NRDE_protein_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NRDE protein - putative

Species:

Leishmania infantum

UniProt:

A4HTT8_LEIIN

TriTrypDb:

LINF_090007600

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTT8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.533
CLV_C14_Caspase3-7	285	289	PF00656	0.375
CLV_NRD_NRD_1	233	235	PF00675	0.415
CLV_NRD_NRD_1	465	467	PF00675	0.279
CLV_NRD_NRD_1	47	49	PF00675	0.304
CLV_NRD_NRD_1	70	72	PF00675	0.328
CLV_PCSK_KEX2_1	233	235	PF00082	0.415
CLV_PCSK_KEX2_1	47	49	PF00082	0.304
CLV_PCSK_KEX2_1	70	72	PF00082	0.328
CLV_PCSK_SKI1_1	155	159	PF00082	0.719
CLV_PCSK_SKI1_1	172	176	PF00082	0.378
CLV_PCSK_SKI1_1	356	360	PF00082	0.507
DEG_Nend_UBRbox_4	1	3	PF02207	0.269
DEG_SPOP_SBC_1	319	323	PF00917	0.542
DOC_PP1_RVXF_1	464	471	PF00149	0.394
DOC_PP2B_LxvP_1	215	218	PF13499	0.457
DOC_PP2B_PxIxI_1	14	20	PF00149	0.386
DOC_PP4_FxxP_1	349	352	PF00568	0.409
DOC_PP4_FxxP_1	421	424	PF00568	0.392
DOC_SPAK_OSR1_1	62	66	PF12202	0.269
DOC_USP7_MATH_1	142	146	PF00917	0.607
DOC_USP7_MATH_1	148	152	PF00917	0.746
DOC_USP7_MATH_1	197	201	PF00917	0.717
DOC_USP7_MATH_1	239	243	PF00917	0.673
DOC_USP7_MATH_1	443	447	PF00917	0.513
DOC_USP7_MATH_1	473	477	PF00917	0.523
DOC_USP7_MATH_1	49	53	PF00917	0.274
DOC_WW_Pin1_4	184	189	PF00397	0.599
DOC_WW_Pin1_4	324	329	PF00397	0.531
DOC_WW_Pin1_4	69	74	PF00397	0.328
LIG_14-3-3_CanoR_1	155	160	PF00244	0.523
LIG_14-3-3_CanoR_1	265	273	PF00244	0.364
LIG_14-3-3_CanoR_1	346	350	PF00244	0.326
LIG_14-3-3_CanoR_1	466	471	PF00244	0.509
LIG_Actin_WH2_2	480	497	PF00022	0.375
LIG_BRCT_BRCA1_1	400	404	PF00533	0.535
LIG_BRCT_BRCA1_1	417	421	PF00533	0.216
LIG_BRCT_BRCA1_1	59	63	PF00533	0.328
LIG_DLG_GKlike_1	466	474	PF00625	0.335
LIG_eIF4E_1	221	227	PF01652	0.463
LIG_FHA_1	121	127	PF00498	0.573
LIG_FHA_1	154	160	PF00498	0.594
LIG_FHA_1	175	181	PF00498	0.433
LIG_FHA_1	28	34	PF00498	0.300
LIG_FHA_1	294	300	PF00498	0.448
LIG_FHA_1	302	308	PF00498	0.444
LIG_FHA_1	321	327	PF00498	0.381
LIG_FHA_1	37	43	PF00498	0.341
LIG_FHA_1	456	462	PF00498	0.392
LIG_FHA_1	472	478	PF00498	0.383
LIG_FHA_2	138	144	PF00498	0.703
LIG_FHA_2	190	196	PF00498	0.747
LIG_FHA_2	379	385	PF00498	0.477
LIG_LIR_Apic_2	158	164	PF02991	0.644
LIG_LIR_Apic_2	348	352	PF02991	0.319
LIG_LIR_Apic_2	418	424	PF02991	0.385
LIG_LIR_Nem_3	12	17	PF02991	0.272
LIG_LIR_Nem_3	52	56	PF02991	0.269
LIG_LIR_Nem_3	60	66	PF02991	0.269
LIG_Pex14_2	421	425	PF04695	0.546
LIG_SH2_CRK	161	165	PF00017	0.569
LIG_SH2_CRK	485	489	PF00017	0.379
LIG_SH2_NCK_1	161	165	PF00017	0.623
LIG_SH2_SRC	161	164	PF00017	0.628
LIG_SH2_STAT3	428	431	PF00017	0.277
LIG_SH2_STAT5	261	264	PF00017	0.422
LIG_SH2_STAT5	266	269	PF00017	0.491
LIG_SH2_STAT5	286	289	PF00017	0.441
LIG_SH2_STAT5	388	391	PF00017	0.637
LIG_SH2_STAT5	415	418	PF00017	0.382
LIG_SH3_1	70	76	PF00018	0.386
LIG_SH3_3	270	276	PF00018	0.489
LIG_SH3_3	307	313	PF00018	0.472
LIG_SH3_3	475	481	PF00018	0.427
LIG_SH3_3	70	76	PF00018	0.293
LIG_SUMO_SIM_par_1	434	439	PF11976	0.324
LIG_TYR_ITIM	483	488	PF00017	0.342
LIG_WW_1	218	221	PF00397	0.560
MOD_CK1_1	249	255	PF00069	0.622
MOD_CK1_1	321	327	PF00069	0.591
MOD_CK1_1	446	452	PF00069	0.674
MOD_CK1_1	453	459	PF00069	0.443
MOD_CK2_1	137	143	PF00069	0.701
MOD_CK2_1	189	195	PF00069	0.634
MOD_CK2_1	378	384	PF00069	0.535
MOD_GlcNHglycan	248	251	PF01048	0.639
MOD_GlcNHglycan	252	255	PF01048	0.575
MOD_GlcNHglycan	323	326	PF01048	0.652
MOD_GlcNHglycan	359	362	PF01048	0.540
MOD_GlcNHglycan	391	394	PF01048	0.625
MOD_GlcNHglycan	453	456	PF01048	0.527
MOD_GlcNHglycan	496	499	PF01048	0.648
MOD_GlcNHglycan	59	62	PF01048	0.328
MOD_GlcNHglycan	79	82	PF01048	0.413
MOD_GSK3_1	126	133	PF00069	0.498
MOD_GSK3_1	246	253	PF00069	0.763
MOD_GSK3_1	260	267	PF00069	0.515
MOD_GSK3_1	27	34	PF00069	0.324
MOD_GSK3_1	320	327	PF00069	0.539
MOD_GSK3_1	329	336	PF00069	0.407
MOD_GSK3_1	427	434	PF00069	0.323
MOD_GSK3_1	446	453	PF00069	0.520
MOD_LATS_1	244	250	PF00433	0.645
MOD_N-GLC_1	250	255	PF02516	0.590
MOD_NEK2_1	174	179	PF00069	0.532
MOD_NEK2_1	189	194	PF00069	0.594
MOD_NEK2_1	260	265	PF00069	0.363
MOD_NEK2_1	282	287	PF00069	0.359
MOD_NEK2_1	35	40	PF00069	0.331
MOD_NEK2_1	354	359	PF00069	0.488
MOD_NEK2_1	389	394	PF00069	0.597
MOD_NEK2_1	416	421	PF00069	0.396
MOD_NEK2_1	77	82	PF00069	0.646
MOD_PIKK_1	427	433	PF00454	0.319
MOD_PIKK_1	471	477	PF00454	0.440
MOD_PKA_1	466	472	PF00069	0.299
MOD_PKA_2	264	270	PF00069	0.372
MOD_PKA_2	27	33	PF00069	0.322
MOD_PKA_2	345	351	PF00069	0.312
MOD_PKA_2	494	500	PF00069	0.563
MOD_Plk_1	197	203	PF00069	0.637
MOD_Plk_1	354	360	PF00069	0.441
MOD_Plk_1	398	404	PF00069	0.545
MOD_Plk_2-3	345	351	PF00069	0.399
MOD_Plk_4	121	127	PF00069	0.535
MOD_Plk_4	130	136	PF00069	0.504
MOD_Plk_4	282	288	PF00069	0.375
MOD_Plk_4	416	422	PF00069	0.394
MOD_Plk_4	431	437	PF00069	0.250
MOD_Plk_4	456	462	PF00069	0.358
MOD_Plk_4	473	479	PF00069	0.374
MOD_Plk_4	49	55	PF00069	0.272
MOD_ProDKin_1	184	190	PF00069	0.602
MOD_ProDKin_1	324	330	PF00069	0.526
MOD_ProDKin_1	69	75	PF00069	0.328
MOD_SUMO_for_1	352	355	PF00179	0.422
TRG_DiLeu_BaEn_2	11	17	PF01217	0.386
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.521
TRG_ENDOCYTIC_2	221	224	PF00928	0.390
TRG_ENDOCYTIC_2	485	488	PF00928	0.510
TRG_ER_diArg_1	232	234	PF00400	0.399
TRG_NES_CRM1_1	24	36	PF08389	0.377
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R3	Leptomonas seymouri	45%	100%
A0A1X0NNG0	Trypanosomatidae	33%	100%
A0A3R7K8K9	Trypanosoma rangeli	32%	100%
A0A3S5H6B6	Leishmania donovani	100%	100%
E9AML9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
Q4QI06	Leishmania major	92%	100%
V5BMV9	Trypanosoma cruzi	31%	100%