Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTU2_LEIIN

TriTrypDb:

LINF_090008600

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.635
CLV_NRD_NRD_1	162	164	PF00675	0.650
CLV_NRD_NRD_1	8	10	PF00675	0.413
CLV_PCSK_KEX2_1	162	164	PF00082	0.650
CLV_PCSK_KEX2_1	8	10	PF00082	0.389
CLV_PCSK_SKI1_1	162	166	PF00082	0.647
CLV_PCSK_SKI1_1	40	44	PF00082	0.355
DEG_APCC_DBOX_1	39	47	PF00400	0.416
DOC_CDC14_PxL_1	107	115	PF14671	0.522
DOC_PP4_FxxP_1	165	168	PF00568	0.626
DOC_USP7_MATH_1	11	15	PF00917	0.575
DOC_USP7_MATH_1	83	87	PF00917	0.591
DOC_USP7_UBL2_3	166	170	PF12436	0.549
DOC_WW_Pin1_4	101	106	PF00397	0.683
LIG_FHA_1	115	121	PF00498	0.416
LIG_FHA_1	223	229	PF00498	0.379
LIG_FHA_2	137	143	PF00498	0.513
LIG_FHA_2	169	175	PF00498	0.460
LIG_GBD_Chelix_1	118	126	PF00786	0.355
LIG_HP1_1	25	29	PF01393	0.426
LIG_LIR_Apic_2	16	22	PF02991	0.340
LIG_SH2_CRK	19	23	PF00017	0.323
LIG_SH2_STAP1	133	137	PF00017	0.442
LIG_SH2_STAT5	191	194	PF00017	0.645
LIG_SH3_1	19	25	PF00018	0.331
LIG_SH3_3	19	25	PF00018	0.546
LIG_SH3_3	63	69	PF00018	0.669
LIG_SUMO_SIM_anti_2	127	136	PF11976	0.468
LIG_SUMO_SIM_par_1	114	121	PF11976	0.407
LIG_TRAF2_1	171	174	PF00917	0.451
MOD_CK1_1	135	141	PF00069	0.516
MOD_CK1_1	86	92	PF00069	0.723
MOD_CK2_1	11	17	PF00069	0.451
MOD_CK2_1	136	142	PF00069	0.558
MOD_CK2_1	153	159	PF00069	0.608
MOD_CK2_1	168	174	PF00069	0.498
MOD_CK2_1	192	198	PF00069	0.635
MOD_GlcNHglycan	201	205	PF01048	0.611
MOD_GlcNHglycan	54	57	PF01048	0.513
MOD_GlcNHglycan	74	77	PF01048	0.569
MOD_GlcNHglycan	88	91	PF01048	0.540
MOD_GSK3_1	114	121	PF00069	0.389
MOD_GSK3_1	132	139	PF00069	0.590
MOD_N-GLC_1	101	106	PF02516	0.604
MOD_NEK2_1	118	123	PF00069	0.477
MOD_NEK2_1	185	190	PF00069	0.576
MOD_NEK2_1	212	217	PF00069	0.454
MOD_NEK2_1	71	76	PF00069	0.701
MOD_PKA_1	169	175	PF00069	0.539
MOD_PKA_2	52	58	PF00069	0.455
MOD_Plk_1	114	120	PF00069	0.328
MOD_Plk_1	133	139	PF00069	0.438
MOD_Plk_4	118	124	PF00069	0.382
MOD_ProDKin_1	101	107	PF00069	0.678
MOD_SUMO_for_1	216	219	PF00179	0.460
TRG_ER_diArg_1	161	163	PF00400	0.642
TRG_ER_diArg_1	8	10	PF00400	0.389
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R6	Leptomonas seymouri	44%	94%
A0A3S7WQM1	Leishmania donovani	100%	100%
A4H5K4	Leishmania braziliensis	71%	99%
D0A9A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AMM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QHZ6	Leishmania major	89%	100%
V5B2V2	Trypanosoma cruzi	33%	100%