Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTW8_LEIIN

TriTrypDb:

LINF_090011300

Length:

1109

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1043	1047	PF00656	0.587
CLV_C14_Caspase3-7	55	59	PF00656	0.641
CLV_NRD_NRD_1	113	115	PF00675	0.736
CLV_NRD_NRD_1	15	17	PF00675	0.734
CLV_NRD_NRD_1	31	33	PF00675	0.485
CLV_NRD_NRD_1	333	335	PF00675	0.682
CLV_NRD_NRD_1	402	404	PF00675	0.771
CLV_NRD_NRD_1	524	526	PF00675	0.698
CLV_NRD_NRD_1	586	588	PF00675	0.607
CLV_NRD_NRD_1	615	617	PF00675	0.627
CLV_NRD_NRD_1	649	651	PF00675	0.650
CLV_NRD_NRD_1	668	670	PF00675	0.542
CLV_NRD_NRD_1	821	823	PF00675	0.609
CLV_NRD_NRD_1	927	929	PF00675	0.705
CLV_NRD_NRD_1	969	971	PF00675	0.621
CLV_PCSK_FUR_1	967	971	PF00082	0.583
CLV_PCSK_KEX2_1	113	115	PF00082	0.736
CLV_PCSK_KEX2_1	15	17	PF00082	0.734
CLV_PCSK_KEX2_1	257	259	PF00082	0.732
CLV_PCSK_KEX2_1	31	33	PF00082	0.485
CLV_PCSK_KEX2_1	333	335	PF00082	0.682
CLV_PCSK_KEX2_1	402	404	PF00082	0.770
CLV_PCSK_KEX2_1	524	526	PF00082	0.674
CLV_PCSK_KEX2_1	585	587	PF00082	0.721
CLV_PCSK_KEX2_1	615	617	PF00082	0.687
CLV_PCSK_KEX2_1	820	822	PF00082	0.628
CLV_PCSK_KEX2_1	927	929	PF00082	0.705
CLV_PCSK_KEX2_1	969	971	PF00082	0.705
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.732
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.721
CLV_PCSK_PC1ET2_1	820	822	PF00082	0.611
CLV_PCSK_SKI1_1	287	291	PF00082	0.668
CLV_PCSK_SKI1_1	587	591	PF00082	0.558
CLV_PCSK_SKI1_1	620	624	PF00082	0.689
CLV_PCSK_SKI1_1	73	77	PF00082	0.665
CLV_PCSK_SKI1_1	865	869	PF00082	0.690
DEG_SPOP_SBC_1	386	390	PF00917	0.629
DEG_SPOP_SBC_1	916	920	PF00917	0.625
DOC_CDC14_PxL_1	106	114	PF14671	0.635
DOC_CKS1_1	362	367	PF01111	0.657
DOC_CKS1_1	94	99	PF01111	0.641
DOC_CYCLIN_RxL_1	584	592	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	1066	1072	PF00134	0.664
DOC_MAPK_gen_1	31	38	PF00069	0.596
DOC_MAPK_gen_1	444	452	PF00069	0.584
DOC_MAPK_MEF2A_6	232	239	PF00069	0.670
DOC_MAPK_MEF2A_6	73	81	PF00069	0.661
DOC_PP1_RVXF_1	190	196	PF00149	0.568
DOC_USP7_MATH_1	1072	1076	PF00917	0.662
DOC_USP7_MATH_1	1077	1081	PF00917	0.638
DOC_USP7_MATH_1	1094	1098	PF00917	0.552
DOC_USP7_MATH_1	1100	1104	PF00917	0.608
DOC_USP7_MATH_1	218	222	PF00917	0.736
DOC_USP7_MATH_1	230	234	PF00917	0.604
DOC_USP7_MATH_1	312	316	PF00917	0.685
DOC_USP7_MATH_1	335	339	PF00917	0.614
DOC_USP7_MATH_1	343	347	PF00917	0.673
DOC_USP7_MATH_1	377	381	PF00917	0.784
DOC_USP7_MATH_1	386	390	PF00917	0.629
DOC_USP7_MATH_1	4	8	PF00917	0.728
DOC_USP7_MATH_1	459	463	PF00917	0.651
DOC_USP7_MATH_1	485	489	PF00917	0.699
DOC_USP7_MATH_1	557	561	PF00917	0.801
DOC_USP7_MATH_1	622	626	PF00917	0.714
DOC_USP7_MATH_1	694	698	PF00917	0.680
DOC_USP7_MATH_1	728	732	PF00917	0.682
DOC_USP7_MATH_1	877	881	PF00917	0.678
DOC_USP7_MATH_1	88	92	PF00917	0.660
DOC_USP7_MATH_1	894	898	PF00917	0.585
DOC_USP7_MATH_1	916	920	PF00917	0.625
DOC_USP7_MATH_1	976	980	PF00917	0.729
DOC_WW_Pin1_4	1084	1089	PF00397	0.643
DOC_WW_Pin1_4	114	119	PF00397	0.625
DOC_WW_Pin1_4	16	21	PF00397	0.704
DOC_WW_Pin1_4	214	219	PF00397	0.734
DOC_WW_Pin1_4	248	253	PF00397	0.632
DOC_WW_Pin1_4	280	285	PF00397	0.720
DOC_WW_Pin1_4	354	359	PF00397	0.717
DOC_WW_Pin1_4	361	366	PF00397	0.662
DOC_WW_Pin1_4	402	407	PF00397	0.651
DOC_WW_Pin1_4	48	53	PF00397	0.682
DOC_WW_Pin1_4	535	540	PF00397	0.659
DOC_WW_Pin1_4	549	554	PF00397	0.576
DOC_WW_Pin1_4	574	579	PF00397	0.614
DOC_WW_Pin1_4	929	934	PF00397	0.699
DOC_WW_Pin1_4	93	98	PF00397	0.642
DOC_WW_Pin1_4	99	104	PF00397	0.544
LIG_14-3-3_CanoR_1	192	196	PF00244	0.590
LIG_14-3-3_CanoR_1	209	218	PF00244	0.660
LIG_14-3-3_CanoR_1	25	30	PF00244	0.618
LIG_14-3-3_CanoR_1	287	292	PF00244	0.672
LIG_14-3-3_CanoR_1	333	342	PF00244	0.689
LIG_14-3-3_CanoR_1	369	373	PF00244	0.688
LIG_14-3-3_CanoR_1	402	406	PF00244	0.640
LIG_14-3-3_CanoR_1	586	590	PF00244	0.633
LIG_14-3-3_CanoR_1	597	607	PF00244	0.635
LIG_14-3-3_CanoR_1	824	833	PF00244	0.572
LIG_14-3-3_CanoR_1	843	847	PF00244	0.487
LIG_AP2alpha_2	490	492	PF02296	0.647
LIG_APCC_ABBA_1	741	746	PF00400	0.596
LIG_APCC_ABBAyCdc20_2	651	657	PF00400	0.608
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BIR_III_1	1	5	PF00653	0.596
LIG_BIR_III_2	271	275	PF00653	0.576
LIG_BIR_III_3	1	5	PF00653	0.596
LIG_BIR_III_4	162	166	PF00653	0.660
LIG_BRCT_BRCA1_1	826	830	PF00533	0.662
LIG_eIF4E_1	977	983	PF01652	0.676
LIG_FHA_1	17	23	PF00498	0.704
LIG_FHA_1	265	271	PF00498	0.684
LIG_FHA_1	410	416	PF00498	0.589
LIG_FHA_1	543	549	PF00498	0.697
LIG_FHA_1	598	604	PF00498	0.601
LIG_FHA_1	64	70	PF00498	0.681
LIG_FHA_1	749	755	PF00498	0.605
LIG_FHA_1	835	841	PF00498	0.758
LIG_FHA_1	976	982	PF00498	0.681
LIG_FHA_2	303	309	PF00498	0.594
LIG_FHA_2	373	379	PF00498	0.646
LIG_FHA_2	492	498	PF00498	0.697
LIG_FHA_2	553	559	PF00498	0.599
LIG_FHA_2	725	731	PF00498	0.562
LIG_FHA_2	982	988	PF00498	0.645
LIG_Integrin_isoDGR_2	222	224	PF01839	0.611
LIG_Integrin_isoDGR_2	667	669	PF01839	0.695
LIG_LIR_Apic_2	845	851	PF02991	0.677
LIG_LIR_Gen_1	1001	1012	PF02991	0.568
LIG_LIR_LC3C_4	411	415	PF02991	0.587
LIG_LIR_Nem_3	1001	1007	PF02991	0.662
LIG_LIR_Nem_3	632	638	PF02991	0.588
LIG_LIR_Nem_3	74	79	PF02991	0.661
LIG_LIR_Nem_3	827	833	PF02991	0.578
LIG_MYND_1	890	894	PF01753	0.659
LIG_PDZ_Class_2	1104	1109	PF00595	0.603
LIG_Pex14_2	944	948	PF04695	0.598
LIG_RPA_C_Fungi	204	216	PF08784	0.664
LIG_SH2_CRK	848	852	PF00017	0.706
LIG_SH2_CRK	977	981	PF00017	0.682
LIG_SH2_NCK_1	493	497	PF00017	0.694
LIG_SH2_NCK_1	848	852	PF00017	0.706
LIG_SH2_STAP1	977	981	PF00017	0.634
LIG_SH2_STAT3	173	176	PF00017	0.664
LIG_SH2_STAT3	317	320	PF00017	0.690
LIG_SH2_STAT3	707	710	PF00017	0.574
LIG_SH2_STAT5	1004	1007	PF00017	0.676
LIG_SH2_STAT5	493	496	PF00017	0.694
LIG_SH2_STAT5	753	756	PF00017	0.643
LIG_SH2_STAT5	801	804	PF00017	0.647
LIG_SH2_STAT5	942	945	PF00017	0.650
LIG_SH2_STAT5	977	980	PF00017	0.686
LIG_SH3_1	793	799	PF00018	0.611
LIG_SH3_1	887	893	PF00018	0.743
LIG_SH3_2	860	865	PF14604	0.656
LIG_SH3_3	112	118	PF00018	0.693
LIG_SH3_3	236	242	PF00018	0.743
LIG_SH3_3	353	359	PF00018	0.658
LIG_SH3_3	572	578	PF00018	0.661
LIG_SH3_3	74	80	PF00018	0.780
LIG_SH3_3	793	799	PF00018	0.611
LIG_SH3_3	833	839	PF00018	0.728
LIG_SH3_3	857	863	PF00018	0.634
LIG_SH3_3	887	893	PF00018	0.743
LIG_Sin3_3	1070	1077	PF02671	0.555
LIG_SUMO_SIM_anti_2	978	985	PF11976	0.666
LIG_SUMO_SIM_par_1	978	985	PF11976	0.666
LIG_TRAF2_1	1040	1043	PF00917	0.613
LIG_TRAF2_1	246	249	PF00917	0.582
LIG_TRAF2_1	306	309	PF00917	0.641
LIG_TRAF2_1	318	321	PF00917	0.593
LIG_TRAF2_1	52	55	PF00917	0.643
LIG_TRAF2_1	682	685	PF00917	0.698
LIG_TRFH_1	76	80	PF08558	0.659
LIG_WW_3	166	170	PF00397	0.718
LIG_WW_3	573	577	PF00397	0.719
LIG_WW_3	850	854	PF00397	0.662
MOD_CAAXbox	1106	1109	PF01239	0.601
MOD_CDK_SPK_2	1084	1089	PF00069	0.595
MOD_CDK_SPxxK_3	280	287	PF00069	0.672
MOD_CK1_1	102	108	PF00069	0.593
MOD_CK1_1	1061	1067	PF00069	0.576
MOD_CK1_1	1087	1093	PF00069	0.639
MOD_CK1_1	116	122	PF00069	0.630
MOD_CK1_1	210	216	PF00069	0.662
MOD_CK1_1	226	232	PF00069	0.558
MOD_CK1_1	251	257	PF00069	0.723
MOD_CK1_1	293	299	PF00069	0.636
MOD_CK1_1	371	377	PF00069	0.623
MOD_CK1_1	433	439	PF00069	0.729
MOD_CK1_1	464	470	PF00069	0.652
MOD_CK1_1	549	555	PF00069	0.602
MOD_CK1_1	592	598	PF00069	0.796
MOD_CK1_1	7	13	PF00069	0.736
MOD_CK1_1	724	730	PF00069	0.597
MOD_CK1_1	834	840	PF00069	0.765
MOD_CK1_1	880	886	PF00069	0.718
MOD_CK1_1	917	923	PF00069	0.827
MOD_CK2_1	214	220	PF00069	0.734
MOD_CK2_1	222	228	PF00069	0.659
MOD_CK2_1	243	249	PF00069	0.697
MOD_CK2_1	302	308	PF00069	0.724
MOD_CK2_1	372	378	PF00069	0.649
MOD_CK2_1	471	477	PF00069	0.622
MOD_CK2_1	527	533	PF00069	0.699
MOD_CK2_1	552	558	PF00069	0.601
MOD_CK2_1	598	604	PF00069	0.794
MOD_CK2_1	694	700	PF00069	0.589
MOD_CK2_1	711	717	PF00069	0.588
MOD_CK2_1	724	730	PF00069	0.577
MOD_CK2_1	767	773	PF00069	0.633
MOD_Cter_Amidation	331	334	PF01082	0.679
MOD_Cter_Amidation	400	403	PF01082	0.656
MOD_Cter_Amidation	667	670	PF01082	0.692
MOD_DYRK1A_RPxSP_1	114	118	PF00069	0.669
MOD_GlcNHglycan	1074	1077	PF01048	0.620
MOD_GlcNHglycan	1096	1099	PF01048	0.690
MOD_GlcNHglycan	128	131	PF01048	0.702
MOD_GlcNHglycan	209	212	PF01048	0.684
MOD_GlcNHglycan	225	228	PF01048	0.602
MOD_GlcNHglycan	337	340	PF01048	0.600
MOD_GlcNHglycan	432	435	PF01048	0.728
MOD_GlcNHglycan	461	464	PF01048	0.693
MOD_GlcNHglycan	473	476	PF01048	0.615
MOD_GlcNHglycan	48	51	PF01048	0.658
MOD_GlcNHglycan	513	516	PF01048	0.695
MOD_GlcNHglycan	517	521	PF01048	0.654
MOD_GlcNHglycan	558	562	PF01048	0.700
MOD_GlcNHglycan	580	584	PF01048	0.748
MOD_GlcNHglycan	713	716	PF01048	0.651
MOD_GlcNHglycan	73	76	PF01048	0.668
MOD_GlcNHglycan	785	788	PF01048	0.666
MOD_GlcNHglycan	827	830	PF01048	0.773
MOD_GlcNHglycan	848	851	PF01048	0.730
MOD_GlcNHglycan	882	885	PF01048	0.719
MOD_GlcNHglycan	90	93	PF01048	0.502
MOD_GlcNHglycan	906	909	PF01048	0.730
MOD_GlcNHglycan	920	923	PF01048	0.605
MOD_GSK3_1	1024	1031	PF00069	0.661
MOD_GSK3_1	1072	1079	PF00069	0.659
MOD_GSK3_1	1096	1103	PF00069	0.573
MOD_GSK3_1	210	217	PF00069	0.700
MOD_GSK3_1	218	225	PF00069	0.655
MOD_GSK3_1	226	233	PF00069	0.590
MOD_GSK3_1	23	30	PF00069	0.501
MOD_GSK3_1	244	251	PF00069	0.651
MOD_GSK3_1	260	267	PF00069	0.688
MOD_GSK3_1	312	319	PF00069	0.734
MOD_GSK3_1	360	367	PF00069	0.705
MOD_GSK3_1	368	375	PF00069	0.697
MOD_GSK3_1	377	384	PF00069	0.668
MOD_GSK3_1	42	49	PF00069	0.512
MOD_GSK3_1	433	440	PF00069	0.679
MOD_GSK3_1	471	478	PF00069	0.572
MOD_GSK3_1	498	505	PF00069	0.692
MOD_GSK3_1	516	523	PF00069	0.673
MOD_GSK3_1	542	549	PF00069	0.644
MOD_GSK3_1	581	588	PF00069	0.803
MOD_GSK3_1	589	596	PF00069	0.741
MOD_GSK3_1	7	14	PF00069	0.725
MOD_GSK3_1	720	727	PF00069	0.590
MOD_GSK3_1	748	755	PF00069	0.583
MOD_GSK3_1	842	849	PF00069	0.720
MOD_GSK3_1	878	885	PF00069	0.714
MOD_GSK3_1	910	917	PF00069	0.763
MOD_GSK3_1	929	936	PF00069	0.634
MOD_GSK3_1	95	102	PF00069	0.695
MOD_N-GLC_1	1028	1033	PF02516	0.686
MOD_N-GLC_1	141	146	PF02516	0.650
MOD_N-GLC_1	324	329	PF02516	0.649
MOD_NEK2_1	1013	1018	PF00069	0.681
MOD_NEK2_1	46	51	PF00069	0.600
MOD_NEK2_1	502	507	PF00069	0.664
MOD_NEK2_1	511	516	PF00069	0.603
MOD_NEK2_1	589	594	PF00069	0.678
MOD_NEK2_1	767	772	PF00069	0.656
MOD_NEK2_1	846	851	PF00069	0.701
MOD_NEK2_1	86	91	PF00069	0.545
MOD_NEK2_1	878	883	PF00069	0.790
MOD_NEK2_1	981	986	PF00069	0.742
MOD_NEK2_2	1028	1033	PF00069	0.686
MOD_NEK2_2	343	348	PF00069	0.618
MOD_NEK2_2	446	451	PF00069	0.668
MOD_NEK2_2	475	480	PF00069	0.577
MOD_PIKK_1	1006	1012	PF00454	0.673
MOD_PIKK_1	1061	1067	PF00454	0.527
MOD_PIKK_1	260	266	PF00454	0.657
MOD_PIKK_1	316	322	PF00454	0.743
MOD_PIKK_1	333	339	PF00454	0.551
MOD_PIKK_1	464	470	PF00454	0.661
MOD_PIKK_1	546	552	PF00454	0.629
MOD_PIKK_1	609	615	PF00454	0.680
MOD_PIKK_1	761	767	PF00454	0.644
MOD_PKA_1	113	119	PF00069	0.697
MOD_PKA_1	333	339	PF00069	0.685
MOD_PKA_1	585	591	PF00069	0.707
MOD_PKA_2	113	119	PF00069	0.751
MOD_PKA_2	191	197	PF00069	0.638
MOD_PKA_2	223	229	PF00069	0.695
MOD_PKA_2	312	318	PF00069	0.734
MOD_PKA_2	333	339	PF00069	0.769
MOD_PKA_2	368	374	PF00069	0.687
MOD_PKA_2	401	407	PF00069	0.661
MOD_PKA_2	479	485	PF00069	0.701
MOD_PKA_2	585	591	PF00069	0.722
MOD_PKA_2	592	598	PF00069	0.673
MOD_PKA_2	694	700	PF00069	0.636
MOD_PKA_2	721	727	PF00069	0.588
MOD_PKA_2	728	734	PF00069	0.570
MOD_PKA_2	823	829	PF00069	0.688
MOD_PKA_2	842	848	PF00069	0.490
MOD_PKB_1	822	830	PF00069	0.624
MOD_Plk_1	1028	1034	PF00069	0.691
MOD_Plk_1	1061	1067	PF00069	0.554
MOD_Plk_1	293	299	PF00069	0.613
MOD_Plk_1	377	383	PF00069	0.638
MOD_Plk_1	543	549	PF00069	0.663
MOD_Plk_1	737	743	PF00069	0.590
MOD_Plk_2-3	1024	1030	PF00069	0.554
MOD_Plk_2-3	324	330	PF00069	0.698
MOD_Plk_4	119	125	PF00069	0.715
MOD_Plk_4	377	383	PF00069	0.672
MOD_Plk_4	409	415	PF00069	0.716
MOD_Plk_4	498	504	PF00069	0.691
MOD_Plk_4	527	533	PF00069	0.699
MOD_Plk_4	622	628	PF00069	0.595
MOD_Plk_4	63	69	PF00069	0.683
MOD_Plk_4	976	982	PF00069	0.632
MOD_ProDKin_1	1084	1090	PF00069	0.641
MOD_ProDKin_1	114	120	PF00069	0.629
MOD_ProDKin_1	16	22	PF00069	0.701
MOD_ProDKin_1	214	220	PF00069	0.734
MOD_ProDKin_1	248	254	PF00069	0.635
MOD_ProDKin_1	280	286	PF00069	0.720
MOD_ProDKin_1	354	360	PF00069	0.718
MOD_ProDKin_1	361	367	PF00069	0.663
MOD_ProDKin_1	402	408	PF00069	0.653
MOD_ProDKin_1	48	54	PF00069	0.683
MOD_ProDKin_1	535	541	PF00069	0.664
MOD_ProDKin_1	549	555	PF00069	0.577
MOD_ProDKin_1	574	580	PF00069	0.614
MOD_ProDKin_1	929	935	PF00069	0.696
MOD_ProDKin_1	93	99	PF00069	0.641
MOD_SUMO_for_1	397	400	PF00179	0.584
MOD_SUMO_rev_2	612	622	PF00179	0.658
TRG_DiLeu_BaLyEn_6	1033	1038	PF01217	0.708
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.707
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.661
TRG_ENDOCYTIC_2	1004	1007	PF00928	0.676
TRG_ENDOCYTIC_2	528	531	PF00928	0.626
TRG_ENDOCYTIC_2	977	980	PF00928	0.686
TRG_ER_diArg_1	112	114	PF00400	0.739
TRG_ER_diArg_1	153	156	PF00400	0.645
TRG_ER_diArg_1	168	171	PF00400	0.648
TRG_ER_diArg_1	310	313	PF00400	0.684
TRG_ER_diArg_1	821	824	PF00400	0.620
TRG_ER_diArg_1	926	928	PF00400	0.709
TRG_ER_diArg_1	967	970	PF00400	0.578
TRG_ER_diArg_1	988	991	PF00400	0.576
TRG_ER_FFAT_2	748	758	PF00635	0.643
TRG_NLS_MonoExtC_3	819	824	PF00514	0.585
TRG_NLS_MonoExtN_4	819	824	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	960	965	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGY4	Leishmania donovani	98%	100%
A4H5N1	Leishmania braziliensis	58%	98%
E9AMQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
Q4QHX0	Leishmania major	87%	100%