LeishMANIAdb
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Calmodulin

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Calmodulin
Gene product:
calmodulin-like protein containing EF hand domain
Species:
Leishmania infantum
UniProt:
A4HTS8_LEIIN
TriTrypDb:
LINF_090006100
Length:
582

Annotations

Annotations by Jardim et al.

Flagella, flagellar pocket cytoskeletal bilbo1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 154
Promastigote/Amastigote: 576

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HTS8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTS8

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0030030 cell projection organization 4 1
GO:0044782 cilium organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 14
GO:0005509 calcium ion binding 5 14
GO:0043167 ion binding 2 14
GO:0043169 cation binding 3 14
GO:0046872 metal ion binding 4 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 168 172 PF00656 0.612
CLV_C14_Caspase3-7 292 296 PF00656 0.569
CLV_C14_Caspase3-7 375 379 PF00656 0.362
CLV_C14_Caspase3-7 45 49 PF00656 0.557
CLV_C14_Caspase3-7 473 477 PF00656 0.607
CLV_C14_Caspase3-7 543 547 PF00656 0.390
CLV_NRD_NRD_1 152 154 PF00675 0.586
CLV_NRD_NRD_1 261 263 PF00675 0.397
CLV_NRD_NRD_1 324 326 PF00675 0.521
CLV_NRD_NRD_1 352 354 PF00675 0.384
CLV_NRD_NRD_1 368 370 PF00675 0.429
CLV_NRD_NRD_1 474 476 PF00675 0.375
CLV_NRD_NRD_1 521 523 PF00675 0.413
CLV_PCSK_KEX2_1 152 154 PF00082 0.586
CLV_PCSK_KEX2_1 368 370 PF00082 0.436
CLV_PCSK_KEX2_1 395 397 PF00082 0.429
CLV_PCSK_KEX2_1 474 476 PF00082 0.376
CLV_PCSK_KEX2_1 521 523 PF00082 0.494
CLV_PCSK_PC1ET2_1 395 397 PF00082 0.430
CLV_PCSK_SKI1_1 179 183 PF00082 0.237
CLV_PCSK_SKI1_1 508 512 PF00082 0.435
DEG_APCC_DBOX_1 23 31 PF00400 0.474
DEG_APCC_DBOX_1 352 360 PF00400 0.384
DEG_Nend_Nbox_1 1 3 PF02207 0.354
DEG_SCF_FBW7_1 121 128 PF00400 0.678
DEG_SPOP_SBC_1 131 135 PF00917 0.614
DOC_CYCLIN_yClb1_LxF_4 12 17 PF00134 0.442
DOC_PP1_RVXF_1 12 18 PF00149 0.333
DOC_PP1_RVXF_1 177 183 PF00149 0.230
DOC_USP7_MATH_1 119 123 PF00917 0.590
DOC_USP7_MATH_1 125 129 PF00917 0.590
DOC_USP7_MATH_1 130 134 PF00917 0.536
DOC_USP7_MATH_1 157 161 PF00917 0.584
DOC_USP7_MATH_1 272 276 PF00917 0.483
DOC_USP7_MATH_1 282 286 PF00917 0.413
DOC_USP7_MATH_1 360 364 PF00917 0.430
DOC_USP7_MATH_1 372 376 PF00917 0.411
DOC_USP7_MATH_1 571 575 PF00917 0.534
DOC_USP7_UBL2_3 350 354 PF12436 0.514
DOC_USP7_UBL2_3 488 492 PF12436 0.332
DOC_USP7_UBL2_3 96 100 PF12436 0.491
DOC_WW_Pin1_4 121 126 PF00397 0.653
DOC_WW_Pin1_4 170 175 PF00397 0.561
LIG_14-3-3_CanoR_1 129 138 PF00244 0.690
LIG_14-3-3_CanoR_1 152 156 PF00244 0.524
LIG_14-3-3_CanoR_1 228 237 PF00244 0.300
LIG_14-3-3_CanoR_1 32 38 PF00244 0.489
LIG_APCC_ABBA_1 60 65 PF00400 0.308
LIG_APCC_ABBAyCdc20_2 59 65 PF00400 0.313
LIG_BIR_III_2 171 175 PF00653 0.499
LIG_BRCT_BRCA1_1 251 255 PF00533 0.297
LIG_FHA_1 110 116 PF00498 0.697
LIG_FHA_1 160 166 PF00498 0.642
LIG_FHA_1 188 194 PF00498 0.267
LIG_FHA_1 52 58 PF00498 0.444
LIG_FHA_2 211 217 PF00498 0.259
LIG_FHA_2 230 236 PF00498 0.297
LIG_FHA_2 43 49 PF00498 0.582
LIG_FHA_2 526 532 PF00498 0.452
LIG_LIR_Gen_1 230 238 PF02991 0.230
LIG_LIR_Gen_1 68 74 PF02991 0.427
LIG_LIR_Gen_1 80 90 PF02991 0.302
LIG_LIR_Nem_3 230 234 PF02991 0.230
LIG_LIR_Nem_3 235 240 PF02991 0.284
LIG_LIR_Nem_3 68 73 PF02991 0.420
LIG_LIR_Nem_3 80 85 PF02991 0.302
LIG_LYPXL_S_1 240 244 PF13949 0.307
LIG_LYPXL_yS_3 241 244 PF13949 0.288
LIG_Pex14_2 17 21 PF04695 0.320
LIG_Pex14_2 198 202 PF04695 0.300
LIG_RPA_C_Fungi 481 493 PF08784 0.462
LIG_SH2_CRK 82 86 PF00017 0.364
LIG_SH2_STAT3 86 89 PF00017 0.303
LIG_SH2_STAT5 141 144 PF00017 0.590
LIG_SH2_STAT5 231 234 PF00017 0.424
LIG_SH2_STAT5 249 252 PF00017 0.316
LIG_SH2_STAT5 562 565 PF00017 0.558
LIG_SH2_STAT5 82 85 PF00017 0.375
LIG_SH3_3 19 25 PF00018 0.390
LIG_SH3_3 87 93 PF00018 0.407
LIG_SH3_3 98 104 PF00018 0.456
LIG_Sin3_3 370 377 PF02671 0.525
LIG_SUMO_SIM_par_1 190 197 PF11976 0.269
LIG_TRAF2_1 173 176 PF00917 0.399
LIG_TRAF2_1 26 29 PF00917 0.369
MOD_CDK_SPxxK_3 170 177 PF00069 0.540
MOD_CK1_1 210 216 PF00069 0.256
MOD_CK1_1 23 29 PF00069 0.443
MOD_CK1_1 275 281 PF00069 0.473
MOD_CK1_1 36 42 PF00069 0.387
MOD_CK1_1 557 563 PF00069 0.419
MOD_CK2_1 170 176 PF00069 0.454
MOD_CK2_1 227 233 PF00069 0.247
MOD_CK2_1 23 29 PF00069 0.424
MOD_CK2_1 264 270 PF00069 0.447
MOD_CK2_1 525 531 PF00069 0.386
MOD_GlcNHglycan 117 120 PF01048 0.665
MOD_GlcNHglycan 125 128 PF01048 0.636
MOD_GlcNHglycan 210 213 PF01048 0.324
MOD_GlcNHglycan 297 300 PF01048 0.458
MOD_GlcNHglycan 35 38 PF01048 0.428
MOD_GlcNHglycan 458 461 PF01048 0.401
MOD_GSK3_1 103 110 PF00069 0.521
MOD_GSK3_1 115 122 PF00069 0.585
MOD_GSK3_1 139 146 PF00069 0.626
MOD_GSK3_1 147 154 PF00069 0.599
MOD_GSK3_1 33 40 PF00069 0.413
MOD_GSK3_1 51 58 PF00069 0.531
MOD_GSK3_1 550 557 PF00069 0.417
MOD_GSK3_1 569 576 PF00069 0.458
MOD_NEK2_1 115 120 PF00069 0.747
MOD_NEK2_1 151 156 PF00069 0.509
MOD_NEK2_1 207 212 PF00069 0.319
MOD_NEK2_1 55 60 PF00069 0.509
MOD_NEK2_2 51 56 PF00069 0.520
MOD_PIKK_1 525 531 PF00454 0.386
MOD_PIKK_1 95 101 PF00454 0.477
MOD_PKA_2 151 157 PF00069 0.567
MOD_PKA_2 227 233 PF00069 0.300
MOD_PKA_2 23 29 PF00069 0.410
MOD_PKA_2 31 37 PF00069 0.445
MOD_PKA_2 360 366 PF00069 0.464
MOD_PKA_2 544 550 PF00069 0.395
MOD_Plk_1 275 281 PF00069 0.518
MOD_Plk_1 28 34 PF00069 0.399
MOD_Plk_1 530 536 PF00069 0.514
MOD_Plk_2-3 264 270 PF00069 0.336
MOD_ProDKin_1 121 127 PF00069 0.652
MOD_ProDKin_1 170 176 PF00069 0.557
MOD_SUMO_for_1 434 437 PF00179 0.509
MOD_SUMO_rev_2 171 178 PF00179 0.376
MOD_SUMO_rev_2 183 190 PF00179 0.217
MOD_SUMO_rev_2 375 384 PF00179 0.413
MOD_SUMO_rev_2 392 397 PF00179 0.430
MOD_SUMO_rev_2 546 556 PF00179 0.411
MOD_SUMO_rev_2 64 68 PF00179 0.433
TRG_ENDOCYTIC_2 231 234 PF00928 0.309
TRG_ENDOCYTIC_2 241 244 PF00928 0.309
TRG_ENDOCYTIC_2 82 85 PF00928 0.367
TRG_ER_diArg_1 151 153 PF00400 0.614
TRG_ER_diArg_1 521 524 PF00400 0.495
TRG_ER_diArg_1 539 542 PF00400 0.276
TRG_Pf-PMV_PEXEL_1 315 320 PF00026 0.388
TRG_Pf-PMV_PEXEL_1 508 512 PF00026 0.422
TRG_Pf-PMV_PEXEL_1 524 529 PF00026 0.306
TRG_Pf-PMV_PEXEL_1 532 536 PF00026 0.353

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1II86 Leptomonas seymouri 82% 99%
A0A0S4JFD7 Bodo saltans 33% 95%
A0A0S4JWH7 Bodo saltans 50% 98%
A0A0S4KKB4 Bodo saltans 23% 85%
A0A1X0NMV7 Trypanosomatidae 58% 98%
A0A3S5H6A9 Leishmania donovani 100% 100%
A0A3S7X1F4 Leishmania donovani 23% 100%
A0A422NE50 Trypanosoma rangeli 56% 100%
A4H5I7 Leishmania braziliensis 92% 100%
A4HGH2 Leishmania braziliensis 25% 98%
A4I3K4 Leishmania infantum 23% 100%
D0A836 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 100%
D0A989 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 99%
E9AML1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9AZU4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
Q4Q8E1 Leishmania major 24% 100%
Q4QI25 Leishmania major 98% 100%
V5DJB6 Trypanosoma cruzi 56% 90%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS