LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HTU5_LEIIN
TriTrypDb:
LINF_090008900
Length:
849

Annotations

LeishMANIAdb annotations

Appears to be an enzyme-linked receptor, putatively a receptor nucleotide cyclase (cAMP synthase).. Expanded on the Leishmaniid lineage. The first helical segment is very similar to a signal peptide.. Localization: Cell surface (by feature)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4HTU5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTU5

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 5
GO:0006163 purine nucleotide metabolic process 5 5
GO:0006164 purine nucleotide biosynthetic process 6 5
GO:0006171 cAMP biosynthetic process 8 5
GO:0006725 cellular aromatic compound metabolic process 3 5
GO:0006753 nucleoside phosphate metabolic process 4 5
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0006807 nitrogen compound metabolic process 2 5
GO:0008152 metabolic process 1 5
GO:0009058 biosynthetic process 2 5
GO:0009117 nucleotide metabolic process 5 5
GO:0009150 purine ribonucleotide metabolic process 6 5
GO:0009152 purine ribonucleotide biosynthetic process 7 5
GO:0009165 nucleotide biosynthetic process 6 5
GO:0009187 cyclic nucleotide metabolic process 6 5
GO:0009190 cyclic nucleotide biosynthetic process 7 5
GO:0009259 ribonucleotide metabolic process 5 5
GO:0009260 ribonucleotide biosynthetic process 6 5
GO:0009987 cellular process 1 5
GO:0018130 heterocycle biosynthetic process 4 5
GO:0019438 aromatic compound biosynthetic process 4 5
GO:0019637 organophosphate metabolic process 3 5
GO:0019693 ribose phosphate metabolic process 4 5
GO:0034641 cellular nitrogen compound metabolic process 3 5
GO:0034654 nucleobase-containing compound biosynthetic process 4 5
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 5
GO:0044249 cellular biosynthetic process 3 5
GO:0044271 cellular nitrogen compound biosynthetic process 4 5
GO:0044281 small molecule metabolic process 2 5
GO:0046058 cAMP metabolic process 7 5
GO:0046390 ribose phosphate biosynthetic process 5 5
GO:0046483 heterocycle metabolic process 3 5
GO:0052652 cyclic purine nucleotide metabolic process 6 5
GO:0055086 nucleobase-containing small molecule metabolic process 3 5
GO:0071704 organic substance metabolic process 2 5
GO:0072521 purine-containing compound metabolic process 4 5
GO:0072522 purine-containing compound biosynthetic process 5 5
GO:0090407 organophosphate biosynthetic process 4 5
GO:1901135 carbohydrate derivative metabolic process 3 5
GO:1901137 carbohydrate derivative biosynthetic process 4 5
GO:1901293 nucleoside phosphate biosynthetic process 5 5
GO:1901360 organic cyclic compound metabolic process 3 5
GO:1901362 organic cyclic compound biosynthetic process 4 5
GO:1901564 organonitrogen compound metabolic process 3 5
GO:1901566 organonitrogen compound biosynthetic process 4 5
GO:1901576 organic substance biosynthetic process 3 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 647 651 PF00656 0.495
CLV_NRD_NRD_1 128 130 PF00675 0.611
CLV_NRD_NRD_1 205 207 PF00675 0.533
CLV_NRD_NRD_1 24 26 PF00675 0.259
CLV_NRD_NRD_1 562 564 PF00675 0.480
CLV_NRD_NRD_1 598 600 PF00675 0.422
CLV_NRD_NRD_1 785 787 PF00675 0.624
CLV_PCSK_KEX2_1 128 130 PF00082 0.608
CLV_PCSK_KEX2_1 205 207 PF00082 0.533
CLV_PCSK_KEX2_1 24 26 PF00082 0.259
CLV_PCSK_KEX2_1 249 251 PF00082 0.666
CLV_PCSK_KEX2_1 562 564 PF00082 0.480
CLV_PCSK_KEX2_1 598 600 PF00082 0.422
CLV_PCSK_KEX2_1 785 787 PF00082 0.624
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.666
CLV_PCSK_PC7_1 20 26 PF00082 0.324
CLV_PCSK_SKI1_1 151 155 PF00082 0.567
CLV_PCSK_SKI1_1 441 445 PF00082 0.398
CLV_PCSK_SKI1_1 449 453 PF00082 0.386
CLV_PCSK_SKI1_1 541 545 PF00082 0.460
CLV_PCSK_SKI1_1 599 603 PF00082 0.312
CLV_PCSK_SKI1_1 638 642 PF00082 0.670
CLV_PCSK_SKI1_1 724 728 PF00082 0.660
CLV_PCSK_SKI1_1 740 744 PF00082 0.489
CLV_PCSK_SKI1_1 769 773 PF00082 0.572
CLV_PCSK_SKI1_1 786 790 PF00082 0.580
DEG_APCC_DBOX_1 12 20 PF00400 0.677
DEG_APCC_DBOX_1 723 731 PF00400 0.422
DEG_SCF_FBW7_1 172 177 PF00400 0.372
DEG_SPOP_SBC_1 407 411 PF00917 0.593
DEG_SPOP_SBC_1 566 570 PF00917 0.643
DOC_CYCLIN_yCln2_LP_2 726 732 PF00134 0.373
DOC_CYCLIN_yCln2_LP_2 771 777 PF00134 0.419
DOC_MAPK_DCC_7 13 21 PF00069 0.620
DOC_MAPK_gen_1 13 21 PF00069 0.765
DOC_MAPK_gen_1 24 32 PF00069 0.466
DOC_MAPK_gen_1 516 523 PF00069 0.510
DOC_MAPK_MEF2A_6 13 21 PF00069 0.625
DOC_MAPK_MEF2A_6 733 741 PF00069 0.445
DOC_MAPK_MEF2A_6 753 761 PF00069 0.260
DOC_PP1_RVXF_1 738 744 PF00149 0.381
DOC_PP1_RVXF_1 767 773 PF00149 0.386
DOC_PP1_RVXF_1 814 821 PF00149 0.347
DOC_PP2B_LxvP_1 104 107 PF13499 0.376
DOC_PP2B_LxvP_1 775 778 PF13499 0.427
DOC_PP2B_LxvP_1 99 102 PF13499 0.361
DOC_PP4_FxxP_1 147 150 PF00568 0.364
DOC_PP4_FxxP_1 489 492 PF00568 0.538
DOC_PP4_FxxP_1 791 794 PF00568 0.365
DOC_USP7_MATH_1 188 192 PF00917 0.327
DOC_USP7_MATH_1 242 246 PF00917 0.339
DOC_USP7_MATH_1 490 494 PF00917 0.578
DOC_USP7_MATH_1 566 570 PF00917 0.702
DOC_USP7_MATH_1 573 577 PF00917 0.702
DOC_USP7_MATH_1 622 626 PF00917 0.583
DOC_USP7_MATH_1 649 653 PF00917 0.528
DOC_USP7_MATH_1 662 666 PF00917 0.650
DOC_USP7_MATH_1 694 698 PF00917 0.522
DOC_USP7_MATH_2 573 579 PF00917 0.700
DOC_WW_Pin1_4 146 151 PF00397 0.406
DOC_WW_Pin1_4 170 175 PF00397 0.412
DOC_WW_Pin1_4 291 296 PF00397 0.459
DOC_WW_Pin1_4 310 315 PF00397 0.491
DOC_WW_Pin1_4 42 47 PF00397 0.341
DOC_WW_Pin1_4 547 552 PF00397 0.657
DOC_WW_Pin1_4 641 646 PF00397 0.623
DOC_WW_Pin1_4 681 686 PF00397 0.504
DOC_WW_Pin1_4 831 836 PF00397 0.548
LIG_14-3-3_CanoR_1 128 134 PF00244 0.498
LIG_14-3-3_CanoR_1 190 196 PF00244 0.474
LIG_14-3-3_CanoR_1 211 215 PF00244 0.485
LIG_14-3-3_CanoR_1 286 292 PF00244 0.410
LIG_14-3-3_CanoR_1 525 530 PF00244 0.680
LIG_14-3-3_CanoR_1 565 574 PF00244 0.646
LIG_14-3-3_CanoR_1 785 794 PF00244 0.418
LIG_14-3-3_CanoR_1 814 819 PF00244 0.335
LIG_14-3-3_CterR_2 846 849 PF00244 0.452
LIG_APCC_ABBA_1 256 261 PF00400 0.339
LIG_BRCT_BRCA1_1 694 698 PF00533 0.426
LIG_BRCT_BRCA1_1 713 717 PF00533 0.475
LIG_BRCT_BRCA1_1 816 820 PF00533 0.394
LIG_EH_1 238 242 PF12763 0.386
LIG_EH1_1 92 100 PF00400 0.285
LIG_FHA_1 129 135 PF00498 0.352
LIG_FHA_1 190 196 PF00498 0.412
LIG_FHA_1 260 266 PF00498 0.408
LIG_FHA_1 381 387 PF00498 0.609
LIG_FHA_1 408 414 PF00498 0.541
LIG_FHA_1 542 548 PF00498 0.699
LIG_FHA_1 556 562 PF00498 0.691
LIG_FHA_1 581 587 PF00498 0.676
LIG_FHA_1 705 711 PF00498 0.566
LIG_FHA_1 721 727 PF00498 0.357
LIG_FHA_1 747 753 PF00498 0.414
LIG_FHA_2 116 122 PF00498 0.358
LIG_FHA_2 171 177 PF00498 0.379
LIG_FHA_2 210 216 PF00498 0.370
LIG_FHA_2 425 431 PF00498 0.596
LIG_FHA_2 494 500 PF00498 0.580
LIG_FHA_2 591 597 PF00498 0.587
LIG_FHA_2 670 676 PF00498 0.486
LIG_LIR_Apic_2 789 794 PF02991 0.418
LIG_LIR_Gen_1 118 127 PF02991 0.365
LIG_LIR_Gen_1 173 183 PF02991 0.459
LIG_LIR_Gen_1 283 291 PF02991 0.423
LIG_LIR_Gen_1 744 752 PF02991 0.374
LIG_LIR_Nem_3 118 123 PF02991 0.329
LIG_LIR_Nem_3 173 178 PF02991 0.451
LIG_LIR_Nem_3 221 225 PF02991 0.360
LIG_LIR_Nem_3 23 29 PF02991 0.526
LIG_LIR_Nem_3 283 287 PF02991 0.465
LIG_LIR_Nem_3 60 66 PF02991 0.455
LIG_LIR_Nem_3 744 748 PF02991 0.379
LIG_LIR_Nem_3 751 757 PF02991 0.380
LIG_LIR_Nem_3 766 771 PF02991 0.382
LIG_MAD2 10 18 PF02301 0.648
LIG_MYND_1 14 18 PF01753 0.648
LIG_NRBOX 324 330 PF00104 0.350
LIG_NRBOX 590 596 PF00104 0.594
LIG_NRP_CendR_1 846 849 PF00754 0.652
LIG_PCNA_PIPBox_1 795 804 PF02747 0.386
LIG_Pex14_1 223 227 PF04695 0.289
LIG_Pex14_2 40 44 PF04695 0.364
LIG_SH2_CRK 745 749 PF00017 0.418
LIG_SH2_CRK 76 80 PF00017 0.343
LIG_SH2_CRK 768 772 PF00017 0.444
LIG_SH2_CRK 841 845 PF00017 0.442
LIG_SH2_NCK_1 214 218 PF00017 0.376
LIG_SH2_NCK_1 346 350 PF00017 0.577
LIG_SH2_NCK_1 66 70 PF00017 0.406
LIG_SH2_PTP2 185 188 PF00017 0.355
LIG_SH2_PTP2 26 29 PF00017 0.364
LIG_SH2_SRC 546 549 PF00017 0.598
LIG_SH2_SRC 754 757 PF00017 0.428
LIG_SH2_STAP1 346 350 PF00017 0.577
LIG_SH2_STAP1 454 458 PF00017 0.558
LIG_SH2_STAP1 57 61 PF00017 0.372
LIG_SH2_STAT3 400 403 PF00017 0.607
LIG_SH2_STAT5 185 188 PF00017 0.355
LIG_SH2_STAT5 254 257 PF00017 0.345
LIG_SH2_STAT5 26 29 PF00017 0.409
LIG_SH2_STAT5 412 415 PF00017 0.556
LIG_SH2_STAT5 546 549 PF00017 0.696
LIG_SH2_STAT5 63 66 PF00017 0.389
LIG_SH2_STAT5 763 766 PF00017 0.337
LIG_SH2_STAT5 93 96 PF00017 0.354
LIG_SH3_3 292 298 PF00018 0.405
LIG_SH3_3 545 551 PF00018 0.669
LIG_SH3_3 639 645 PF00018 0.523
LIG_SH3_3 684 690 PF00018 0.498
LIG_SH3_3 726 732 PF00018 0.416
LIG_SH3_3 8 14 PF00018 0.720
LIG_SH3_3 819 825 PF00018 0.439
LIG_SUMO_SIM_par_1 316 323 PF11976 0.332
LIG_SUMO_SIM_par_1 77 82 PF11976 0.324
LIG_TRAF2_1 427 430 PF00917 0.649
LIG_TYR_ITIM 752 757 PF00017 0.359
LIG_UBA3_1 47 55 PF00899 0.468
LIG_WRC_WIRS_1 219 224 PF05994 0.371
MOD_CDK_SPK_2 146 151 PF00069 0.283
MOD_CK1_1 213 219 PF00069 0.507
MOD_CK1_1 310 316 PF00069 0.409
MOD_CK1_1 411 417 PF00069 0.574
MOD_CK1_1 493 499 PF00069 0.555
MOD_CK1_1 512 518 PF00069 0.589
MOD_CK1_1 550 556 PF00069 0.717
MOD_CK1_1 577 583 PF00069 0.680
MOD_CK1_1 615 621 PF00069 0.653
MOD_CK1_1 644 650 PF00069 0.539
MOD_CK1_1 665 671 PF00069 0.573
MOD_CK1_1 681 687 PF00069 0.526
MOD_CK1_1 692 698 PF00069 0.470
MOD_CK2_1 170 176 PF00069 0.410
MOD_CK2_1 209 215 PF00069 0.338
MOD_CK2_1 423 429 PF00069 0.592
MOD_CK2_1 493 499 PF00069 0.579
MOD_CK2_1 575 581 PF00069 0.720
MOD_CK2_1 669 675 PF00069 0.527
MOD_GlcNHglycan 104 107 PF01048 0.588
MOD_GlcNHglycan 179 182 PF01048 0.647
MOD_GlcNHglycan 215 218 PF01048 0.634
MOD_GlcNHglycan 232 235 PF01048 0.444
MOD_GlcNHglycan 261 265 PF01048 0.634
MOD_GlcNHglycan 325 328 PF01048 0.447
MOD_GlcNHglycan 541 544 PF01048 0.469
MOD_GlcNHglycan 617 620 PF01048 0.750
MOD_GlcNHglycan 624 627 PF01048 0.738
MOD_GlcNHglycan 646 649 PF01048 0.827
MOD_GlcNHglycan 652 655 PF01048 0.793
MOD_GlcNHglycan 664 667 PF01048 0.685
MOD_GlcNHglycan 680 683 PF01048 0.784
MOD_GSK3_1 170 177 PF00069 0.414
MOD_GSK3_1 209 216 PF00069 0.499
MOD_GSK3_1 260 267 PF00069 0.424
MOD_GSK3_1 287 294 PF00069 0.327
MOD_GSK3_1 319 326 PF00069 0.404
MOD_GSK3_1 407 414 PF00069 0.556
MOD_GSK3_1 465 472 PF00069 0.651
MOD_GSK3_1 547 554 PF00069 0.699
MOD_GSK3_1 573 580 PF00069 0.824
MOD_GSK3_1 590 597 PF00069 0.515
MOD_GSK3_1 657 664 PF00069 0.575
MOD_GSK3_1 665 672 PF00069 0.547
MOD_GSK3_1 689 696 PF00069 0.554
MOD_GSK3_1 700 707 PF00069 0.586
MOD_N-GLC_1 102 107 PF02516 0.666
MOD_N-GLC_1 115 120 PF02516 0.668
MOD_N-GLC_1 129 134 PF02516 0.542
MOD_N-GLC_1 151 156 PF02516 0.687
MOD_N-GLC_1 209 214 PF02516 0.611
MOD_N-GLC_1 230 235 PF02516 0.564
MOD_N-GLC_1 259 264 PF02516 0.599
MOD_N-GLC_1 310 315 PF02516 0.602
MOD_NEK2_1 225 230 PF00069 0.323
MOD_NEK2_1 241 246 PF00069 0.430
MOD_NEK2_1 269 274 PF00069 0.446
MOD_NEK2_1 287 292 PF00069 0.245
MOD_NEK2_1 299 304 PF00069 0.336
MOD_NEK2_1 340 345 PF00069 0.630
MOD_NEK2_1 408 413 PF00069 0.578
MOD_NEK2_1 423 428 PF00069 0.567
MOD_NEK2_1 469 474 PF00069 0.712
MOD_NEK2_1 594 599 PF00069 0.581
MOD_NEK2_1 680 685 PF00069 0.487
MOD_NEK2_1 764 769 PF00069 0.386
MOD_NEK2_1 84 89 PF00069 0.408
MOD_NEK2_2 254 259 PF00069 0.322
MOD_PIKK_1 276 282 PF00454 0.369
MOD_PIKK_1 580 586 PF00454 0.709
MOD_PIKK_1 84 90 PF00454 0.355
MOD_PKA_1 128 134 PF00069 0.321
MOD_PKA_2 128 134 PF00069 0.321
MOD_PKA_2 157 163 PF00069 0.408
MOD_PKA_2 189 195 PF00069 0.441
MOD_PKA_2 210 216 PF00069 0.481
MOD_PKB_1 563 571 PF00069 0.645
MOD_Plk_1 129 135 PF00069 0.359
MOD_Plk_1 209 215 PF00069 0.416
MOD_Plk_1 53 59 PF00069 0.365
MOD_Plk_1 64 70 PF00069 0.423
MOD_Plk_2-3 575 581 PF00069 0.663
MOD_Plk_2-3 669 675 PF00069 0.498
MOD_Plk_4 129 135 PF00069 0.415
MOD_Plk_4 174 180 PF00069 0.390
MOD_Plk_4 320 326 PF00069 0.336
MOD_Plk_4 408 414 PF00069 0.534
MOD_Plk_4 490 496 PF00069 0.573
MOD_Plk_4 541 547 PF00069 0.709
MOD_ProDKin_1 146 152 PF00069 0.407
MOD_ProDKin_1 170 176 PF00069 0.412
MOD_ProDKin_1 291 297 PF00069 0.458
MOD_ProDKin_1 310 316 PF00069 0.488
MOD_ProDKin_1 42 48 PF00069 0.341
MOD_ProDKin_1 547 553 PF00069 0.661
MOD_ProDKin_1 641 647 PF00069 0.623
MOD_ProDKin_1 681 687 PF00069 0.502
MOD_ProDKin_1 831 837 PF00069 0.547
TRG_DiLeu_BaEn_1 447 452 PF01217 0.677
TRG_DiLeu_BaEn_1 675 680 PF01217 0.454
TRG_DiLeu_BaEn_1 756 761 PF01217 0.424
TRG_DiLeu_BaEn_4 369 375 PF01217 0.624
TRG_DiLeu_BaLyEn_6 446 451 PF01217 0.619
TRG_DiLeu_BaLyEn_6 726 731 PF01217 0.463
TRG_ENDOCYTIC_2 145 148 PF00928 0.408
TRG_ENDOCYTIC_2 26 29 PF00928 0.364
TRG_ENDOCYTIC_2 745 748 PF00928 0.369
TRG_ENDOCYTIC_2 754 757 PF00928 0.344
TRG_ENDOCYTIC_2 76 79 PF00928 0.348
TRG_ENDOCYTIC_2 768 771 PF00928 0.382
TRG_ENDOCYTIC_2 841 844 PF00928 0.461
TRG_ER_diArg_1 12 15 PF00400 0.696
TRG_ER_diArg_1 127 129 PF00400 0.358
TRG_ER_diArg_1 204 206 PF00400 0.331
TRG_ER_diArg_1 24 26 PF00400 0.459
TRG_ER_diArg_1 303 306 PF00400 0.457
TRG_ER_diArg_1 524 527 PF00400 0.687
TRG_ER_diArg_1 561 563 PF00400 0.653
TRG_ER_diArg_1 598 600 PF00400 0.622
TRG_ER_diArg_1 784 786 PF00400 0.423
TRG_Pf-PMV_PEXEL_1 724 728 PF00026 0.715

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5C6 Leptomonas seymouri 50% 99%
A0A3S5H6C4 Leishmania donovani 99% 100%
A0A3S7WQJ6 Leishmania donovani 50% 92%
A4H5K7 Leishmania braziliensis 69% 100%
A4HTU4 Leishmania infantum 51% 100%
D0A9A6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 99%
E9AMN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E9AMN2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4QHZ3 Leishmania major 89% 99%
Q4QHZ4 Leishmania major 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS