Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTU0_LEIIN

TriTrypDb:

LINF_090008400

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTU0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	40	44	PF00656	0.806
CLV_C14_Caspase3-7	60	64	PF00656	0.577
CLV_C14_Caspase3-7	604	608	PF00656	0.734
CLV_C14_Caspase3-7	663	667	PF00656	0.743
CLV_NRD_NRD_1	122	124	PF00675	0.491
CLV_NRD_NRD_1	186	188	PF00675	0.531
CLV_NRD_NRD_1	189	191	PF00675	0.545
CLV_NRD_NRD_1	204	206	PF00675	0.527
CLV_NRD_NRD_1	295	297	PF00675	0.623
CLV_NRD_NRD_1	320	322	PF00675	0.551
CLV_NRD_NRD_1	348	350	PF00675	0.628
CLV_NRD_NRD_1	732	734	PF00675	0.486
CLV_NRD_NRD_1	751	753	PF00675	0.590
CLV_PCSK_FUR_1	187	191	PF00082	0.550
CLV_PCSK_KEX2_1	122	124	PF00082	0.490
CLV_PCSK_KEX2_1	185	187	PF00082	0.531
CLV_PCSK_KEX2_1	189	191	PF00082	0.546
CLV_PCSK_KEX2_1	204	206	PF00082	0.527
CLV_PCSK_KEX2_1	320	322	PF00082	0.551
CLV_PCSK_KEX2_1	348	350	PF00082	0.628
CLV_PCSK_KEX2_1	732	734	PF00082	0.550
CLV_PCSK_KEX2_1	751	753	PF00082	0.569
CLV_PCSK_PC7_1	182	188	PF00082	0.543
CLV_PCSK_SKI1_1	104	108	PF00082	0.426
CLV_PCSK_SKI1_1	297	301	PF00082	0.621
CLV_PCSK_SKI1_1	349	353	PF00082	0.562
DEG_APCC_DBOX_1	295	303	PF00400	0.762
DEG_Nend_Nbox_1	1	3	PF02207	0.346
DEG_SCF_FBW7_1	488	494	PF00400	0.771
DOC_CKS1_1	199	204	PF01111	0.735
DOC_CKS1_1	488	493	PF01111	0.772
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.677
DOC_MAPK_gen_1	296	304	PF00069	0.820
DOC_MAPK_gen_1	317	326	PF00069	0.773
DOC_MAPK_gen_1	771	781	PF00069	0.775
DOC_MAPK_MEF2A_6	296	304	PF00069	0.723
DOC_MAPK_MEF2A_6	317	326	PF00069	0.843
DOC_MAPK_MEF2A_6	722	731	PF00069	0.676
DOC_MAPK_MEF2A_6	774	783	PF00069	0.708
DOC_PP1_RVXF_1	567	573	PF00149	0.651
DOC_PP2B_LxvP_1	24	27	PF13499	0.676
DOC_PP2B_LxvP_1	292	295	PF13499	0.754
DOC_PP2B_LxvP_1	394	397	PF13499	0.736
DOC_PP2B_LxvP_1	552	555	PF13499	0.705
DOC_PP2B_LxvP_1	75	78	PF13499	0.769
DOC_PP4_FxxP_1	523	526	PF00568	0.655
DOC_PP4_MxPP_1	486	489	PF00568	0.802
DOC_SPAK_OSR1_1	533	537	PF12202	0.763
DOC_USP7_MATH_1	333	337	PF00917	0.792
DOC_USP7_MATH_1	37	41	PF00917	0.788
DOC_USP7_MATH_1	415	419	PF00917	0.763
DOC_USP7_MATH_1	491	495	PF00917	0.785
DOC_USP7_MATH_1	504	508	PF00917	0.619
DOC_USP7_MATH_1	51	55	PF00917	0.641
DOC_USP7_MATH_1	512	516	PF00917	0.694
DOC_USP7_MATH_1	603	607	PF00917	0.727
DOC_USP7_MATH_1	616	620	PF00917	0.647
DOC_USP7_MATH_1	711	715	PF00917	0.803
DOC_WW_Pin1_4	111	116	PF00397	0.666
DOC_WW_Pin1_4	198	203	PF00397	0.738
DOC_WW_Pin1_4	274	279	PF00397	0.829
DOC_WW_Pin1_4	336	341	PF00397	0.836
DOC_WW_Pin1_4	355	360	PF00397	0.820
DOC_WW_Pin1_4	487	492	PF00397	0.807
DOC_WW_Pin1_4	494	499	PF00397	0.726
DOC_WW_Pin1_4	506	511	PF00397	0.621
LIG_14-3-3_CanoR_1	158	167	PF00244	0.754
LIG_14-3-3_CanoR_1	282	291	PF00244	0.810
LIG_14-3-3_CanoR_1	321	327	PF00244	0.759
LIG_14-3-3_CanoR_1	385	395	PF00244	0.771
LIG_14-3-3_CanoR_1	513	520	PF00244	0.670
LIG_14-3-3_CanoR_1	569	573	PF00244	0.665
LIG_14-3-3_CanoR_1	774	780	PF00244	0.681
LIG_14-3-3_CanoR_1	89	94	PF00244	0.710
LIG_Actin_WH2_2	304	319	PF00022	0.764
LIG_BIR_III_4	332	336	PF00653	0.846
LIG_BRCT_BRCA1_1	514	518	PF00533	0.734
LIG_DCNL_PONY_1	1	4	PF03556	0.346
LIG_EH1_1	208	216	PF00400	0.730
LIG_eIF4E_1	395	401	PF01652	0.689
LIG_eIF4E_1	71	77	PF01652	0.699
LIG_FHA_1	232	238	PF00498	0.674
LIG_FHA_1	411	417	PF00498	0.734
LIG_FHA_1	571	577	PF00498	0.640
LIG_FHA_1	589	595	PF00498	0.640
LIG_FHA_1	774	780	PF00498	0.671
LIG_FHA_1	86	92	PF00498	0.730
LIG_FHA_1	96	102	PF00498	0.651
LIG_FHA_2	313	319	PF00498	0.706
LIG_FHA_2	58	64	PF00498	0.754
LIG_LIR_Gen_1	207	218	PF02991	0.657
LIG_LIR_Gen_1	22	30	PF02991	0.493
LIG_LIR_Gen_1	88	94	PF02991	0.643
LIG_LIR_Nem_3	207	213	PF02991	0.670
LIG_LIR_Nem_3	22	26	PF02991	0.466
LIG_LIR_Nem_3	737	743	PF02991	0.694
LIG_LIR_Nem_3	88	93	PF02991	0.649
LIG_LYPXL_yS_3	740	743	PF13949	0.696
LIG_MYND_1	678	682	PF01753	0.733
LIG_NRBOX	1	7	PF00104	0.346
LIG_PCNA_yPIPBox_3	720	733	PF02747	0.681
LIG_Pex14_1	127	131	PF04695	0.731
LIG_PTAP_UEV_1	589	594	PF05743	0.743
LIG_SH2_CRK	71	75	PF00017	0.762
LIG_SH2_CRK	84	88	PF00017	0.584
LIG_SH2_GRB2like	252	255	PF00017	0.752
LIG_SH2_NCK_1	672	676	PF00017	0.775
LIG_SH2_NCK_1	84	88	PF00017	0.695
LIG_SH2_PTP2	90	93	PF00017	0.649
LIG_SH2_SRC	395	398	PF00017	0.665
LIG_SH2_STAP1	131	135	PF00017	0.807
LIG_SH2_STAP1	252	256	PF00017	0.723
LIG_SH2_STAT3	529	532	PF00017	0.666
LIG_SH2_STAT5	129	132	PF00017	0.757
LIG_SH2_STAT5	20	23	PF00017	0.513
LIG_SH2_STAT5	651	654	PF00017	0.736
LIG_SH2_STAT5	84	87	PF00017	0.648
LIG_SH2_STAT5	90	93	PF00017	0.664
LIG_SH3_2	199	204	PF14604	0.715
LIG_SH3_2	678	683	PF14604	0.742
LIG_SH3_3	132	138	PF00018	0.655
LIG_SH3_3	196	202	PF00018	0.721
LIG_SH3_3	273	279	PF00018	0.672
LIG_SH3_3	292	298	PF00018	0.819
LIG_SH3_3	316	322	PF00018	0.735
LIG_SH3_3	461	467	PF00018	0.746
LIG_SH3_3	485	491	PF00018	0.794
LIG_SH3_3	587	593	PF00018	0.671
LIG_SH3_3	675	681	PF00018	0.767
LIG_SH3_5	437	441	PF00018	0.756
LIG_Sin3_3	595	602	PF02671	0.647
LIG_SUMO_SIM_anti_2	72	78	PF11976	0.694
LIG_SUMO_SIM_anti_2	725	730	PF11976	0.674
LIG_SUMO_SIM_par_1	303	309	PF11976	0.813
LIG_SUMO_SIM_par_1	472	477	PF11976	0.733
LIG_TYR_ITIM	101	106	PF00017	0.641
LIG_TYR_ITIM	738	743	PF00017	0.695
LIG_UBA3_1	734	742	PF00899	0.700
LIG_WRC_WIRS_1	20	25	PF05994	0.299
LIG_WW_2	678	681	PF00397	0.722
LIG_WW_3	680	684	PF00397	0.742
MOD_CDK_SPK_2	111	116	PF00069	0.666
MOD_CDK_SPxK_1	198	204	PF00069	0.737
MOD_CDK_SPxK_1	336	342	PF00069	0.770
MOD_CDK_SPxK_1	494	500	PF00069	0.765
MOD_CDK_SPxxK_3	198	205	PF00069	0.809
MOD_CDK_SPxxK_3	341	348	PF00069	0.690
MOD_CDK_SPxxK_3	506	513	PF00069	0.652
MOD_CK1_1	166	172	PF00069	0.731
MOD_CK1_1	177	183	PF00069	0.772
MOD_CK1_1	284	290	PF00069	0.753
MOD_CK1_1	331	337	PF00069	0.824
MOD_CK1_1	35	41	PF00069	0.665
MOD_CK1_1	376	382	PF00069	0.710
MOD_CK1_1	399	405	PF00069	0.751
MOD_CK1_1	417	423	PF00069	0.741
MOD_CK1_1	494	500	PF00069	0.761
MOD_CK1_1	588	594	PF00069	0.743
MOD_CK1_1	606	612	PF00069	0.643
MOD_CK1_1	688	694	PF00069	0.832
MOD_CK1_1	701	707	PF00069	0.665
MOD_CK2_1	111	117	PF00069	0.666
MOD_CK2_1	611	617	PF00069	0.751
MOD_CK2_1	89	95	PF00069	0.659
MOD_DYRK1A_RPxSP_1	487	491	PF00069	0.774
MOD_GlcNHglycan	138	141	PF01048	0.617
MOD_GlcNHglycan	148	151	PF01048	0.527
MOD_GlcNHglycan	160	163	PF01048	0.602
MOD_GlcNHglycan	168	171	PF01048	0.497
MOD_GlcNHglycan	206	209	PF01048	0.560
MOD_GlcNHglycan	271	274	PF01048	0.590
MOD_GlcNHglycan	286	289	PF01048	0.640
MOD_GlcNHglycan	308	311	PF01048	0.603
MOD_GlcNHglycan	332	336	PF01048	0.579
MOD_GlcNHglycan	363	366	PF01048	0.605
MOD_GlcNHglycan	39	42	PF01048	0.609
MOD_GlcNHglycan	425	428	PF01048	0.586
MOD_GlcNHglycan	45	48	PF01048	0.540
MOD_GlcNHglycan	456	459	PF01048	0.563
MOD_GlcNHglycan	502	505	PF01048	0.590
MOD_GlcNHglycan	506	509	PF01048	0.491
MOD_GlcNHglycan	514	517	PF01048	0.428
MOD_GlcNHglycan	53	56	PF01048	0.440
MOD_GlcNHglycan	609	612	PF01048	0.562
MOD_GlcNHglycan	628	631	PF01048	0.609
MOD_GlcNHglycan	635	638	PF01048	0.602
MOD_GlcNHglycan	683	686	PF01048	0.601
MOD_GlcNHglycan	688	691	PF01048	0.626
MOD_GlcNHglycan	700	703	PF01048	0.478
MOD_GlcNHglycan	709	712	PF01048	0.539
MOD_GlcNHglycan	753	756	PF01048	0.601
MOD_GSK3_1	153	160	PF00069	0.800
MOD_GSK3_1	165	172	PF00069	0.720
MOD_GSK3_1	174	181	PF00069	0.774
MOD_GSK3_1	33	40	PF00069	0.747
MOD_GSK3_1	375	382	PF00069	0.739
MOD_GSK3_1	395	402	PF00069	0.777
MOD_GSK3_1	406	413	PF00069	0.699
MOD_GSK3_1	414	421	PF00069	0.683
MOD_GSK3_1	423	430	PF00069	0.658
MOD_GSK3_1	487	494	PF00069	0.709
MOD_GSK3_1	500	507	PF00069	0.686
MOD_GSK3_1	602	609	PF00069	0.777
MOD_GSK3_1	641	648	PF00069	0.700
MOD_GSK3_1	681	688	PF00069	0.757
MOD_GSK3_1	707	714	PF00069	0.752
MOD_GSK3_1	85	92	PF00069	0.655
MOD_N-GLC_1	376	381	PF02516	0.576
MOD_N-GLC_1	494	499	PF02516	0.536
MOD_N-GLC_1	691	696	PF02516	0.575
MOD_NEK2_1	178	183	PF00069	0.749
MOD_NEK2_1	312	317	PF00069	0.699
MOD_NEK2_1	400	405	PF00069	0.739
MOD_NEK2_1	626	631	PF00069	0.692
MOD_NEK2_1	647	652	PF00069	0.703
MOD_NEK2_1	686	691	PF00069	0.834
MOD_NEK2_1	734	739	PF00069	0.674
MOD_NEK2_1	770	775	PF00069	0.787
MOD_NEK2_1	8	13	PF00069	0.411
MOD_NEK2_1	83	88	PF00069	0.670
MOD_NEK2_2	224	229	PF00069	0.663
MOD_PIKK_1	282	288	PF00454	0.814
MOD_PIKK_1	649	655	PF00454	0.732
MOD_PKA_1	204	210	PF00069	0.776
MOD_PKA_1	751	757	PF00069	0.801
MOD_PKA_2	153	159	PF00069	0.754
MOD_PKA_2	181	187	PF00069	0.744
MOD_PKA_2	204	210	PF00069	0.760
MOD_PKA_2	281	287	PF00069	0.843
MOD_PKA_2	421	427	PF00069	0.743
MOD_PKA_2	512	518	PF00069	0.662
MOD_PKA_2	568	574	PF00069	0.666
MOD_PKA_2	626	632	PF00069	0.691
MOD_PKA_2	668	674	PF00069	0.832
MOD_PKA_2	751	757	PF00069	0.801
MOD_PKA_2	770	776	PF00069	0.724
MOD_Plk_1	376	382	PF00069	0.784
MOD_Plk_1	585	591	PF00069	0.677
MOD_Plk_1	655	661	PF00069	0.823
MOD_Plk_1	691	697	PF00069	0.776
MOD_Plk_1	94	100	PF00069	0.720
MOD_Plk_2-3	472	478	PF00069	0.735
MOD_Plk_4	396	402	PF00069	0.781
MOD_Plk_4	655	661	PF00069	0.698
MOD_ProDKin_1	111	117	PF00069	0.666
MOD_ProDKin_1	198	204	PF00069	0.737
MOD_ProDKin_1	274	280	PF00069	0.831
MOD_ProDKin_1	336	342	PF00069	0.837
MOD_ProDKin_1	355	361	PF00069	0.820
MOD_ProDKin_1	487	493	PF00069	0.805
MOD_ProDKin_1	494	500	PF00069	0.727
MOD_ProDKin_1	506	512	PF00069	0.620
MOD_SUMO_for_1	228	231	PF00179	0.667
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.814
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.749
TRG_DiLeu_BaLyEn_6	523	528	PF01217	0.666
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.789
TRG_DiLeu_BaLyEn_6	730	735	PF01217	0.665
TRG_ENDOCYTIC_2	103	106	PF00928	0.637
TRG_ENDOCYTIC_2	20	23	PF00928	0.513
TRG_ENDOCYTIC_2	577	580	PF00928	0.658
TRG_ENDOCYTIC_2	71	74	PF00928	0.761
TRG_ENDOCYTIC_2	740	743	PF00928	0.696
TRG_ENDOCYTIC_2	84	87	PF00928	0.573
TRG_ENDOCYTIC_2	90	93	PF00928	0.531
TRG_ER_diArg_1	122	125	PF00400	0.692
TRG_ER_diArg_1	185	187	PF00400	0.740
TRG_ER_diArg_1	188	190	PF00400	0.750
TRG_ER_diArg_1	203	205	PF00400	0.710
TRG_ER_diArg_1	256	259	PF00400	0.676
TRG_ER_diArg_1	319	321	PF00400	0.750
TRG_ER_diArg_1	731	733	PF00400	0.745
TRG_ER_diArg_1	751	753	PF00400	0.790
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	732	736	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK26	Leptomonas seymouri	43%	94%
A0A3S5H6C2	Leishmania donovani	99%	100%
A4H5K2	Leishmania braziliensis	69%	96%
E9AMM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QHZ8	Leishmania major	91%	100%