Putative DNA photolyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA photolyase - putative

Species:

Leishmania infantum

UniProt:

A4HTU9_LEIIN

TriTrypDb:

LINF_090009300

Length:

932

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTU9

Function

Biological processes
Term	Name	Level	Count
GO:0000719	photoreactive repair	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006290	pyrimidine dimer repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003904	deoxyribodipyrimidine photo-lyase activity	5	8
GO:0003913	DNA photolyase activity	4	8
GO:0016829	lyase activity	2	12
GO:0016830	carbon-carbon lyase activity	3	8
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:0000166	nucleotide binding	3	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	551	555	PF00656	0.602
CLV_NRD_NRD_1	104	106	PF00675	0.642
CLV_NRD_NRD_1	305	307	PF00675	0.303
CLV_NRD_NRD_1	350	352	PF00675	0.308
CLV_NRD_NRD_1	358	360	PF00675	0.248
CLV_NRD_NRD_1	583	585	PF00675	0.620
CLV_NRD_NRD_1	608	610	PF00675	0.307
CLV_NRD_NRD_1	641	643	PF00675	0.314
CLV_NRD_NRD_1	676	678	PF00675	0.352
CLV_NRD_NRD_1	911	913	PF00675	0.711
CLV_PCSK_FUR_1	581	585	PF00082	0.608
CLV_PCSK_KEX2_1	104	106	PF00082	0.812
CLV_PCSK_KEX2_1	305	307	PF00082	0.303
CLV_PCSK_KEX2_1	350	352	PF00082	0.306
CLV_PCSK_KEX2_1	358	360	PF00082	0.246
CLV_PCSK_KEX2_1	583	585	PF00082	0.602
CLV_PCSK_KEX2_1	641	643	PF00082	0.314
CLV_PCSK_KEX2_1	928	930	PF00082	0.676
CLV_PCSK_PC1ET2_1	928	930	PF00082	0.676
CLV_PCSK_SKI1_1	519	523	PF00082	0.482
CLV_PCSK_SKI1_1	624	628	PF00082	0.478
CLV_PCSK_SKI1_1	655	659	PF00082	0.490
CLV_PCSK_SKI1_1	711	715	PF00082	0.274
CLV_Separin_Metazoa	613	617	PF03568	0.408
CLV_Separin_Metazoa	762	766	PF03568	0.470
DEG_APCC_DBOX_1	518	526	PF00400	0.467
DEG_APCC_DBOX_1	632	640	PF00400	0.353
DEG_APCC_DBOX_1	710	718	PF00400	0.439
DEG_Nend_UBRbox_1	1	4	PF02207	0.579
DEG_SCF_FBW7_1	17	22	PF00400	0.671
DEG_SPOP_SBC_1	232	236	PF00917	0.591
DOC_CKS1_1	133	138	PF01111	0.662
DOC_CKS1_1	454	459	PF01111	0.518
DOC_CYCLIN_yCln2_LP_2	312	318	PF00134	0.439
DOC_CYCLIN_yCln2_LP_2	454	460	PF00134	0.490
DOC_MAPK_DCC_7	322	332	PF00069	0.452
DOC_MAPK_DCC_7	816	824	PF00069	0.450
DOC_MAPK_gen_1	104	111	PF00069	0.564
DOC_MAPK_gen_1	305	314	PF00069	0.450
DOC_MAPK_gen_1	350	357	PF00069	0.497
DOC_MAPK_gen_1	593	603	PF00069	0.431
DOC_MAPK_HePTP_8	304	316	PF00069	0.450
DOC_MAPK_MEF2A_6	131	140	PF00069	0.475
DOC_MAPK_MEF2A_6	224	233	PF00069	0.492
DOC_MAPK_MEF2A_6	307	316	PF00069	0.445
DOC_MAPK_MEF2A_6	596	603	PF00069	0.416
DOC_MAPK_RevD_3	595	610	PF00069	0.456
DOC_PP1_RVXF_1	653	659	PF00149	0.489
DOC_PP2B_LxvP_1	143	146	PF13499	0.537
DOC_PP2B_LxvP_1	17	20	PF13499	0.620
DOC_PP2B_LxvP_1	207	210	PF13499	0.561
DOC_PP2B_LxvP_1	312	315	PF13499	0.456
DOC_PP2B_LxvP_1	59	62	PF13499	0.602
DOC_PP2B_PxIxI_1	264	270	PF00149	0.465
DOC_PP2B_PxIxI_1	402	408	PF00149	0.504
DOC_PP4_FxxP_1	277	280	PF00568	0.439
DOC_PP4_FxxP_1	760	763	PF00568	0.482
DOC_USP7_MATH_1	247	251	PF00917	0.550
DOC_USP7_MATH_1	278	282	PF00917	0.463
DOC_USP7_MATH_1	513	517	PF00917	0.522
DOC_USP7_MATH_1	547	551	PF00917	0.447
DOC_USP7_MATH_1	828	832	PF00917	0.537
DOC_USP7_MATH_1	911	915	PF00917	0.700
DOC_USP7_MATH_1	922	926	PF00917	0.645
DOC_WW_Pin1_4	132	137	PF00397	0.652
DOC_WW_Pin1_4	15	20	PF00397	0.678
DOC_WW_Pin1_4	21	26	PF00397	0.699
DOC_WW_Pin1_4	259	264	PF00397	0.428
DOC_WW_Pin1_4	287	292	PF00397	0.468
DOC_WW_Pin1_4	385	390	PF00397	0.736
DOC_WW_Pin1_4	453	458	PF00397	0.507
DOC_WW_Pin1_4	51	56	PF00397	0.669
DOC_WW_Pin1_4	595	600	PF00397	0.330
DOC_WW_Pin1_4	604	609	PF00397	0.294
DOC_WW_Pin1_4	869	874	PF00397	0.550
LIG_14-3-3_CanoR_1	177	183	PF00244	0.549
LIG_14-3-3_CanoR_1	655	661	PF00244	0.494
LIG_14-3-3_CanoR_1	735	739	PF00244	0.450
LIG_14-3-3_CanoR_1	830	837	PF00244	0.645
LIG_14-3-3_CanoR_1	912	916	PF00244	0.491
LIG_Actin_WH2_2	348	363	PF00022	0.535
LIG_AP2alpha_2	741	743	PF02296	0.439
LIG_Clathr_ClatBox_1	448	452	PF01394	0.358
LIG_deltaCOP1_diTrp_1	643	652	PF00928	0.321
LIG_deltaCOP1_diTrp_1	725	732	PF00928	0.440
LIG_FHA_1	133	139	PF00498	0.653
LIG_FHA_1	16	22	PF00498	0.728
LIG_FHA_1	177	183	PF00498	0.544
LIG_FHA_1	309	315	PF00498	0.577
LIG_FHA_1	485	491	PF00498	0.505
LIG_FHA_1	572	578	PF00498	0.391
LIG_FHA_1	665	671	PF00498	0.450
LIG_FHA_1	701	707	PF00498	0.439
LIG_FHA_2	199	205	PF00498	0.444
LIG_FHA_2	33	39	PF00498	0.590
LIG_FHA_2	4	10	PF00498	0.727
LIG_FHA_2	503	509	PF00498	0.450
LIG_Integrin_isoDGR_2	149	151	PF01839	0.516
LIG_LIR_Apic_2	193	199	PF02991	0.459
LIG_LIR_Apic_2	276	280	PF02991	0.506
LIG_LIR_Apic_2	758	763	PF02991	0.482
LIG_LIR_Gen_1	539	547	PF02991	0.632
LIG_LIR_Gen_1	598	608	PF02991	0.399
LIG_LIR_Gen_1	643	652	PF02991	0.388
LIG_LIR_Gen_1	880	889	PF02991	0.628
LIG_LIR_Nem_3	273	277	PF02991	0.465
LIG_LIR_Nem_3	539	545	PF02991	0.602
LIG_LIR_Nem_3	598	603	PF02991	0.410
LIG_LIR_Nem_3	654	660	PF02991	0.472
LIG_LIR_Nem_3	737	743	PF02991	0.439
LIG_LIR_Nem_3	888	893	PF02991	0.591
LIG_LYPXL_SIV_4	482	490	PF13949	0.442
LIG_MYND_3	522	526	PF01753	0.522
LIG_NRBOX	713	719	PF00104	0.439
LIG_PCNA_yPIPBox_3	563	577	PF02747	0.510
LIG_PDZ_Class_2	927	932	PF00595	0.668
LIG_PTB_Apo_2	745	752	PF02174	0.422
LIG_PTB_Apo_2	763	770	PF02174	0.517
LIG_PTB_Phospho_1	745	751	PF10480	0.422
LIG_PTB_Phospho_1	763	769	PF10480	0.517
LIG_REV1ctd_RIR_1	284	290	PF16727	0.482
LIG_SH2_NCK_1	483	487	PF00017	0.440
LIG_SH2_NCK_1	530	534	PF00017	0.452
LIG_SH2_NCK_1	80	84	PF00017	0.473
LIG_SH2_PTP2	600	603	PF00017	0.406
LIG_SH2_SRC	345	348	PF00017	0.450
LIG_SH2_SRC	749	752	PF00017	0.567
LIG_SH2_SRC	851	854	PF00017	0.477
LIG_SH2_STAP1	530	534	PF00017	0.502
LIG_SH2_STAP1	590	594	PF00017	0.416
LIG_SH2_STAP1	851	855	PF00017	0.482
LIG_SH2_STAT3	840	843	PF00017	0.605
LIG_SH2_STAT5	196	199	PF00017	0.432
LIG_SH2_STAT5	600	603	PF00017	0.313
LIG_SH2_STAT5	769	772	PF00017	0.501
LIG_SH2_STAT5	780	783	PF00017	0.403
LIG_SH2_STAT5	795	798	PF00017	0.439
LIG_SH2_STAT5	80	83	PF00017	0.533
LIG_SH2_STAT5	813	816	PF00017	0.439
LIG_SH2_STAT5	875	878	PF00017	0.594
LIG_SH3_3	136	142	PF00018	0.627
LIG_SH3_3	476	482	PF00018	0.419
LIG_SH3_3	52	58	PF00018	0.672
LIG_SH3_3	843	849	PF00018	0.550
LIG_SH3_3	858	864	PF00018	0.580
LIG_SUMO_SIM_anti_2	456	463	PF11976	0.423
LIG_SUMO_SIM_par_1	141	147	PF11976	0.613
LIG_SUMO_SIM_par_1	228	237	PF11976	0.419
LIG_SUMO_SIM_par_1	399	409	PF11976	0.593
LIG_SUMO_SIM_par_1	57	64	PF11976	0.621
LIG_TRAF2_1	367	370	PF00917	0.497
LIG_TRAF2_1	397	400	PF00917	0.577
LIG_TRAF2_1	541	544	PF00917	0.554
LIG_TRAF2_1	94	97	PF00917	0.549
LIG_UBA3_1	121	126	PF00899	0.562
LIG_WRC_WIRS_1	274	279	PF05994	0.371
LIG_WW_1	792	795	PF00397	0.292
MOD_CDC14_SPxK_1	290	293	PF00782	0.307
MOD_CDC14_SPxK_1	607	610	PF00782	0.300
MOD_CDK_SPK_2	604	609	PF00069	0.294
MOD_CDK_SPxK_1	287	293	PF00069	0.307
MOD_CDK_SPxK_1	604	610	PF00069	0.298
MOD_CK1_1	167	173	PF00069	0.661
MOD_CK1_1	219	225	PF00069	0.607
MOD_CK1_1	32	38	PF00069	0.715
MOD_CK2_1	167	173	PF00069	0.707
MOD_CK2_1	198	204	PF00069	0.463
MOD_CK2_1	3	9	PF00069	0.744
MOD_CK2_1	364	370	PF00069	0.432
MOD_CK2_1	393	399	PF00069	0.703
MOD_CK2_1	502	508	PF00069	0.427
MOD_CK2_1	830	836	PF00069	0.543
MOD_CK2_1	901	907	PF00069	0.682
MOD_Cter_Amidation	102	105	PF01082	0.623
MOD_GlcNHglycan	101	104	PF01048	0.515
MOD_GlcNHglycan	168	172	PF01048	0.671
MOD_GlcNHglycan	219	222	PF01048	0.722
MOD_GlcNHglycan	31	34	PF01048	0.540
MOD_GlcNHglycan	385	388	PF01048	0.748
MOD_GlcNHglycan	395	398	PF01048	0.589
MOD_GlcNHglycan	530	533	PF01048	0.566
MOD_GlcNHglycan	832	835	PF01048	0.569
MOD_GlcNHglycan	858	861	PF01048	0.581
MOD_GlcNHglycan	86	89	PF01048	0.640
MOD_GlcNHglycan	887	890	PF01048	0.476
MOD_GlcNHglycan	913	916	PF01048	0.680
MOD_GSK3_1	15	22	PF00069	0.731
MOD_GSK3_1	439	446	PF00069	0.341
MOD_GSK3_1	473	480	PF00069	0.429
MOD_GSK3_1	584	591	PF00069	0.490
MOD_N-GLC_1	29	34	PF02516	0.538
MOD_NEK2_1	121	126	PF00069	0.562
MOD_NEK2_1	297	302	PF00069	0.322
MOD_NEK2_1	308	313	PF00069	0.357
MOD_NEK2_1	340	345	PF00069	0.285
MOD_NEK2_1	439	444	PF00069	0.451
MOD_NEK2_1	45	50	PF00069	0.683
MOD_NEK2_1	528	533	PF00069	0.587
MOD_NEK2_1	637	642	PF00069	0.333
MOD_NEK2_1	656	661	PF00069	0.262
MOD_NEK2_1	700	705	PF00069	0.277
MOD_NEK2_2	923	928	PF00069	0.541
MOD_PIKK_1	219	225	PF00454	0.551
MOD_PIKK_1	340	346	PF00454	0.285
MOD_PIKK_1	545	551	PF00454	0.475
MOD_PIKK_1	588	594	PF00454	0.424
MOD_PKA_2	176	182	PF00069	0.667
MOD_PKA_2	184	190	PF00069	0.554
MOD_PKA_2	477	483	PF00069	0.388
MOD_PKA_2	535	541	PF00069	0.655
MOD_PKA_2	582	588	PF00069	0.502
MOD_PKA_2	637	643	PF00069	0.334
MOD_PKA_2	734	740	PF00069	0.277
MOD_PKA_2	911	917	PF00069	0.698
MOD_PKB_1	359	367	PF00069	0.412
MOD_Plk_1	167	173	PF00069	0.659
MOD_Plk_1	308	314	PF00069	0.320
MOD_Plk_1	470	476	PF00069	0.462
MOD_Plk_1	835	841	PF00069	0.497
MOD_Plk_2-3	369	375	PF00069	0.332
MOD_Plk_2-3	734	740	PF00069	0.277
MOD_Plk_4	361	367	PF00069	0.347
MOD_Plk_4	439	445	PF00069	0.349
MOD_Plk_4	456	462	PF00069	0.497
MOD_Plk_4	513	519	PF00069	0.480
MOD_Plk_4	572	578	PF00069	0.396
MOD_Plk_4	880	886	PF00069	0.658
MOD_ProDKin_1	132	138	PF00069	0.652
MOD_ProDKin_1	15	21	PF00069	0.678
MOD_ProDKin_1	259	265	PF00069	0.261
MOD_ProDKin_1	287	293	PF00069	0.318
MOD_ProDKin_1	385	391	PF00069	0.738
MOD_ProDKin_1	453	459	PF00069	0.514
MOD_ProDKin_1	51	57	PF00069	0.669
MOD_ProDKin_1	595	601	PF00069	0.328
MOD_ProDKin_1	604	610	PF00069	0.298
MOD_ProDKin_1	869	875	PF00069	0.549
MOD_SUMO_rev_2	672	680	PF00179	0.277
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.670
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.578
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.292
TRG_DiLeu_LyEn_5	400	405	PF01217	0.538
TRG_ENDOCYTIC_2	274	277	PF00928	0.292
TRG_ENDOCYTIC_2	600	603	PF00928	0.356
TRG_ENDOCYTIC_2	611	614	PF00928	0.282
TRG_ENDOCYTIC_2	740	743	PF00928	0.286
TRG_ER_diArg_1	304	306	PF00400	0.364
TRG_ER_diArg_1	350	352	PF00400	0.388
TRG_ER_diArg_1	357	359	PF00400	0.328
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXX3	Leptomonas seymouri	65%	92%
A0A0S4IZG6	Bodo saltans	42%	100%
A0A1X0NMQ9	Trypanosomatidae	55%	100%
A0A3S7WQJ5	Leishmania donovani	99%	100%
A0A422N7E2	Trypanosoma rangeli	57%	100%
A4H5L0	Leishmania braziliensis	83%	100%
D0A9A9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AMN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QHY9	Leishmania major	94%	100%
V5B2X6	Trypanosoma cruzi	58%	100%