Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTU7_LEIIN

TriTrypDb:

LINF_090009100

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.610
CLV_NRD_NRD_1	150	152	PF00675	0.558
CLV_NRD_NRD_1	212	214	PF00675	0.697
CLV_NRD_NRD_1	218	220	PF00675	0.640
CLV_PCSK_FUR_1	212	216	PF00082	0.626
CLV_PCSK_KEX2_1	132	134	PF00082	0.678
CLV_PCSK_KEX2_1	140	142	PF00082	0.609
CLV_PCSK_KEX2_1	149	151	PF00082	0.526
CLV_PCSK_KEX2_1	212	214	PF00082	0.681
CLV_PCSK_KEX2_1	215	217	PF00082	0.656
CLV_PCSK_KEX2_1	218	220	PF00082	0.648
CLV_PCSK_KEX2_1	7	9	PF00082	0.527
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.602
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.772
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.527
CLV_PCSK_PC7_1	146	152	PF00082	0.537
CLV_PCSK_PC7_1	212	218	PF00082	0.580
CLV_PCSK_PC7_1	3	9	PF00082	0.531
CLV_PCSK_SKI1_1	62	66	PF00082	0.523
DOC_MAPK_gen_1	7	16	PF00069	0.501
DOC_MAPK_JIP1_4	10	16	PF00069	0.563
DOC_MAPK_MEF2A_6	7	15	PF00069	0.516
DOC_PP2B_PxIxI_1	10	16	PF00149	0.525
DOC_USP7_MATH_1	122	126	PF00917	0.652
DOC_USP7_MATH_1	205	209	PF00917	0.744
DOC_WW_Pin1_4	114	119	PF00397	0.674
DOC_WW_Pin1_4	41	46	PF00397	0.628
LIG_14-3-3_CanoR_1	176	182	PF00244	0.514
LIG_14-3-3_CanoR_1	216	224	PF00244	0.657
LIG_FHA_1	126	132	PF00498	0.608
LIG_FHA_1	184	190	PF00498	0.746
LIG_FHA_1	54	60	PF00498	0.451
LIG_FHA_2	218	224	PF00498	0.682
LIG_FHA_2	237	243	PF00498	0.572
LIG_LIR_Gen_1	90	101	PF02991	0.511
LIG_LIR_Nem_3	90	96	PF02991	0.529
LIG_NRP_CendR_1	248	251	PF00754	0.702
LIG_SH2_STAP1	60	64	PF00017	0.411
LIG_SH3_3	184	190	PF00018	0.552
LIG_SUMO_SIM_anti_2	83	90	PF11976	0.437
MOD_CDK_SPK_2	41	46	PF00069	0.659
MOD_CDK_SPxxK_3	41	48	PF00069	0.633
MOD_CK1_1	125	131	PF00069	0.656
MOD_CK1_1	40	46	PF00069	0.781
MOD_CK2_1	236	242	PF00069	0.555
MOD_CK2_1	41	47	PF00069	0.711
MOD_GlcNHglycan	118	121	PF01048	0.713
MOD_GlcNHglycan	151	154	PF01048	0.683
MOD_GlcNHglycan	197	202	PF01048	0.573
MOD_GlcNHglycan	53	56	PF01048	0.504
MOD_GlcNHglycan	89	92	PF01048	0.443
MOD_GSK3_1	114	121	PF00069	0.766
MOD_GSK3_1	122	129	PF00069	0.678
MOD_GSK3_1	145	152	PF00069	0.604
MOD_GSK3_1	36	43	PF00069	0.738
MOD_GSK3_1	80	87	PF00069	0.459
MOD_NEK2_1	101	106	PF00069	0.551
MOD_NEK2_1	123	128	PF00069	0.634
MOD_NEK2_1	145	150	PF00069	0.671
MOD_NEK2_1	161	166	PF00069	0.449
MOD_NEK2_1	175	180	PF00069	0.392
MOD_PIKK_1	189	195	PF00454	0.659
MOD_PKA_1	149	155	PF00069	0.539
MOD_PKA_1	217	223	PF00069	0.614
MOD_PKA_2	145	151	PF00069	0.595
MOD_PKA_2	175	181	PF00069	0.507
MOD_PKA_2	217	223	PF00069	0.614
MOD_PKB_1	215	223	PF00069	0.660
MOD_Plk_1	183	189	PF00069	0.595
MOD_Plk_4	84	90	PF00069	0.459
MOD_ProDKin_1	114	120	PF00069	0.672
MOD_ProDKin_1	41	47	PF00069	0.627
MOD_SUMO_for_1	6	9	PF00179	0.522
TRG_ENDOCYTIC_2	71	74	PF00928	0.517
TRG_ER_diArg_1	140	142	PF00400	0.610
TRG_ER_diArg_1	149	151	PF00400	0.564
TRG_ER_diArg_1	212	215	PF00400	0.614
TRG_ER_diArg_1	216	219	PF00400	0.620
TRG_ER_diArg_1	248	251	PF00400	0.679
TRG_NLS_MonoCore_2	212	217	PF00514	0.668
TRG_NLS_MonoExtC_3	212	217	PF00514	0.668
TRG_NLS_MonoExtN_4	212	218	PF00514	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I643	Leptomonas seymouri	47%	100%
A0A3S7WQK0	Leishmania donovani	100%	100%
E9AI35	Leishmania braziliensis	68%	98%
E9AMN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%
Q4QHZ1	Leishmania major	90%	100%