LeishMANIAdb
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Putative leucine-rich repeat protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative leucine-rich repeat protein
Gene product:
leucine-rich repeat protein - putative
Species:
Leishmania infantum
UniProt:
A4HTW7_LEIIN
TriTrypDb:
LINF_090011200
Length:
997

Annotations

Annotations by Jardim et al.

Structural Proteins, leucine-rich repeat

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005929 cilium 4 7
GO:0042995 cell projection 2 7
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0110165 cellular anatomical entity 1 8
GO:0120025 plasma membrane bounded cell projection 3 7
GO:0000151 ubiquitin ligase complex 3 1
GO:0005930 axoneme 2 1
GO:0019005 SCF ubiquitin ligase complex 5 1
GO:0031461 cullin-RING ubiquitin ligase complex 4 1
GO:0032991 protein-containing complex 1 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

A4HTW7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTW7

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030163 protein catabolic process 4 1
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 7 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 17 21 PF00656 0.645
CLV_C14_Caspase3-7 282 286 PF00656 0.436
CLV_C14_Caspase3-7 721 725 PF00656 0.677
CLV_C14_Caspase3-7 780 784 PF00656 0.702
CLV_NRD_NRD_1 131 133 PF00675 0.670
CLV_NRD_NRD_1 522 524 PF00675 0.585
CLV_NRD_NRD_1 874 876 PF00675 0.737
CLV_PCSK_KEX2_1 131 133 PF00082 0.728
CLV_PCSK_KEX2_1 522 524 PF00082 0.613
CLV_PCSK_KEX2_1 585 587 PF00082 0.647
CLV_PCSK_KEX2_1 874 876 PF00082 0.737
CLV_PCSK_KEX2_1 934 936 PF00082 0.770
CLV_PCSK_PC1ET2_1 585 587 PF00082 0.566
CLV_PCSK_PC1ET2_1 934 936 PF00082 0.770
CLV_PCSK_SKI1_1 147 151 PF00082 0.781
CLV_PCSK_SKI1_1 234 238 PF00082 0.485
CLV_PCSK_SKI1_1 495 499 PF00082 0.537
CLV_PCSK_SKI1_1 603 607 PF00082 0.583
CLV_PCSK_SKI1_1 611 615 PF00082 0.451
CLV_PCSK_SKI1_1 698 702 PF00082 0.732
CLV_PCSK_SKI1_1 730 734 PF00082 0.606
CLV_Separin_Metazoa 519 523 PF03568 0.524
DEG_APCC_DBOX_1 460 468 PF00400 0.587
DEG_APCC_DBOX_1 494 502 PF00400 0.604
DEG_SIAH_1 40 48 PF03145 0.576
DOC_CDC14_PxL_1 288 296 PF14671 0.567
DOC_CKS1_1 830 835 PF01111 0.630
DOC_CYCLIN_RxL_1 319 328 PF00134 0.576
DOC_CYCLIN_RxL_1 446 454 PF00134 0.475
DOC_CYCLIN_RxL_1 734 747 PF00134 0.708
DOC_CYCLIN_yCln2_LP_2 400 403 PF00134 0.605
DOC_CYCLIN_yCln2_LP_2 830 836 PF00134 0.766
DOC_CYCLIN_yCln2_LP_2 869 872 PF00134 0.757
DOC_MAPK_DCC_7 322 331 PF00069 0.578
DOC_MAPK_DCC_7 483 492 PF00069 0.601
DOC_MAPK_gen_1 418 427 PF00069 0.578
DOC_MAPK_gen_1 483 492 PF00069 0.540
DOC_MAPK_HePTP_8 480 492 PF00069 0.594
DOC_MAPK_MEF2A_6 322 331 PF00069 0.520
DOC_MAPK_MEF2A_6 483 492 PF00069 0.524
DOC_PP2B_LxvP_1 324 327 PF13499 0.449
DOC_PP2B_LxvP_1 399 402 PF13499 0.509
DOC_PP2B_LxvP_1 488 491 PF13499 0.521
DOC_PP2B_LxvP_1 501 504 PF13499 0.527
DOC_PP2B_LxvP_1 825 828 PF13499 0.740
DOC_PP2B_LxvP_1 869 872 PF13499 0.757
DOC_PP4_FxxP_1 991 994 PF00568 0.623
DOC_USP7_MATH_1 210 214 PF00917 0.630
DOC_USP7_MATH_1 227 231 PF00917 0.284
DOC_USP7_MATH_1 278 282 PF00917 0.455
DOC_USP7_MATH_1 359 363 PF00917 0.717
DOC_USP7_MATH_1 364 368 PF00917 0.717
DOC_USP7_MATH_1 479 483 PF00917 0.509
DOC_USP7_MATH_1 687 691 PF00917 0.770
DOC_USP7_MATH_1 710 714 PF00917 0.669
DOC_USP7_MATH_1 761 765 PF00917 0.827
DOC_USP7_MATH_1 853 857 PF00917 0.738
DOC_USP7_MATH_1 929 933 PF00917 0.741
DOC_USP7_MATH_1 943 947 PF00917 0.714
DOC_USP7_MATH_1 948 952 PF00917 0.773
DOC_WW_Pin1_4 236 241 PF00397 0.568
DOC_WW_Pin1_4 34 39 PF00397 0.801
DOC_WW_Pin1_4 829 834 PF00397 0.631
DOC_WW_Pin1_4 859 864 PF00397 0.728
DOC_WW_Pin1_4 874 879 PF00397 0.842
DOC_WW_Pin1_4 890 895 PF00397 0.638
DOC_WW_Pin1_4 901 906 PF00397 0.761
LIG_14-3-3_CanoR_1 10 18 PF00244 0.670
LIG_14-3-3_CanoR_1 107 111 PF00244 0.430
LIG_14-3-3_CanoR_1 191 199 PF00244 0.611
LIG_14-3-3_CanoR_1 234 243 PF00244 0.563
LIG_14-3-3_CanoR_1 267 272 PF00244 0.515
LIG_14-3-3_CanoR_1 406 412 PF00244 0.580
LIG_14-3-3_CanoR_1 421 426 PF00244 0.357
LIG_14-3-3_CanoR_1 432 440 PF00244 0.581
LIG_14-3-3_CanoR_1 495 504 PF00244 0.560
LIG_14-3-3_CanoR_1 505 511 PF00244 0.485
LIG_14-3-3_CanoR_1 539 544 PF00244 0.564
LIG_14-3-3_CanoR_1 603 610 PF00244 0.576
LIG_14-3-3_CanoR_1 643 650 PF00244 0.347
LIG_14-3-3_CanoR_1 874 878 PF00244 0.731
LIG_14-3-3_CanoR_1 95 104 PF00244 0.635
LIG_14-3-3_CanoR_1 958 966 PF00244 0.749
LIG_BIR_II_1 1 5 PF00653 0.776
LIG_BIR_III_4 848 852 PF00653 0.701
LIG_BRCT_BRCA1_1 167 171 PF00533 0.583
LIG_BRCT_BRCA1_1 269 273 PF00533 0.532
LIG_BRCT_BRCA1_1 541 545 PF00533 0.479
LIG_BRCT_BRCA1_1 801 805 PF00533 0.770
LIG_BRCT_BRCA1_1 855 859 PF00533 0.604
LIG_BRCT_BRCA1_1 945 949 PF00533 0.683
LIG_FAT_LD_1 467 475 PF03623 0.512
LIG_FHA_1 266 272 PF00498 0.544
LIG_FHA_1 310 316 PF00498 0.472
LIG_FHA_1 352 358 PF00498 0.768
LIG_FHA_1 372 378 PF00498 0.518
LIG_FHA_1 406 412 PF00498 0.569
LIG_FHA_1 422 428 PF00498 0.276
LIG_FHA_1 594 600 PF00498 0.537
LIG_FHA_1 659 665 PF00498 0.580
LIG_FHA_1 822 828 PF00498 0.727
LIG_FHA_2 280 286 PF00498 0.430
LIG_FHA_2 542 548 PF00498 0.557
LIG_FHA_2 602 608 PF00498 0.581
LIG_FHA_2 778 784 PF00498 0.757
LIG_FHA_2 875 881 PF00498 0.848
LIG_GBD_Chelix_1 664 672 PF00786 0.501
LIG_Integrin_isoDGR_2 525 527 PF01839 0.656
LIG_LIR_Apic_2 989 994 PF02991 0.624
LIG_LIR_LC3C_4 328 331 PF02991 0.507
LIG_LIR_Nem_3 274 280 PF02991 0.575
LIG_LIR_Nem_3 553 559 PF02991 0.560
LIG_LIR_Nem_3 946 952 PF02991 0.700
LIG_MAD2 449 457 PF02301 0.468
LIG_NRBOX 231 237 PF00104 0.568
LIG_NRBOX 338 344 PF00104 0.579
LIG_PCNA_yPIPBox_3 183 191 PF02747 0.512
LIG_Pex14_2 269 273 PF04695 0.532
LIG_Pex14_2 991 995 PF04695 0.629
LIG_SH2_CRK 277 281 PF00017 0.477
LIG_SH2_STAT3 916 919 PF00017 0.728
LIG_SH2_STAT5 189 192 PF00017 0.454
LIG_SH2_STAT5 195 198 PF00017 0.482
LIG_SH2_STAT5 916 919 PF00017 0.767
LIG_SH3_1 875 881 PF00018 0.767
LIG_SH3_3 193 199 PF00018 0.590
LIG_SH3_3 35 41 PF00018 0.753
LIG_SH3_3 58 64 PF00018 0.620
LIG_SH3_3 657 663 PF00018 0.603
LIG_SH3_3 704 710 PF00018 0.579
LIG_SH3_3 830 836 PF00018 0.764
LIG_SH3_3 857 863 PF00018 0.695
LIG_SH3_3 875 881 PF00018 0.574
LIG_SUMO_SIM_anti_2 122 129 PF11976 0.705
LIG_SUMO_SIM_anti_2 395 400 PF11976 0.467
LIG_SUMO_SIM_anti_2 465 473 PF11976 0.590
LIG_SUMO_SIM_anti_2 596 601 PF11976 0.542
LIG_SUMO_SIM_par_1 122 129 PF11976 0.663
LIG_SUMO_SIM_par_1 373 378 PF11976 0.566
LIG_SUMO_SIM_par_1 423 428 PF11976 0.443
LIG_SUMO_SIM_par_1 449 454 PF11976 0.587
LIG_SUMO_SIM_par_1 823 829 PF11976 0.733
LIG_TRAF2_1 920 923 PF00917 0.834
LIG_TRAF2_1 994 997 PF00917 0.824
LIG_WRC_WIRS_1 266 271 PF05994 0.476
MOD_CK1_1 11 17 PF00069 0.686
MOD_CK1_1 281 287 PF00069 0.460
MOD_CK1_1 290 296 PF00069 0.476
MOD_CK1_1 507 513 PF00069 0.605
MOD_CK1_1 546 552 PF00069 0.534
MOD_CK1_1 631 637 PF00069 0.580
MOD_CK1_1 713 719 PF00069 0.634
MOD_CK1_1 775 781 PF00069 0.736
MOD_CK1_1 820 826 PF00069 0.747
MOD_CK1_1 829 835 PF00069 0.850
MOD_CK1_1 904 910 PF00069 0.775
MOD_CK1_1 911 917 PF00069 0.719
MOD_CK1_1 960 966 PF00069 0.759
MOD_CK1_1 967 973 PF00069 0.646
MOD_CK2_1 209 215 PF00069 0.627
MOD_CK2_1 322 328 PF00069 0.453
MOD_CK2_1 541 547 PF00069 0.563
MOD_CK2_1 720 726 PF00069 0.596
MOD_CK2_1 874 880 PF00069 0.857
MOD_CK2_1 917 923 PF00069 0.728
MOD_GlcNHglycan 212 215 PF01048 0.639
MOD_GlcNHglycan 254 258 PF01048 0.604
MOD_GlcNHglycan 376 380 PF01048 0.516
MOD_GlcNHglycan 426 430 PF01048 0.495
MOD_GlcNHglycan 442 445 PF01048 0.505
MOD_GlcNHglycan 527 530 PF01048 0.618
MOD_GlcNHglycan 578 581 PF01048 0.509
MOD_GlcNHglycan 710 713 PF01048 0.639
MOD_GlcNHglycan 746 749 PF01048 0.724
MOD_GlcNHglycan 787 791 PF01048 0.811
MOD_GlcNHglycan 819 822 PF01048 0.706
MOD_GlcNHglycan 910 913 PF01048 0.676
MOD_GlcNHglycan 945 948 PF01048 0.698
MOD_GSK3_1 165 172 PF00069 0.653
MOD_GSK3_1 253 260 PF00069 0.535
MOD_GSK3_1 371 378 PF00069 0.514
MOD_GSK3_1 4 11 PF00069 0.681
MOD_GSK3_1 401 408 PF00069 0.579
MOD_GSK3_1 421 428 PF00069 0.242
MOD_GSK3_1 539 546 PF00069 0.522
MOD_GSK3_1 708 715 PF00069 0.749
MOD_GSK3_1 716 723 PF00069 0.511
MOD_GSK3_1 817 824 PF00069 0.642
MOD_GSK3_1 903 910 PF00069 0.777
MOD_GSK3_1 914 921 PF00069 0.739
MOD_GSK3_1 929 936 PF00069 0.548
MOD_GSK3_1 957 964 PF00069 0.787
MOD_LATS_1 265 271 PF00433 0.549
MOD_LATS_1 573 579 PF00433 0.577
MOD_N-GLC_1 4 9 PF02516 0.553
MOD_NEK2_1 106 111 PF00069 0.541
MOD_NEK2_1 209 214 PF00069 0.521
MOD_NEK2_1 287 292 PF00069 0.495
MOD_NEK2_1 345 350 PF00069 0.591
MOD_NEK2_1 375 380 PF00069 0.447
MOD_NEK2_1 4 9 PF00069 0.749
MOD_NEK2_1 407 412 PF00069 0.565
MOD_NEK2_1 425 430 PF00069 0.361
MOD_NEK2_1 440 445 PF00069 0.577
MOD_NEK2_1 470 475 PF00069 0.440
MOD_NEK2_1 559 564 PF00069 0.473
MOD_NEK2_1 777 782 PF00069 0.823
MOD_NEK2_1 933 938 PF00069 0.782
MOD_NEK2_2 929 934 PF00069 0.758
MOD_PIKK_1 165 171 PF00454 0.580
MOD_PIKK_1 234 240 PF00454 0.597
MOD_PIKK_1 316 322 PF00454 0.588
MOD_PIKK_1 504 510 PF00454 0.596
MOD_PIKK_1 559 565 PF00454 0.563
MOD_PIKK_1 611 617 PF00454 0.496
MOD_PIKK_1 914 920 PF00454 0.804
MOD_PK_1 267 273 PF00069 0.544
MOD_PK_1 539 545 PF00069 0.559
MOD_PKA_2 106 112 PF00069 0.486
MOD_PKA_2 190 196 PF00069 0.611
MOD_PKA_2 345 351 PF00069 0.577
MOD_PKA_2 405 411 PF00069 0.592
MOD_PKA_2 431 437 PF00069 0.579
MOD_PKA_2 504 510 PF00069 0.577
MOD_PKA_2 538 544 PF00069 0.489
MOD_PKA_2 642 648 PF00069 0.356
MOD_PKA_2 761 767 PF00069 0.789
MOD_PKA_2 873 879 PF00069 0.729
MOD_PKA_2 9 15 PF00069 0.714
MOD_PKA_2 94 100 PF00069 0.480
MOD_PKA_2 957 963 PF00069 0.717
MOD_PKA_2 964 970 PF00069 0.757
MOD_Plk_1 253 259 PF00069 0.523
MOD_Plk_1 322 328 PF00069 0.504
MOD_Plk_1 546 552 PF00069 0.451
MOD_Plk_1 634 640 PF00069 0.569
MOD_Plk_4 227 233 PF00069 0.507
MOD_Plk_4 4 10 PF00069 0.653
MOD_Plk_4 407 413 PF00069 0.591
MOD_Plk_4 470 476 PF00069 0.429
MOD_Plk_4 497 503 PF00069 0.589
MOD_Plk_4 546 552 PF00069 0.498
MOD_Plk_4 567 573 PF00069 0.547
MOD_Plk_4 772 778 PF00069 0.791
MOD_ProDKin_1 236 242 PF00069 0.578
MOD_ProDKin_1 34 40 PF00069 0.798
MOD_ProDKin_1 829 835 PF00069 0.629
MOD_ProDKin_1 859 865 PF00069 0.727
MOD_ProDKin_1 874 880 PF00069 0.842
MOD_ProDKin_1 890 896 PF00069 0.636
MOD_ProDKin_1 901 907 PF00069 0.761
MOD_SUMO_for_1 70 73 PF00179 0.528
TRG_DiLeu_BaEn_1 122 127 PF01217 0.633
TRG_DiLeu_BaEn_4 122 128 PF01217 0.704
TRG_DiLeu_BaEn_4 535 541 PF01217 0.492
TRG_DiLeu_BaEn_4 73 79 PF01217 0.504
TRG_DiLeu_BaLyEn_6 231 236 PF01217 0.564
TRG_DiLeu_BaLyEn_6 338 343 PF01217 0.494
TRG_ENDOCYTIC_2 277 280 PF00928 0.561
TRG_ER_diArg_1 131 134 PF00400 0.677
TRG_ER_diArg_1 521 523 PF00400 0.570
TRG_ER_diArg_1 873 875 PF00400 0.738
TRG_NES_CRM1_1 646 658 PF08389 0.535
TRG_Pf-PMV_PEXEL_1 234 238 PF00026 0.462
TRG_Pf-PMV_PEXEL_1 449 454 PF00026 0.522
TRG_Pf-PMV_PEXEL_1 603 607 PF00026 0.583
TRG_Pf-PMV_PEXEL_1 611 615 PF00026 0.451
TRG_Pf-PMV_PEXEL_1 739 744 PF00026 0.707
TRG_Pf-PMV_PEXEL_1 80 84 PF00026 0.544
TRG_Pf-PMV_PEXEL_1 935 939 PF00026 0.761

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WQP1 Leishmania donovani 100% 100%
A0A422NV64 Trypanosoma rangeli 28% 92%
A4H5N0 Leishmania braziliensis 71% 98%
D0A9D1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 95%
E9AMQ4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 99%
Q4QHX1 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS