LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HTW2_LEIIN
TriTrypDb:
LINF_090010700
Length:
744

Annotations

Annotations by Jardim et al.

Transporters, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0005886 plasma membrane 3 1

Phosphorylation

Amastigote: 560, 6

Expansion

Sequence features

A4HTW2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTW2

Function

Biological processes
Term Name Level Count
GO:0032879 regulation of localization 3 6
GO:0034762 regulation of transmembrane transport 4 6
GO:0034765 regulation of monoatomic ion transmembrane transport 5 6
GO:0043269 regulation of monoatomic ion transport 5 6
GO:0050789 regulation of biological process 2 6
GO:0050794 regulation of cellular process 3 6
GO:0051049 regulation of transport 4 6
GO:0065007 biological regulation 1 6
GO:0006810 transport 3 1
GO:0006811 monoatomic ion transport 4 1
GO:0006812 monoatomic cation transport 5 1
GO:0006813 potassium ion transport 7 1
GO:0009987 cellular process 1 1
GO:0030001 metal ion transport 6 1
GO:0034220 monoatomic ion transmembrane transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0055085 transmembrane transport 2 1
GO:0071805 potassium ion transmembrane transport 6 1
GO:0098655 monoatomic cation transmembrane transport 4 1
GO:0098657 import into cell 4 1
GO:0098659 inorganic cation import across plasma membrane 5 1
GO:0098660 inorganic ion transmembrane transport 4 1
GO:0098662 inorganic cation transmembrane transport 5 1
GO:0098739 import across plasma membrane 3 1
GO:0099587 inorganic ion import across plasma membrane 4 1
GO:1990573 potassium ion import across plasma membrane 6 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 6
GO:0005216 monoatomic ion channel activity 4 6
GO:0005242 inward rectifier potassium channel activity 7 6
GO:0005244 voltage-gated monoatomic ion channel activity 4 6
GO:0005249 voltage-gated potassium channel activity 6 6
GO:0005261 monoatomic cation channel activity 5 6
GO:0005267 potassium channel activity 6 6
GO:0008324 monoatomic cation transmembrane transporter activity 4 6
GO:0015075 monoatomic ion transmembrane transporter activity 3 6
GO:0015079 potassium ion transmembrane transporter activity 6 6
GO:0015267 channel activity 4 6
GO:0015276 ligand-gated monoatomic ion channel activity 5 6
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 6
GO:0022803 passive transmembrane transporter activity 3 6
GO:0022832 voltage-gated channel activity 6 6
GO:0022834 ligand-gated channel activity 6 6
GO:0022836 gated channel activity 5 6
GO:0022843 voltage-gated monoatomic cation channel activity 5 6
GO:0022857 transmembrane transporter activity 2 6
GO:0022890 inorganic cation transmembrane transporter activity 4 6
GO:0046873 metal ion transmembrane transporter activity 5 6
GO:0099094 ligand-gated monoatomic cation channel activity 6 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 192 196 PF00656 0.670
CLV_C14_Caspase3-7 417 421 PF00656 0.541
CLV_C14_Caspase3-7 516 520 PF00656 0.544
CLV_NRD_NRD_1 399 401 PF00675 0.718
CLV_NRD_NRD_1 423 425 PF00675 0.772
CLV_NRD_NRD_1 498 500 PF00675 0.753
CLV_PCSK_FUR_1 496 500 PF00082 0.710
CLV_PCSK_KEX2_1 357 359 PF00082 0.857
CLV_PCSK_KEX2_1 399 401 PF00082 0.716
CLV_PCSK_KEX2_1 423 425 PF00082 0.790
CLV_PCSK_KEX2_1 498 500 PF00082 0.708
CLV_PCSK_KEX2_1 558 560 PF00082 0.819
CLV_PCSK_KEX2_1 691 693 PF00082 0.699
CLV_PCSK_PC1ET2_1 357 359 PF00082 0.857
CLV_PCSK_PC1ET2_1 558 560 PF00082 0.819
CLV_PCSK_PC1ET2_1 691 693 PF00082 0.699
CLV_PCSK_PC7_1 395 401 PF00082 0.717
CLV_PCSK_SKI1_1 12 16 PF00082 0.637
CLV_PCSK_SKI1_1 239 243 PF00082 0.672
CLV_PCSK_SKI1_1 259 263 PF00082 0.674
CLV_PCSK_SKI1_1 305 309 PF00082 0.757
CLV_PCSK_SKI1_1 358 362 PF00082 0.804
CLV_PCSK_SKI1_1 635 639 PF00082 0.589
CLV_PCSK_SKI1_1 84 88 PF00082 0.570
DEG_Nend_Nbox_1 1 3 PF02207 0.843
DEG_SPOP_SBC_1 491 495 PF00917 0.598
DOC_CYCLIN_yCln2_LP_2 29 35 PF00134 0.647
DOC_CYCLIN_yCln2_LP_2 618 624 PF00134 0.439
DOC_MAPK_gen_1 202 210 PF00069 0.580
DOC_MAPK_gen_1 610 618 PF00069 0.486
DOC_MAPK_HePTP_8 628 640 PF00069 0.492
DOC_MAPK_MEF2A_6 25 33 PF00069 0.717
DOC_MAPK_MEF2A_6 586 595 PF00069 0.488
DOC_MAPK_MEF2A_6 631 640 PF00069 0.495
DOC_PP1_RVXF_1 237 243 PF00149 0.485
DOC_PP1_RVXF_1 257 263 PF00149 0.479
DOC_PP2B_LxvP_1 29 32 PF13499 0.765
DOC_PP2B_LxvP_1 638 641 PF13499 0.524
DOC_PP4_FxxP_1 34 37 PF00568 0.815
DOC_USP7_MATH_1 375 379 PF00917 0.639
DOC_USP7_MATH_1 436 440 PF00917 0.528
DOC_USP7_MATH_1 457 461 PF00917 0.617
DOC_USP7_MATH_1 477 481 PF00917 0.507
DOC_USP7_MATH_1 485 489 PF00917 0.508
DOC_USP7_MATH_1 491 495 PF00917 0.598
DOC_USP7_MATH_1 526 530 PF00917 0.597
DOC_USP7_MATH_1 569 573 PF00917 0.630
DOC_USP7_MATH_1 714 718 PF00917 0.490
DOC_USP7_MATH_1 73 77 PF00917 0.780
DOC_USP7_UBL2_3 357 361 PF12436 0.632
DOC_WW_Pin1_4 418 423 PF00397 0.639
DOC_WW_Pin1_4 506 511 PF00397 0.605
DOC_WW_Pin1_4 52 57 PF00397 0.817
DOC_WW_Pin1_4 539 544 PF00397 0.577
DOC_WW_Pin1_4 557 562 PF00397 0.515
DOC_WW_Pin1_4 576 581 PF00397 0.417
DOC_WW_Pin1_4 629 634 PF00397 0.517
DOC_WW_Pin1_4 71 76 PF00397 0.575
LIG_14-3-3_CanoR_1 106 114 PF00244 0.678
LIG_14-3-3_CanoR_1 118 123 PF00244 0.660
LIG_14-3-3_CanoR_1 202 210 PF00244 0.580
LIG_14-3-3_CanoR_1 239 248 PF00244 0.473
LIG_14-3-3_CanoR_1 3 8 PF00244 0.839
LIG_14-3-3_CanoR_1 302 308 PF00244 0.441
LIG_14-3-3_CanoR_1 365 370 PF00244 0.614
LIG_14-3-3_CanoR_1 426 436 PF00244 0.640
LIG_14-3-3_CanoR_1 448 457 PF00244 0.550
LIG_14-3-3_CanoR_1 599 607 PF00244 0.542
LIG_14-3-3_CanoR_1 613 619 PF00244 0.309
LIG_14-3-3_CanoR_1 81 90 PF00244 0.801
LIG_APCC_ABBA_1 634 639 PF00400 0.522
LIG_APCC_ABBA_1 710 715 PF00400 0.485
LIG_BRCT_BRCA1_1 478 482 PF00533 0.569
LIG_BRCT_BRCA1_1 551 555 PF00533 0.544
LIG_BRCT_BRCA1_1 79 83 PF00533 0.745
LIG_CtBP_PxDLS_1 731 735 PF00389 0.519
LIG_deltaCOP1_diTrp_1 256 262 PF00928 0.432
LIG_EH1_1 143 151 PF00400 0.530
LIG_eIF4E_1 144 150 PF01652 0.530
LIG_FHA_1 107 113 PF00498 0.575
LIG_FHA_1 132 138 PF00498 0.630
LIG_FHA_1 203 209 PF00498 0.636
LIG_FHA_1 231 237 PF00498 0.524
LIG_FHA_1 316 322 PF00498 0.475
LIG_FHA_1 93 99 PF00498 0.784
LIG_FHA_2 190 196 PF00498 0.678
LIG_FHA_2 604 610 PF00498 0.524
LIG_FHA_2 678 684 PF00498 0.513
LIG_FHA_2 693 699 PF00498 0.431
LIG_FHA_2 738 744 PF00498 0.633
LIG_GBD_Chelix_1 141 149 PF00786 0.433
LIG_Integrin_isoDGR_2 104 106 PF01839 0.374
LIG_KLC1_Yacidic_2 605 609 PF13176 0.522
LIG_LIR_Apic_2 655 661 PF02991 0.408
LIG_LIR_Gen_1 130 141 PF02991 0.636
LIG_LIR_Gen_1 212 221 PF02991 0.530
LIG_LIR_Gen_1 243 252 PF02991 0.484
LIG_LIR_Gen_1 542 551 PF02991 0.479
LIG_LIR_Gen_1 722 731 PF02991 0.495
LIG_LIR_Nem_3 116 122 PF02991 0.758
LIG_LIR_Nem_3 123 128 PF02991 0.621
LIG_LIR_Nem_3 130 136 PF02991 0.470
LIG_LIR_Nem_3 138 142 PF02991 0.282
LIG_LIR_Nem_3 170 176 PF02991 0.530
LIG_LIR_Nem_3 212 216 PF02991 0.530
LIG_LIR_Nem_3 243 248 PF02991 0.471
LIG_LIR_Nem_3 256 261 PF02991 0.327
LIG_LIR_Nem_3 542 547 PF02991 0.481
LIG_LIR_Nem_3 722 726 PF02991 0.498
LIG_Pex14_1 258 262 PF04695 0.477
LIG_PTB_Apo_2 212 219 PF02174 0.530
LIG_SH2_CRK 139 143 PF00017 0.452
LIG_SH2_CRK 658 662 PF00017 0.405
LIG_SH2_GRB2like 213 216 PF00017 0.530
LIG_SH2_GRB2like 694 697 PF00017 0.453
LIG_SH2_GRB2like 725 728 PF00017 0.486
LIG_SH2_PTP2 213 216 PF00017 0.530
LIG_SH2_SRC 144 147 PF00017 0.530
LIG_SH2_SRC 213 216 PF00017 0.530
LIG_SH2_STAP1 139 143 PF00017 0.530
LIG_SH2_STAT5 126 129 PF00017 0.694
LIG_SH2_STAT5 144 147 PF00017 0.232
LIG_SH2_STAT5 173 176 PF00017 0.530
LIG_SH2_STAT5 213 216 PF00017 0.530
LIG_SH2_STAT5 232 235 PF00017 0.480
LIG_SH2_STAT5 607 610 PF00017 0.527
LIG_SH2_STAT5 694 697 PF00017 0.436
LIG_SH2_STAT5 725 728 PF00017 0.394
LIG_SH3_1 367 373 PF00018 0.517
LIG_SH3_3 367 373 PF00018 0.629
LIG_SH3_3 568 574 PF00018 0.552
LIG_SH3_3 630 636 PF00018 0.434
LIG_SH3_5 99 103 PF00018 0.665
LIG_Sin3_3 223 230 PF02671 0.601
LIG_SUMO_SIM_par_1 133 138 PF11976 0.501
LIG_SUMO_SIM_par_1 146 152 PF11976 0.336
LIG_SUMO_SIM_par_1 205 212 PF11976 0.530
LIG_SUMO_SIM_par_1 672 678 PF11976 0.475
LIG_TRAF2_1 531 534 PF00917 0.552
LIG_TYR_ITIM 137 142 PF00017 0.452
LIG_WRC_WIRS_1 114 119 PF05994 0.706
MOD_CDC14_SPxK_1 421 424 PF00782 0.704
MOD_CDC14_SPxK_1 632 635 PF00782 0.504
MOD_CDK_SPK_2 418 423 PF00069 0.676
MOD_CDK_SPK_2 506 511 PF00069 0.768
MOD_CDK_SPxK_1 418 424 PF00069 0.706
MOD_CDK_SPxK_1 629 635 PF00069 0.527
MOD_CK1_1 313 319 PF00069 0.722
MOD_CK1_1 378 384 PF00069 0.786
MOD_CK1_1 388 394 PF00069 0.617
MOD_CK1_1 430 436 PF00069 0.658
MOD_CK1_1 444 450 PF00069 0.734
MOD_CK1_1 452 458 PF00069 0.719
MOD_CK1_1 460 466 PF00069 0.801
MOD_CK1_1 468 474 PF00069 0.764
MOD_CK1_1 476 482 PF00069 0.641
MOD_CK1_1 484 490 PF00069 0.561
MOD_CK1_1 494 500 PF00069 0.693
MOD_CK1_1 509 515 PF00069 0.643
MOD_CK1_1 528 534 PF00069 0.815
MOD_CK1_1 542 548 PF00069 0.695
MOD_CK1_1 646 652 PF00069 0.633
MOD_CK1_1 686 692 PF00069 0.637
MOD_CK1_1 74 80 PF00069 0.731
MOD_CK2_1 225 231 PF00069 0.530
MOD_CK2_1 528 534 PF00069 0.741
MOD_CK2_1 576 582 PF00069 0.616
MOD_CK2_1 677 683 PF00069 0.463
MOD_CK2_1 735 741 PF00069 0.758
MOD_Cter_Amidation 556 559 PF01082 0.707
MOD_GlcNHglycan 169 172 PF01048 0.530
MOD_GlcNHglycan 315 318 PF01048 0.670
MOD_GlcNHglycan 367 370 PF01048 0.745
MOD_GlcNHglycan 377 380 PF01048 0.786
MOD_GlcNHglycan 385 390 PF01048 0.645
MOD_GlcNHglycan 409 412 PF01048 0.846
MOD_GlcNHglycan 45 48 PF01048 0.721
MOD_GlcNHglycan 451 454 PF01048 0.727
MOD_GlcNHglycan 465 468 PF01048 0.592
MOD_GlcNHglycan 475 478 PF01048 0.755
MOD_GlcNHglycan 483 486 PF01048 0.729
MOD_GlcNHglycan 487 490 PF01048 0.682
MOD_GlcNHglycan 49 52 PF01048 0.684
MOD_GlcNHglycan 515 518 PF01048 0.757
MOD_GlcNHglycan 58 61 PF01048 0.515
MOD_GlcNHglycan 648 651 PF01048 0.608
MOD_GlcNHglycan 652 655 PF01048 0.622
MOD_GlcNHglycan 685 688 PF01048 0.473
MOD_GlcNHglycan 84 87 PF01048 0.696
MOD_GSK3_1 127 134 PF00069 0.565
MOD_GSK3_1 240 247 PF00069 0.582
MOD_GSK3_1 311 318 PF00069 0.628
MOD_GSK3_1 35 42 PF00069 0.731
MOD_GSK3_1 361 368 PF00069 0.797
MOD_GSK3_1 409 416 PF00069 0.777
MOD_GSK3_1 43 50 PF00069 0.701
MOD_GSK3_1 451 458 PF00069 0.793
MOD_GSK3_1 459 466 PF00069 0.741
MOD_GSK3_1 468 475 PF00069 0.722
MOD_GSK3_1 477 484 PF00069 0.609
MOD_GSK3_1 485 492 PF00069 0.537
MOD_GSK3_1 509 516 PF00069 0.637
MOD_GSK3_1 52 59 PF00069 0.491
MOD_GSK3_1 525 532 PF00069 0.583
MOD_GSK3_1 557 564 PF00069 0.679
MOD_GSK3_1 646 653 PF00069 0.580
MOD_GSK3_1 67 74 PF00069 0.600
MOD_GSK3_1 677 684 PF00069 0.470
MOD_GSK3_1 686 693 PF00069 0.643
MOD_GSK3_1 735 742 PF00069 0.765
MOD_GSK3_1 88 95 PF00069 0.680
MOD_LATS_1 359 365 PF00433 0.749
MOD_N-GLC_1 526 531 PF02516 0.666
MOD_NEK2_1 1 6 PF00069 0.604
MOD_NEK2_1 127 132 PF00069 0.598
MOD_NEK2_1 149 154 PF00069 0.483
MOD_NEK2_1 209 214 PF00069 0.530
MOD_NEK2_1 225 230 PF00069 0.285
MOD_NEK2_1 24 29 PF00069 0.721
MOD_NEK2_1 301 306 PF00069 0.706
MOD_NEK2_1 310 315 PF00069 0.682
MOD_NEK2_1 407 412 PF00069 0.842
MOD_NEK2_1 473 478 PF00069 0.749
MOD_NEK2_1 483 488 PF00069 0.634
MOD_NEK2_1 598 603 PF00069 0.646
MOD_NEK2_2 113 118 PF00069 0.709
MOD_PIKK_1 127 133 PF00454 0.599
MOD_PIKK_1 509 515 PF00454 0.634
MOD_PIKK_1 529 535 PF00454 0.699
MOD_PKA_2 105 111 PF00069 0.368
MOD_PKA_2 301 307 PF00069 0.666
MOD_PKA_2 458 464 PF00069 0.738
MOD_PKA_2 598 604 PF00069 0.655
MOD_PKA_2 88 94 PF00069 0.677
MOD_PKB_1 118 126 PF00069 0.673
MOD_Plk_1 194 200 PF00069 0.579
MOD_Plk_1 468 474 PF00069 0.764
MOD_Plk_1 526 532 PF00069 0.750
MOD_Plk_2-3 189 195 PF00069 0.586
MOD_Plk_4 120 126 PF00069 0.663
MOD_Plk_4 137 143 PF00069 0.249
MOD_Plk_4 209 215 PF00069 0.530
MOD_Plk_4 24 30 PF00069 0.723
MOD_Plk_4 603 609 PF00069 0.664
MOD_Plk_4 614 620 PF00069 0.448
MOD_Plk_4 74 80 PF00069 0.743
MOD_ProDKin_1 418 424 PF00069 0.816
MOD_ProDKin_1 506 512 PF00069 0.766
MOD_ProDKin_1 52 58 PF00069 0.783
MOD_ProDKin_1 539 545 PF00069 0.727
MOD_ProDKin_1 557 563 PF00069 0.639
MOD_ProDKin_1 576 582 PF00069 0.504
MOD_ProDKin_1 629 635 PF00069 0.643
MOD_ProDKin_1 71 77 PF00069 0.435
MOD_SUMO_rev_2 19 27 PF00179 0.722
TRG_DiLeu_BaLyEn_6 53 58 PF01217 0.703
TRG_ENDOCYTIC_2 139 142 PF00928 0.510
TRG_ENDOCYTIC_2 144 147 PF00928 0.467
TRG_ENDOCYTIC_2 173 176 PF00928 0.530
TRG_ENDOCYTIC_2 213 216 PF00928 0.530
TRG_ER_diArg_1 201 204 PF00400 0.527
TRG_ER_diArg_1 422 424 PF00400 0.674
TRG_ER_diArg_1 496 499 PF00400 0.633
TRG_NLS_MonoExtN_4 354 360 PF00514 0.750

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WQM3 Leishmania donovani 100% 100%
A4H5M5 Leishmania braziliensis 62% 90%
E9AMP9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 98%
Q4QHX6 Leishmania major 88% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS