Hypothetical tetratricopeptide repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat - putative

Species:

Leishmania infantum

UniProt:

A4HTV8_LEIIN

TriTrypDb:

LINF_090010300

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0034464	BBSome	2	12
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0030666	endocytic vesicle membrane	5	1
GO:0030669	clathrin-coated endocytic vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0060170	ciliary membrane	5	1
GO:0097730	non-motile cilium	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HTV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTV8

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0044782	cilium organization	5	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12
GO:1905515	non-motile cilium assembly	7	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.508
CLV_NRD_NRD_1	29	31	PF00675	0.343
CLV_NRD_NRD_1	470	472	PF00675	0.358
CLV_NRD_NRD_1	564	566	PF00675	0.498
CLV_NRD_NRD_1	571	573	PF00675	0.483
CLV_PCSK_FUR_1	27	31	PF00082	0.312
CLV_PCSK_KEX2_1	27	29	PF00082	0.369
CLV_PCSK_KEX2_1	470	472	PF00082	0.358
CLV_PCSK_KEX2_1	564	566	PF00082	0.542
CLV_PCSK_KEX2_1	571	573	PF00082	0.500
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.479
CLV_PCSK_SKI1_1	180	184	PF00082	0.542
CLV_PCSK_SKI1_1	195	199	PF00082	0.561
CLV_PCSK_SKI1_1	236	240	PF00082	0.377
CLV_PCSK_SKI1_1	247	251	PF00082	0.494
CLV_PCSK_SKI1_1	313	317	PF00082	0.432
CLV_PCSK_SKI1_1	329	333	PF00082	0.286
CLV_PCSK_SKI1_1	470	474	PF00082	0.365
CLV_PCSK_SKI1_1	571	575	PF00082	0.505
DEG_SPOP_SBC_1	339	343	PF00917	0.462
DOC_ANK_TNKS_1	170	177	PF00023	0.689
DOC_CKS1_1	252	257	PF01111	0.629
DOC_CYCLIN_RxL_1	565	576	PF00134	0.513
DOC_MAPK_gen_1	234	241	PF00069	0.415
DOC_MAPK_gen_1	27	37	PF00069	0.356
DOC_MAPK_gen_1	313	323	PF00069	0.427
DOC_MAPK_gen_1	467	477	PF00069	0.374
DOC_MAPK_gen_1	627	635	PF00069	0.516
DOC_MAPK_MEF2A_6	234	241	PF00069	0.415
DOC_MAPK_MEF2A_6	250	259	PF00069	0.590
DOC_MAPK_MEF2A_6	459	466	PF00069	0.399
DOC_PP2B_LxvP_1	284	287	PF13499	0.713
DOC_PP2B_LxvP_1	579	582	PF13499	0.540
DOC_PP4_FxxP_1	336	339	PF00568	0.563
DOC_USP7_MATH_1	106	110	PF00917	0.512
DOC_USP7_MATH_1	114	118	PF00917	0.429
DOC_USP7_MATH_1	150	154	PF00917	0.531
DOC_USP7_MATH_1	258	262	PF00917	0.729
DOC_USP7_MATH_1	291	295	PF00917	0.709
DOC_USP7_MATH_1	350	354	PF00917	0.720
DOC_USP7_UBL2_3	385	389	PF12436	0.315
DOC_USP7_UBL2_3	564	568	PF12436	0.560
DOC_WW_Pin1_4	251	256	PF00397	0.621
DOC_WW_Pin1_4	335	340	PF00397	0.387
DOC_WW_Pin1_4	44	49	PF00397	0.560
DOC_WW_Pin1_4	50	55	PF00397	0.593
DOC_WW_Pin1_4	58	63	PF00397	0.530
LIG_14-3-3_CanoR_1	113	119	PF00244	0.482
LIG_14-3-3_CanoR_1	140	150	PF00244	0.563
LIG_14-3-3_CanoR_1	501	509	PF00244	0.439
LIG_Actin_WH2_2	104	121	PF00022	0.593
LIG_Actin_WH2_2	182	197	PF00022	0.667
LIG_Actin_WH2_2	234	249	PF00022	0.520
LIG_Actin_WH2_2	317	334	PF00022	0.475
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_BRCT_BRCA1_1	63	67	PF00533	0.609
LIG_BRCT_BRCA1_1	70	74	PF00533	0.500
LIG_Clathr_ClatBox_1	228	232	PF01394	0.379
LIG_deltaCOP1_diTrp_1	307	310	PF00928	0.395
LIG_eIF4E_1	20	26	PF01652	0.325
LIG_eIF4E_1	330	336	PF01652	0.452
LIG_FHA_1	189	195	PF00498	0.561
LIG_FHA_1	241	247	PF00498	0.488
LIG_FHA_1	252	258	PF00498	0.671
LIG_FHA_1	288	294	PF00498	0.591
LIG_FHA_1	37	43	PF00498	0.379
LIG_FHA_1	375	381	PF00498	0.473
LIG_FHA_1	477	483	PF00498	0.372
LIG_FHA_1	574	580	PF00498	0.477
LIG_FHA_1	583	589	PF00498	0.408
LIG_FHA_2	393	399	PF00498	0.341
LIG_FHA_2	427	433	PF00498	0.468
LIG_FHA_2	547	553	PF00498	0.508
LIG_GBD_Chelix_1	220	228	PF00786	0.359
LIG_LIR_Gen_1	183	194	PF02991	0.604
LIG_LIR_Gen_1	38	48	PF02991	0.421
LIG_LIR_Gen_1	432	440	PF02991	0.428
LIG_LIR_Gen_1	480	491	PF02991	0.337
LIG_LIR_Gen_1	602	612	PF02991	0.412
LIG_LIR_Gen_1	630	635	PF02991	0.492
LIG_LIR_Nem_3	17	23	PF02991	0.329
LIG_LIR_Nem_3	183	189	PF02991	0.607
LIG_LIR_Nem_3	226	230	PF02991	0.422
LIG_LIR_Nem_3	38	44	PF02991	0.385
LIG_LIR_Nem_3	429	434	PF02991	0.408
LIG_LIR_Nem_3	518	523	PF02991	0.296
LIG_LIR_Nem_3	602	608	PF02991	0.385
LIG_LIR_Nem_3	630	635	PF02991	0.492
LIG_MYND_1	10	14	PF01753	0.462
LIG_PDZ_Class_2	630	635	PF00595	0.525
LIG_PTAP_UEV_1	259	264	PF05743	0.635
LIG_PTB_Apo_2	529	536	PF02174	0.415
LIG_SH2_CRK	157	161	PF00017	0.549
LIG_SH2_CRK	434	438	PF00017	0.384
LIG_SH2_CRK	469	473	PF00017	0.349
LIG_SH2_CRK	605	609	PF00017	0.388
LIG_SH2_NCK_1	157	161	PF00017	0.607
LIG_SH2_NCK_1	86	90	PF00017	0.535
LIG_SH2_SRC	230	233	PF00017	0.411
LIG_SH2_SRC	86	89	PF00017	0.525
LIG_SH2_STAP1	21	25	PF00017	0.317
LIG_SH2_STAP1	400	404	PF00017	0.420
LIG_SH2_STAP1	492	496	PF00017	0.363
LIG_SH2_STAT3	492	495	PF00017	0.370
LIG_SH2_STAT5	227	230	PF00017	0.369
LIG_SH2_STAT5	330	333	PF00017	0.467
LIG_SH2_STAT5	387	390	PF00017	0.420
LIG_SH2_STAT5	41	44	PF00017	0.399
LIG_SH2_STAT5	492	495	PF00017	0.491
LIG_SH3_3	245	251	PF00018	0.566
LIG_SH3_3	252	258	PF00018	0.632
LIG_SH3_3	4	10	PF00018	0.492
LIG_SH3_3	613	619	PF00018	0.413
LIG_TRAF2_1	295	298	PF00917	0.688
LIG_TYR_ITIM	603	608	PF00017	0.445
LIG_WRC_WIRS_1	491	496	PF05994	0.492
LIG_WRC_WIRS_1	593	598	PF05994	0.437
MOD_CDK_SPK_2	44	49	PF00069	0.436
MOD_CK1_1	169	175	PF00069	0.652
MOD_CK1_1	193	199	PF00069	0.612
MOD_CK1_1	338	344	PF00069	0.661
MOD_CK2_1	392	398	PF00069	0.325
MOD_CK2_1	440	446	PF00069	0.374
MOD_CK2_1	546	552	PF00069	0.498
MOD_Cter_Amidation	569	572	PF01082	0.505
MOD_GlcNHglycan	143	146	PF01048	0.645
MOD_GlcNHglycan	171	174	PF01048	0.617
MOD_GlcNHglycan	260	263	PF01048	0.680
MOD_GlcNHglycan	293	296	PF01048	0.665
MOD_GlcNHglycan	360	364	PF01048	0.674
MOD_GlcNHglycan	544	547	PF01048	0.369
MOD_GlcNHglycan	63	66	PF01048	0.627
MOD_GSK3_1	287	294	PF00069	0.678
MOD_GSK3_1	335	342	PF00069	0.596
MOD_GSK3_1	36	43	PF00069	0.433
MOD_GSK3_1	392	399	PF00069	0.432
MOD_GSK3_1	477	484	PF00069	0.505
MOD_GSK3_1	542	549	PF00069	0.435
MOD_GSK3_1	57	64	PF00069	0.651
MOD_GSK3_1	588	595	PF00069	0.438
MOD_N-GLC_1	114	119	PF02516	0.563
MOD_N-GLC_1	375	380	PF02516	0.503
MOD_NEK2_1	141	146	PF00069	0.627
MOD_NEK2_1	440	445	PF00069	0.389
MOD_NEK2_1	496	501	PF00069	0.353
MOD_NEK2_1	573	578	PF00069	0.441
MOD_NEK2_1	588	593	PF00069	0.415
MOD_NEK2_1	601	606	PF00069	0.481
MOD_NEK2_1	68	73	PF00069	0.478
MOD_NEK2_1	74	79	PF00069	0.341
MOD_NEK2_2	114	119	PF00069	0.575
MOD_NEK2_2	190	195	PF00069	0.676
MOD_PIKK_1	511	517	PF00454	0.524
MOD_PK_1	166	172	PF00069	0.685
MOD_Plk_1	114	120	PF00069	0.584
MOD_Plk_1	375	381	PF00069	0.500
MOD_Plk_1	496	502	PF00069	0.454
MOD_Plk_1	601	607	PF00069	0.469
MOD_Plk_1	68	74	PF00069	0.493
MOD_Plk_4	21	27	PF00069	0.347
MOD_Plk_4	375	381	PF00069	0.500
MOD_Plk_4	68	74	PF00069	0.506
MOD_Plk_4	81	87	PF00069	0.388
MOD_ProDKin_1	251	257	PF00069	0.624
MOD_ProDKin_1	335	341	PF00069	0.399
MOD_ProDKin_1	44	50	PF00069	0.572
MOD_ProDKin_1	58	64	PF00069	0.522
MOD_SUMO_rev_2	226	235	PF00179	0.474
TRG_DiLeu_BaEn_2	69	75	PF01217	0.429
TRG_DiLeu_BaLyEn_6	468	473	PF01217	0.366
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.494
TRG_ENDOCYTIC_2	20	23	PF00928	0.342
TRG_ENDOCYTIC_2	387	390	PF00928	0.384
TRG_ENDOCYTIC_2	41	44	PF00928	0.399
TRG_ENDOCYTIC_2	434	437	PF00928	0.417
TRG_ENDOCYTIC_2	469	472	PF00928	0.350
TRG_ENDOCYTIC_2	605	608	PF00928	0.367
TRG_ER_diArg_1	26	29	PF00400	0.354
TRG_ER_diArg_1	469	471	PF00400	0.359
TRG_ER_diArg_1	571	573	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	571	575	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	610	615	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKM3	Leptomonas seymouri	69%	95%
A0A0S4IWH2	Bodo saltans	38%	100%
A0A1X0NMP5	Trypanosomatidae	45%	100%
A0A3S5H6D1	Leishmania donovani	100%	100%
A0A422NV89	Trypanosoma rangeli	45%	100%
A4H5M0	Leishmania braziliensis	87%	100%
D0A9C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AMP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
Q23049	Caenorhabditis elegans	29%	100%
Q4QHY0	Leishmania major	94%	100%
Q8TAM2	Homo sapiens	32%	100%
Q8VD72	Mus musculus	30%	100%
V5DJG5	Trypanosoma cruzi	44%	100%