N-acetylglucosaminylphosphatidylinositol deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase

Species:

Leishmania infantum

UniProt:

A4HTS2_LEIIN

TriTrypDb:

LINF_090005500

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	12
GO:0016020	membrane	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HTS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTS2

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006505	GPI anchor metabolic process	6	12
GO:0006506	GPI anchor biosynthetic process	6	12
GO:0006629	lipid metabolic process	3	12
GO:0006643	membrane lipid metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006664	glycolipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009247	glycolipid biosynthetic process	5	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019637	organophosphate metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046467	membrane lipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0046488	phosphatidylinositol metabolic process	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1903509	liposaccharide metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0000225	N-acetylglucosaminylphosphatidylinositol deacetylase activity	4	12
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	12
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	12
GO:0019213	deacetylase activity	3	12
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.411
CLV_NRD_NRD_1	120	122	PF00675	0.254
CLV_NRD_NRD_1	220	222	PF00675	0.399
CLV_NRD_NRD_1	95	97	PF00675	0.254
CLV_PCSK_KEX2_1	120	122	PF00082	0.254
CLV_PCSK_KEX2_1	95	97	PF00082	0.254
CLV_PCSK_SKI1_1	158	162	PF00082	0.304
CLV_PCSK_SKI1_1	176	180	PF00082	0.277
CLV_PCSK_SKI1_1	231	235	PF00082	0.252
DEG_APCC_KENBOX_2	160	164	PF00400	0.451
DOC_AGCK_PIF_1	237	242	PF00069	0.185
DOC_CKS1_1	48	53	PF01111	0.454
DOC_MAPK_gen_1	57	65	PF00069	0.411
DOC_MAPK_MEF2A_6	57	65	PF00069	0.411
DOC_PP1_RVXF_1	174	181	PF00149	0.556
DOC_PP4_FxxP_1	39	42	PF00568	0.356
DOC_PP4_FxxP_1	48	51	PF00568	0.366
DOC_USP7_MATH_1	27	31	PF00917	0.416
DOC_USP7_UBL2_3	78	82	PF12436	0.454
DOC_WW_Pin1_4	112	117	PF00397	0.368
DOC_WW_Pin1_4	47	52	PF00397	0.366
LIG_14-3-3_CanoR_1	174	179	PF00244	0.451
LIG_14-3-3_CanoR_1	201	205	PF00244	0.413
LIG_14-3-3_CanoR_1	60	64	PF00244	0.420
LIG_BRCT_BRCA1_1	86	90	PF00533	0.479
LIG_CaM_IQ_9	168	183	PF13499	0.488
LIG_CSL_BTD_1	113	116	PF09270	0.368
LIG_FHA_1	173	179	PF00498	0.398
LIG_FHA_1	200	206	PF00498	0.445
LIG_FHA_1	48	54	PF00498	0.454
LIG_GBD_Chelix_1	11	19	PF00786	0.252
LIG_LIR_Apic_2	45	51	PF02991	0.360
LIG_LIR_Gen_1	202	211	PF02991	0.463
LIG_LIR_Gen_1	212	220	PF02991	0.383
LIG_LIR_Gen_1	238	246	PF02991	0.192
LIG_LIR_Gen_1	62	73	PF02991	0.356
LIG_LIR_Nem_3	138	142	PF02991	0.454
LIG_LIR_Nem_3	177	183	PF02991	0.505
LIG_LIR_Nem_3	202	207	PF02991	0.483
LIG_LIR_Nem_3	238	243	PF02991	0.283
LIG_LIR_Nem_3	62	68	PF02991	0.461
LIG_LIR_Nem_3	87	93	PF02991	0.375
LIG_NRBOX	12	18	PF00104	0.312
LIG_PALB2_WD40_1	225	233	PF16756	0.360
LIG_PCNA_yPIPBox_3	107	121	PF02747	0.356
LIG_PDZ_Class_3	244	249	PF00595	0.283
LIG_Pex14_2	230	234	PF04695	0.238
LIG_PTB_Apo_2	67	74	PF02174	0.375
LIG_PTB_Phospho_1	67	73	PF10480	0.389
LIG_SH2_CRK	240	244	PF00017	0.193
LIG_SH2_GRB2like	242	245	PF00017	0.178
LIG_SH2_PTP2	182	185	PF00017	0.446
LIG_SH2_STAT5	182	185	PF00017	0.437
LIG_SH2_STAT5	191	194	PF00017	0.427
LIG_SH2_STAT5	232	235	PF00017	0.277
LIG_SH2_STAT5	240	243	PF00017	0.196
LIG_SH3_3	110	116	PF00018	0.421
LIG_SH3_3	204	210	PF00018	0.385
LIG_Sin3_3	14	21	PF02671	0.171
LIG_Sin3_3	204	211	PF02671	0.393
LIG_SUMO_SIM_anti_2	202	209	PF11976	0.392
LIG_SUMO_SIM_anti_2	3	8	PF11976	0.332
LIG_UBA3_1	15	22	PF00899	0.187
LIG_WRC_WIRS_1	136	141	PF05994	0.360
MOD_CK1_1	132	138	PF00069	0.336
MOD_CK1_1	200	206	PF00069	0.450
MOD_CK1_1	238	244	PF00069	0.185
MOD_CK1_1	30	36	PF00069	0.520
MOD_CK2_1	209	215	PF00069	0.586
MOD_GlcNHglycan	144	147	PF01048	0.211
MOD_GlcNHglycan	86	89	PF01048	0.237
MOD_GSK3_1	131	138	PF00069	0.426
MOD_GSK3_1	193	200	PF00069	0.496
MOD_GSK3_1	209	216	PF00069	0.364
MOD_GSK3_1	26	33	PF00069	0.420
MOD_NEK2_1	193	198	PF00069	0.549
MOD_NEK2_1	26	31	PF00069	0.542
MOD_NEK2_1	52	57	PF00069	0.389
MOD_NEK2_1	66	71	PF00069	0.336
MOD_NEK2_1	84	89	PF00069	0.462
MOD_NEK2_2	27	32	PF00069	0.423
MOD_PK_1	129	135	PF00069	0.336
MOD_PKA_2	200	206	PF00069	0.410
MOD_PKA_2	59	65	PF00069	0.499
MOD_Plk_4	122	128	PF00069	0.449
MOD_Plk_4	132	138	PF00069	0.375
MOD_Plk_4	200	206	PF00069	0.439
MOD_Plk_4	209	215	PF00069	0.392
MOD_Plk_4	238	244	PF00069	0.185
MOD_ProDKin_1	112	118	PF00069	0.368
MOD_ProDKin_1	47	53	PF00069	0.366
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.533
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.375
TRG_ENDOCYTIC_2	182	185	PF00928	0.412
TRG_ENDOCYTIC_2	232	235	PF00928	0.176
TRG_ENDOCYTIC_2	240	243	PF00928	0.194
TRG_ENDOCYTIC_2	73	76	PF00928	0.479
TRG_ER_diArg_1	119	121	PF00400	0.454
TRG_ER_diArg_1	173	176	PF00400	0.413
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P5	Leptomonas seymouri	70%	100%
A0A0S4JQJ0	Bodo saltans	50%	100%
A0A1X0NPJ2	Trypanosomatidae	61%	100%
A0A3R7NBF4	Trypanosoma rangeli	54%	99%
A0A3S5H6A6	Leishmania donovani	100%	100%
A4H5I1	Leishmania braziliensis	92%	100%
A6QQ24	Bos taurus	37%	98%
D0A982	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	91%
D4B4K9	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	26%	74%
E9AMK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O35790	Rattus norvegicus	38%	99%
P23797	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	82%
Q54C64	Dictyostelium discoideum	33%	97%
Q5SX19	Mus musculus	38%	99%
Q8I8A4	Leishmania major	97%	100%
Q9HDW9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q9Y2B2	Homo sapiens	33%	99%
V5DJB0	Trypanosoma cruzi	55%	99%