Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTW5_LEIIN

TriTrypDb:

LINF_090011000

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.618
CLV_NRD_NRD_1	164	166	PF00675	0.527
CLV_NRD_NRD_1	168	170	PF00675	0.530
CLV_NRD_NRD_1	188	190	PF00675	0.626
CLV_NRD_NRD_1	197	199	PF00675	0.647
CLV_NRD_NRD_1	248	250	PF00675	0.700
CLV_NRD_NRD_1	55	57	PF00675	0.350
CLV_NRD_NRD_1	81	83	PF00675	0.471
CLV_PCSK_KEX2_1	108	110	PF00082	0.729
CLV_PCSK_KEX2_1	164	166	PF00082	0.527
CLV_PCSK_KEX2_1	168	170	PF00082	0.530
CLV_PCSK_KEX2_1	188	190	PF00082	0.647
CLV_PCSK_KEX2_1	247	249	PF00082	0.748
CLV_PCSK_KEX2_1	55	57	PF00082	0.366
CLV_PCSK_KEX2_1	81	83	PF00082	0.471
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.710
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.733
CLV_PCSK_PC7_1	104	110	PF00082	0.650
CLV_PCSK_PC7_1	164	170	PF00082	0.493
CLV_PCSK_SKI1_1	136	140	PF00082	0.350
CLV_PCSK_SKI1_1	297	301	PF00082	0.665
CLV_PCSK_SKI1_1	400	404	PF00082	0.593
CLV_PCSK_SKI1_1	82	86	PF00082	0.299
DEG_SCF_FBW7_1	274	281	PF00400	0.711
DOC_CKS1_1	275	280	PF01111	0.718
DOC_CYCLIN_RxL_1	133	143	PF00134	0.463
DOC_MAPK_gen_1	55	63	PF00069	0.361
DOC_MAPK_gen_1	81	88	PF00069	0.441
DOC_MAPK_MEF2A_6	19	26	PF00069	0.337
DOC_MAPK_MEF2A_6	56	65	PF00069	0.377
DOC_PP1_RVXF_1	134	140	PF00149	0.365
DOC_PP2B_LxvP_1	63	66	PF13499	0.359
DOC_PP4_FxxP_1	32	35	PF00568	0.483
DOC_PP4_FxxP_1	84	87	PF00568	0.462
DOC_USP7_MATH_1	15	19	PF00917	0.488
DOC_USP7_MATH_1	206	210	PF00917	0.640
DOC_USP7_MATH_1	250	254	PF00917	0.563
DOC_USP7_MATH_1	278	282	PF00917	0.723
DOC_USP7_MATH_1	306	310	PF00917	0.545
DOC_USP7_MATH_1	329	333	PF00917	0.447
DOC_USP7_MATH_1	4	8	PF00917	0.452
DOC_USP7_MATH_1	45	49	PF00917	0.389
DOC_WW_Pin1_4	146	151	PF00397	0.435
DOC_WW_Pin1_4	254	259	PF00397	0.725
DOC_WW_Pin1_4	274	279	PF00397	0.621
DOC_WW_Pin1_4	288	293	PF00397	0.780
DOC_WW_Pin1_4	34	39	PF00397	0.518
LIG_14-3-3_CanoR_1	19	23	PF00244	0.521
LIG_14-3-3_CanoR_1	198	203	PF00244	0.607
LIG_14-3-3_CanoR_1	205	213	PF00244	0.660
LIG_14-3-3_CanoR_1	249	259	PF00244	0.703
LIG_14-3-3_CanoR_1	44	50	PF00244	0.403
LIG_BIR_II_1	1	5	PF00653	0.500
LIG_BRCT_BRCA1_1	175	179	PF00533	0.630
LIG_EH_1	176	180	PF12763	0.650
LIG_FHA_1	115	121	PF00498	0.493
LIG_FHA_1	132	138	PF00498	0.490
LIG_FHA_1	151	157	PF00498	0.365
LIG_FHA_1	19	25	PF00498	0.294
LIG_FHA_1	222	228	PF00498	0.550
LIG_FHA_1	309	315	PF00498	0.434
LIG_FHA_1	342	348	PF00498	0.530
LIG_FHA_2	128	134	PF00498	0.524
LIG_FHA_2	284	290	PF00498	0.630
LIG_FHA_2	390	396	PF00498	0.579
LIG_FHA_2	65	71	PF00498	0.524
LIG_LIR_Apic_2	29	35	PF02991	0.456
LIG_LIR_Apic_2	83	87	PF02991	0.459
LIG_LIR_Gen_1	117	127	PF02991	0.493
LIG_LIR_Gen_1	317	327	PF02991	0.365
LIG_LIR_Nem_3	117	122	PF02991	0.441
LIG_LIR_Nem_3	157	162	PF02991	0.482
LIG_LIR_Nem_3	176	182	PF02991	0.637
LIG_LIR_Nem_3	317	322	PF02991	0.371
LIG_LIR_Nem_3	85	91	PF02991	0.432
LIG_MAD2	270	278	PF02301	0.536
LIG_Pex14_2	84	88	PF04695	0.470
LIG_PTB_Apo_2	74	81	PF02174	0.426
LIG_PTB_Phospho_1	74	80	PF10480	0.422
LIG_REV1ctd_RIR_1	400	404	PF16727	0.618
LIG_SH2_CRK	175	179	PF00017	0.580
LIG_SH2_CRK	319	323	PF00017	0.348
LIG_SH2_GRB2like	175	178	PF00017	0.576
LIG_SH2_GRB2like	90	93	PF00017	0.445
LIG_SH2_NCK_1	175	179	PF00017	0.580
LIG_SH2_NCK_1	319	323	PF00017	0.348
LIG_SH2_STAP1	116	120	PF00017	0.482
LIG_SH2_STAP1	223	227	PF00017	0.479
LIG_SH2_STAP1	319	323	PF00017	0.348
LIG_SH2_STAT5	116	119	PF00017	0.403
LIG_SH2_STAT5	223	226	PF00017	0.489
LIG_SH2_STAT5	341	344	PF00017	0.446
LIG_SH2_STAT5	361	364	PF00017	0.304
LIG_SH2_STAT5	39	42	PF00017	0.439
LIG_SH2_STAT5	46	49	PF00017	0.329
LIG_SH2_STAT5	90	93	PF00017	0.458
LIG_SH3_3	255	261	PF00018	0.640
LIG_SH3_3	32	38	PF00018	0.440
LIG_SH3_3	348	354	PF00018	0.515
LIG_SUMO_SIM_anti_2	368	374	PF11976	0.524
LIG_SUMO_SIM_par_1	152	157	PF11976	0.363
LIG_SUMO_SIM_par_1	2	10	PF11976	0.516
LIG_SUMO_SIM_par_1	309	315	PF11976	0.615
LIG_SUMO_SIM_par_1	320	326	PF11976	0.438
LIG_TRAF2_1	229	232	PF00917	0.589
LIG_TRAF2_1	392	395	PF00917	0.577
LIG_TYR_ITSM	115	122	PF00017	0.497
MOD_CK1_1	18	24	PF00069	0.395
MOD_CK1_1	253	259	PF00069	0.645
MOD_CK1_1	283	289	PF00069	0.650
MOD_CK1_1	334	340	PF00069	0.519
MOD_CK1_1	7	13	PF00069	0.426
MOD_CK2_1	329	335	PF00069	0.515
MOD_CK2_1	389	395	PF00069	0.594
MOD_CK2_1	64	70	PF00069	0.509
MOD_GlcNHglycan	101	104	PF01048	0.677
MOD_GlcNHglycan	2	5	PF01048	0.481
MOD_GlcNHglycan	208	211	PF01048	0.671
MOD_GlcNHglycan	252	255	PF01048	0.617
MOD_GlcNHglycan	282	285	PF01048	0.617
MOD_GlcNHglycan	330	334	PF01048	0.544
MOD_GSK3_1	127	134	PF00069	0.534
MOD_GSK3_1	146	153	PF00069	0.412
MOD_GSK3_1	250	257	PF00069	0.800
MOD_GSK3_1	274	281	PF00069	0.632
MOD_GSK3_1	304	311	PF00069	0.629
MOD_GSK3_1	329	336	PF00069	0.560
MOD_GSK3_1	389	396	PF00069	0.585
MOD_GSK3_1	45	52	PF00069	0.426
MOD_N-GLC_1	114	119	PF02516	0.518
MOD_N-GLC_1	127	132	PF02516	0.539
MOD_NEK2_1	26	31	PF00069	0.335
MOD_NEK2_1	308	313	PF00069	0.484
MOD_NEK2_1	50	55	PF00069	0.327
MOD_PKA_1	198	204	PF00069	0.572
MOD_PKA_2	18	24	PF00069	0.526
MOD_PKA_2	197	203	PF00069	0.566
MOD_PKB_1	196	204	PF00069	0.571
MOD_Plk_1	132	138	PF00069	0.464
MOD_Plk_1	317	323	PF00069	0.367
MOD_Plk_1	334	340	PF00069	0.411
MOD_Plk_1	82	88	PF00069	0.330
MOD_Plk_4	150	156	PF00069	0.380
MOD_Plk_4	317	323	PF00069	0.379
MOD_Plk_4	45	51	PF00069	0.415
MOD_ProDKin_1	146	152	PF00069	0.429
MOD_ProDKin_1	254	260	PF00069	0.727
MOD_ProDKin_1	274	280	PF00069	0.621
MOD_ProDKin_1	288	294	PF00069	0.785
MOD_ProDKin_1	34	40	PF00069	0.516
MOD_SUMO_for_1	342	345	PF00179	0.503
MOD_SUMO_rev_2	394	402	PF00179	0.602
TRG_DiLeu_BaEn_1	317	322	PF01217	0.394
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.508
TRG_ENDOCYTIC_2	119	122	PF00928	0.492
TRG_ENDOCYTIC_2	159	162	PF00928	0.542
TRG_ENDOCYTIC_2	223	226	PF00928	0.489
TRG_ENDOCYTIC_2	319	322	PF00928	0.349
TRG_ER_diArg_1	168	170	PF00400	0.583
TRG_ER_diArg_1	188	190	PF00400	0.604
TRG_ER_diArg_1	202	205	PF00400	0.641
TRG_ER_diArg_1	248	250	PF00400	0.667
TRG_ER_diArg_1	268	271	PF00400	0.710
TRG_ER_diArg_1	54	56	PF00400	0.348
TRG_ER_diArg_1	80	82	PF00400	0.441
TRG_NLS_MonoExtN_4	104	111	PF00514	0.624
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB46	Leptomonas seymouri	63%	100%
A0A1X0NNC7	Trypanosomatidae	32%	100%
A0A3Q8IAS3	Leishmania donovani	97%	97%
A4H5M8	Leishmania braziliensis	77%	96%
D0A9C9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AMQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	94%
Q4QHX3	Leishmania major	91%	100%