LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Plus-3 domain/Zinc finger- C3HC4 type (RING finger) containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HTV7_LEIIN
TriTrypDb:
LINF_090010200
Length:
467

Annotations

Annotations by Jardim et al.

Metal Binding, Zinc finger, C3HC4 type (RING finger), putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTV7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTV7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 8
GO:0003677 DNA binding 4 8
GO:0005488 binding 1 8
GO:0097159 organic cyclic compound binding 2 8
GO:1901363 heterocyclic compound binding 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 226 230 PF00656 0.730
CLV_C14_Caspase3-7 333 337 PF00656 0.635
CLV_NRD_NRD_1 201 203 PF00675 0.718
CLV_NRD_NRD_1 233 235 PF00675 0.702
CLV_NRD_NRD_1 366 368 PF00675 0.532
CLV_PCSK_FUR_1 199 203 PF00082 0.726
CLV_PCSK_KEX2_1 14 16 PF00082 0.455
CLV_PCSK_KEX2_1 201 203 PF00082 0.722
CLV_PCSK_KEX2_1 233 235 PF00082 0.702
CLV_PCSK_KEX2_1 366 368 PF00082 0.564
CLV_PCSK_PC1ET2_1 14 16 PF00082 0.455
CLV_PCSK_SKI1_1 136 140 PF00082 0.565
CLV_PCSK_SKI1_1 319 323 PF00082 0.831
CLV_PCSK_SKI1_1 350 354 PF00082 0.739
CLV_PCSK_SKI1_1 42 46 PF00082 0.401
DEG_APCC_DBOX_1 114 122 PF00400 0.429
DEG_COP1_1 124 132 PF00400 0.569
DEG_Nend_Nbox_1 1 3 PF02207 0.608
DEG_SPOP_SBC_1 342 346 PF00917 0.752
DOC_CYCLIN_RxL_1 39 49 PF00134 0.401
DOC_CYCLIN_yCln2_LP_2 213 216 PF00134 0.744
DOC_CYCLIN_yCln2_LP_2 87 93 PF00134 0.526
DOC_MAPK_MEF2A_6 122 129 PF00069 0.590
DOC_PP2B_LxvP_1 127 130 PF13499 0.573
DOC_PP2B_LxvP_1 213 216 PF13499 0.744
DOC_PP2B_LxvP_1 443 446 PF13499 0.401
DOC_PP2B_LxvP_1 45 48 PF13499 0.455
DOC_PP2B_LxvP_1 85 88 PF13499 0.401
DOC_PP4_FxxP_1 322 325 PF00568 0.612
DOC_USP7_MATH_1 158 162 PF00917 0.844
DOC_USP7_MATH_1 16 20 PF00917 0.480
DOC_USP7_MATH_1 206 210 PF00917 0.672
DOC_USP7_MATH_1 251 255 PF00917 0.726
DOC_USP7_MATH_1 257 261 PF00917 0.613
DOC_USP7_MATH_1 301 305 PF00917 0.729
DOC_USP7_MATH_1 309 313 PF00917 0.680
DOC_USP7_MATH_1 332 336 PF00917 0.812
DOC_USP7_MATH_1 343 347 PF00917 0.652
LIG_14-3-3_CanoR_1 20 27 PF00244 0.455
LIG_14-3-3_CanoR_1 201 206 PF00244 0.688
LIG_14-3-3_CanoR_1 233 240 PF00244 0.694
LIG_14-3-3_CanoR_1 350 355 PF00244 0.732
LIG_14-3-3_CanoR_1 58 68 PF00244 0.526
LIG_BIR_III_4 386 390 PF00653 0.574
LIG_BRCT_BRCA1_1 6 10 PF00533 0.541
LIG_FHA_1 124 130 PF00498 0.569
LIG_FHA_1 137 143 PF00498 0.643
LIG_FHA_1 209 215 PF00498 0.742
LIG_FHA_1 427 433 PF00498 0.427
LIG_FHA_1 448 454 PF00498 0.435
LIG_FHA_1 76 82 PF00498 0.442
LIG_FHA_2 47 53 PF00498 0.512
LIG_FHA_2 61 67 PF00498 0.322
LIG_Integrin_isoDGR_2 165 167 PF01839 0.710
LIG_LIR_Apic_2 320 325 PF02991 0.613
LIG_LIR_Gen_1 116 125 PF02991 0.521
LIG_LIR_Gen_1 79 90 PF02991 0.401
LIG_LIR_Nem_3 66 71 PF02991 0.377
LIG_LIR_Nem_3 79 85 PF02991 0.401
LIG_PDZ_Class_3 462 467 PF00595 0.606
LIG_SH2_NCK_1 306 310 PF00017 0.826
LIG_SH2_STAT5 306 309 PF00017 0.787
LIG_SH2_STAT5 405 408 PF00017 0.539
LIG_SH2_STAT5 54 57 PF00017 0.401
LIG_SH2_STAT5 82 85 PF00017 0.401
LIG_SH3_3 174 180 PF00018 0.702
LIG_SH3_3 378 384 PF00018 0.513
LIG_SH3_3 443 449 PF00018 0.498
LIG_SUMO_SIM_anti_2 429 434 PF11976 0.455
LIG_TRAF2_1 312 315 PF00917 0.691
LIG_WRC_WIRS_1 302 307 PF05994 0.600
MOD_CK1_1 105 111 PF00069 0.455
MOD_CK1_1 154 160 PF00069 0.709
MOD_CK1_1 161 167 PF00069 0.735
MOD_CK1_1 19 25 PF00069 0.480
MOD_CK1_1 208 214 PF00069 0.747
MOD_CK1_1 253 259 PF00069 0.775
MOD_CK1_1 304 310 PF00069 0.696
MOD_CK1_1 346 352 PF00069 0.730
MOD_CK1_1 447 453 PF00069 0.405
MOD_CK1_1 69 75 PF00069 0.455
MOD_CK2_1 105 111 PF00069 0.412
MOD_CK2_1 293 299 PF00069 0.836
MOD_CK2_1 309 315 PF00069 0.734
MOD_CK2_1 356 362 PF00069 0.611
MOD_CK2_1 46 52 PF00069 0.512
MOD_CK2_1 60 66 PF00069 0.357
MOD_GlcNHglycan 156 159 PF01048 0.768
MOD_GlcNHglycan 172 176 PF01048 0.653
MOD_GlcNHglycan 192 195 PF01048 0.698
MOD_GlcNHglycan 226 229 PF01048 0.788
MOD_GlcNHglycan 235 238 PF01048 0.672
MOD_GlcNHglycan 243 247 PF01048 0.642
MOD_GlcNHglycan 252 256 PF01048 0.713
MOD_GlcNHglycan 68 71 PF01048 0.420
MOD_GSK3_1 100 107 PF00069 0.401
MOD_GSK3_1 145 152 PF00069 0.704
MOD_GSK3_1 154 161 PF00069 0.693
MOD_GSK3_1 201 208 PF00069 0.723
MOD_GSK3_1 253 260 PF00069 0.693
MOD_GSK3_1 289 296 PF00069 0.799
MOD_GSK3_1 342 349 PF00069 0.657
MOD_GSK3_1 66 73 PF00069 0.415
MOD_N-GLC_1 105 110 PF02516 0.427
MOD_N-GLC_1 158 163 PF02516 0.782
MOD_N-GLC_1 30 35 PF02516 0.449
MOD_NEK2_1 205 210 PF00069 0.745
MOD_NEK2_1 232 237 PF00069 0.787
MOD_NEK2_1 341 346 PF00069 0.812
MOD_NEK2_2 301 306 PF00069 0.695
MOD_OFUCOSY 441 448 PF10250 0.465
MOD_PIKK_1 206 212 PF00454 0.758
MOD_PIKK_1 309 315 PF00454 0.711
MOD_PKA_1 201 207 PF00069 0.716
MOD_PKA_1 233 239 PF00069 0.695
MOD_PKA_2 19 25 PF00069 0.455
MOD_PKA_2 201 207 PF00069 0.686
MOD_PKA_2 232 238 PF00069 0.807
MOD_PKB_1 149 157 PF00069 0.720
MOD_PKB_1 199 207 PF00069 0.707
MOD_Plk_1 105 111 PF00069 0.412
MOD_Plk_1 30 36 PF00069 0.449
MOD_Plk_1 4 10 PF00069 0.556
MOD_Plk_4 208 214 PF00069 0.743
MOD_Plk_4 272 278 PF00069 0.758
MOD_Plk_4 301 307 PF00069 0.735
MOD_Plk_4 343 349 PF00069 0.813
MOD_Plk_4 426 432 PF00069 0.366
TRG_DiLeu_BaLyEn_6 393 398 PF01217 0.572
TRG_ENDOCYTIC_2 68 71 PF00928 0.366
TRG_ENDOCYTIC_2 82 85 PF00928 0.401
TRG_ER_diArg_1 199 202 PF00400 0.710
TRG_ER_diArg_1 232 234 PF00400 0.700
TRG_ER_diArg_1 366 369 PF00400 0.618
TRG_ER_diArg_1 394 397 PF00400 0.569
TRG_ER_FFAT_2 299 310 PF00635 0.603
TRG_Pf-PMV_PEXEL_1 366 370 PF00026 0.559
TRG_Pf-PMV_PEXEL_1 396 401 PF00026 0.560
TRG_Pf-PMV_PEXEL_1 42 46 PF00026 0.401

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I698 Leptomonas seymouri 62% 97%
A0A3S5H6D0 Leishmania donovani 100% 100%
A4H5L9 Leishmania braziliensis 75% 98%
E9AMP4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QHY1 Leishmania major 96% 100%
V5BIH0 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS