LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HTW6_LEIIN
TriTrypDb:
LINF_090011100
Length:
770

Annotations

Annotations by Jardim et al.

Flagella, Flagellum attachment zone 3

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005856 cytoskeleton 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 752
Promastigote/Amastigote: 748

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HTW6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTW6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0071889 14-3-3 protein binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 171 175 PF00656 0.692
CLV_NRD_NRD_1 265 267 PF00675 0.468
CLV_NRD_NRD_1 410 412 PF00675 0.422
CLV_NRD_NRD_1 463 465 PF00675 0.526
CLV_NRD_NRD_1 696 698 PF00675 0.484
CLV_NRD_NRD_1 715 717 PF00675 0.690
CLV_NRD_NRD_1 754 756 PF00675 0.690
CLV_PCSK_KEX2_1 214 216 PF00082 0.440
CLV_PCSK_KEX2_1 239 241 PF00082 0.476
CLV_PCSK_KEX2_1 410 412 PF00082 0.422
CLV_PCSK_KEX2_1 463 465 PF00082 0.526
CLV_PCSK_KEX2_1 616 618 PF00082 0.528
CLV_PCSK_KEX2_1 696 698 PF00082 0.428
CLV_PCSK_KEX2_1 715 717 PF00082 0.690
CLV_PCSK_KEX2_1 754 756 PF00082 0.690
CLV_PCSK_PC1ET2_1 214 216 PF00082 0.440
CLV_PCSK_PC1ET2_1 239 241 PF00082 0.476
CLV_PCSK_PC1ET2_1 616 618 PF00082 0.545
CLV_PCSK_SKI1_1 112 116 PF00082 0.548
CLV_PCSK_SKI1_1 229 233 PF00082 0.449
CLV_PCSK_SKI1_1 342 346 PF00082 0.417
CLV_PCSK_SKI1_1 400 404 PF00082 0.530
CLV_PCSK_SKI1_1 451 455 PF00082 0.375
CLV_PCSK_SKI1_1 466 470 PF00082 0.449
CLV_PCSK_SKI1_1 542 546 PF00082 0.446
CLV_PCSK_SKI1_1 58 62 PF00082 0.343
CLV_PCSK_SKI1_1 631 635 PF00082 0.663
CLV_PCSK_SKI1_1 71 75 PF00082 0.361
DOC_CKS1_1 725 730 PF01111 0.459
DOC_CYCLIN_yCln2_LP_2 725 731 PF00134 0.479
DOC_MAPK_gen_1 239 247 PF00069 0.468
DOC_MAPK_gen_1 436 444 PF00069 0.363
DOC_MAPK_HePTP_8 526 538 PF00069 0.441
DOC_MAPK_MEF2A_6 436 444 PF00069 0.439
DOC_MAPK_MEF2A_6 529 538 PF00069 0.442
DOC_PP4_FxxP_1 384 387 PF00568 0.575
DOC_USP7_MATH_1 387 391 PF00917 0.587
DOC_USP7_MATH_1 543 547 PF00917 0.486
DOC_USP7_MATH_1 562 566 PF00917 0.663
DOC_USP7_MATH_1 644 648 PF00917 0.730
DOC_USP7_MATH_1 709 713 PF00917 0.598
DOC_USP7_MATH_1 753 757 PF00917 0.733
DOC_USP7_UBL2_3 183 187 PF12436 0.641
DOC_USP7_UBL2_3 529 533 PF12436 0.504
DOC_WW_Pin1_4 417 422 PF00397 0.344
DOC_WW_Pin1_4 626 631 PF00397 0.679
DOC_WW_Pin1_4 640 645 PF00397 0.656
DOC_WW_Pin1_4 647 652 PF00397 0.670
DOC_WW_Pin1_4 674 679 PF00397 0.528
DOC_WW_Pin1_4 724 729 PF00397 0.467
LIG_14-3-3_CanoR_1 158 164 PF00244 0.562
LIG_14-3-3_CanoR_1 259 264 PF00244 0.386
LIG_14-3-3_CanoR_1 484 490 PF00244 0.536
LIG_14-3-3_CanoR_1 542 548 PF00244 0.464
LIG_14-3-3_CanoR_1 625 630 PF00244 0.618
LIG_14-3-3_CanoR_1 645 653 PF00244 0.722
LIG_14-3-3_CanoR_1 696 700 PF00244 0.516
LIG_14-3-3_CanoR_1 763 768 PF00244 0.733
LIG_14-3-3_CanoR_1 92 101 PF00244 0.541
LIG_Actin_WH2_2 44 60 PF00022 0.355
LIG_APCC_ABBA_1 729 734 PF00400 0.424
LIG_APCC_ABBAyCdc20_2 248 254 PF00400 0.408
LIG_BIR_II_1 1 5 PF00653 0.519
LIG_BIR_III_2 743 747 PF00653 0.692
LIG_EVH1_2 548 552 PF00568 0.422
LIG_FHA_1 151 157 PF00498 0.479
LIG_FHA_1 357 363 PF00498 0.476
LIG_FHA_1 435 441 PF00498 0.527
LIG_FHA_1 46 52 PF00498 0.448
LIG_FHA_1 762 768 PF00498 0.695
LIG_FHA_2 160 166 PF00498 0.609
LIG_FHA_2 189 195 PF00498 0.615
LIG_FHA_2 374 380 PF00498 0.494
LIG_FHA_2 499 505 PF00498 0.426
LIG_HCF-1_HBM_1 289 292 PF13415 0.443
LIG_IBAR_NPY_1 567 569 PF08397 0.499
LIG_LIR_Apic_2 698 702 PF02991 0.600
LIG_LIR_Gen_1 217 226 PF02991 0.536
LIG_LIR_Gen_1 242 252 PF02991 0.432
LIG_LIR_Gen_1 321 327 PF02991 0.532
LIG_LIR_Gen_1 515 526 PF02991 0.464
LIG_LIR_Gen_1 572 578 PF02991 0.574
LIG_LIR_Nem_3 242 247 PF02991 0.402
LIG_LIR_Nem_3 250 255 PF02991 0.348
LIG_LIR_Nem_3 308 314 PF02991 0.441
LIG_LIR_Nem_3 349 355 PF02991 0.391
LIG_LIR_Nem_3 379 384 PF02991 0.487
LIG_LIR_Nem_3 490 496 PF02991 0.562
LIG_LIR_Nem_3 514 520 PF02991 0.482
LIG_LIR_Nem_3 572 576 PF02991 0.622
LIG_Pex14_2 350 354 PF04695 0.366
LIG_PTB_Apo_2 246 253 PF02174 0.470
LIG_PTB_Apo_2 698 705 PF02174 0.516
LIG_PTB_Phospho_1 698 704 PF10480 0.404
LIG_REV1ctd_RIR_1 91 101 PF16727 0.398
LIG_SH2_CRK 301 305 PF00017 0.455
LIG_SH2_GRB2like 314 317 PF00017 0.484
LIG_SH2_GRB2like 489 492 PF00017 0.588
LIG_SH2_NCK_1 573 577 PF00017 0.615
LIG_SH2_SRC 314 317 PF00017 0.485
LIG_SH2_SRC 392 395 PF00017 0.521
LIG_SH2_SRC 573 576 PF00017 0.622
LIG_SH2_STAP1 489 493 PF00017 0.579
LIG_SH2_STAT3 189 192 PF00017 0.674
LIG_SH2_STAT3 489 492 PF00017 0.558
LIG_SH2_STAT3 527 530 PF00017 0.614
LIG_SH2_STAT5 168 171 PF00017 0.637
LIG_SH2_STAT5 189 192 PF00017 0.679
LIG_SH2_STAT5 292 295 PF00017 0.556
LIG_SH2_STAT5 314 317 PF00017 0.372
LIG_SH2_STAT5 392 395 PF00017 0.521
LIG_SH2_STAT5 505 508 PF00017 0.452
LIG_SH2_STAT5 518 521 PF00017 0.478
LIG_SH2_STAT5 551 554 PF00017 0.414
LIG_SH2_STAT5 704 707 PF00017 0.534
LIG_SH2_STAT5 83 86 PF00017 0.415
LIG_SH3_3 531 537 PF00018 0.543
LIG_SH3_3 672 678 PF00018 0.464
LIG_SH3_3 681 687 PF00018 0.419
LIG_Sin3_3 479 486 PF02671 0.409
LIG_SUMO_SIM_anti_2 450 457 PF11976 0.400
LIG_SUMO_SIM_par_1 452 457 PF11976 0.448
LIG_TRAF2_1 162 165 PF00917 0.582
LIG_TRAF2_1 231 234 PF00917 0.458
LIG_TRAF2_1 472 475 PF00917 0.504
LIG_TRAF2_1 669 672 PF00917 0.604
LIG_UBA3_1 180 187 PF00899 0.680
LIG_WW_1 548 551 PF00397 0.419
LIG_WW_3 547 551 PF00397 0.432
MOD_CDK_SPK_2 626 631 PF00069 0.709
MOD_CDK_SPK_2 640 645 PF00069 0.656
MOD_CK1_1 150 156 PF00069 0.460
MOD_CK1_1 170 176 PF00069 0.396
MOD_CK1_1 262 268 PF00069 0.517
MOD_CK1_1 356 362 PF00069 0.455
MOD_CK1_1 395 401 PF00069 0.474
MOD_CK1_1 41 47 PF00069 0.523
MOD_CK1_1 420 426 PF00069 0.373
MOD_CK1_1 485 491 PF00069 0.545
MOD_CK1_1 561 567 PF00069 0.629
MOD_CK1_1 647 653 PF00069 0.702
MOD_CK1_1 748 754 PF00069 0.642
MOD_CK1_1 761 767 PF00069 0.634
MOD_CK2_1 159 165 PF00069 0.537
MOD_CK2_1 170 176 PF00069 0.566
MOD_CK2_1 188 194 PF00069 0.561
MOD_CK2_1 30 36 PF00069 0.500
MOD_CK2_1 373 379 PF00069 0.525
MOD_CK2_1 456 462 PF00069 0.490
MOD_CK2_1 498 504 PF00069 0.399
MOD_CK2_1 601 607 PF00069 0.426
MOD_GlcNHglycan 1 4 PF01048 0.629
MOD_GlcNHglycan 149 152 PF01048 0.456
MOD_GlcNHglycan 332 335 PF01048 0.553
MOD_GlcNHglycan 484 487 PF01048 0.515
MOD_GlcNHglycan 560 563 PF01048 0.529
MOD_GlcNHglycan 747 750 PF01048 0.628
MOD_GlcNHglycan 751 754 PF01048 0.609
MOD_GSK3_1 136 143 PF00069 0.554
MOD_GSK3_1 166 173 PF00069 0.576
MOD_GSK3_1 394 401 PF00069 0.571
MOD_GSK3_1 41 48 PF00069 0.546
MOD_GSK3_1 558 565 PF00069 0.596
MOD_GSK3_1 640 647 PF00069 0.679
MOD_GSK3_1 7 14 PF00069 0.495
MOD_GSK3_1 745 752 PF00069 0.585
MOD_GSK3_1 759 766 PF00069 0.578
MOD_LATS_1 202 208 PF00433 0.501
MOD_N-GLC_1 398 403 PF02516 0.512
MOD_N-GLC_1 457 462 PF02516 0.601
MOD_NEK2_1 136 141 PF00069 0.518
MOD_NEK2_1 147 152 PF00069 0.447
MOD_NEK2_1 327 332 PF00069 0.485
MOD_NEK2_1 39 44 PF00069 0.590
MOD_NEK2_1 454 459 PF00069 0.554
MOD_NEK2_1 593 598 PF00069 0.503
MOD_NEK2_1 612 617 PF00069 0.589
MOD_NEK2_1 633 638 PF00069 0.698
MOD_PIKK_1 140 146 PF00454 0.616
MOD_PIKK_1 188 194 PF00454 0.601
MOD_PIKK_1 204 210 PF00454 0.366
MOD_PIKK_1 92 98 PF00454 0.517
MOD_PK_1 763 769 PF00069 0.725
MOD_PKA_2 634 640 PF00069 0.641
MOD_PKA_2 644 650 PF00069 0.683
MOD_PKA_2 695 701 PF00069 0.596
MOD_PKA_2 709 715 PF00069 0.598
MOD_PKA_2 753 759 PF00069 0.696
MOD_PKB_1 90 98 PF00069 0.537
MOD_Plk_1 279 285 PF00069 0.535
MOD_Plk_1 398 404 PF00069 0.506
MOD_Plk_4 136 142 PF00069 0.548
MOD_Plk_4 185 191 PF00069 0.680
MOD_Plk_4 21 27 PF00069 0.534
MOD_Plk_4 7 13 PF00069 0.513
MOD_ProDKin_1 417 423 PF00069 0.344
MOD_ProDKin_1 626 632 PF00069 0.679
MOD_ProDKin_1 640 646 PF00069 0.657
MOD_ProDKin_1 647 653 PF00069 0.665
MOD_ProDKin_1 674 680 PF00069 0.525
MOD_ProDKin_1 724 730 PF00069 0.468
MOD_SUMO_rev_2 379 384 PF00179 0.482
TRG_DiLeu_BaEn_1 127 132 PF01217 0.464
TRG_DiLeu_BaEn_1 450 455 PF01217 0.387
TRG_DiLeu_BaEn_4 109 115 PF01217 0.542
TRG_DiLeu_BaEn_4 671 677 PF01217 0.501
TRG_ENDOCYTIC_2 160 163 PF00928 0.523
TRG_ENDOCYTIC_2 218 221 PF00928 0.529
TRG_ENDOCYTIC_2 314 317 PF00928 0.374
TRG_ENDOCYTIC_2 352 355 PF00928 0.353
TRG_ENDOCYTIC_2 381 384 PF00928 0.482
TRG_ENDOCYTIC_2 493 496 PF00928 0.533
TRG_ENDOCYTIC_2 517 520 PF00928 0.480
TRG_ENDOCYTIC_2 551 554 PF00928 0.398
TRG_ENDOCYTIC_2 573 576 PF00928 0.622
TRG_ENDOCYTIC_2 704 707 PF00928 0.627
TRG_ER_diArg_1 463 466 PF00400 0.536
TRG_ER_diArg_1 707 710 PF00400 0.601
TRG_ER_diArg_1 714 716 PF00400 0.619
TRG_ER_diArg_1 90 93 PF00400 0.530
TRG_Pf-PMV_PEXEL_1 112 116 PF00026 0.548

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3D7 Leptomonas seymouri 79% 100%
A0A1X0NMP1 Trypanosomatidae 56% 96%
A0A3R7MX09 Trypanosoma rangeli 56% 97%
A0A3S5H6D5 Leishmania donovani 100% 100%
A4H5M9 Leishmania braziliensis 90% 100%
D0A9D0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 96%
E9AMQ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4QHX2 Leishmania major 97% 100%
V5BSM8 Trypanosoma cruzi 55% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS