Secreted protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTR9_LEIIN

TriTrypDb:

LINF_090005200

Length:

107

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HTR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	69	71	PF00675	0.574
CLV_PCSK_FUR_1	67	71	PF00082	0.560
CLV_PCSK_KEX2_1	69	71	PF00082	0.574
CLV_PCSK_PC7_1	65	71	PF00082	0.573
DOC_PP2B_LxvP_1	9	12	PF13499	0.538
LIG_14-3-3_CanoR_1	26	34	PF00244	0.415
LIG_14-3-3_CanoR_1	48	56	PF00244	0.391
LIG_Actin_WH2_2	32	50	PF00022	0.297
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_EH_1	60	64	PF12763	0.354
LIG_FHA_1	4	10	PF00498	0.566
LIG_FHA_2	99	105	PF00498	0.398
LIG_LIR_Apic_2	55	59	PF02991	0.351
LIG_LIR_Gen_1	60	71	PF02991	0.369
LIG_LIR_Nem_3	50	56	PF02991	0.387
LIG_LIR_Nem_3	60	66	PF02991	0.377
LIG_LIR_Nem_3	95	100	PF02991	0.356
LIG_Pex14_2	76	80	PF04695	0.375
LIG_SH2_STAT5	100	103	PF00017	0.361
LIG_SH2_STAT5	53	56	PF00017	0.378
LIG_SH3_1	56	62	PF00018	0.349
LIG_SH3_3	56	62	PF00018	0.349
LIG_SH3_3	9	15	PF00018	0.536
LIG_TYR_ITIM	42	47	PF00017	0.363
MOD_CK1_1	3	9	PF00069	0.584
MOD_CK2_1	98	104	PF00069	0.359
MOD_N-GLC_1	17	22	PF02516	0.342
MOD_NEK2_1	16	21	PF00069	0.593
MOD_NEK2_1	25	30	PF00069	0.523
MOD_NEK2_1	47	52	PF00069	0.342
MOD_PKA_2	25	31	PF00069	0.415
MOD_PKA_2	47	53	PF00069	0.430
MOD_Plk_1	17	23	PF00069	0.603
TRG_ENDOCYTIC_2	44	47	PF00928	0.304
TRG_ER_diArg_1	66	69	PF00400	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8M9	Bodo saltans	65%	100%
A0A1X0NMV9	Trypanosomatidae	84%	100%
A0A3S5H6A4	Leishmania donovani	100%	100%
A0A422NE39	Trypanosoma rangeli	85%	100%
A4H5H8	Leishmania braziliensis	99%	100%
D0A978	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	67%
E9AMK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5B330	Trypanosoma cruzi	84%	100%