LeishMANIAdb
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Putative integral membrane transport protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative integral membrane transport protein
Gene product:
integral membrane transport protein - putative
Species:
Leishmania infantum
UniProt:
A4HTX4_LEIIN
TriTrypDb:
LINF_090008300
Length:
621

Annotations

LeishMANIAdb annotations

Related to yeast azole resistance protein AZR1 and aspergullus citrate exporter CEX1.. Expanded on multiple lineages

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

A4HTX4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTX4

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0009987 cellular process 1 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 10
GO:0022857 transmembrane transporter activity 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 257 261 PF00656 0.754
CLV_C14_Caspase3-7 285 289 PF00656 0.770
CLV_NRD_NRD_1 382 384 PF00675 0.495
CLV_NRD_NRD_1 562 564 PF00675 0.602
CLV_NRD_NRD_1 607 609 PF00675 0.759
CLV_NRD_NRD_1 64 66 PF00675 0.308
CLV_PCSK_KEX2_1 562 564 PF00082 0.674
CLV_PCSK_KEX2_1 607 609 PF00082 0.759
CLV_PCSK_KEX2_1 64 66 PF00082 0.356
CLV_PCSK_SKI1_1 145 149 PF00082 0.356
CLV_PCSK_SKI1_1 158 162 PF00082 0.356
CLV_PCSK_SKI1_1 383 387 PF00082 0.493
CLV_PCSK_SKI1_1 84 88 PF00082 0.389
DEG_APCC_DBOX_1 157 165 PF00400 0.556
DEG_APCC_DBOX_1 367 375 PF00400 0.440
DEG_MDM2_SWIB_1 359 366 PF02201 0.551
DEG_SCF_FBW7_1 233 240 PF00400 0.742
DEG_SPOP_SBC_1 589 593 PF00917 0.452
DOC_CDC14_PxL_1 546 554 PF14671 0.532
DOC_CYCLIN_RxL_1 380 388 PF00134 0.294
DOC_CYCLIN_RxL_1 81 88 PF00134 0.576
DOC_CYCLIN_yCln2_LP_2 268 271 PF00134 0.758
DOC_CYCLIN_yCln2_LP_2 87 93 PF00134 0.576
DOC_MAPK_gen_1 155 164 PF00069 0.511
DOC_MAPK_gen_1 380 389 PF00069 0.294
DOC_MAPK_HePTP_8 98 110 PF00069 0.576
DOC_MAPK_MEF2A_6 101 110 PF00069 0.556
DOC_MAPK_MEF2A_6 35 43 PF00069 0.588
DOC_MAPK_MEF2A_6 368 375 PF00069 0.328
DOC_MAPK_MEF2A_6 380 389 PF00069 0.294
DOC_MAPK_MEF2A_6 84 91 PF00069 0.556
DOC_MAPK_NFAT4_5 101 109 PF00069 0.576
DOC_MAPK_RevD_3 52 65 PF00069 0.556
DOC_PP1_RVXF_1 99 106 PF00149 0.556
DOC_PP2B_LxvP_1 13 16 PF13499 0.721
DOC_PP2B_LxvP_1 268 271 PF13499 0.752
DOC_PP2B_LxvP_1 87 90 PF13499 0.576
DOC_PP2B_PxIxI_1 43 49 PF00149 0.596
DOC_USP7_MATH_1 177 181 PF00917 0.410
DOC_USP7_MATH_1 211 215 PF00917 0.615
DOC_USP7_MATH_1 237 241 PF00917 0.750
DOC_USP7_MATH_1 272 276 PF00917 0.772
DOC_USP7_MATH_1 277 281 PF00917 0.709
DOC_USP7_MATH_1 334 338 PF00917 0.767
DOC_USP7_MATH_1 399 403 PF00917 0.356
DOC_USP7_MATH_1 581 585 PF00917 0.459
DOC_USP7_MATH_1 587 591 PF00917 0.420
DOC_WW_Pin1_4 233 238 PF00397 0.737
DOC_WW_Pin1_4 302 307 PF00397 0.786
DOC_WW_Pin1_4 585 590 PF00397 0.561
LIG_14-3-3_CanoR_1 191 195 PF00244 0.356
LIG_14-3-3_CanoR_1 226 230 PF00244 0.665
LIG_14-3-3_CanoR_1 300 306 PF00244 0.767
LIG_14-3-3_CanoR_1 393 403 PF00244 0.364
LIG_14-3-3_CanoR_1 506 512 PF00244 0.613
LIG_Actin_WH2_2 157 172 PF00022 0.556
LIG_APCC_ABBAyCdc20_2 235 241 PF00400 0.768
LIG_BIR_III_4 466 470 PF00653 0.328
LIG_BRCT_BRCA1_1 179 183 PF00533 0.440
LIG_BRCT_BRCA1_1 201 205 PF00533 0.433
LIG_BRCT_BRCA1_1 407 411 PF00533 0.356
LIG_deltaCOP1_diTrp_1 361 367 PF00928 0.476
LIG_eIF4E_1 263 269 PF01652 0.768
LIG_FHA_1 205 211 PF00498 0.391
LIG_FHA_1 264 270 PF00498 0.743
LIG_FHA_1 448 454 PF00498 0.425
LIG_FHA_1 541 547 PF00498 0.535
LIG_FHA_1 575 581 PF00498 0.566
LIG_FHA_2 255 261 PF00498 0.773
LIG_FHA_2 27 33 PF00498 0.636
LIG_FHA_2 356 362 PF00498 0.596
LIG_FHA_2 493 499 PF00498 0.503
LIG_FHA_2 83 89 PF00498 0.556
LIG_HCF-1_HBM_1 5 8 PF13415 0.719
LIG_LIR_Apic_2 248 254 PF02991 0.785
LIG_LIR_Gen_1 189 200 PF02991 0.356
LIG_LIR_Gen_1 27 38 PF02991 0.628
LIG_LIR_Gen_1 353 362 PF02991 0.555
LIG_LIR_Gen_1 408 418 PF02991 0.371
LIG_LIR_Gen_1 75 82 PF02991 0.527
LIG_LIR_Nem_3 154 160 PF02991 0.539
LIG_LIR_Nem_3 180 186 PF02991 0.375
LIG_LIR_Nem_3 189 195 PF02991 0.246
LIG_LIR_Nem_3 202 208 PF02991 0.328
LIG_LIR_Nem_3 27 33 PF02991 0.602
LIG_LIR_Nem_3 353 359 PF02991 0.548
LIG_LIR_Nem_3 361 366 PF02991 0.471
LIG_LIR_Nem_3 408 414 PF02991 0.371
LIG_LIR_Nem_3 460 465 PF02991 0.387
LIG_LIR_Nem_3 531 537 PF02991 0.419
LIG_LIR_Nem_3 613 618 PF02991 0.579
LIG_LIR_Nem_3 75 79 PF02991 0.527
LIG_LIR_Nem_3 94 100 PF02991 0.528
LIG_NRBOX 164 170 PF00104 0.401
LIG_PCNA_PIPBox_1 523 532 PF02747 0.469
LIG_Pex14_2 105 109 PF04695 0.469
LIG_Pex14_2 359 363 PF04695 0.605
LIG_Pex14_2 407 411 PF04695 0.416
LIG_Pex14_2 530 534 PF04695 0.440
LIG_PTB_Apo_2 99 106 PF02174 0.556
LIG_REV1ctd_RIR_1 139 149 PF16727 0.348
LIG_SH2_CRK 157 161 PF00017 0.556
LIG_SH2_CRK 192 196 PF00017 0.356
LIG_SH2_CRK 537 541 PF00017 0.390
LIG_SH2_CRK 615 619 PF00017 0.583
LIG_SH2_CRK 70 74 PF00017 0.576
LIG_SH2_NCK_1 70 74 PF00017 0.556
LIG_SH2_PTP2 372 375 PF00017 0.348
LIG_SH2_PTP2 76 79 PF00017 0.476
LIG_SH2_PTP2 97 100 PF00017 0.576
LIG_SH2_STAP1 192 196 PF00017 0.356
LIG_SH2_STAP1 30 34 PF00017 0.635
LIG_SH2_STAP1 70 74 PF00017 0.530
LIG_SH2_STAT5 25 28 PF00017 0.605
LIG_SH2_STAT5 263 266 PF00017 0.773
LIG_SH2_STAT5 372 375 PF00017 0.331
LIG_SH2_STAT5 403 406 PF00017 0.436
LIG_SH2_STAT5 456 459 PF00017 0.358
LIG_SH2_STAT5 76 79 PF00017 0.476
LIG_SH2_STAT5 97 100 PF00017 0.581
LIG_SH3_3 171 177 PF00018 0.348
LIG_SH3_3 38 44 PF00018 0.579
LIG_SH3_3 544 550 PF00018 0.523
LIG_Sin3_3 265 272 PF02671 0.726
LIG_SUMO_SIM_anti_2 75 81 PF11976 0.556
LIG_SUMO_SIM_par_1 206 212 PF11976 0.433
LIG_SUMO_SIM_par_1 573 584 PF11976 0.476
LIG_TRAF2_1 16 19 PF00917 0.750
LIG_TRAF2_1 240 243 PF00917 0.724
LIG_TRAF2_1 344 347 PF00917 0.759
LIG_TRAF2_1 573 576 PF00917 0.538
LIG_TYR_ITIM 190 195 PF00017 0.356
LIG_TYR_ITIM 28 33 PF00017 0.652
LIG_TYR_ITIM 360 365 PF00017 0.533
LIG_TYR_ITIM 95 100 PF00017 0.576
LIG_WRC_WIRS_1 386 391 PF05994 0.291
LIG_WW_3 481 485 PF00397 0.617
MOD_CK1_1 134 140 PF00069 0.406
MOD_CK1_1 228 234 PF00069 0.696
MOD_CK1_1 275 281 PF00069 0.733
MOD_CK1_1 329 335 PF00069 0.707
MOD_CK1_1 568 574 PF00069 0.507
MOD_CK1_1 590 596 PF00069 0.550
MOD_CK2_1 237 243 PF00069 0.708
MOD_CK2_1 26 32 PF00069 0.612
MOD_CK2_1 538 544 PF00069 0.470
MOD_CK2_1 570 576 PF00069 0.535
MOD_Cter_Amidation 62 65 PF01082 0.306
MOD_GlcNHglycan 133 136 PF01048 0.387
MOD_GlcNHglycan 165 168 PF01048 0.371
MOD_GlcNHglycan 179 182 PF01048 0.371
MOD_GlcNHglycan 186 189 PF01048 0.556
MOD_GlcNHglycan 196 199 PF01048 0.440
MOD_GlcNHglycan 279 282 PF01048 0.579
MOD_GlcNHglycan 288 291 PF01048 0.555
MOD_GlcNHglycan 328 331 PF01048 0.568
MOD_GlcNHglycan 334 337 PF01048 0.561
MOD_GlcNHglycan 459 462 PF01048 0.405
MOD_GlcNHglycan 50 53 PF01048 0.306
MOD_GlcNHglycan 583 586 PF01048 0.691
MOD_GSK3_1 119 126 PF00069 0.408
MOD_GSK3_1 190 197 PF00069 0.350
MOD_GSK3_1 221 228 PF00069 0.651
MOD_GSK3_1 229 236 PF00069 0.668
MOD_GSK3_1 277 284 PF00069 0.779
MOD_GSK3_1 320 327 PF00069 0.711
MOD_GSK3_1 330 337 PF00069 0.682
MOD_GSK3_1 350 357 PF00069 0.566
MOD_GSK3_1 566 573 PF00069 0.502
MOD_GSK3_1 581 588 PF00069 0.591
MOD_GSK3_1 589 596 PF00069 0.411
MOD_GSK3_1 614 621 PF00069 0.583
MOD_N-GLC_1 119 124 PF02516 0.462
MOD_N-GLC_1 300 305 PF02516 0.496
MOD_N-GLC_1 68 73 PF02516 0.251
MOD_NEK2_1 119 124 PF00069 0.378
MOD_NEK2_1 194 199 PF00069 0.390
MOD_NEK2_1 229 234 PF00069 0.687
MOD_NEK2_1 26 31 PF00069 0.630
MOD_NEK2_1 312 317 PF00069 0.798
MOD_NEK2_1 350 355 PF00069 0.617
MOD_NEK2_1 385 390 PF00069 0.312
MOD_NEK2_1 405 410 PF00069 0.361
MOD_NEK2_1 566 571 PF00069 0.387
MOD_NEK2_1 82 87 PF00069 0.556
MOD_NEK2_2 221 226 PF00069 0.670
MOD_NEK2_2 334 339 PF00069 0.766
MOD_PIKK_1 209 215 PF00454 0.551
MOD_PIKK_1 568 574 PF00454 0.496
MOD_PKA_2 190 196 PF00069 0.356
MOD_PKA_2 225 231 PF00069 0.686
MOD_PKB_1 324 332 PF00069 0.782
MOD_Plk_1 68 74 PF00069 0.526
MOD_Plk_4 112 118 PF00069 0.405
MOD_Plk_4 123 129 PF00069 0.302
MOD_Plk_4 190 196 PF00069 0.322
MOD_Plk_4 204 210 PF00069 0.303
MOD_Plk_4 351 357 PF00069 0.572
MOD_Plk_4 374 380 PF00069 0.466
MOD_Plk_4 399 405 PF00069 0.328
MOD_Plk_4 507 513 PF00069 0.532
MOD_Plk_4 57 63 PF00069 0.516
MOD_ProDKin_1 233 239 PF00069 0.741
MOD_ProDKin_1 302 308 PF00069 0.789
MOD_ProDKin_1 585 591 PF00069 0.562
TRG_DiLeu_BaEn_4 575 581 PF01217 0.546
TRG_ENDOCYTIC_2 157 160 PF00928 0.556
TRG_ENDOCYTIC_2 192 195 PF00928 0.276
TRG_ENDOCYTIC_2 25 28 PF00928 0.655
TRG_ENDOCYTIC_2 30 33 PF00928 0.614
TRG_ENDOCYTIC_2 362 365 PF00928 0.359
TRG_ENDOCYTIC_2 372 375 PF00928 0.305
TRG_ENDOCYTIC_2 514 517 PF00928 0.623
TRG_ENDOCYTIC_2 615 618 PF00928 0.584
TRG_ENDOCYTIC_2 70 73 PF00928 0.492
TRG_ENDOCYTIC_2 76 79 PF00928 0.457
TRG_ENDOCYTIC_2 97 100 PF00928 0.576
TRG_ER_diArg_1 562 564 PF00400 0.402
TRG_ER_diArg_1 606 608 PF00400 0.564
TRG_ER_diArg_1 64 66 PF00400 0.556
TRG_NES_CRM1_1 412 424 PF08389 0.401
TRG_Pf-PMV_PEXEL_1 84 88 PF00026 0.289

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWA0 Leptomonas seymouri 61% 100%
A0A1X0NN50 Trypanosomatidae 37% 100%
A0A3S5H6C1 Leishmania donovani 100% 100%
A0A422NDI8 Trypanosoma rangeli 36% 100%
D0A9A1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AMM6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QHZ9 Leishmania major 94% 100%
V5B2U4 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS