Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dual specificity phosphatase- catalytic domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HTX6_LEIIN

TriTrypDb:

LINF_090011400

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTX6

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0044237	cellular metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.608
CLV_NRD_NRD_1	148	150	PF00675	0.640
CLV_NRD_NRD_1	195	197	PF00675	0.526
CLV_NRD_NRD_1	230	232	PF00675	0.756
CLV_NRD_NRD_1	447	449	PF00675	0.629
CLV_NRD_NRD_1	547	549	PF00675	0.366
CLV_NRD_NRD_1	560	562	PF00675	0.383
CLV_PCSK_FUR_1	558	562	PF00082	0.383
CLV_PCSK_KEX2_1	148	150	PF00082	0.640
CLV_PCSK_KEX2_1	195	197	PF00082	0.577
CLV_PCSK_KEX2_1	259	261	PF00082	0.388
CLV_PCSK_KEX2_1	447	449	PF00082	0.629
CLV_PCSK_KEX2_1	547	549	PF00082	0.390
CLV_PCSK_KEX2_1	558	560	PF00082	0.381
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.440
CLV_PCSK_SKI1_1	171	175	PF00082	0.438
CLV_PCSK_SKI1_1	426	430	PF00082	0.367
CLV_PCSK_SKI1_1	499	503	PF00082	0.368
DEG_APCC_DBOX_1	400	408	PF00400	0.370
DEG_SCF_FBW7_1	415	422	PF00400	0.388
DEG_SPOP_SBC_1	301	305	PF00917	0.558
DEG_SPOP_SBC_1	332	336	PF00917	0.575
DEG_SPOP_SBC_1	96	100	PF00917	0.625
DOC_CYCLIN_RxL_1	192	202	PF00134	0.426
DOC_MAPK_gen_1	398	406	PF00069	0.424
DOC_MAPK_gen_1	558	568	PF00069	0.369
DOC_MAPK_MEF2A_6	167	176	PF00069	0.417
DOC_MAPK_MEF2A_6	182	191	PF00069	0.386
DOC_MAPK_MEF2A_6	23	31	PF00069	0.503
DOC_MAPK_MEF2A_6	398	406	PF00069	0.488
DOC_MAPK_MEF2A_6	484	491	PF00069	0.339
DOC_MAPK_MEF2A_6	558	566	PF00069	0.369
DOC_PP1_RVXF_1	497	504	PF00149	0.315
DOC_PP2B_LxvP_1	114	117	PF13499	0.649
DOC_PP2B_LxvP_1	402	405	PF13499	0.356
DOC_USP7_MATH_1	165	169	PF00917	0.495
DOC_USP7_MATH_1	206	210	PF00917	0.754
DOC_USP7_MATH_1	227	231	PF00917	0.698
DOC_USP7_MATH_1	283	287	PF00917	0.738
DOC_USP7_MATH_1	299	303	PF00917	0.563
DOC_USP7_MATH_1	326	330	PF00917	0.589
DOC_USP7_MATH_1	332	336	PF00917	0.543
DOC_USP7_MATH_1	419	423	PF00917	0.365
DOC_USP7_MATH_1	457	461	PF00917	0.632
DOC_USP7_MATH_1	495	499	PF00917	0.358
DOC_USP7_MATH_1	50	54	PF00917	0.647
DOC_USP7_MATH_1	58	62	PF00917	0.571
DOC_USP7_MATH_1	97	101	PF00917	0.563
DOC_WW_Pin1_4	318	323	PF00397	0.618
DOC_WW_Pin1_4	328	333	PF00397	0.600
DOC_WW_Pin1_4	365	370	PF00397	0.608
DOC_WW_Pin1_4	406	411	PF00397	0.410
DOC_WW_Pin1_4	415	420	PF00397	0.375
DOC_WW_Pin1_4	452	457	PF00397	0.536
LIG_14-3-3_CanoR_1	148	154	PF00244	0.467
LIG_14-3-3_CanoR_1	167	175	PF00244	0.362
LIG_14-3-3_CanoR_1	196	206	PF00244	0.526
LIG_14-3-3_CanoR_1	387	397	PF00244	0.507
LIG_14-3-3_CanoR_1	401	405	PF00244	0.414
LIG_14-3-3_CanoR_1	426	432	PF00244	0.475
LIG_14-3-3_CanoR_1	499	504	PF00244	0.316
LIG_Actin_WH2_2	136	153	PF00022	0.444
LIG_Actin_WH2_2	178	194	PF00022	0.436
LIG_BRCT_BRCA1_1	499	503	PF00533	0.329
LIG_deltaCOP1_diTrp_1	348	352	PF00928	0.448
LIG_deltaCOP1_diTrp_1	511	515	PF00928	0.336
LIG_EVH1_1	114	118	PF00568	0.605
LIG_EVH1_2	118	122	PF00568	0.597
LIG_FHA_1	139	145	PF00498	0.382
LIG_FHA_1	192	198	PF00498	0.427
LIG_FHA_1	199	205	PF00498	0.559
LIG_FHA_1	305	311	PF00498	0.430
LIG_FHA_1	392	398	PF00498	0.685
LIG_FHA_1	401	407	PF00498	0.425
LIG_FHA_1	410	416	PF00498	0.382
LIG_FHA_1	419	425	PF00498	0.361
LIG_FHA_1	88	94	PF00498	0.589
LIG_FHA_1	97	103	PF00498	0.521
LIG_FHA_2	266	272	PF00498	0.552
LIG_FHA_2	334	340	PF00498	0.528
LIG_FHA_2	343	349	PF00498	0.452
LIG_FHA_2	428	434	PF00498	0.408
LIG_FHA_2	453	459	PF00498	0.663
LIG_GBD_Chelix_1	27	35	PF00786	0.373
LIG_LIR_Gen_1	135	144	PF02991	0.398
LIG_LIR_Gen_1	346	356	PF02991	0.386
LIG_LIR_Gen_1	572	582	PF02991	0.466
LIG_LIR_LC3C_4	24	29	PF02991	0.404
LIG_LIR_Nem_3	135	139	PF02991	0.394
LIG_LIR_Nem_3	255	261	PF02991	0.380
LIG_LIR_Nem_3	346	352	PF02991	0.425
LIG_LIR_Nem_3	396	402	PF02991	0.394
LIG_PCNA_yPIPBox_3	251	260	PF02747	0.360
LIG_Pex14_1	512	516	PF04695	0.340
LIG_Pex14_2	34	38	PF04695	0.403
LIG_Pex14_2	503	507	PF04695	0.321
LIG_SH2_CRK	258	262	PF00017	0.384
LIG_SH2_STAT5	106	109	PF00017	0.553
LIG_SH2_STAT5	132	135	PF00017	0.366
LIG_SH2_STAT5	293	296	PF00017	0.542
LIG_SH2_STAT5	417	420	PF00017	0.365
LIG_SH2_STAT5	556	559	PF00017	0.375
LIG_SH3_2	115	120	PF14604	0.606
LIG_SH3_3	109	115	PF00018	0.714
LIG_SH3_3	181	187	PF00018	0.353
LIG_SH3_3	316	322	PF00018	0.442
LIG_SH3_CIN85_PxpxPR_1	115	120	PF14604	0.649
LIG_SUMO_SIM_par_1	27	32	PF11976	0.495
LIG_TRAF2_1	430	433	PF00917	0.458
LIG_TYR_ITIM	397	402	PF00017	0.431
LIG_WW_3	110	114	PF00397	0.595
LIG_WW_3	117	121	PF00397	0.551
MOD_CDC14_SPxK_1	325	328	PF00782	0.626
MOD_CDK_SPxK_1	322	328	PF00069	0.605
MOD_CDK_SPxxK_3	406	413	PF00069	0.483
MOD_CK1_1	152	158	PF00069	0.603
MOD_CK1_1	161	167	PF00069	0.557
MOD_CK1_1	274	280	PF00069	0.583
MOD_CK1_1	302	308	PF00069	0.618
MOD_CK1_1	331	337	PF00069	0.570
MOD_CK1_1	342	348	PF00069	0.446
MOD_CK1_1	365	371	PF00069	0.559
MOD_CK1_1	391	397	PF00069	0.542
MOD_CK1_1	409	415	PF00069	0.418
MOD_CK1_1	53	59	PF00069	0.583
MOD_CK1_1	87	93	PF00069	0.600
MOD_CK1_1	95	101	PF00069	0.563
MOD_CK2_1	284	290	PF00069	0.579
MOD_CK2_1	427	433	PF00069	0.402
MOD_CMANNOS	512	515	PF00535	0.333
MOD_DYRK1A_RPxSP_1	328	332	PF00069	0.584
MOD_GlcNHglycan	294	297	PF01048	0.669
MOD_GlcNHglycan	307	310	PF01048	0.479
MOD_GlcNHglycan	328	331	PF01048	0.592
MOD_GlcNHglycan	341	344	PF01048	0.397
MOD_GlcNHglycan	345	348	PF01048	0.360
MOD_GlcNHglycan	362	367	PF01048	0.439
MOD_GlcNHglycan	390	393	PF01048	0.616
MOD_GlcNHglycan	52	55	PF01048	0.597
MOD_GlcNHglycan	80	83	PF01048	0.627
MOD_GlcNHglycan	94	97	PF01048	0.577
MOD_GSK3_1	1	8	PF00069	0.828
MOD_GSK3_1	134	141	PF00069	0.411
MOD_GSK3_1	154	161	PF00069	0.509
MOD_GSK3_1	299	306	PF00069	0.622
MOD_GSK3_1	318	325	PF00069	0.548
MOD_GSK3_1	328	335	PF00069	0.564
MOD_GSK3_1	339	346	PF00069	0.385
MOD_GSK3_1	358	365	PF00069	0.447
MOD_GSK3_1	388	395	PF00069	0.647
MOD_GSK3_1	415	422	PF00069	0.431
MOD_GSK3_1	49	56	PF00069	0.597
MOD_GSK3_1	495	502	PF00069	0.336
MOD_GSK3_1	9	16	PF00069	0.546
MOD_GSK3_1	92	99	PF00069	0.739
MOD_N-GLC_1	452	457	PF02516	0.727
MOD_N-GLC_1	9	14	PF02516	0.603
MOD_NEK2_1	191	196	PF00069	0.480
MOD_NEK2_1	549	554	PF00069	0.352
MOD_NEK2_1	78	83	PF00069	0.624
MOD_PIKK_1	166	172	PF00454	0.407
MOD_PIKK_1	219	225	PF00454	0.647
MOD_PIKK_1	569	575	PF00454	0.363
MOD_PK_1	149	155	PF00069	0.482
MOD_PK_1	497	503	PF00069	0.359
MOD_PK_1	541	547	PF00069	0.417
MOD_PKA_2	166	172	PF00069	0.409
MOD_PKA_2	191	197	PF00069	0.473
MOD_PKA_2	400	406	PF00069	0.462
MOD_PKB_1	149	157	PF00069	0.590
MOD_PKB_1	196	204	PF00069	0.567
MOD_PKB_1	539	547	PF00069	0.435
MOD_Plk_1	274	280	PF00069	0.604
MOD_Plk_4	13	19	PF00069	0.643
MOD_Plk_4	274	280	PF00069	0.585
MOD_Plk_4	419	425	PF00069	0.344
MOD_Plk_4	499	505	PF00069	0.310
MOD_Plk_4	549	555	PF00069	0.382
MOD_ProDKin_1	318	324	PF00069	0.616
MOD_ProDKin_1	328	334	PF00069	0.594
MOD_ProDKin_1	365	371	PF00069	0.614
MOD_ProDKin_1	406	412	PF00069	0.407
MOD_ProDKin_1	415	421	PF00069	0.370
MOD_ProDKin_1	452	458	PF00069	0.535
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.509
TRG_DiLeu_BaLyEn_6	410	415	PF01217	0.430
TRG_ENDOCYTIC_2	258	261	PF00928	0.392
TRG_ENDOCYTIC_2	399	402	PF00928	0.353
TRG_ENDOCYTIC_2	417	420	PF00928	0.401
TRG_ER_diArg_1	148	151	PF00400	0.654
TRG_ER_diArg_1	195	198	PF00400	0.651
TRG_ER_diArg_1	547	549	PF00400	0.365
TRG_ER_diArg_1	557	560	PF00400	0.367
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F1	Leptomonas seymouri	35%	100%
A0A3S7WQM8	Leishmania donovani	99%	99%
A4H5N2	Leishmania braziliensis	67%	97%
E9AMQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QHW9	Leishmania major	88%	100%