LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

SPX domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
SPX domain-containing protein
Gene product:
catalytic subunit of the vacuolar transporter chaperone 4 - putative
Species:
Leishmania infantum
UniProt:
A4HTX5_LEIIN
TriTrypDb:
LINF_090007800
Length:
813

Annotations

Annotations by Jardim et al.

Acidocalcisome, vacuolar transporter chaperone 4

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0020022 acidocalcisome 5 1
GO:0032991 protein-containing complex 1 1
GO:0033254 vacuolar transporter chaperone complex 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0101031 protein folding chaperone complex 3 1
GO:0140535 intracellular protein-containing complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HTX5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTX5

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006797 polyphosphate metabolic process 4 1
GO:0006799 polyphosphate biosynthetic process 4 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 1
GO:0043436 oxoacid metabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 427 431 PF00656 0.451
CLV_C14_Caspase3-7 808 812 PF00656 0.394
CLV_NRD_NRD_1 212 214 PF00675 0.232
CLV_NRD_NRD_1 275 277 PF00675 0.211
CLV_NRD_NRD_1 327 329 PF00675 0.211
CLV_NRD_NRD_1 355 357 PF00675 0.298
CLV_NRD_NRD_1 629 631 PF00675 0.287
CLV_NRD_NRD_1 63 65 PF00675 0.340
CLV_NRD_NRD_1 764 766 PF00675 0.283
CLV_NRD_NRD_1 769 771 PF00675 0.339
CLV_NRD_NRD_1 801 803 PF00675 0.585
CLV_PCSK_FUR_1 762 766 PF00082 0.222
CLV_PCSK_KEX2_1 105 107 PF00082 0.428
CLV_PCSK_KEX2_1 212 214 PF00082 0.258
CLV_PCSK_KEX2_1 275 277 PF00082 0.211
CLV_PCSK_KEX2_1 326 328 PF00082 0.211
CLV_PCSK_KEX2_1 354 356 PF00082 0.297
CLV_PCSK_KEX2_1 605 607 PF00082 0.467
CLV_PCSK_KEX2_1 629 631 PF00082 0.274
CLV_PCSK_KEX2_1 675 677 PF00082 0.374
CLV_PCSK_KEX2_1 764 766 PF00082 0.283
CLV_PCSK_KEX2_1 769 771 PF00082 0.339
CLV_PCSK_KEX2_1 801 803 PF00082 0.585
CLV_PCSK_PC1ET2_1 105 107 PF00082 0.435
CLV_PCSK_PC1ET2_1 326 328 PF00082 0.211
CLV_PCSK_PC1ET2_1 354 356 PF00082 0.297
CLV_PCSK_PC1ET2_1 605 607 PF00082 0.467
CLV_PCSK_PC1ET2_1 675 677 PF00082 0.374
CLV_PCSK_PC7_1 323 329 PF00082 0.211
CLV_PCSK_PC7_1 765 771 PF00082 0.354
CLV_PCSK_SKI1_1 105 109 PF00082 0.332
CLV_PCSK_SKI1_1 213 217 PF00082 0.235
CLV_PCSK_SKI1_1 269 273 PF00082 0.236
CLV_PCSK_SKI1_1 28 32 PF00082 0.291
CLV_PCSK_SKI1_1 383 387 PF00082 0.221
CLV_PCSK_SKI1_1 392 396 PF00082 0.196
CLV_PCSK_SKI1_1 531 535 PF00082 0.372
CLV_PCSK_SKI1_1 675 679 PF00082 0.408
CLV_PCSK_SKI1_1 686 690 PF00082 0.155
CLV_PCSK_SKI1_1 717 721 PF00082 0.497
CLV_PCSK_SKI1_1 81 85 PF00082 0.389
CLV_PCSK_SKI1_1 92 96 PF00082 0.432
CLV_Separin_Metazoa 122 126 PF03568 0.431
DEG_APCC_KENBOX_2 34 38 PF00400 0.607
DEG_SPOP_SBC_1 585 589 PF00917 0.700
DOC_CKS1_1 41 46 PF01111 0.505
DOC_CYCLIN_RxL_1 101 111 PF00134 0.640
DOC_CYCLIN_RxL_1 714 724 PF00134 0.297
DOC_MAPK_gen_1 212 221 PF00069 0.451
DOC_MAPK_gen_1 245 254 PF00069 0.419
DOC_MAPK_gen_1 64 72 PF00069 0.467
DOC_MAPK_HePTP_8 501 513 PF00069 0.629
DOC_MAPK_MEF2A_6 230 237 PF00069 0.435
DOC_MAPK_MEF2A_6 504 513 PF00069 0.638
DOC_MAPK_MEF2A_6 65 74 PF00069 0.495
DOC_MAPK_MEF2A_6 787 796 PF00069 0.233
DOC_PP1_RVXF_1 529 535 PF00149 0.583
DOC_PP2B_LxvP_1 198 201 PF13499 0.694
DOC_PP2B_LxvP_1 719 722 PF13499 0.297
DOC_SPAK_OSR1_1 328 332 PF12202 0.471
DOC_USP7_MATH_1 204 208 PF00917 0.671
DOC_USP7_MATH_1 259 263 PF00917 0.422
DOC_USP7_MATH_1 365 369 PF00917 0.460
DOC_USP7_MATH_1 39 43 PF00917 0.562
DOC_USP7_MATH_1 576 580 PF00917 0.701
DOC_USP7_MATH_1 6 10 PF00917 0.479
DOC_USP7_MATH_1 654 658 PF00917 0.606
DOC_USP7_UBL2_3 101 105 PF12436 0.683
DOC_USP7_UBL2_3 241 245 PF12436 0.419
DOC_USP7_UBL2_3 678 682 PF12436 0.590
DOC_WW_Pin1_4 255 260 PF00397 0.422
DOC_WW_Pin1_4 40 45 PF00397 0.508
DOC_WW_Pin1_4 428 433 PF00397 0.451
DOC_WW_Pin1_4 726 731 PF00397 0.271
LIG_14-3-3_CanoR_1 130 140 PF00244 0.491
LIG_14-3-3_CanoR_1 184 192 PF00244 0.523
LIG_14-3-3_CanoR_1 212 216 PF00244 0.422
LIG_14-3-3_CanoR_1 412 420 PF00244 0.436
LIG_14-3-3_CanoR_1 504 511 PF00244 0.578
LIG_14-3-3_CanoR_1 563 569 PF00244 0.543
LIG_14-3-3_CanoR_1 787 792 PF00244 0.099
LIG_14-3-3_CanoR_1 92 97 PF00244 0.607
LIG_Actin_WH2_2 112 127 PF00022 0.450
LIG_Actin_WH2_2 370 385 PF00022 0.422
LIG_APCC_ABBA_1 312 317 PF00400 0.411
LIG_APCC_ABBA_1 639 644 PF00400 0.555
LIG_APCC_ABBAyCdc20_2 8 14 PF00400 0.466
LIG_BRCT_BRCA1_1 206 210 PF00533 0.586
LIG_BRCT_BRCA1_1 711 715 PF00533 0.377
LIG_BRCT_BRCA1_1 809 813 PF00533 0.378
LIG_BRCT_BRCA1_2 711 717 PF00533 0.383
LIG_EH1_1 225 233 PF00400 0.411
LIG_eIF4E_1 683 689 PF01652 0.505
LIG_FHA_1 132 138 PF00498 0.494
LIG_FHA_1 25 31 PF00498 0.501
LIG_FHA_1 484 490 PF00498 0.475
LIG_FHA_1 515 521 PF00498 0.528
LIG_FHA_1 539 545 PF00498 0.625
LIG_FHA_1 634 640 PF00498 0.557
LIG_FHA_1 645 651 PF00498 0.614
LIG_FHA_1 69 75 PF00498 0.496
LIG_FHA_1 738 744 PF00498 0.334
LIG_FHA_2 200 206 PF00498 0.695
LIG_FHA_2 237 243 PF00498 0.411
LIG_FHA_2 292 298 PF00498 0.497
LIG_FHA_2 41 47 PF00498 0.499
LIG_FHA_2 425 431 PF00498 0.487
LIG_FHA_2 505 511 PF00498 0.534
LIG_FHA_2 591 597 PF00498 0.684
LIG_FHA_2 806 812 PF00498 0.315
LIG_FHA_2 82 88 PF00498 0.564
LIG_GBD_Chelix_1 115 123 PF00786 0.245
LIG_LIR_Gen_1 163 174 PF02991 0.483
LIG_LIR_Gen_1 179 189 PF02991 0.431
LIG_LIR_Gen_1 297 306 PF02991 0.412
LIG_LIR_Gen_1 45 56 PF02991 0.469
LIG_LIR_Gen_1 486 496 PF02991 0.475
LIG_LIR_Gen_1 555 565 PF02991 0.497
LIG_LIR_Gen_1 589 599 PF02991 0.558
LIG_LIR_Gen_1 734 744 PF02991 0.265
LIG_LIR_Gen_1 751 761 PF02991 0.279
LIG_LIR_Gen_1 781 789 PF02991 0.285
LIG_LIR_Gen_1 790 799 PF02991 0.269
LIG_LIR_Nem_3 155 160 PF02991 0.494
LIG_LIR_Nem_3 163 169 PF02991 0.462
LIG_LIR_Nem_3 172 178 PF02991 0.414
LIG_LIR_Nem_3 179 185 PF02991 0.450
LIG_LIR_Nem_3 297 302 PF02991 0.405
LIG_LIR_Nem_3 306 312 PF02991 0.408
LIG_LIR_Nem_3 364 369 PF02991 0.436
LIG_LIR_Nem_3 45 51 PF02991 0.479
LIG_LIR_Nem_3 555 560 PF02991 0.499
LIG_LIR_Nem_3 589 595 PF02991 0.555
LIG_LIR_Nem_3 635 640 PF02991 0.485
LIG_LIR_Nem_3 703 708 PF02991 0.358
LIG_LIR_Nem_3 734 739 PF02991 0.265
LIG_LIR_Nem_3 751 757 PF02991 0.285
LIG_LIR_Nem_3 781 785 PF02991 0.285
LIG_LIR_Nem_3 790 794 PF02991 0.269
LIG_LIR_Nem_3 9 15 PF02991 0.469
LIG_LYPXL_S_1 11 15 PF13949 0.265
LIG_LYPXL_SIV_4 437 445 PF13949 0.411
LIG_MYND_1 617 621 PF01753 0.634
LIG_PCNA_yPIPBox_3 168 180 PF02747 0.547
LIG_PDZ_Class_3 808 813 PF00595 0.305
LIG_Pex14_1 157 161 PF04695 0.568
LIG_Pex14_1 732 736 PF04695 0.222
LIG_PTB_Apo_2 264 271 PF02174 0.451
LIG_Rb_LxCxE_1 442 459 PF01857 0.411
LIG_RPA_C_Fungi 760 772 PF08784 0.416
LIG_RPA_C_Fungi 782 794 PF08784 0.099
LIG_SH2_CRK 147 151 PF00017 0.394
LIG_SH2_CRK 166 170 PF00017 0.332
LIG_SH2_CRK 182 186 PF00017 0.294
LIG_SH2_CRK 48 52 PF00017 0.341
LIG_SH2_CRK 557 561 PF00017 0.349
LIG_SH2_CRK 666 670 PF00017 0.595
LIG_SH2_CRK 754 758 PF00017 0.279
LIG_SH2_GRB2like 265 268 PF00017 0.348
LIG_SH2_NCK_1 166 170 PF00017 0.431
LIG_SH2_NCK_1 438 442 PF00017 0.263
LIG_SH2_NCK_1 557 561 PF00017 0.397
LIG_SH2_SRC 475 478 PF00017 0.279
LIG_SH2_SRC 754 757 PF00017 0.298
LIG_SH2_SRC 774 777 PF00017 0.192
LIG_SH2_STAP1 291 295 PF00017 0.348
LIG_SH2_STAP1 3 7 PF00017 0.456
LIG_SH2_STAP1 48 52 PF00017 0.461
LIG_SH2_STAP1 557 561 PF00017 0.375
LIG_SH2_STAP1 774 778 PF00017 0.445
LIG_SH2_STAT5 161 164 PF00017 0.460
LIG_SH2_STAT5 21 24 PF00017 0.327
LIG_SH2_STAT5 426 429 PF00017 0.333
LIG_SH2_STAT5 634 637 PF00017 0.385
LIG_SH2_STAT5 756 759 PF00017 0.298
LIG_SH2_STAT5 82 85 PF00017 0.409
LIG_SH3_1 230 236 PF00018 0.279
LIG_SH3_3 146 152 PF00018 0.408
LIG_SH3_3 230 236 PF00018 0.279
LIG_SH3_3 38 44 PF00018 0.412
LIG_SH3_3 774 780 PF00018 0.452
LIG_SH3_5 553 557 PF00018 0.472
LIG_Sin3_3 746 753 PF02671 0.235
LIG_SUMO_SIM_par_1 68 73 PF11976 0.343
LIG_TRAF2_1 170 173 PF00917 0.428
LIG_TRAF2_1 301 304 PF00917 0.410
LIG_TRAF2_1 358 361 PF00917 0.349
LIG_TRAF2_1 84 87 PF00917 0.483
LIG_TRFH_1 380 384 PF08558 0.279
LIG_TRFH_1 637 641 PF08558 0.438
LIG_TYR_ITIM 664 669 PF00017 0.584
LIG_TYR_ITIM 752 757 PF00017 0.275
LIG_TYR_ITIM 772 777 PF00017 0.285
LIG_TYR_ITSM 553 560 PF00017 0.448
LIG_UBA3_1 30 35 PF00899 0.386
LIG_WRC_WIRS_1 237 242 PF05994 0.298
LIG_WRC_WIRS_1 634 639 PF05994 0.482
MOD_CK1_1 199 205 PF00069 0.663
MOD_CK1_1 258 264 PF00069 0.289
MOD_CK1_1 406 412 PF00069 0.263
MOD_CK1_1 431 437 PF00069 0.320
MOD_CK1_1 487 493 PF00069 0.353
MOD_CK2_1 167 173 PF00069 0.325
MOD_CK2_1 199 205 PF00069 0.663
MOD_CK2_1 240 246 PF00069 0.354
MOD_CK2_1 291 297 PF00069 0.383
MOD_CK2_1 356 362 PF00069 0.320
MOD_CK2_1 40 46 PF00069 0.398
MOD_CK2_1 47 53 PF00069 0.342
MOD_CK2_1 504 510 PF00069 0.434
MOD_CK2_1 81 87 PF00069 0.466
MOD_Cter_Amidation 673 676 PF01082 0.497
MOD_GlcNHglycan 101 104 PF01048 0.579
MOD_GlcNHglycan 192 195 PF01048 0.494
MOD_GlcNHglycan 319 322 PF01048 0.279
MOD_GlcNHglycan 369 372 PF01048 0.358
MOD_GlcNHglycan 413 416 PF01048 0.293
MOD_GlcNHglycan 577 581 PF01048 0.626
MOD_GlcNHglycan 8 11 PF01048 0.364
MOD_GSK3_1 236 243 PF00069 0.279
MOD_GSK3_1 255 262 PF00069 0.279
MOD_GSK3_1 317 324 PF00069 0.279
MOD_GSK3_1 424 431 PF00069 0.342
MOD_GSK3_1 483 490 PF00069 0.357
MOD_GSK3_1 540 547 PF00069 0.529
MOD_GSK3_1 572 579 PF00069 0.562
MOD_GSK3_1 580 587 PF00069 0.566
MOD_GSK3_1 640 647 PF00069 0.550
MOD_GSK3_1 684 691 PF00069 0.263
MOD_GSK3_1 77 84 PF00069 0.373
MOD_GSK3_1 783 790 PF00069 0.250
MOD_GSK3_1 805 812 PF00069 0.485
MOD_GSK3_1 90 97 PF00069 0.459
MOD_N-GLC_1 356 361 PF02516 0.320
MOD_N-GLC_1 580 585 PF02516 0.558
MOD_N-GLC_1 644 649 PF02516 0.492
MOD_N-GLC_1 90 95 PF02516 0.508
MOD_NEK2_1 240 245 PF00069 0.279
MOD_NEK2_1 47 52 PF00069 0.355
MOD_NEK2_1 632 637 PF00069 0.537
MOD_NEK2_1 70 75 PF00069 0.439
MOD_NEK2_1 701 706 PF00069 0.351
MOD_NEK2_1 708 713 PF00069 0.301
MOD_NEK2_1 783 788 PF00069 0.238
MOD_NEK2_2 236 241 PF00069 0.279
MOD_NEK2_2 259 264 PF00069 0.279
MOD_NEK2_2 478 483 PF00069 0.279
MOD_NEK2_2 633 638 PF00069 0.461
MOD_NEK2_2 709 714 PF00069 0.371
MOD_PIKK_1 204 210 PF00454 0.504
MOD_PIKK_1 385 391 PF00454 0.263
MOD_PIKK_1 538 544 PF00454 0.523
MOD_PKA_2 190 196 PF00069 0.499
MOD_PKA_2 211 217 PF00069 0.289
MOD_PKA_2 403 409 PF00069 0.263
MOD_PKA_2 411 417 PF00069 0.263
MOD_PKA_2 424 430 PF00069 0.296
MOD_PKA_2 503 509 PF00069 0.417
MOD_PKB_1 287 295 PF00069 0.320
MOD_Plk_1 580 586 PF00069 0.548
MOD_Plk_1 90 96 PF00069 0.488
MOD_Plk_2-3 167 173 PF00069 0.430
MOD_Plk_4 259 265 PF00069 0.263
MOD_Plk_4 281 287 PF00069 0.263
MOD_Plk_4 342 348 PF00069 0.339
MOD_Plk_4 47 53 PF00069 0.358
MOD_Plk_4 478 484 PF00069 0.274
MOD_Plk_4 684 690 PF00069 0.263
MOD_Plk_4 778 784 PF00069 0.257
MOD_Plk_4 787 793 PF00069 0.237
MOD_ProDKin_1 255 261 PF00069 0.279
MOD_ProDKin_1 40 46 PF00069 0.398
MOD_ProDKin_1 428 434 PF00069 0.320
MOD_ProDKin_1 726 732 PF00069 0.348
MOD_SUMO_rev_2 17 27 PF00179 0.446
MOD_SUMO_rev_2 305 314 PF00179 0.271
MOD_SUMO_rev_2 375 385 PF00179 0.300
MOD_SUMO_rev_2 50 56 PF00179 0.394
MOD_SUMO_rev_2 596 603 PF00179 0.674
MOD_SUMO_rev_2 60 67 PF00179 0.268
MOD_SUMO_rev_2 648 657 PF00179 0.629
TRG_DiLeu_BaEn_1 281 286 PF01217 0.279
TRG_DiLeu_BaEn_2 121 127 PF01217 0.297
TRG_DiLeu_BaEn_2 334 340 PF01217 0.383
TRG_DiLeu_BaLyEn_6 103 108 PF01217 0.550
TRG_DiLeu_BaLyEn_6 110 115 PF01217 0.402
TRG_DiLeu_BaLyEn_6 528 533 PF01217 0.565
TRG_ENDOCYTIC_2 12 15 PF00928 0.324
TRG_ENDOCYTIC_2 147 150 PF00928 0.395
TRG_ENDOCYTIC_2 166 169 PF00928 0.336
TRG_ENDOCYTIC_2 182 185 PF00928 0.251
TRG_ENDOCYTIC_2 438 441 PF00928 0.297
TRG_ENDOCYTIC_2 48 51 PF00928 0.343
TRG_ENDOCYTIC_2 557 560 PF00928 0.354
TRG_ENDOCYTIC_2 561 564 PF00928 0.344
TRG_ENDOCYTIC_2 634 637 PF00928 0.385
TRG_ENDOCYTIC_2 666 669 PF00928 0.585
TRG_ENDOCYTIC_2 754 757 PF00928 0.263
TRG_ENDOCYTIC_2 774 777 PF00928 0.192
TRG_ENDOCYTIC_2 803 806 PF00928 0.363
TRG_ER_diArg_1 275 277 PF00400 0.263
TRG_ER_diArg_1 286 289 PF00400 0.263
TRG_ER_diArg_1 327 329 PF00400 0.263
TRG_ER_diArg_1 402 405 PF00400 0.293
TRG_ER_diArg_1 762 765 PF00400 0.279
TRG_ER_diArg_1 801 803 PF00400 0.508
TRG_NLS_MonoExtC_3 769 775 PF00514 0.424
TRG_NLS_MonoExtN_4 323 330 PF00514 0.263
TRG_NLS_MonoExtN_4 352 358 PF00514 0.383
TRG_NLS_MonoExtN_4 769 774 PF00514 0.429
TRG_Pf-PMV_PEXEL_1 106 111 PF00026 0.496
TRG_Pf-PMV_PEXEL_1 113 117 PF00026 0.360
TRG_Pf-PMV_PEXEL_1 130 135 PF00026 0.202
TRG_Pf-PMV_PEXEL_1 566 571 PF00026 0.531
TRG_Pf-PMV_PEXEL_1 81 85 PF00026 0.522

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5C3 Leptomonas seymouri 82% 99%
A0A0S4J2S6 Bodo saltans 58% 100%
A0A0S4JCW1 Bodo saltans 25% 83%
A0A1X0NMU3 Trypanosomatidae 69% 100%
A0A3S7WQI7 Leishmania donovani 100% 100%
A0A422NDG2 Trypanosoma rangeli 68% 100%
A4H5J7 Leishmania braziliensis 88% 100%
D0A996 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
E9AMM1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
P47075 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P78810 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 100%
Q4QI04 Leishmania major 97% 100%
V5BIC5 Trypanosoma cruzi 67% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS