J domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTS0_LEIIN

TriTrypDb:

LINF_090005300

Length:

619

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTS0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	3
GO:0031123	RNA 3'-end processing	7	3
GO:0031124	mRNA 3'-end processing	8	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.507
CLV_NRD_NRD_1	117	119	PF00675	0.425
CLV_NRD_NRD_1	189	191	PF00675	0.308
CLV_NRD_NRD_1	226	228	PF00675	0.521
CLV_NRD_NRD_1	278	280	PF00675	0.472
CLV_NRD_NRD_1	414	416	PF00675	0.385
CLV_NRD_NRD_1	567	569	PF00675	0.675
CLV_PCSK_KEX2_1	117	119	PF00082	0.533
CLV_PCSK_KEX2_1	189	191	PF00082	0.308
CLV_PCSK_KEX2_1	278	280	PF00082	0.455
CLV_PCSK_KEX2_1	413	415	PF00082	0.393
CLV_PCSK_KEX2_1	479	481	PF00082	0.719
CLV_PCSK_KEX2_1	567	569	PF00082	0.623
CLV_PCSK_KEX2_1	580	582	PF00082	0.455
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.478
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.614
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.634
CLV_PCSK_SKI1_1	12	16	PF00082	0.390
CLV_PCSK_SKI1_1	149	153	PF00082	0.475
CLV_PCSK_SKI1_1	18	22	PF00082	0.388
CLV_PCSK_SKI1_1	368	372	PF00082	0.435
CLV_PCSK_SKI1_1	410	414	PF00082	0.452
CLV_PCSK_SKI1_1	603	607	PF00082	0.639
DEG_Nend_UBRbox_2	1	3	PF02207	0.484
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.365
DOC_MAPK_gen_1	278	286	PF00069	0.475
DOC_MAPK_gen_1	522	531	PF00069	0.491
DOC_MAPK_gen_1	567	574	PF00069	0.540
DOC_MAPK_MEF2A_6	399	408	PF00069	0.532
DOC_MAPK_MEF2A_6	567	576	PF00069	0.513
DOC_PP2B_LxvP_1	102	105	PF13499	0.309
DOC_PP2B_LxvP_1	76	79	PF13499	0.374
DOC_PP4_FxxP_1	497	500	PF00568	0.509
DOC_USP7_MATH_1	237	241	PF00917	0.363
DOC_USP7_MATH_1	296	300	PF00917	0.479
DOC_USP7_MATH_1	489	493	PF00917	0.559
DOC_USP7_MATH_1	561	565	PF00917	0.454
DOC_USP7_UBL2_3	330	334	PF12436	0.488
DOC_USP7_UBL2_3	550	554	PF12436	0.731
DOC_WW_Pin1_4	343	348	PF00397	0.441
DOC_WW_Pin1_4	460	465	PF00397	0.572
DOC_WW_Pin1_4	485	490	PF00397	0.559
LIG_14-3-3_CanoR_1	227	231	PF00244	0.501
LIG_14-3-3_CanoR_1	295	301	PF00244	0.552
LIG_14-3-3_CanoR_1	423	427	PF00244	0.509
LIG_14-3-3_CanoR_1	9	19	PF00244	0.410
LIG_Actin_WH2_2	174	191	PF00022	0.368
LIG_Actin_WH2_2	282	300	PF00022	0.495
LIG_APCC_ABBA_1	424	429	PF00400	0.343
LIG_APCC_ABBAyCdc20_2	423	429	PF00400	0.351
LIG_Clathr_ClatBox_1	397	401	PF01394	0.427
LIG_CtBP_PxDLS_1	571	575	PF00389	0.510
LIG_deltaCOP1_diTrp_1	205	215	PF00928	0.307
LIG_deltaCOP1_diTrp_1	311	318	PF00928	0.324
LIG_deltaCOP1_diTrp_1	43	51	PF00928	0.313
LIG_deltaCOP1_diTrp_1	490	497	PF00928	0.569
LIG_DLG_GKlike_1	399	406	PF00625	0.468
LIG_FHA_1	269	275	PF00498	0.434
LIG_FHA_1	346	352	PF00498	0.477
LIG_FHA_1	577	583	PF00498	0.597
LIG_FHA_1	58	64	PF00498	0.399
LIG_FHA_2	153	159	PF00498	0.468
LIG_FHA_2	486	492	PF00498	0.575
LIG_FHA_2	593	599	PF00498	0.483
LIG_FHA_2	602	608	PF00498	0.495
LIG_LIR_Apic_2	495	500	PF02991	0.642
LIG_LIR_Gen_1	148	157	PF02991	0.445
LIG_LIR_Gen_1	168	178	PF02991	0.417
LIG_LIR_Gen_1	393	400	PF02991	0.355
LIG_LIR_Gen_1	443	453	PF02991	0.455
LIG_LIR_Nem_3	148	153	PF02991	0.406
LIG_LIR_Nem_3	206	212	PF02991	0.330
LIG_LIR_Nem_3	310	315	PF02991	0.327
LIG_LIR_Nem_3	393	397	PF02991	0.352
LIG_LIR_Nem_3	43	48	PF02991	0.359
LIG_LIR_Nem_3	443	449	PF02991	0.394
LIG_LIR_Nem_3	462	468	PF02991	0.520
LIG_LIR_Nem_3	491	497	PF02991	0.509
LIG_PCNA_yPIPBox_3	423	437	PF02747	0.582
LIG_Pex14_1	109	113	PF04695	0.461
LIG_Pex14_1	146	150	PF04695	0.357
LIG_Pex14_1	166	170	PF04695	0.324
LIG_Pex14_1	45	49	PF04695	0.312
LIG_Pex14_2	6	10	PF04695	0.518
LIG_SH2_CRK	360	364	PF00017	0.500
LIG_SH2_STAT3	373	376	PF00017	0.519
LIG_SH2_STAT5	41	44	PF00017	0.369
LIG_SH2_STAT5	436	439	PF00017	0.424
LIG_SH2_STAT5	48	51	PF00017	0.350
LIG_SH3_3	493	499	PF00018	0.571
LIG_SUMO_SIM_par_1	19	27	PF11976	0.538
LIG_SUMO_SIM_par_1	30	38	PF11976	0.448
LIG_SUMO_SIM_par_1	592	598	PF11976	0.514
LIG_TRAF2_1	280	283	PF00917	0.437
LIG_TRAF2_1	459	462	PF00917	0.582
LIG_TRAF2_1	506	509	PF00917	0.614
LIG_UBA3_1	403	410	PF00899	0.418
LIG_WW_3	469	473	PF00397	0.603
MOD_CK1_1	13	19	PF00069	0.343
MOD_CK1_1	22	28	PF00069	0.399
MOD_CK1_1	257	263	PF00069	0.614
MOD_CK1_1	393	399	PF00069	0.487
MOD_CK1_1	90	96	PF00069	0.487
MOD_CK2_1	127	133	PF00069	0.469
MOD_CK2_1	152	158	PF00069	0.550
MOD_CK2_1	456	462	PF00069	0.553
MOD_CK2_1	489	495	PF00069	0.572
MOD_CK2_1	503	509	PF00069	0.587
MOD_CK2_1	592	598	PF00069	0.481
MOD_CK2_1	601	607	PF00069	0.490
MOD_CK2_1	93	99	PF00069	0.419
MOD_GlcNHglycan	12	15	PF01048	0.330
MOD_GlcNHglycan	231	234	PF01048	0.451
MOD_GlcNHglycan	263	266	PF01048	0.683
MOD_GlcNHglycan	585	588	PF01048	0.525
MOD_GlcNHglycan	76	79	PF01048	0.324
MOD_GSK3_1	135	142	PF00069	0.454
MOD_GSK3_1	168	175	PF00069	0.412
MOD_GSK3_1	19	26	PF00069	0.473
MOD_GSK3_1	257	264	PF00069	0.615
MOD_GSK3_1	266	273	PF00069	0.533
MOD_GSK3_1	341	348	PF00069	0.588
MOD_GSK3_1	456	463	PF00069	0.605
MOD_GSK3_1	485	492	PF00069	0.577
MOD_GSK3_1	499	506	PF00069	0.556
MOD_GSK3_1	542	549	PF00069	0.673
MOD_GSK3_1	572	579	PF00069	0.582
MOD_GSK3_1	611	618	PF00069	0.602
MOD_N-GLC_1	572	577	PF02516	0.511
MOD_NEK2_1	100	105	PF00069	0.433
MOD_NEK2_1	173	178	PF00069	0.382
MOD_NEK2_1	268	273	PF00069	0.603
MOD_NEK2_1	31	36	PF00069	0.391
MOD_NEK2_1	404	409	PF00069	0.503
MOD_NEK2_1	601	606	PF00069	0.522
MOD_PIKK_1	197	203	PF00454	0.291
MOD_PIKK_1	313	319	PF00454	0.501
MOD_PIKK_1	489	495	PF00454	0.564
MOD_PIKK_1	90	96	PF00454	0.286
MOD_PK_1	581	587	PF00069	0.587
MOD_PKA_1	117	123	PF00069	0.452
MOD_PKA_2	117	123	PF00069	0.452
MOD_PKA_2	226	232	PF00069	0.505
MOD_PKA_2	422	428	PF00069	0.477
MOD_PKB_1	546	554	PF00069	0.545
MOD_Plk_1	204	210	PF00069	0.467
MOD_Plk_1	439	445	PF00069	0.563
MOD_Plk_1	489	495	PF00069	0.619
MOD_Plk_1	572	578	PF00069	0.477
MOD_Plk_1	601	607	PF00069	0.671
MOD_Plk_2-3	456	462	PF00069	0.607
MOD_Plk_4	177	183	PF00069	0.438
MOD_Plk_4	245	251	PF00069	0.361
MOD_Plk_4	270	276	PF00069	0.323
MOD_Plk_4	31	37	PF00069	0.389
MOD_Plk_4	393	399	PF00069	0.380
MOD_Plk_4	561	567	PF00069	0.485
MOD_Plk_4	93	99	PF00069	0.521
MOD_ProDKin_1	343	349	PF00069	0.437
MOD_ProDKin_1	460	466	PF00069	0.575
MOD_ProDKin_1	485	491	PF00069	0.558
MOD_SUMO_rev_2	310	315	PF00179	0.407
MOD_SUMO_rev_2	322	332	PF00179	0.443
TRG_DiLeu_BaEn_2	26	32	PF01217	0.348
TRG_ENDOCYTIC_2	150	153	PF00928	0.497
TRG_ENDOCYTIC_2	360	363	PF00928	0.449
TRG_ENDOCYTIC_2	48	51	PF00928	0.451
TRG_ER_diArg_1	116	118	PF00400	0.413
TRG_ER_diArg_1	188	190	PF00400	0.312
TRG_ER_diArg_1	566	568	PF00400	0.687
TRG_NES_CRM1_1	244	258	PF08389	0.372
TRG_NES_CRM1_1	520	532	PF08389	0.647
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9R7	Leptomonas seymouri	65%	99%
A0A0S4IQN5	Bodo saltans	28%	100%
A0A1X0NMW7	Trypanosomatidae	34%	98%
A0A3S7WQJ2	Leishmania donovani	100%	100%
A0A422NEC5	Trypanosoma rangeli	35%	99%
A4H5H9	Leishmania braziliensis	85%	100%
D0A979	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	97%
E9AMK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QI33	Leishmania major	94%	100%
V5BN50	Trypanosoma cruzi	36%	100%