_PKA_2	292	298	PF00069	0.622
MOD_PKA_2	388	394	PF00069	0.463
MOD_PKA_2	397	403	PF00069	0.546
MOD_Plk_1	168	174	PF00069	0.413
MOD_Plk_1	175	181	PF00069	0.371
MOD_Plk_1	323	329	PF00069	0.623
MOD_Plk_2-3	304	310	PF00069	0.690
MOD_Plk_4	120	126	PF00069	0.587
MOD_Plk_4	161	167	PF00069	0.508
MOD_Plk_4	168	174	PF00069	0.401
MOD_Plk_4	175	181	PF00069	0.334
MOD_Plk_4	32	38	PF00069	0.407
MOD_Plk_4	362	368	PF00069	0.428
MOD_Plk_4	388	394	PF00069	0.385
MOD_ProDKin_1	1	7	PF00069	0.772
MOD_ProDKin_1	13	19	PF00069	0.549
MOD_ProDKin_1	262	268	PF00069	0.621
MOD_ProDKin_1	341	347	PF00069	0.436
MOD_ProDKin_1	62	68	PF00069	0.463
MOD_ProDKin_1	94	100	PF00069	0.658
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.464
TRG_ENDOCYTIC_2	410	413	PF00928	0.442
TRG_ER_diArg_1	211	213	PF00400	0.549
TRG_ER_diArg_1	376	379	PF00400	0.425
TRG_ER_diArg_1	380	383	PF00400	0.392
TRG_ER_diArg_1	388	390	PF00400	0.392
TRG_ER_diArg_1	79	81	PF00400	0.416
TRG_NLS_MonoExtN_4	230	236	PF00514	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U2	Leptomonas seymouri	40%	100%
A0A3S7WQQ0	Leishmania donovani	100%	100%
A4H5N4	Leishmania braziliensis	71%	100%
E9AMQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHW7	Leishmania major	91%	100%